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Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis

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World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： yu-zhe cao Guang-Lei zheng Tian-Qi Zhang Hong-Yan Shao Jia-yu Pan Zi-Lin Huang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocellular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-L1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-L1 blockades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,P<0.001)and a greater incidence of adverse events(94.3%vs 75.4%,P<0.001).CONCLUSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

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Camrelizumab,apatinib and hepatic artery infusion chemotherapy combined with microwave ablation for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3481-3495页

作者： Meng-Xuan Zuo Chao An yu-zhe cao Jia-yu Pan Lu-Ping Xie Xin-Jing Yang Wang Li Pei-Hong Wu Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Interventional Ultrasound Chinese General PLA HospitalBeijing 100853China Department of Medical Imaging and Interventional Radiology Sun Yatsen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy and camrelizumab plus apatinib(TRIPLET protocol)is promising for advanced hepatocellular carcinoma(Ad-HCC).However,the usefulness of microwave ablation(MWA)after TRIPLET is still *** To compare the efficacy and safety of TRIPLET alone(T-A)vs TRIPLET-MWA(TM)for *** From January 2018 to March 2022,217 Ad-HCC patients were retrospectively *** them,122 were included in the T-A group,and 95 were included in the T-M group.A propensity score matching(PSM)was applied to balance *** survival(OS)was compared using the Kaplan-Meier curve with the log-rank *** overall objective response rate(ORR)and major complications were also *** After PSM,82 patients were included both the T-A group and the T-M *** ORR(85.4%)in the T-M group was significantly higher than that(65.9%)in the T-A group(P<0.001).The cumulative 1-,2-,and 3-year OS rates were 98.7%,93.4%,and 82.0%in the T-M group and 85.1%,63.1%,and 55.0%in the T-A group(hazard ratio=0.22;95%confidence interval:0.10-0.49;P<0.001).The incidence of major complications was 4.9%(6/122)in the T-A group and 5.3%(5/95)in the T-M group,which were not significantly different(P=1.000).CONCLUSION T-M can provide better survival outcomes and comparable safety for Ad-HCC than T-A.

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Molecular targeting agent Programmed cell death protein 1 inhibitors Microwave ablation

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Particles attrition of binary mixtures in the coal-fueled chemical looping system based on fluidized bed

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Particuology 2024年第3期86卷 281-290页

作者： Heyu Li zhe Sun Yan cao Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Bejing 100049China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China College of Chemistry and Chemical Engineering Anhui UniversityHefei230601China

In this work,a reactive air jet attrition device with auto-recording and collection of elutriated fines was *** established insights into the physiochemical interaction and further correlated attrition behaviors between char and oxygen carriers under various operation *** attrition rate increased by over 110% upon the introduced CO_(2),which brought in the significant effect of thermo-chemical stress,similarly in effects of the increased char addition ratio and the decreased sizes of char or hematite in different *** the char-hematite co-attrition process,the elutriated carbon loss of char with poor mechanical strength was found to be over 10%,while the reactive iron loss of hematite was found to be 6.3%,and was enriched in elutriated *** reaction-derived thermochemical stress and the collision-derived mechanical stress jointly controls the particle attrition during the cyclic transformation of oxygen carrier particles in coal-fueled chemical looping fluidization,especially sig-nificant in its reduction stage.

关键词： Attrition Binary species Chemical looping Oxygen carrier CO_(2)capture

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Dynamic Setting Method of Assessment Indicators for Power Curves of Renewable Energy Sources Considering Scarcity of Reserve Resources

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 101-114页

作者： Minghao cao Jilai yu the Department of Electrical Engineering Harbin Institute of TechnologyHarbinChina

With the increasing proportion of renewable energy sources(RESs)in power grid,the reserve resource(RR)scarcity for correcting power deviation of RESs has become a potential ***,the power curve of RES needs to be more rigorously *** RR scarcity varies during different time periods,so the values of assessment indicators should be dynamically *** assessment indicators in this paper include two aspects,i.e.,deviation exemption ratio and penalty ***,this paper proposes a method for dynamically calculating the supply capacity and RR cost,primarily taking into account the operating status of thermal units,forecast information of RES,and load ***,after clarifying the logical relationship between the degree of RR scarcity and the values of assessment indicators,this paper establishes a mapping function between *** on this mapping function,a dynamic setting method for assessment indicators is *** the future,RES will generally be equipped with battery energy storage systems(BESSs).Reasonably utilizing BESSs to reduce the power deviation of RESs can increase the expected income of ***,this paper proposes a power curve optimization strategy for RESs considering self-owned *** case study demonstrates that the dynamic setting method of assessment indicators can increase the revenue of RESs while ensuring that the penalty fees paid by RESs to the grid are sufficient to cover the RR ***,the power curve optimization strategy can help RESs further increase income and fully utilize BESSs to reduce power deviation.

关键词： Renewable energy battery energy storage system(BESS) power curve assessment reserve service parameter setting

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Biological sources, paleoenvironment, and organic matter enrichment in source rocks of the Ordovician Majiagou Formation, Ordos Basin, China:Evidence from biomarkers,microfossils, and inorganic geochemical analyses

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Journal of Palaeogeography 2024年第1期13卷 92-115页

作者： Jing-Jing cao Wen-zhe Gang Shang-Ru Yang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China College of Geosciences China University of Petroleum(Bejing)Beijing 102249China Oil and Gas Technology Research Institute PetroChina Changqing Oifield CompanyXi'an 710018Shaanxi ProvinceChina

Carbonate deposits in the Ordovivian Majiagou Formation are significant source rocks for natural gas generation in the Ordos Basin, northwestern China. Previous studies mainly focused on the organic matter enrichment mechanism of shales rather than carbonate rocks. The biological sources and paleoenvironment of carbonate source rocks, and the main controlling factors of organic matter enrichment in the carbonate source rocks were studied in this paper in combination with evidence from biomarkers, microfossils and inorganic geochemistry analysis. The results show that four types of microfacies were identified in the Majiagou Formation, respectively as: mud flat microfacies, mud-dolomite flat microfacies, dolomite flat microfacies, and open marine microfacies. The biological sources of organic matter are chiefly planktonic algae, followed by bacteria. The mud flat and mud-dolomite flat contain a high abundance of terrigenous detrital inputs, as indicated by the high content of Al_(2)O_(3), TiO_(2), Th, and Zr. The low Sr/Cu and high Rb/Sr values reveal warm and humid paleoclimate conditions in the mud flat and mud-dolomite flat, whereas the dolomite flat and open marine were likely formed in hot and arid paleoclimate conditions. The mud flat and mud-dolomite flat deposits were characterized by high paleoproductivity of the Majiagou Formation. Low Sr/Ba values were found in the mud flat samples, indicating fresh to brackish water condition, whereas samples of other facies have a relatively high degree of salinity. Based on U_(auth), Mo_(auth), Cr_(auth), Co_(auth), δCe, and δEu values, the mud flat microfacies was formed in a suboxic and anoxic environment, whereas the mud-dolomite flat, dolomite flat and open marine microfacies were within dysoxic to oxic conditions. A model of organic matter enrichment in the Majiagou Formation is thus established. The level of terrigenous detrital inputs is the principal factor of organic matter enrichment in the Majiagou Formation,

关键词： Biological source Microfacies Trace elements Organic matter Majiagou Formation Ordos Basin

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Sub-10-nm-sized Au@AuxIr1-x metal-core/alloy-shell nanoparticles as highly durable catalysts for acidic water splitting

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National Science Review 2024年第4期11卷 130-140页

作者： Huimin Wang zhe-ning Chen yuanyuan Wang Dongshuang Wu Minna cao Fanfei Sun Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences School of Materials Science and Engineering Nanyang Technological University Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

The absence of efficient and durable catalysts for oxygen evolution reaction（OER） is the main obstacle to hydrogen production through water splitting in an acidic ele ***,we report a controllable synthesis method of surface IrOxwith changing Au/Ir compositions by constructing a range of sub-10-nm-sized core-shell nanocatalysts composed of an Au core and AuxIr1-xalloy *** particular,Au@Au0.43Ir0.57exhibits 4.5 times higher intrinsic OER activity than that of the commercial Ir/*** X-ray-based spectroscopies,electron microscopy and density functional theory calculations revealed a balanced binding of reaction intermediates with enhanced *** water-splitting cell using a load of 0.02 mgIr/cm2of Au@Au0.43Ir0.57as both anode and cathode can reach 10 mA/cm2at 1.52 V and maintain activity for at least194 h,which is better than the cell using the commercial couple Ir/C‖Pt/C（1.63 V,0.2 h）.

关键词： controllable synthesis of surface IrOx oxygen evolution reaction acidic water splitting catalytic stability transition metal catalysts

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A novel control strategy for reproducing the floor motions of high-rise buildings by earthquake-simulating shake tables

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Earthquake Research Advances 2024年第1期4卷 67-75页

作者： yuteng cao zhe Qu Xiaodong Ji Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin150080China Key Laboratory of Civil Engineering Safety and Durability of China Education Ministry Department of Civil EngineeringTsinghua UniversityBeijing100084China

To enable the experimental assessment of the seismic performance of full-scale nonstructural elements with multiple engineering parameters(EDPs),a three-layer testbed named Nonstructural Element Simulator on Shake Table(NEST)has been *** testbed consists of three consecutive floors of steel *** bottom two floors provide a space to accommodate a full-scale *** fully explore the flexibility of NEST,we propose a novel control strategy to generate the required shake table input time histories for the testbed to track the target floor motions of the buildings of interest with high *** control strategy contains two parts:an inverse dynamic compensation via simulation of feedback control systems(IDCS)algorithm and an offline iteration procedure based on a refined nonlinear numerical model of the *** key aspects of the control strategy were introduced in this *** tests were conducted to simulate the seismic responses of a full-scale office room on the 21^(st)floor of a 42-story high-rise *** test results show that the proposed control strategy can reproduce the target floor motions of the building of interest with less than 20%errors within the specified frequency range.

关键词： Shake table test Nonstructural element High-rise building Open-loop IDCS algorithm Off-line iteration

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Effect of relative humidity on the desulfurization performance of calcium-based desulfurizer

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Journal of Environmental Sciences 2024年第4期138卷 179-188页

作者： Juan Lǖ yu Fu Haiyan yu HuanWang zhe Wang Haiyan Chen School of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China Guangyuan Emergency Management bureau Guangyuan 628000China

Low desulfurization efficiency impedes the wide application of dry desulfurization technology,which is a low-cost and simple process,and one significant solution is the development and manufacture of high-performance *** this study,firstly,a steam jet mill was used to digest quicklime;then,we utilized numerical simulation to study the flow field distribution and analyze the driving factors of quicklime digestion;and lastly,the desulfurization performance of the desulfurizer was evaluated under different relative *** results show that the desulfurizer prepared via the steam jet mill had better apparent activity than traditional ***,the entire jet flow field of the steam jet mill is in a supersonic and highly turbulent flow state,with high crushing intensity and good particle acceleration *** contact with the nascent surface maximizes the formation of slaked *** experiments demonstrated that the operating time with 100%desulfurization efficiency and the“break-through”time for the desulfurizer prepared via the steam jet mill is longer than that of traditional desulfurizers,and has significant advantages,especially at low flue gas relative *** with traditional desulfurizers,the desulfurizer prepared via steam jet mill expands the range of acceptable flue gas temperature,and the failure temperature is 1.625 times that of traditional *** work breaks through the technical bottleneck of low dry desulfurization efficiency,which is an important step in pushing forward the application of dry desulfurization.

关键词： Dry desulfurization Relative humidity Desulfurization efficiency High-efficiency desulfurizer Quicklime digestion

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A Temporal Convolutional Network Based Hybrid Model for Short-term Electricity Price Forecasting

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1119-1130页

作者： Haoran Zhang Weihao Hu Di cao Qi Huang zhe Chen Frede Blaabjerg School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengduChina Department of Energy Technology Aalborg UniversityAalborgDenmark IEEE

Electricity prices have complex features,such as high frequency,multiple seasonality,and *** factors will make the prediction of electricity prices ***,accurate electricity price prediction is important for energy producers and consumers to develop bidding *** improve the accuracy of prediction by using each algorithms’advantages,this paper proposes a hybrid model that uses the Empirical Mode Decomposition(EMD),Autoregressive Integrated Moving Average(ARIMA),and Temporal Convolutional Network(TCN).EMD is used to decompose the electricity prices into low and high frequency *** frequency components are forecasted by the ARIMA model and the high frequency series are predicted by the TCN *** results using the realistic electricity price data from Pennsylvania-New Jersey-Maryland(PJM)electricity markets show that the proposed method has a higher prediction accuracy than other single methods and hybrid methods.

关键词： Autoregressive integrated moving average model electricity price forecasting empirical mode decomposition temporal convolutional network

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Homological dimensions of gentle algebras via geometric models

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Science China Mathematics 2024年第4期67卷 733-766页

作者： yu-zhe Liu Hanpeng Gao Zhaoyong Huang Department of Mathematics Nanjing UniversityNanjing 210093China School of Mathematical Sciences Anhui UniversityHefei 230601China

Let A=kQ/I be a finite-dimensional basic algebra over an algebraically closed field k,which is a gentle algebra with the marked ribbon surface(SA,MA,ΓA).It is known that SAcan be divided into some elementary polygons{Δi|1≤i≤d}byΓA,which has exactly one side in the boundary of ***■(Δi)be the number of sides ofΔibelonging toΓAif the unmarked boundary component of SAis not a side ofΔi;otherwise,■(Δi)=∞,and let f-Δbe the set of all the non-co-elementary polygons and FA(resp.f-FA)be the set of all the forbidden threads(*** finite length).Then we have(1)the global dimension of A is max1≤i≤d■(Δi)-1=maxΠ∈FAl(Π),where l(Π)is the length ofΠ;(2)the left and right self-injective dimensions of A are 0,if Q is either a point or an oriented cycle with full ***Δi∈f-Δ{1,■(Δi)-1}=max n∈f-F_(A)l(П),otherwise,As a consequence,we get that the finiteness of the global dimension of gentle algebras is invariant under AvellaGeiss(AG)-*** addition,we get that the number of indecomposable non-projective Gorenstein projective modules over gentle algebras is also invariant under AG-equivalence.

关键词： global dimension self-injective dimension gentle algebras marked ribbon surfaces geometric models AG-equivalence

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