检索结果-南通市图书馆

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu Tao Zhu Cheng zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Response of Ecosystem Respiration to Experimental Warming and Clipping at Daily Time Scale in an Alpine Meadow of Tibet

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2013年第3期10卷 455-463页

作者： FU Gang SHEN Zhen-xi ZHANG Xian-zhou yu Cheng-qun zhou yu-ting LI yun-long YANG Peng-wan Lhasa Plateau Ecosystem Research Station Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences University of Chinese Academy of Sciences

The alpine meadow, as one of the typical vegetation types on the Tibetan Plateau, is one of the most sensitive terrestrial ecosystems to climate warming. However, how climate warming affects the carbon cycling of the alpine meadow on the Tibetan Plateau is not very dear. A field experiment under controlled experimental warming and clipping conditions was conducted in an alpine meadow on the Northern Tibetan Plateau since July 2008. Open top chambers （0TCs） were used to simulate climate warming. The main objective of this study was to examine the responses of ecosystem respiration （Reco） and its temperature sensitivity to experimental warming and clipping at daily time scale. Therefore, we measured Reco once or twice a month from July to September in 2010, from June to September in 2011 and from August to September in 2012. Air temperature dominated daily variation of Reco whether or not experimental warming and clipping were present. Air temperature was exponentially correlated with Reco and it could significantly explain 58-96% variation of Redo at daily time scale. Experimental warming and clipping decreased daily mean Reco by 5.8-37.7% and -11.9-23.0%, respectively, although not all these changes were significant. Experimental warming tended to decrease the temperature sensitivity of Reco, whereas clipping tended to increase the temperature sensitivity of Reco at daily time scale. Our findings suggest that Reco wasmainly controlled by air temperature and may acclimate to climate warming due to its lower temperature sensitivity under experimental warming at daily time scale.

关键词： Acclimation Air temperature Open topchamber Temperature sensitivity Respirationquotient ( Q10)

弘扬“抗击非典精神” 加强军队医学伦理学教育

在线全文

学校读者我要写书评

暂无评论

中国医学伦理学 2003年第5期16卷 57-58页

作者：覃昱林云周辉李涛石燕飞刘江峰 76160部队卫生处

医学伦理学教育是医疗卫生事业中一个重要组成部分 ,而军队的医学伦理学教育既有其特殊性又有重大的现实意义。结合广大医务人员在抗击非典中表现出来的“抗击非典精神”及我军医学伦理学现状。

关键词：军队医学伦理学教育抗击非典医疗卫生事业

Advancing Modernisation Through Exchanges

在线全文

学校读者我要写书评

暂无评论

ChinAfrica 2025年第1期17卷 16-17页

作者： zhou QIAN HU LANYIN Institute of African Studies Zhejiang Normal University Zhejiang Normal University

In his keynote speech at the open-ing ceremony of the Beijing Summit of the Forum on China Africa Cooperation(FOCAC)in September 2024,Chinese President Xi Jinping emphasised that China will enhance people-to-people and cultural exchanges with Africa,champion mutual respect,inclusiveness and coexistence of di"erent civilisations on the way to modernisation,and strive together for more fruitful outcomes under the Global Civilisation Initiative.

关键词： mutual Africa fruitful

Management of corneal ulceration with a moisture chamber due to temporary lagophthalmos in a brain injury patient:A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第5期9卷 1127-1131页

作者： Xiao-Yan yu Lu-yu Xue yun zhou Jun Shen Li Yin Department of Critical Care Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND This study describes the use of a moisture chamber to treat corneal ulceration due to temporary lagophthalmos in a critically ill *** SUMMARY A 46-year-old woman was admitted to the intensive care unit after a car *** suffered multiple injuries that included brain injury and presented with moderately decreased consciousness and lagophthalmos in her right *** 6 d,her consciousness improved considerably;at which time,exposure keratopathy occurred and worsened to corneal *** gel,antibiotic ointment,and bandage contact lens were all ineffective in preventing or treating the exposure *** of tarsorrhaphy,a moisture chamber was applied which successfully controlled the corneal *** moisture chamber was discontinued when complete eyelid closure recovered a week *** A moisture chamber may be an effective,noninvasive alternative to tarsorrhaphy for treating severe exposure keratopathy due to temporary lagophthalmos.

关键词： Exposure keratopathy Corneal ulceration Moisture chamber Lubrication Bandage contact lens Case report

A Constitutive Model Describing Molecular Configuration Evolution and Transient Rheological Behavior of Entangled Polymer Solutions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2021年第12期39卷 1680-1694页

作者： Wen-Jie yu Guan-Cheng Shen Xiao-Wei zhou Mao-yuan Li yun Zhang Hua-Min zhou De-Qun Li State Key Laboratory of Materials Processing and Die Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Entanglement network is an important structural feature in concentrated polymer solutions and polymer melts,which has a great influe nee on the transie nt rheological behavior and molecular con figurati on ***,the existi ng constitutive models have limitations in describi ng the influe nee of dyn amic entan glement behavior on molecular chain motion,resulti ng in inaccurate descriptions of the transient rheological ***,a molecular con figuration evoluti on model for polymer solutions considering the dyn amic entanglement effect is proposed by introducing an intermolecular force that changes with the orientation of the molecular chain in this *** intermolecular force is introduced by consider!ng the friction coefficient as anisotropic,and the orientation effect is considered by introducing an excluded volume depende nt an isotropic diffusi *** proposed model can better describe the stress relaxation,stress growth,and dielectric an isotropy of polymer soluti ons compared with the an isotropy FENE model and FENE *** addition,the in fluence of different model parameters on the transient and steady shear response of polymer soluti on is investigated,and the results show that the in fluence of volume loss on the fricti on anisotropy factor k0 in creases as the solution concen tration in creases.

关键词： Molecular configuration Polymer solutions Transient rheology Dumbbell model

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

Freeze–thaw resistance of eco–material stabilized loess

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2021年第3期18卷 794-805页

作者： LI Guo-yu HOU Xin zhou yu MA Wei MU Yan-hu CHEN Dun TANG Li-yun Da Xing'anling Observation and Research Station of Frozen–Ground Engineering and Environment Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesJiagedaqi 165000HeilongjiangChina State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Architecture and Civil Engineering Xi'an University of Science and TechnologyXi'an 710054China University of Chinese Academy of Sciences Beijing 100049China yuexiu Property Company Limited Guangzhou 510623China

In the Loess Plateau in Northern China,repeated freeze–thaw(FT)cycles deteriorate the strength and structure of loess as a foundation soil,resulting in the instability or failure of supporting *** is an eco–material,utilized as an effective and nontraditional stabilizer to improve the engineering properties of metastable soils.A series of laboratory tests,including unconfined compression tests,cyclic loading–unloading tests and scanning electron microscopy,on calcium lignosulfonate(CL)-and sodium lignosulfonate(SL)-stabilized loess were performed to investigate the stabilization effect,deterioration mechanisms of the FT cycles,and the resistance to FT *** traditional stabilizers,quicklime(QL)and sodium silicate(SS),were selected,and the engineering properties of QL-and SS-stabilized loess were compared with those of CL-and SLstabilized *** results showed that the strength values of CL-and SL-stabilized loess specimens decreased by 34.2%and 50%respectively,after 20 FT cycles,whereas those of the traditionally SS-and QL-stabilized specimens decreased by 85.3%and 82.87%,*** elastic moduli of SL-and QL-stabilized loess specimens decreased by 22.1%and 92.0%,*** mean energy dissipations of nontraditionally treated specimens also decreased significantly less than those of traditionally treated ***,the results showed CL and SL had better stabilization effects on engineering properties of loess than QL and SS,and their stabilized loess specimens exhibited stronger resistance to FT *** study findings demonstrated the significant potential of lignosulfonate for extensive application in cold loess areas.

关键词： Freeze thaw cycle Lignosulfonate Loess mechanics Eco-material Cold region engineering Scanning electron microscopy

Effects of single lance configuration on coal combustion process in tuyere from viewpoint of coal plume

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2021年第7期28卷 785-798页

作者： yun-hua zhou Ping zhou Jia-yun Dan Hong-jie Yan Dong-ling Wu Valin Xiangtan Iron and Steel Corporation Xiangtan 411101HunanChina School of Energy Science and Engineering Central South UniversityChangsha 410083HunanChina

Pulverized coal utilization in the blast furnace is decided by the particle flow and combustion behaviors in the *** a specific operating condition,these behaviors are directly related to the lance configuration in the upstream tuyere *** on single straight lance,six types of single lance configurations were designed by assembling four parameters in different *** four parameters are the lance diameter,lance insertion angle,and the horizontal and vertical distances from the lance tip to the tuyere *** different lance configuration schemes applied,the pulverized coal combustion process in the lance-blowpipe-tuyere zone was *** simulation results regarding particle diffusion and combustion behaviors were characterized by three indicators from the viewpoint of a coal *** are the plume diffusion angle,diffusion uniformity,and the average plume temperature at the tuyere *** promote coal utilization,the values of these indicators under different configurations were analyzed,yielding two optimal *** first one is to reduce the lance length immersed in the blowpipe-tuyere by 100 *** other is to increase the horizontal distance from the lance tip to the tuyere outlet by 50 mm,and the insertion angle to 11° with the lance tip located at the tuyere *** findings can enhance the understanding of the influence mechanism of lance con-figuration on the coal utilization and provide guidelines for the design of new lance configurations.

关键词： Pulverized coal plume Particle dispersion Lance configuration Blast furnace