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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai Li-Hui Cao Xu-Yong Chen Jia-yu Wang Zi-Ye zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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黄病毒属病毒复制子载体研究进展

生物技术通讯 2006年第2期17卷 228-231页

作者：余云舟俞炜源军事医学科学院生物工程研究所北京100071

RNA复制子是一种能自主复制的RNA载体,保留了病毒非结构蛋白(复制/转录酶)基因,而结构蛋白基因缺失或由外源抗原基因替代,复制/转录酶可控制载体RNA在细胞质中高水平复制以及外源基因的高水平表达。在黄病毒属病毒感染性克隆基础上,其... 详细信息

RNA复制子是一种能自主复制的RNA载体,保留了病毒非结构蛋白(复制/转录酶)基因,而结构蛋白基因缺失或由外源抗原基因替代,复制/转录酶可控制载体RNA在细胞质中高水平复制以及外源基因的高水平表达。在黄病毒属病毒感染性克隆基础上,其复制子载体得到了成功的构建。黄病毒属病毒复制子为病毒基因组结构功能研究、表达载体构建、假病毒包装及新型疫苗制备等提供了新的技术平台。本文综述黄病毒属病毒复制子的构建原理、方法及应用。

关键词：黄病毒属病毒 RNA复制子新型疫苗复制机制

波阻抗反演在吉林探区煤层特征分析及储层预测中的应用

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地球物理学进展 2011年第5期26卷 1788-1795页

作者：苗广文刘聪王典李鹏刘洋于赟舟吉林大学地球探测科学与技术学院长春130026 吉林大学地球科学学院长春130026 吉林省煤田地质物探公司长春130031

地震勘探已经从认识地下构造形态的构造勘探,逐渐发展成直接应用地震信息判断岩性、分析岩相、定量计算岩层物性参数等的岩性勘探,地震反演技术是这一发展过程的产物.利用地震方法解决煤田勘探问题一直以来是一个研究的热门课题.由于煤... 详细信息

地震勘探已经从认识地下构造形态的构造勘探,逐渐发展成直接应用地震信息判断岩性、分析岩相、定量计算岩层物性参数等的岩性勘探,地震反演技术是这一发展过程的产物.利用地震方法解决煤田勘探问题一直以来是一个研究的热门课题.由于煤层的构造特征常常较差,常规的构造地震勘探方法一般很难获得良好的储层特征,而波阻抗是反映储集岩的一种重要物性参数,与振幅等反映界面性质的参数相比,波阻抗具有更低的多解性和更高的储层横向预测精度,因此在煤田勘探中得到广泛应用.本文主要回顾了波阻抗反演方法的基本原理及特点,并以吉林某煤层采区岩性勘探为例,说明波阻抗反演结果在该探区煤层中的响应特征及储层分析结果.实际数据处理的结果表明,在波阻抗反演时间剖面上,该地区各地层单元之间和地层单元内部岩层之间的接触关系特征更加明显,特别是地层的不整合接触关系表现得尤为突出,能够提供较普通地震时间剖面更好的煤层识别特征和更加可靠的储层预测依据.

关键词：波阻抗反演煤层特征岩性勘探

Microstructure and Wear/corrosion Resistance of Stainless Steel Laser-alloyed with Mn+W_(2)C, Mn+NiWC and Mn+SiC

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 283-294页

作者： zhou Rui DIAO Xiaogang SUN Yixin School of Metallurgical Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China CITIC Heavy Cast Iron Industry Co. Ltd.Luoyang 417039China

In-situ formed high Mn steel coating reinforced by carbides was formed by laser surface alloying(LSA).Laser alloyed layers on 1Cr18Ni9Ti steel with Mn+W_(2)C(specimen A),Mn+NiWC(specimen B)and Mn+SiC(specimen C)powders were fabricated to improve the wear and corrosion behavior of 1Cr18Ni9Ti steel blades in high speed *** evolution,phases,element distribution,microhardness,wear and corrosion behavior of the laser alloyed layers were *** indicated that high Mn steel matrix composites with undissolved W_(2)C,WC and other in-situ formed carbides were formed by LSA with Mn+W_(2)C and Mn+NiWC while SiC totally dissolved into the high Mn matrix when adding Mn+*** as the binding phase in Ni-WC powder decreased the crack sensitivity of the alloyed layer as compared with the addition of W_(2)C *** improvement in average microhardness was achieved in the matrix in specimen A,B and C,with the value of 615,602 and 277 HV_(0.5),while that of the substrate was 212 HV_(0.5).The increase of microhardness,wear and corrosion resistance is highly corelated to microstructure,formed phases,type and content of carbides,micro-hardness and toughness of the alloyed layers.

关键词： laser surface alloying stainless steel carbide type microstructure wear and corrosion resistance

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang Wang Wenyong zhou yu Xu Jianchun Duan Qiaoxia zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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Thermally triggered topological polymerization in diacetylene-functionalized covalent organic framework toward enhanced memristive properties

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Science China Chemistry 2025年

作者： Panke zhou yuxing Huang Ziyue yu Cong Zhang Qian Chen Yiping Li Chao Lin Xiong Chen State Key Laboratory of Photocatalysis on Energy and Environment Key Laboratory of Advanced Carbon-Based Functional MaterialsCollege of Chemistry Fuzhou University

The development of stimuli-responsive switching memory devices and the elucidation of their switching mechanisms in specific environments are crucial for advancing the field of molecular electronics. Herein, we propose two distinct two-dimensional covalent organic frameworks (COFs), namely Py-EDA and Py-BDA, incorporating acetylene (-C≡C-) or diacetylene(-C≡C-C≡C-) moieties, respectively, targeting fabricate memory devices exhibiting stimuli-responsive switching *** findings demonstrate that the incorporation of acetylene units effectively modulates the electronic band structure and enhances the degree ofπ-conjugation, resulting in devices that exhibit typical bipolar nonvolatile memory performance. Notably,upon thermal treatment, the memory behavior of the ITO/Py-BDA/Ag device transitions to a write-once-read-many-times(WORM) mode, displaying decreased SET voltage, increased ON/OFF current ratio, and remarkable retention reliability and cycle stability. This switching behavior is attributed to the occurrence of interlayer solid-state topological polymerization at 350℃, leading to the transformation of diacetylene columnar arrays into enyne chains within Py-BDA, thereby further promoting interlayer charge transfer and separation.

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用正电子湮没方法研究有机导体

化学学报 1988年第6期46卷 528-531页

作者：王蕴玉周光明朱道本中国科学院高能物理研究所北京中国科学院化学研究所北京

本文测量一些新的复合物型有机导体中正电子湮没的寿命谱,线形参数和3γ湮没的相对产额.结果表明,在电荷完全转移的绝缘体和电荷部分转移的导体中.

关键词：正电子湮没有机导体复合物离域电荷顺磁性正电子源粒子源电导率电性导电性能寿命谱仪

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肉毒毒素防治药物的研究进展

军事医学 2012年第12期36卷 954-958页

作者：余云舟孙志伟郑涛黄培堂军事医学科学院生物工程研究所北京10007

肉毒毒素是目前已知毒性最强的蛋白质,可以引发严重的突发公共卫生事件,也是重要的生物战剂和生物恐怖剂,因此迫切需要研制医学防治药物以应对其威胁。本文概述了国内外在肉毒毒素预防性疫苗和治疗性中和抗体防治药物研发进展,同时分析... 详细信息

肉毒毒素是目前已知毒性最强的蛋白质,可以引发严重的突发公共卫生事件,也是重要的生物战剂和生物恐怖剂,因此迫切需要研制医学防治药物以应对其威胁。本文概述了国内外在肉毒毒素预防性疫苗和治疗性中和抗体防治药物研发进展,同时分析了肉毒毒素防治药物的新趋势和今后的主要发展方向。

关键词：肉毒毒素类疫苗中和抗体生物安全

抑制剂联用或与抗毒素联用对肉毒毒素中毒小鼠的解毒活性研究

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军事医学 2020年第6期44卷 443-448页

作者：黄超黄秋园张敏余硕陈荣芳余云舟刘佳肖新荣戴秋云南华大学化学化工学院湖南衡阳421000 军事科学院军事医学研究院生物工程研究所北京100071

目的为提高单个小分子及A型肉毒毒素抗毒素的解毒活性,研究小分子抑制剂[包括川楝素、3,4-二氨基吡啶(DAP)、依布硒啉(ebselen)、4-溴苯甲醛N-(2,6-二甲基苯基)缩氨基脲(EGA)]联用、A型肉毒毒素抗毒素与小分子抑制剂联用对A型肉毒毒素... 详细信息

目的为提高单个小分子及A型肉毒毒素抗毒素的解毒活性,研究小分子抑制剂[包括川楝素、3,4-二氨基吡啶(DAP)、依布硒啉(ebselen)、4-溴苯甲醛N-(2,6-二甲基苯基)缩氨基脲(EGA)]联用、A型肉毒毒素抗毒素与小分子抑制剂联用对A型肉毒毒素中毒小鼠的解毒活性。方法昆明小鼠雌雄各半,每组10只,对照组、实验组小鼠均分别腹腔注射A型肉毒毒素(2×LD50/只)。小分子联用实验中,A型肉毒毒素给毒后4 h,分别腹腔注射(或灌胃)溶媒(对照组)、小分子抑制剂川楝素、DAP、ebselen、EGA,或8 h时第2次腹腔注射(或灌胃)上述小分子抑制剂或混合物。抗毒素与小分子联用实验中,A型肉毒毒素给毒后6 h,实验组均分别腹腔注射抗毒素(5 U/只)或抗毒素标准品(4 U/只),7 h后分别腹腔注射溶媒、小分子抑制剂或混合物。观察72 h内上述各对照组及给药组小鼠的生存情况,采用Log-rank检验分析各小组间的存活率差异。结果对照组12 h存活30%~40%,24 h内基本全部死亡。与对照组相比,腹腔注射小分子川楝素(3 mg/kg)、DAP(5 mg/kg)、EGA(10 mg/kg),存活率无显著差异(P>0.05)。川楝素与DAP联用、川楝素与EGA联用、川楝素与DAP及EGA混合物联用能延长中毒小鼠的存活时间(P值分别为0.038、0.022、0.016),但与单用各小分子抑制剂相比存活率无显著差异(P>0.05)。DAP与EGA联用与单用DAP、EGA相比,能延长中毒性小鼠的存活时间(P值分别为0.030、0.031)。与单用抗毒素相比,抗毒素与小分子川楝素、DAP、ebselen、EGA联用,存活率无显著差异(P>0.05)。结论川楝素分别与DAP、EGA联用,DAP与EGA联用,川楝素与(DAP+EGA)混合物联用均能延长中毒小鼠死亡时间,抗毒素与小分子川楝素、DAP、ebselen、EGA联用不能显著提高抗毒素的抗毒活性。

关键词：肉毒杆菌毒素,A型抑制剂抗毒素类联用解毒活性