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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong SHAO Ming-yi FU yu ZHAO Rui-xia WANG Jing-wen FANG yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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Exploration of the ground state properties of neutron-rich sodium isotopes using the deformed relativistic mean field theory in complex momentumrepresentations with BCS pairings

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Chinese Physics C 2024年第4期48卷 115-129页

作者：罗雨轩刘泉郭建友 School of physics and Optoelectronic Engineering Anhui UniversityHefei 230601China

This study explores the ground-state characteristics of neutron-rich sodium isotopes,encompassing two-neutron separation energies,root-mean-square radii,quadrupole moments of proton and neutron distributions,single-particle levels of bound and resonant states,and neutron density distributions and ***,special attention is paid to the distinctive physical phenomena associated with these *** deformed relativistic mean field theory in complex momentum representations with BCS pairings(DRMF-CMR-BCS)employed in our research provides resonant states with real physics,offering insights into deformed halo *** effective interactions(NL3,NL3^(*),PK1,and NLSH)were considered to assess the influence of continuum and deformation effects on halo *** for odd-even nuclei ^(35–43)Na revealed the dependence on the chosen effective interaction and number of considered resonant *** occupation patterns near the Fermi surface,particularly in orbitals 1/2^(−)_(3) and 3/2^(−)_(2),were determined to be crucial in halo *** study provided detailed insights into the density distributions,shape evolution,and structure of neutron-rich sodium isotopes,contributing valuably to the field of nuclear physics.

关键词： relativistic mean field complex momentum representations resonant states halo nuclei

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Design and construction of charged-particle telescope array for study of exotic nuclear clustering structure

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Nuclear Science and Techniques 2024年第8期35卷 114-123页

作者： Zheng‑Li Liao Xi‑Guang Cao yu‑xuan Yang Chang‑Bo Fu Xian‑Gai Deng Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Zhengzhou University Zhengzhou 450001China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan University Shanghai 200438China

The exploration of exotic shapes and properties of atomic nuclei,e.g.,αcluster and toroidal shape,is a fascinating field in nuclear *** study the decay of these nuclei,a novel detector aimed at detecting multipleα-particle events was designed and *** detector comprises two layers of double-sided silicon strip detectors(DSSD)and a cesium iodide scintillator array coupled with silicon photomultipliers array as light sensors,which has the advantages of their small size,fast response,and large dynamic *** coupled with cesium iodide crystal arrays are used to distinguish multipleα*** detector array has a compact and integrated design that can be adapted to different experimental *** detector array was simulated using Geant4,and the excitation energy spectra of someα-clustering nuclei were reconstructed to demonstrate the *** simulation results show that the detector array has excellent angular and energy resolutions,enabling effective reconstruction of the nuclear excited state by multipleαparticle *** detector offers a new and powerful tool for nuclear physics experiments and has the potential to discover interesting physical phenomena related to exotic nuclear structures and their decay mechanisms.

关键词： Cluster decay Toroidal structure Telescope array SiPM Energy resolution

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Generic Existence of Infinitely Many Non-contractible Closed Geodesics on Compact Space Forms

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1674-1684页

作者： Hui liu yu Chen Wang School of Mathematics and Statistics Wuhan UniversityWuhan430072P.R.China School of Mathematics Tianjin Normal UniversityTianjin300384P.R.China

Let M=S^(n)/Γand h be a nontrivial element of finite order p inπ_(1)(Μ),where the integers n,p≥2,Γis a finite abelian group which acts freely and isometrically on the n-sphere and therefore M is diffeomorphic to a compact space *** this paper,we prove that there are infinitely many non-contractible closed geodesics of class[h]on the compact space form with C^(r)-generic Finsler metrics,where 4≤r≤∞.The conclusion also holds for Cr-generic Riemannian metrics for 2≤r≤∞.The proof is based on the resonance identity of non-contractible closed geodesics on compact space forms.

关键词： Compact space forms non-contractible closed geodesics generic Finsler metrics resonance identity

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Relative Broken Family Sensitivity

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2297-2306页

作者： Zhuo Wei liu Tao yu Department of Mathematics Shantou UniversityShantou 515063P.R.China

Letπ:(X,T)→(Y,S)be a factor map between two topological dynamical systems,and F_(a) Furstenberg family of *** introduce the notion of relative broken *** Fs(***,Finf)be the families consisting of all syndetic subsets(*** upper Banach density subsets,infinite subsets).We show that for a factor mapπ:(X,T)→(Y,S)between transitive systems,πis relatively broken F-sensitive for F=Fs or Fpubd if and only if there exists a relative sensitive pair which is an F-recurrent point of(R_(π),T^((2)));is relatively broken Finf-sensitive if and only if there exists a relative sensitive pair which is not *** a factor mapπ:(X,T)→(Y,S)between minimal systems,we get the structure of relative broken F-sensitivity by the factor map to its maximal equicontinuous factor.

关键词： Relative sensitivity recurrent points Furstenberg family relative sensitive pairs maximal equicontinuous factor

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Atmospheric iron deposition in a megacity of northwest China:Solubility,speciation,and deposition fluxes

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Particuology 2024年第7期90卷 383-393页

作者： Xiaotao Yang Pingping liu Zhiwei Xue Hao Zhang xuan Li Hongmei Xu Zhenxing Shen Department of Environmental Science and Engineering Xi'an Jiaotong UniversityXi'anChina State Key Laboratory of Loess and Quaternary National Key R&D of China Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'anChina No.203 Research Institute of Nuclear Industry Xi'an710086China Xi'an Environmental Monitoring Station Xi'an 710054China

Atmospheric iron has crucial effects on biogeochemical cycles,atmospheric processing,global climate,and human *** this study,atmospheric dustfall samples were collected from six functional areas in Xi'an,China,from 2020 to *** spatiotemporal distributions and deposition fluxes of total and water-soluble(ws)Fe as well as the speciation and potential sources of ws-Fe were *** areas had the highest concentrations of total Fe and ws-Fe,which were mainly due to copious emissions of heavy metals during *** total Fe concentrations peaked in spring,primarily due to the substantial input of crustal dust,which also led to the lowest Fe solubility in this *** contrast,the highest levels of ws-Fe occurred during winter due to an increase in biomass *** the water-soluble forms,ws-Fe(II)was dominant and accounted for 74.8%of the total amount of *** dust was the main contributor to total Fe,whereas biomass burning primarily contributed to peak ws-Fe *** average total and ws-Fe deposition fluxes in Xi'an were the highest in spring and lowest in autumn,which were related to the distributions of the dustfall deposition fluxes and their Fe contents during these *** study provided a broader and comprehensive understanding of atmospheric iron deposition in Chinese urban area,which is of positive significance for understanding atmospheric chemistry and global climate change.

关键词： Atmospheric dustfall Iron Speciation distribution Seasonal variation Functional area Sources

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Simulation of Two-Phase Flowback Phenomena in Shale Gas Wells

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Fluid Dynamics & Materials Processing 2024年第2期20卷 349-364页

作者： Yongwei Duan Zhaopeng Zhu Hui He Gaoliang xuan Xuemeng yu Oil Gas Engineering Research Institute PetroChina Jilin OilfieldSongyuan138000China

The gas-water two-phaseﬂow occurring as a result of fracturingﬂuidﬂowback phenomena is known to impact signiﬁcantly the productivity of shale gas *** this work,this two-phaseﬂow has been simulated in the framework of a hybrid approach partially relying on the embedded discrete fracture model(EDFM).This model assumes the region outside the stimulated reservoir volume(SRV)as a single-medium while the SRV region itself is described using a double-medium strategy which can account for theﬂuid exchange between the matrix and the *** shale gas adsorption,desorption,diffusion,gas slippage effect,fracture stress sensitivity,and capillary imbibition have been *** shale gas production,pore pressure distribution and water saturation distribution in the reservoir have been *** inﬂuences of hydraulic fracture geometry and nonorthogonal hydraulic fractures on gas production have been determined and discussed *** simulation results show that the daily gas production has an upward and downward trend due to the presence of a large amount of fracturingﬂuid in the reservoir around the hydraulic *** smaller the angle between the hydraulic fracture and the wellbore,the faster the daily production of shale gas wells decreases,and the lower the cumulative *** fractures can increase the control volume of hydraulic fractures and improve the production of shale gas wells.

关键词： Shale gas fracturingﬂuid backﬂow the stimulated reservoir volume gas-water two-phase production

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Stability assessment of tree ring growth of Pinus armandii Franch in response to climate change based on slope directions at the Lubanling in the Funiu Mountains,China

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Journal of Forestry Research 2024年第3期35卷 197-208页

作者： Jinkuan Li Jianfeng Peng Xiaoxu Wei Meng Peng xuan Li Yameng liu Jiaxin Li College of Geography and Environmental Science Henan UniversityKaifeng 475004People’s Republic of China Key Laboratory of Earth System Observation and Simulation of Henan Province Kaifeng 475004People’s Republic of China

Global warming will affect growth strategies and how trees will *** compare the response of tree radial growth to climate warming in different slope directions,samples of Pinus armandii Franch were collected and treering chronologies developed on northern and western slopes from the Lubanling in the Funiu *** analyses showed that two chronologies were mainly limited by temperatures in the previous June–August and the combination of temperatures and moisture in the current May–*** difference of the climate response to slopes was small but not *** growth of the LBL01 site on the northern slope was affected by the combined maximum and minimum temperatures,while that of the LBL02 site was affected by maximum *** regards to moisture,radial growth of the trees on the north slope was influenced by the relative humidity in the current May–July,while on the western slope,it was affected by the relative humidity in the previous June–August,the current May–July and the precipitation in the current May–*** the change in climate,the effects of the main limiting factors on growth on different slopes were visible to a certain extent,but the differences in response of trees on different slopes gradually decreased,which might be caused by factors such as different slope directions and the change in diurnal temperature *** results may provide information for forest protection and ecological construction in this region,and a scientific reference for future climate reconstruction.

关键词： Tree ring width Lubanling Pinus armandii Franch Slope direction Climate response

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A probabilistic generative model for tracking multi-knowledge concept mastery probability

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Frontiers of Computer Science 2024年第3期18卷 155-170页

作者： Hengyu liu Tiancheng ZHANG Fan LI Minghe yu Ge yu School of Computer Science and Engineering Northeastern UniversityShenyang 110169China Software College Northeastern UniversityShenyang 110169China

Knowledge tracing aims to track students’knowledge status over time to predict students’future performance *** a real environment,teachers expect knowledge tracing models to provide the interpretable result of knowledge *** chain-based knowledge tracing(MCKT)models,such as Bayesian Knowledge Tracing,can track knowledge concept mastery probability over ***,as the number of tracked knowledge concepts increases,the time complexity of MCKT predicting student performance increases exponentially(also called explaining away problem).When the number of tracked knowledge concepts is large,we cannot utilize MCKT to track knowledge concept mastery probability over *** addition,the existing MCKT models only consider the relationship between students’knowledge status and problems when modeling students’responses but ignore the relationship between knowledge concepts in the same *** address these challenges,we propose an inTerpretable pRobAbilistiC gEnerative moDel(TRACED),which can track students’numerous knowledge concepts mastery probabilities over *** solve explain away problem,we design long and short-term memory(LSTM)-based networks to approximate the posterior distribution,predict students’future performance,and propose a heuristic algorithm to train LSTMs and probabilistic graphical model *** better model students’exercise responses,we proposed a logarithmic linear model with three interactive strategies,which models students’exercise responses by considering the relationship among students’knowledge status,knowledge concept,and *** conduct experiments with four real-world datasets in three knowledge-driven *** experimental results show that TRACED outperforms existing knowledge tracing methods in predicting students’future performance and can learn the relationship among students,knowledge concepts,and problems from students’exercise *** also conduct several case *** case studies show that

关键词： probabilistic graphical model deep learning knowledge tracing learner modeling

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Hybrid pedestrian positioning system using wearable inertial sensors and ultrasonic ranging

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Defence Technology（防务技术） 2024年第3期33卷 327-338页

作者： Lin Qi yu liu Chuanshun Gao Tao Feng yue yu School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong 999077China

Pedestrian positioning system(PPS)using wearable inertial sensors has wide applications towards various emerging fields such as smart healthcare,emergency rescue,soldier positioning,*** performance of traditional PPS is limited by the cumulative error of inertial sensors,complex motion modes of pedestrians,and the low robustness of the multi-sensor collaboration *** paper presents a hybrid pedestrian positioning system using the combination of wearable inertial sensors and ultrasonic ranging(H-PPS).A robust two nodes integration structure is developed to adaptively combine the motion data acquired from the single waist-mounted and foot-mounted node,and enhanced by a novel ellipsoid constraint *** addition,a deep-learning-based walking speed estimator is proposed by considering all the motion features provided by different nodes,which effectively reduces the cumulative error originating from inertial ***,a comprehensive data and model dual-driven model is presented to effectively combine the motion data provided by different sensor nodes and walking speed estimator,and multi-level constraints are extracted to further improve the performance of the overall *** results indicate that the proposed H-PPS significantly improves the performance of the single PPS and outperforms existing algorithms in accuracy index under complex indoor scenarios.

关键词： Pedestrian positioning system Wearable inertial sensors Ultrasonic ranging Deep-learning Data and model dual-driven

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