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Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1344-1362页

作者： Zi-Ling Hu yu-xuan Wang Zi-yue Lin Wen-Shuo Ren Bo liu Hui Zhao Qiong Qin Five Year Program of Ophthalmology and Optometry 2019 Beijing Tong Ren HospitalCapital Medical UniversityBeijing 100054China Four Year Program of Traditional Chinese Pharmacy 2020 School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of TCM Collateral Disease Theory Research Beijing 100069China Five Year Program of Ophthalmology and Optometry 2021 School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Biochemistry&Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual *** evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological *** factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative *** functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been *** the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD *** the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关键词： Nrf2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress

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Performance analysis and multi-objective optimization based on a modified irreversible Stirling cycle

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Science China(Technological Sciences) 2024年第6期67卷 1668-1684页

作者： XU Lei yu MinJie liu ZhiChun liu Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China

The efficiency of the actual Stirling engine is much lower than the ideal Carnot cycle *** obtain more precise efficiency for Stirling engines,this paper proposes a modified Stirling cycle with a more accurate heat transfer process in Stirling engines based on a thermodynamic function called available *** finite-time thermodynamic method is used to analyze the model performance under constant heat source temperature,finite temperature difference heat transfer,and incomplete regenerative processes.A new polytropic process is introduced to model the heat transfer between the working fluid and external heat sources in which only heat above ambient temperature is converted into technical *** regenerator is divided into numerous smaller heat reservoirs with individual temperature to analyze the incomplete regenerative *** expressions of the output power and thermal efficiency are obtained based on the modified irreversible Stirling cycle,and the effects of irreversible losses are analyzed to evaluate the performance of the proposed *** indicate that the efficiency of the modified cycle is much lower than that of the ideal Stirling cycle with an isothermal *** the increase of the average heat transfer temperature difference,there exists an optimum value for the power of the irreversible *** optimum power of the model was obtained for varying thermodynamic parameters by optimizing the average heat transfer temperature difference between the hot and cold *** optimize the irreversible model,the multi-objective optimization analysis is carried out based on NSGA-Ⅱ,which results in an optimized output power of 40.87 kW and an optimized thermal efficiency of 44%.

关键词： stirling cycle regenerative processes isopotential processes multi-objective optimization finite time thermodynamics

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Emerging high-entropy strategy: A booster to the development of cathode materials for power batteries

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Journal of Advanced Ceramics 2024年第8期13卷 1093-1118页

作者： Liping Huang Jinging Zhu J-xuan liu Houzheng Wu Guo-Jun Zhang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Institute of Functional MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China SIAMC Advanced Materials Cooperation Huzhou 313100China

The coordinated development of new energy vehicles and the energy storage industry has become essential for reducing carbon *** cathode material is the key material that determines the energy density and cost of a power battery,but currently developed and applied cathode materials cannot meet the requirements for high specific capacity,low cost,safety,and good ***-entropy materials(HEMs)are a new type of single-phase material composed of multiple principal elements in equimolar or near-equimolar *** interaction between multiple elements can play an important role in improving the comprehensive properties of the material,which is expected to solve the limitations of battery materials in practical ***,this review provides a comprehensive overview of the current development status and modification strategies of power batteries(lithium-ion batteries(LiBs)and sodium-ion batteries(SIBs)),proposes a high-entropy design strategy,and analyses the structure-activity relationship between the high-entropy effects and battery ***,future research topics related to high-entropy cathode materials,including computational guide design,specific synthesis methods,high-entropy electrochemistry,and high-throughput databases,are *** review aims to provide practical guidance for the development of high-entropy cathode materials for next-generation power batteries.

关键词： cathode materials lithium-ion battery(LIB) sodium-ion battery(SIB) high-entropy strategy

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Gut microbiota and female health

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World Journal of Gastroenterology 2024年第12期30卷 1655-1662页

作者： Meng-Yao Wang Li-xuan Sang Si-yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Endoscopic CenterEngineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological *** advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer *** this,there has been limited discussion on the underlying *** editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite *** focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.

关键词： Gut microbiota Female health Estrogen Polycystic ovarian syndrome Endometriosis

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A STAMP-Game model for accident analysis in oil and gas industry

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Petroleum Science 2024年第3期21卷 2154-2167页

作者： Huixing Meng Xu An Daiwei Li Shijun Zhao Enrico Zio xuan liu Jinduo Xing State Key Laboratory of Explosion Science and Safety Protection Beijing Institute of TechnologyBeijing100081China School of Emergency Management and Safety Engineering China University of Mining and Technology(Beijing)Beijing100083China Energy Department Politecnico di MilanoVia La Masa 34Milan20156Italy Mines Paris PSL Centre de Recherche sur les Risques et les CrisesSophie Antipolis06904France School of Mechanical-Electronic and Vehicle Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China

Accidents in engineered systems are usually generated by complex socio-technical *** is beneficial to investigate the increasing complexity and coupling of these factors from the perspective of system *** on system and control theories,System-Theoretic Accident Model and Processes(STAMP)is a widely recognized approach for accident *** this paper,we propose a STAMP-Game model to analyze accidents in oil and gas storage and transportation *** in accident analysis by STAMP can be regarded as players of a *** theory can,thus,be adopted in accident analysis to depict the competition and cooperation between ***,we established a game model to study the strategies of both supervisory and supervised *** obtained results demonstrate that the proposed game model allows for identifying the effectiveness deficiency of the supervisory entity,and the safety and protection altitudes of the supervised *** STAMP-Game model can generate quantitative parameters for supporting the behavior and strategy selections of the supervisory and supervised *** quantitative data obtained can be used to guide the safety improvement,to reduce the costs of safety regulation violation and accident risk.

关键词： Accident analysis STAMP System engineering Gametheory Oil and gas storage and transportation systems

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Metal-to-insulator transition in platinum group compounds

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Rare Metals 2024年第8期43卷 3460-3474页

作者： yu-xuan Xia Jian-Gang He Nuo-Fu Chen Ji-Kun Chen School of New Energy North China Electric Power UniversityBeijing102206China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for PostMoore Chips(Ministry of Education) School of Materials Science and EngineeringJniversity of Science and Technology BeijingBeijing 100083China

The metal-to-insulator transition(MIT) as usually achieved in 3d-orbital transitional metal(TM) compounds opens up a new paradigm in correlated electronics via triggering abrupt variations in their transportation *** to such 3d-orbital TM compounds,the MIT within the platinum group(Pg) element compounds based on the 4d-and 5d-orbital configurations is more complicated,owing to their elevation in the spinorbit coupling and meanwhile weakened intra-atomic Coulomb *** brings in a new freedom to regulate the balance in their metallic or semiconductive orbital configurations,while their MIT properties can be potentially combined with their spintronic properties to enable new electronic ***,we review the electronic transport and MIT behaviors within the existing family of Pg-containing compounds,particularly those showing first-order MIT behaviors that can be useful in correlated *** is also hoped that summarizing the presently reported Pg-containing MIT compounds will lead to the discovery of more new material families and/or new mechanisms associated with the Pg-containing compounds showing MIT properties.

关键词： Metal-to-insulator transition Platinum group compounds Electron correlation Spin-orbital coupling

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Numerical investigations of the interactions between bubble induced shock waves and particle based on OpenFOAM

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Journal of Hydrodynamics 2024年第2期36卷 355-362页

作者： Jia-xin yu Jin-sen Hu yu-hang liu Yi-fan liu Dan Gao yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System Ministry of EducationSchool of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The presence of particles and the shock waves generated by the cavitation bubbles can significantly affect the safety and the performance of hydrodynamic *** the present paper,the shock waves generated by cavitation bubble collapsing near the particle are numerically investigated based on the OpenFOAM together with the numerical schlieren for the shock wave *** numerical results reveal that the stand-off distance is one of the paramount factors affecting the interactions between the particle and the shock *** different kinds of shock waves(e.g.,bubble-inception,jet formation,particle reflected and jet-split shock waves)are observed during the bubble collapsing near the *** stand-off distance smaller than 0.5 or larger than 1.1,the maximum pressure at particle surface generated by the bubble growth can surpass those of the collapse stage.

关键词： Particle-bubble interaction shockwaves jetdynamics

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Visceral adipose tissue predicts severity and prognosis of acute pancreatitis in obese patients

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 458-462页

作者： yuan Tian Qing Huang yu-Tang Ren xuan Jiang Bo Jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Acute pancreatitis is a common systemic inflammatory disease, manifested by a spectrum of severity, ranging from mild in the majority of patients to severe acute pancreatitis. Patients with severe acute pancreatitis suffer from severe local and systemic complications and organ failure, leading to a poor prognosis. The early recognition of the severe condition is important to improve prognosis. Obesity has risen in tandem with an increase in the severity of acute pancreatitis in recent years. Studies have revealed that adipose tissue, particularly visceral adipose tissue is associated with the prognosis of acute pancreatitis. This review discussed the role of visceral adipose tissue in obese patients with acute pancreatitis and explored the possible mechanism involved.

关键词： Visceral adipose tissue Obesity Acute pancreatitis

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Polymer-to-Monomers Chemically Recyclable Poly(imide-imine)Plastics with Extreme-Condition Resistance and Flame Retardancy

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Chinese Journal of Polymer Science 2024年第10期42卷 1525-1535,I0012页

作者： Zhen-yu Wang Xiao-Kong liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Polyimides are a family of high-tech plastics that have irreplaceable applications in the fields of aerospace,defense,and opto-electronics,but polyimides are difficult to be reprocessed and recycled at the end of their service life,resulting in a significant waste of ***,it is of great significance to develop recyclable polyimides with comparable properties to the commercial ***,we report a novel polymer-to-monomers chemically recyclable poly(imide-imine)(PtM-CR-PII)plastic,synthesized by cross-linking the amine-terminated aromatic bisimide monomer and the hexa-vanillin terminated cyclophosphazene monomer via dynamic imine *** PtM-CR-PII plastic exhibits comparable mechanical and thermal properties as well as chemical stability to the commercial *** PtM-CR-PII plastic possesses a high Young’s modulus of≈3.2 GPa and a tensile strength as high as≈108 MPa,which also exhibits high thermal stability with a glass transition temperature of≈220℃.Moreover,the PtM-CR-PII plastic exhibits outstanding waterproofness,acid/alkali-resistance,and solvent-resistance,its appearance and mechanical properties can be well maintained after long-term soaking in water,highly concentrated acid and base,and various organic ***,the cyclophosphazene moieties endow the PtM-CR-PII plastic with excellent flame *** PtM-CR-PII plastic exhibits the highest UL-94 flame-retarding rating of V-0 and a limiting oxygen index(LOI)value of 45.5%.Importantly,the PtM-CR-PII plastic can be depolymerized in an organic solvents-acid mixture medium at room temperature,allowing easy separation and recovery of both monomers in high *** recovered pure monomers can be used to regenerate new PtM-CR-PII plastics,enabling sustainable polymer-monomers-polymer circulation.

关键词： Chemical recyclability Polyimides Polyimines Dynamic imine bonds Mechanical properties Chemical stability

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An integrative mathematical model of microwave ion thruster for mHz-frequency thrust noise analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 121-136页

作者： Xiang NIU Hui liu Daren yu Plasma Propulsion Laboratory Harbin Institute of TechnologyHarbin 150001China

Many high-precision space missions need thrusters to produce thrust with low noise to compensate for disturbances and ensure satellite platform stability. Microwave ion thruster is characterized with a wide thrust range and potential for these missions. A cost-effective and accurate mathematical model is crucial for mHz-frequency thrust noise analysis and feedback controller design. The Particle-In-Cell(PIC) and global models are two common simulation tools. The PIC model is characterized with high accuracy but huge computation cost, which is difficult to analyze long-time performance characteristics. Now, the global model is only used for the discharge chamber with low accuracy and cannot reflect ion extraction properties. In this paper, an integrative mathematical model is built for a 1-cm microwave ion thruster and can reflect ion beamlet divergence and impingement on the Accelerator Grid(AG). Simulation results show good agreement with experiments at 0.06 sccm. However, the model demonstrates worse consistency with experiments when the flux increases to 0.1 sccm, which may be because the influence of neutral gas on the Electron Cyclotron Resonance(ECR) is not considered in the model. A long-time(1000 s) simulation is conducted with this model under 35 μN. It takes 3 hrs, and the thrust noise reaches 1 μN/Hz^(0.5) at 1 mHz.

关键词： Electric propulsion Microwave ion thruster Integrative model Sheath property Ion beamlet divergence Thrust noise Plasma

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