检索结果-南通市图书馆

Modeling of shell-mixing into the central hotspot in inertial confinement fusion implosion

在线全文

学校读者我要写书评

暂无评论

Modeling of shell-mixing into the central hotspot in inertia...

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

2016第八届全国计算物理会议

作者： yu cheng-xin FAN Zheng-feng Institute of Applied Physics and Computational Mathematics

Starting from the mass conservation and energy conservation of hotspot,the dynamics of hotspot combustion involving shell-mix are constructed by recalculating the special internal energy and heat capacity,in which the bremsstrahlung radiation loss and other energy transfer are *** the power balance in the hotspot,the relations between the fractions of shell-mixing in the hotspot and the ignition threshold and self-sustainable combustion are *** theoretical analysis and numerical simulation show that the enhancement of radiation loss induced by the shell-mixing plays the dominated role in the failure of *** adjusting different materials and the mixing fraction,the effects to the combustion paths are studied.

关键词： Inertial confinement fusion Implosion mixing Hotspot combustion Degradation of shell-mixing

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

磁共振成像评价肝动脉灌注化疗栓塞术治疗肝细胞癌疗效的价值

在线全文

学校读者我要写书评

暂无评论

中华肝脏病杂志 2008年第11期16卷 872-874页

作者：王立丹余成新秦觅湖北省宜昌市中心人民医院放射科三峡大学第一临床医学院放射科宜昌443003 湖北省宜昌市中心人民医院

肝细胞癌（HCC）病情进展迅速，大多数患者就诊时已为较晚期或合并肝硬化，失去了外科手术治疗的机会，因此介入治疗成为肝癌目前非外科手术治疗的主要手段。目前介入治疗比较常用的方法之一为肝动脉灌注化疗栓塞术（transcatheter arte... 详细信息

肝细胞癌（HCC）病情进展迅速，大多数患者就诊时已为较晚期或合并肝硬化，失去了外科手术治疗的机会，因此介入治疗成为肝癌目前非外科手术治疗的主要手段。目前介入治疗比较常用的方法之一为肝动脉灌注化疗栓塞术（transcatheter arterial chemoembolization，TACE）。由于TACE后仅有部分肿瘤组织完全坏死而不能一次性杀灭肿瘤细胞，肿瘤易复发，故通常需要多次重复治疗。

关键词：癌肝细胞化学栓塞治疗性磁共振成像

SBO+MBLOCA事故演习序列应用的仿真研究

在线全文

学校读者我要写书评

暂无评论

计算机仿真 2021年第1期38卷 446-450页

作者：于承鑫郑伟中广核(北京)仿真技术有限公司广东深圳518031

福岛核事故后,人们逐渐意识到当严重事故发生时,事故后的缓解措施以及电厂的应急响应都非常重要,也更显现出核应急演习的必要性。核应急演习的目的就是要验证和评价应急组织的综合应急响应能力,进而检验和提高应急计划的有效性和应急准... 详细信息

福岛核事故后,人们逐渐意识到当严重事故发生时,事故后的缓解措施以及电厂的应急响应都非常重要,也更显现出核应急演习的必要性。核应急演习的目的就是要验证和评价应急组织的综合应急响应能力,进而检验和提高应急计划的有效性和应急准备的完善性。将严重事故演习序列与全范围模拟机自身特点相结合,通过理论分析和计算,对全厂失电叠加一回路破口事故工况堆芯的行为以及事故演习序列执行的合理性进行分析,最终得出能够满足严重事故工况应急演习需求的限制条件,给出严重事故演习序列的改进建议。

关键词：严重事故事故序列全范围模拟机

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： cheng-cheng Wei yu-Qing Huang cheng-Hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水泥稳定级配碎石在公路改造中的应用

筑路机械与施工机械化 2008年第6期25卷 51-53页

作者：郑积相俞晟鑫佛山市南海区公路局广东佛山528200 广州本田汽车公司广东广州510700

分析了旧水泥路面加铺沥青混凝土面层改造的常见病害,并在此基础上提出了加铺水泥稳定级配碎石过渡层的施工方案。结合佛山一环至得胜十字路口公路的实际施工情况,设计了水泥稳定级配碎石过渡层的施工工艺,为今后此类公路的改建工程提... 详细信息

分析了旧水泥路面加铺沥青混凝土面层改造的常见病害,并在此基础上提出了加铺水泥稳定级配碎石过渡层的施工方案。结合佛山一环至得胜十字路口公路的实际施工情况,设计了水泥稳定级配碎石过渡层的施工工艺,为今后此类公路的改建工程提供了参考方案。

关键词：公路改造沥青面层水泥稳定级配碎石施工工艺

在线全文

学校读者我要写书评

暂无评论

住宅工程中的装配式建筑施工技术运用探寻

工程建设与设计 2022年第23期 183-185页

作者：于新成中国建筑第二工程局有限公司北京100070

针对装配式建筑施工技术的应用优势进行分析,深入探讨住宅工程中装配式建筑施工技术内容,从外墙节点防水技术、预制叠合板安装技术、预制构件吊装技术、接缝处理技术等方面进行深入阐述,最后从运输环境条件、人员设备管理等方面提出加... 详细信息

针对装配式建筑施工技术的应用优势进行分析,深入探讨住宅工程中装配式建筑施工技术内容,从外墙节点防水技术、预制叠合板安装技术、预制构件吊装技术、接缝处理技术等方面进行深入阐述,最后从运输环境条件、人员设备管理等方面提出加强装配式住宅项目施工的对策与建议。

关键词：装配式建筑施工技术建设施工水平住宅施工工程技术应用价值

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

农业机械化在农业现代化中的作用

时代农机 2016年第3期43卷 15-15,17页

作者：于新诚绥滨县农业机械化学校黑龙江绥滨156200

在我国农业生产的具体过程中,农业生产的自身结构中就包括了农业机械化这一主要内容,农业机械化的发展,不仅标志着一个国家农业水平的高低,还能从侧面反映出一个国家的经济发展水平。农业机械化在农业现代化中具有十分重要的作用,不仅... 详细信息

在我国农业生产的具体过程中,农业生产的自身结构中就包括了农业机械化这一主要内容,农业机械化的发展,不仅标志着一个国家农业水平的高低,还能从侧面反映出一个国家的经济发展水平。农业机械化在农业现代化中具有十分重要的作用,不仅可以提高农业生产的具体效率,还能解放农业生产力,促进农业经济的发展。文章将简要分析农业机械化在农业现代化中的作用。

关键词：农业机械化农业现代化作用

在线全文

学校读者我要写书评

暂无评论

巴基斯坦电力市场现状及发展简析

应用能源技术 2017年第7期 8-11页

作者：余新成中国大唐集团海外投资有限公司北京100053

巴基斯坦经济增长较快,电力需求供应缺口较大,电源结构不合理,整体发展水平较低,不能满足社会经济发展的需要,文中全面分析了巴基斯坦电力供需情况,并对其电力市场发展状况进行展望。

关键词：巴基斯坦电力市场电价机制