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Covalent inhibitor targets KRas^(G12C):A new paradigm for drugging the undruggable and challenges ahead

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Genes & Diseases 2023年第2期10卷 403-414页

作者： Hui-yu Li Wei-liang Qi yu-xiang wang Ling-hua Meng Division of Anti-tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Pharmacy Nanchang UniversityNanchangJiangxi 330006China

KRAS is one of the most commonly mutated oncogenes in cancers and therapeutics directly targeting the KRas have been *** the different known mutants,KRas^(G12C) has been proved to be successfully targeted *** covalent inhibitors selectively targeting KRas^(G12C) have shown promising efficacy against cancers harboring KRAS G12C mutation in clinical trials and AMG510(sotorasib)has been approved for the treatment of KRAS G12C-mutated locally advanced or metastatic non-small cell lung ***,the overall responsive rate of KRas^(G12C) inhibitors was around 50%in patients with non-small cell lung cancer and the efficacy in patients with colorectal cancer or appendiceal cancer appears to be less *** is of great importance to discover biomarkers to distinguish patients who are likely ***,adaptive resistance would occur inevitably with the persistent administration like other molecularly targeted *** combinatorial regimens have been studied in an effort to potentiate the efficacy of KRas^(G12C) inhibitors in preclinical *** review summarized the recent progress of covalent KRas^(G12C) inhibitors with a focus on identifying biomarkers to predict or monitor the efficacy and proposing rational drug combinations based on elucidation of the mechanisms of drug resistance.

关键词： Biomarkers Covalent KRas^(G12C)inhibitors Drug resistance Human cancers KRAS^(G12C)mutation

Rate compatible reconciliation for continuous-variable quantum key distribution using Raptor-like LDPC codes

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Science China(Physics,Mechanics & Astronomy) 2021年第6期64卷 26-34页

作者： Chao Zhou xiang yu wang ZhiGuo Zhang Song yu ZiYang Chen Hong Guo State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Advanced Optical Communication Systems and NetworksDepartment of Electronicsand Center for Quantum Information TechnologyPeking UniversityBeijing 100871China

In the practical continuous-variable quantum key distribution(CV-QKD)system,the postprocessing process,particularly the error correction part,significantly impacts the system ***-edge type low-density parity-check(MET-LDPC)codes are suitable for CV-QKD systems because of their Shannon-limit-approaching performance at a low signal-to-noise ratio(SNR).However,the process of designing a low-rate MET-LDPC code with good performance is extremely ***,we introduce Raptor-like LDPC(RL-LDPC)codes into the CV-QKD system,exhibiting both the rate compatible property of the Raptor code and capacity-approaching performance of MET-LDPC ***,this technique can significantly reduce the cost of constructing a new *** design the RL-LDPC matrix with a code rate of 0.02 and easily and effectively adjust this rate from 0.016 to *** results show that we can achieve more than 98%reconciliation efficiency in a range of code rate variation using only one RL-LDPC code that can support high-speed decoding with an SNR less than-16.45 d *** code allows the system to maintain a high key extraction rate under various SNRs,paving the way for practical applications of CV-QKD systems with different transmission distances.

关键词： continuous-variable quantum key distribution reconciliation Raptor-like LDPC codes

Pseudoscalar meson and baryon octet interaction with strangeness zero in the unitary coupled-channel approximation

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Chinese Physics C 2019年第6期43卷 107-114页

作者： Bao-Xi Sun Si-yu Zhao xiang-yu wang College of Applied Sciences Beijing University of Technology

The interaction of the pseudoscalar meson and the baryon octet is investigated by solving the Bethe-Salpeter equation in the unitary coupled-channel approximation. In addition to the Weinberg-Tomozawa term, the contribution of the s-and u-channel potentials in the-wave approximation are taken into account. In the sector of isospin I=1/2 and strangeness S =0, a pole is detected in a reasonable region of the complex energy plane of ■ in the center-of-mass frame by analyzing the behavior of the scattering amplitude, which is higher than the ηN threshold and lies on the third Riemann sheet. Thus, it can be regarded as a resonance state and might correspond to the N(1535) particle of the Particle Data Group(PDG) review. The coupling constants of this resonance state to the πN,ηN,KΛ and KΣ channels are calculated, and it is found that this resonance state couples strongly to the hidden strange channels. Apparently, the hidden strange channels play an important role in the generation of resonance states with strangeness zero. The interaction of the pseudoscalar meson and the baryon octet is repulsive in the sector of isospin I = 3/2 and strangeness S = 0, so that no resonance state can be generated dynamically.

关键词： chiral Lagrangian pion-nucleon interaction Bethe-Salpeter equation

Phase-field Modeling of the Influence of Elastic Field on the Nucleation and Microstructure Evolution in Precipitation

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Chinese Journal of Aeronautics 2007年第2期20卷 107-110页

作者： ZHANG yu-xiang wang Jin-cheng YANG yu-juan YANG Gen-cang ZHOU Yao-he State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072 China

A phase-field method was employed to study the influence of elastic field on the nucleation and microstructure evolution. Two kinds of nucleation process were considered： one using fixed nucleation probability and the other calculated from the classical nucleation theory. In the latter case, the simulated results show that the anisotropic elastic strain field yields significant effects on the behavior of nucleation. With a large lattice misfit between the matrixes and the precipitates, the nucleation process does not appear fully random but displays some spatial correlation and has a preference for the elastic soft direction. However, with a small lattice misfit, this bias does not look quite clear. On the contrary, in the case of fixed nucleation probability, the elastic field has no influence on the nucleation process. The lattice mismatch also exerts influences on the microstructure morphology： with lattice mismatch becoming larger, the microstructure proves to align along the elastic soft direction.

关键词： elastic field nucleation phase-field method precipitation

Surface modification of polyester film by glow discharge tunnel at atmospheric pressure

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 459-462页

作者： XU xiang-yu wang Shou-guo YE Tian-chun JING Guang-yin yu Da-peng State Key Laboratory for Mesoscopic Physics School of Physics Beijing 100871 China The Institution of Microelectronics Chinese Academy of Sciences Beijing 100010 China The Institution of Microelectronics Chinese Academy of Sciences Beijing 100010 China The Institution of Microelectronics Chinese Academy of Sciences Beijing 100010 China State Key Laboratory for Mesoscopic Physics School of Physics Beijing 100871 China State Key Laboratory for Mesoscopic Physics School of Physics Beijing 100871 China

A large-area improved dielectric barrier glow discharge tunnel has been developed for modifying the surface of polyester film at atmospheric pressure with argon and oxygen gas mixtures. The electrical properties of the glow discharge tunnel were studied by simultaneous measurement of the voltage and current. In addition, the effect of the glow discharge tunnel treatment on the surface of polyester film were studied. The resultant modifications of the surface properties of the treated samples were investigated through scanning probe microscopy and contact angle measurement.

关键词： glow discharge tunnel electrical characteristics surface modification polyester film

Revealing a peculiar supernova remnant G106.3+2.7 as a petaelectronvolt proton accelerator with X-ray observations

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The Innovation 2021年第2期2卷 166-171页

作者： Chong Ge Ruo-yu Liu Shu Niu Yang Chen xiang-yu wang Department of Physics and Astronomy University of Alabama in HuntsvilleHuntsvilleAL 35899USA School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China University of Chinese Academy of Sciences(CAS) Beijing 100049China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryCASShanghai 200030China

Supernova remnants(SNRs)have long been considered as one of the most promising sources of Galactic cosmic *** the SNR paradigm,petaelectronvolt(PeV)proton acceleration may only be feasible at the early evolution stage,lasting a few hundred years,when the SNR shock speed is *** evidence supporting the acceleration of PeV protons in young SNRs has yet to be discovered,X-ray synchrotron emission is an important indicator of fast ***,we report the first discovery of X-ray synchrotron emission from the possibly middle-aged SNR G106.3+2.7,implying that this SNR is still an energetic particle accelerator despite its *** discovery,along with the ambient environmental information,multiwavelength observation,and theoretical arguments,supports SNR G106.3+2.7 as a likely powerful proton PeV accelerator.

关键词： cosmic rays supernova remnants nonthermal radiation

Coupling effect of micro-textured tools and cooling conditions on the turning performance of aluminum alloy 6061

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Advances in Manufacturing 2023年第4期11卷 663-681页

作者： Guo-Liang Liu Jin-Tao Zheng Chuan-Zhen Huang Shu-Feng Sun Xin-Fu Liu Long-Jie Dai De-xiang wang xiang-yu wang Key Lab of Industrial Fluid Energy Conservation and Pollution Control Ministry of EducationKey Lab of Industrial Fluid Energy Conservation and Pollution ControlMinistry of EducationSchool of Mechanical and Automotive EngineeringQingdao University of TechnologyQingdao266520ShandongPeople’s Republic of China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha410083People’s Republic of China Key Laboratory of High-Efficiency and Clean Mechanical Manufacture(Ministry of Education) School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiPeople’s Republic of China Qingdao Choho Ind Co Ltd Qingdao266705ShandongPeople’s Republic of China School of Mechanical Engineering University of JinanJinan250022People’s Republic of China

Micro-texturing has been widely proven to be an effective technology for achieving sustainable ***,the performance of micro-textured tools under different cooling conditions,especially their coupling effect on machined surface integrity,was scarcely *** this paper,the non-textured,linear micro-grooved,and curvilinear micro-grooved inserts were used to turn aluminum alloy 6061 under dry,emulsion,and liquid nitrogen cryogenic cooling *** coupling effects of different micro-textures and cooling conditions on cutting force,cutting temperature,and machined surface integrity,including the surface roughness,work hardening,and residual stress,were revealed and discussed in *** indicated that the micro-grooved tools,especially the curvilinear micro-grooved tools,not only reduced the cutting force and cutting temperature,but also improved the machined surface *** addition,the micro-grooved tools can cooperate with the emulsion or liquid nitrogen to reduce the cutting force,cutting temperature,and improve the machined surface integrity generally,although the combination of emulsion cooling condition and micro-grooved tools generated negative coupling effects on cutting forces and surface work ***,the combination of curvilinear micro-grooved cutting tools and cryogenic cooling condition resulted in the lowest cutting force and cutting temperature,which generated the surface with low roughness,weak work hardening,and compressive residual stress.

关键词： Micro-grooved cutting tool Cooling condition Cutting force Cutting temperature Surface integrity

How to use the Surveillance,Epidemiology,and End Results(SEER)data:research design and methodology

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Military Medical Research 2024年第5期11卷 686-696页

作者： Wen-Qiang Che yuan-Jie Li Chi-Kwan Tsang yu-Jiao wang Zheng Chen xiang-yu wang An-Ding Xu Jun Lyu Department of Neurosurgery the First Affiliated Hospital of Jinan UniversityGuangzhou510632China Department of Clinical Research the First Affiliated Hospital of Jinan UniversityGuangzhou510632China Planning&Discipline Construction Office the First Affiliated Hospital of Jinan UniversityGuangzhou510632China Clinical Neuroscience Institute the First Affiliated Hospital of Jinan UniversityGuangzhou510632China Department of Pathology Shanxi Provincial People’s HospitalTaiyuan030012China Department of Urology the First Affiliated Hospital of Jinan UniversityGuangzhou510632China Department of Neurology the First Affiliated Hospital of Jinan UniversityGuangzhou510632China Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Guangzhou510632China

In the United States(US),the Surveillance,Epidemiology,and End Results(SEER)program is the only comprehensive source of population-based information that includes stage of cancer at the time of diagnosis and patient survival *** program aims to provide a database about cancer incidence and survival for studies of surveillance and the development of analytical and methodological tools in the cancer ***,the SEER program covers approximately half of the total cancer patients in the US.A growing number of clinical studies have applied the SEER database in various ***,the intrinsic features of the SEER database,such as the huge data volume and complexity of data types,have hindered its *** this review,we provided a systematic overview of the commonly used methodologies and study designs for retrospective epidemiological research in order to illustrate the application of the SEER ***,the goal of this review is to assist researchers in the selection of appropriate methods and study designs for enhancing the robustness and reliability of clinical studies by mining the SEER database.

关键词： Surveillance Epidemiology and End results(SEER) Big data Epidemiology Methodologies Study design

Numerical Simulation of Temperature Field and Thermal Stress Field of Work Roll During Hot Strip Rolling

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Journal of Iron and Steel Research International 2007年第5期14卷 18-21页

作者： LI Chang-sheng yu Hai-liang DENG Guan-yu LIU xiang-hua wang Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Based on the thermal conduction equations, the three-dimensional （3D） temperature field of a work roll was investigated using finite element method （FEM）. The variations in the surface temperature of the work roll during hot strip rolling were described, and the thermal stress field of the work roll was also analyzed. The results showed that the highest roll surface temperature is 593 ℃, and the difference between the minimum and maximum values of thermal stress of the work roll surface is 145.7 MPa. Furthermore, the results of this analysis indicate that temperature and thermal stress are useful parameters for the investigation of roll thermal fatigue and also for improving the quality of strip during rolling.

关键词： hot strip mill roll temperature field thermal stress finite element method