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A numerical investigation of interactions between extreme waves and a vertical cylinder

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Journal of Hydrodynamics 2020年第5期32卷 853-864页

作者： Qun-bin Chen yu-xiang ma Guo-hai Dong Xiao-zhou ma Bing Tai Xu-yang Niu State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

In this paper,the interactions between extreme waves and a vertical cylinder are investigated through a 3-D two-phase flow *** numerical model is verified and validated by experimental ***,two factors are considered,the global wave steepness and the frequency bandwidth of the wave groups,in the studies of the in-line wave forces and the wave run-up around a *** is found that both the in-line wave forces and the wave run-up are remarkably increased with the increase of the global wave steepness,whereas the effect of the frequency bandwidth on the in-line wave forces is relatively weak in comparison with its effect on the wave *** minimum and maximum wave run-ups are located in the directions of 22.5°and 180°with respect to the direction of the incident waves,***,a new empirical formula is proposed for predicting the in-line wave forces by using only the free surface elevations around the *** results of the formula agree well with the simulation results.

关键词： Extreme waves vertical cylinder in-line wave force wave run-up

Myelodysplastic syndrome transformed into B-lineage acute lymphoblastic leukemia: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5191-5196页

作者： Ye-Jing Zhu xiang-yu ma yun-Liang Hao yun Guan Department of Clinical Medicine Clinical College of Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Science and Education People's Hospital of RizhaoRizhao 276800Shandong ProvinceChina Department of Hematology Jining First People’s HospitalJining 272000Shandong ProvinceChina

BACKGROUND Myelodysplastic syndromes(MDSs)are a group of hematological diseases caused by expansion of an abnormal clone of hematopoietic stem *** MDS is a potentially premalignant clonal disorder that may progress to overt acute leukemia in 25%-50%of ***,most of these cases evolve into acute myeloid leukemia and rarely progress to acute lymphoblastic leukemia(ALL).Thus,transformation of MDS into B-cell ALL is *** SUMmaRY A 58-year-old man was admitted to the hospital for reduced blood cell *** on all the test results and the World Health Organization diagnosis and classification,the patient was finally diagnosed with ring-shaped sideroblastic MDS with refractory hemocytopenia due to multilineage *** used red blood cell transfusions and other symptomatic support *** 4 years,the patient felt dizziness,fatigue,and night *** improved bone marrow and peripheral blood and other related auxiliary *** was eventually diagnosed with B-lineage acute lymphocytic leukemia(MDS transformation).CONCLUSION The number of peripheral blood cells,type of MDS,proportion of primitive cells in bone marrow,and number and quality of karyotypes are all closely related to the conversion of MDS to ALL.

关键词： Acute lymphoblastic leukemia B-lineage acute lymphocytic leukemia

Study on the Concept of Per Capita Cumulative Emissions and Allocation Options

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Advances in Climate Change Research 2011年第2期2卷 79-85页

作者： Shengmin yu xiang Gao Cuimei ma Lihua Zhai Energy Research Institute National Development and Reform Commission Beijing 100038 China

Global long-term emission reduction targets need well defined options for equitable allocation of greenhouse gas emissions. Scholars from developing countries put forward the concept of equitable per capita cumulative emission rights. There are four possible operational definitions resulting from this concept. These potential options for allocation of emission rights are expressed with mathematical equations. Through simple simulation, this paper reveals the advantages, disadvantages and characteristics of each option.

关键词： climate change global long-term target per capita historical cumulative emission right equitable allocation

A direct coupling analysis method and its application to the Scientific Research and Demonstration Platform

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Journal of Hydrodynamics 2021年第1期33卷 13-23页

作者： Jun Ding You-sheng Wu Xin-yun Ni Qi-bin Wang yu-chao Chen Yong-lin Ye Xin-yu Zhang yu-xiang ma Wei-nan Yang China Ship Scientific Research Center Wuxi 214082China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Design of a very large floating structure(VLFS)deployed near islands and reefs,different from those in the open sea,inevitably faces new technical challenges including numerical analysis *** this paper,a direct coupling analysis method(DCAM)has been established based on the Boussinesq equations and the three-dimensional hydroelasisity theory with Rankine source method to analyze the responses of a VLFS in shallow sea with complicated geographical *** tests have been carried out to validate the *** further verify the numerical methods and investigate the performance of such a VLFS,a“Scientific Research and Demonstration Platform(SRDP)”was built and deployed in 2019 at the site about 1000 m off an island with water depth around 40m in South China *** is a simplified small model of a two-module semi-submersible-type *** numerical simulation of its responses on severe waves with focus on motions and connector forces is conduct by DCAM,and compared with the on-site *** agreement has been *** approves the DCAM as a feasible tool for design and safety assessment of a VLFS deployed near islands and reefs.

关键词： Very large floating structure(VLFS) hydroelastic analysis near island direct coupling analysis method model test on-site measurement verification

Mechanochromism of polyurethane based on folding-unfolding of cyano-substituted oligo(p-phenylene)vinylene dimer

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Frontiers of materials Science 2023年第2期17卷 169-180页

作者： Na Zhang xiang-yu ma Shun Li yu-Xin Zhang Chen Lv Zheng-Peng mao Zi-Yi Dou Tai-Sheng Wang School of materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China Jiangsu Key Laboratory of Advanced Structural materials and Application Technology Nanjing 211167China

The incorporation of mechanophores,motifs that transform mechanical stimulus into chemical reaction or optical variation,allows creating materials with stressresponsive *** most widely used mechanophore generally features a weak bond,but its cleavage is typical an irreversible ***,we showed that this problem can be solved by folding–unfolding of a molecular *** systematically studied the mechanochromic properties of polyurethanes with cyano-substituted oligo(p-phenylene)vinylene(COP)tweezer(DPU).As a control experiment,a class of polyurethanes containing only a single COP moiety(MPU)was also *** DPU showed prominent mechanochromic properties,due to the intramolecular folding–unfolding of COP tweezer under mechanical *** process was efficient,reversible and optical ***,due to the disability to form either intramolecular folding or intermolecular aggregation,the MPU sample was mechanical inert.

关键词： mechanochromism molecular tweezer folding-unfolding cyanosubstituted oligo(p-phenylene)vinylene polyurethane

The Good Pain management(GPM) Ward Program in China and its impact on Chinese cancer patients: the SYSUCC experience

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Chinese Journal of Cancer 2014年第7期33卷 323-329页

作者： yun-Peng Yang yu-xiang ma Yan Huang yuan-yuan Zhao Fei Xu Ying Tian Ben-Yan Zou Rui-Zhen Gao Li Zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Medical Oncology Sun Yat-sen University Cancer Center

To improve cancer pain management, the Medical Oncology Department of Sun Yat-sen University Cancer Center(SYSUCC) launched the Good Pain management(GPM) Ward Program, which has been recognized by the Chinese Ministry of Health and promoted throughout the nation. This retrospective case-control study was designed to evaluate the effectiveness of the program. Patients diagnosed with malignant solid tumors with bone metastasis were eligible. Patients who were admitted 6 months before the initiation of the GPM program were used as the control group, and patients admitted 6 months after the initiation of the program were used as the GPM group. The pain-reporting rate and pain management index(PMI) were calculated. The pain levels before and after pain management were compared. A total of 475 patients(244 in the control group and 231 in the GPM group) were analyzed. The pain-reporting rate of the GPM group was significantly higher than that of the control group(62.8% vs. 37.7%, P management of cancer patients and provided experience for improving cancer pain management in the future.

关键词：癌症患者管理指数疼痛中国肿瘤防治中心对照组中山大学 PMI

Multiple oncogenic mutations related to targeted therapy in nasopharyngeal carcinoma

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Chinese Journal of Cancer 2015年第4期34卷 177-183页

作者： Jian-Wei Zhang Tao Qin Shao-Dong Hong Jing Zhang Wen-Feng Fang yuan-yuan Zhao yun-Peng Yang Cong Xue Yan Huang Hong-yuan Zhao yu-xiang ma Zhi-Huang Hu Pei-yu Huang Li Zhang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center

Introduction:An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma(NPC).However,targeted therapy-related oncogenic mutations have not been fully *** study aimed to detect targeted therapy-related oncogenic mutations in NPC and to determine which targeted therapy might be potentially effective in treating ***:By using the SNaPshot assay,a rapid detection method,19 mutation hotspots in 6 targeted therapy-related oncogenes were examined in 70 NPC *** associations between oncogenic mutations and clinicopathologic factors were ***:Among 70 patients,12(17.1%) had mutations in 5 oncogenes:7(10.0%) had v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog(KIT) mutation,2(2.8%) had epidermal growth factor receptor(EGFR) mutation,1(1.4%) had phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha(PIK3CA) mutation,1(1.4%) had Kirsten rat sarcoma viral oncogene homolog(KRAS) mutation,and 1(1.4%) had simultaneous EGFR and v-Raf murine sarcoma viral oncogene homolog B1(BRAF) *** significant differences were observed between oncogenic mutations and clinicopathologic ***,these oncogenic mutations were not associated with tumor recurrence or ***:Oncogenic mutations are present in NPC *** efficacy of targeted drugs on patients with the related oncogenic mutations requires further validation.

关键词：基因突变靶向治疗鼻咽癌致癌表皮生长因子受体快速检测方法原癌基因同源基因

The impact of both platinum-based chemotherapy and EGFR-TKIs on overall survival of patients with advanced non-small cell lung cancer

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Chinese Journal of Cancer 2014年第2期33卷 105-114页

作者： Jian-Wei Zhang yuan-yuan Zhao Ying Guo Cong Xue Zhi-Huang Hu Yan Huang Hong-yun Zhao Jing Zhang Xuan Wu Wen-Feng Fang yu-xiang ma Li Zhang State Key Laboratory of Oncology in South China Department of Medical Oncology Sun Yat-sen University Cancer Center Clinical Trials Center Sun Yat-sen University Cancer Center

Both platinum-based doublet chemotherapy(PBC) and epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs) prolong the survival of patients with advanced non-small cell lung cancer(NSCLC). In early studies, most patients underwent PBC as first-line treatment, but not all patients could afford EGFR-TKIs as second-line treatment. To understand the impact of PBC and EGFR-TKIs on NSCLC prognosis, we evaluated the association between the receipt of both regimens and overall survival(OS). Using MEDLINE and EMBASE, we identified prospective, randomized, controlled phase III clinical trials in advanced NSCLC that met the inclusion criteria: in general population with advanced NSCLC, the percentage of patients treated with both PBC and EGFR-TKIs was available in the trial and OS was reported. After collecting data from the selected trials, we correlated the percentage of patients treated with both PBC and EGFR-TKIs with the reported OS, using a weighted analysis. Fifteen phase III clinical trials—involving 11,456 adult patients in 32 arms—were included in the analysis, including 6 trials in Asian populations and 9 in non-Asian(predominantly Caucasian) populations. The OS was positively correlated with the percentage of patients treated with both PBC and EGFR-TKIs(r = 0.797, P may provide a survival benefit to patients with advanced NSCLC, highlighting the importance of having both modalities available for therapy.

关键词：非小细胞肺癌生存期患者晚期化疗中国人民银行酪氨酸激酶抑制剂表皮生长因子受体

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao xiang Feng Gao yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states