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Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

Science China(Life Sciences) 2025年第1期68卷 219-231页

作者： Yingying Feng yuying Wu Jialu Wang Zhenglin Dong Qian yu Shuangshuang xia Chunxue Liu Haihua Wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China ANYOU Biotechnology Group Co.Ltd Taicang 215412China Qingdao Seawin Biotech Group Co. LTDQingdao 266071China

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides_fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

关键词： Enteromorpha prolifera polysaccharide-Fe(III)complex iron deficiency intestinal development gut microbiota weaned piglet

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Control upconversion decay dynamics from perspective of collective response

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Journal of Rare Earths 2025年第1期43卷 57-63,I0003页

作者： Yingdong Han yutong Pan tong Wei yu Ma Xingxing Zhang Lei Jiang Kai Chen Liwei Wu Jiao Cui Chao Gao College of Science Civil Aviation University of ChinaTianjin300300China School of Inspection and Testing Certification Changzhou Vocational Institute of EngineeringChangzhou213164China School of Chemical and Physical Sciences Victoria University of WellingtonWellington6012New Zealand Robinson Research Institute Faculty of EngineeringVictoria University of WellingtonWellington6012New Zealand

Very recently,upconversion luminescence(UCL)lifetime,as a powerful optical dimension,has attracted tremendous research interest due to its advantages of high information capacity and high photophysical *** the implementation and emergence of endlessly fascinating UCL features,it is particularly meaningful to understand the photophysical mechanisms inside UCL materials to enable rational subdivision-level structure design,which is however currently far from *** this work,we take an ordinary upconversion nanoparticle as an example to prove that the UCL decay curves and corresponding lifetimes are indeed a collective response of the entire UCL system to excitations,that exhibits correlated,yet quite different properties from individual ions.A specially developed theoretical random walk model combined with an experimental lifetime control for Yb^(3+)/Er^(3+)UCL demonstrates that ene rgy diffusion principally alters the decay ***,the different extent of the influence of energy diffusion on the emissions of ^(2)H_(11/2)/^(4)S_(3/2)(green)and ^(4)F_(9/2)(red)leads to an extremely uncommon crossover comparison of decay *** work provides new ideas for understanding decay dynamics and practical UCL lifetime manipulation methods.

关键词： Upconversion Lifetime Collective response Decaycurves Random walk model Rare earths

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IPFA-Net: Important Points Feature Aggregating Net for Point Cloud Classification and Segmentation

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Chinese Journal of Electronics 2025年第1期34卷 322-337页

作者： Jingya Wang yu Zhang Bin Zhang Jinxiang xia Weidong Wang School of Information and Software Engineering University of Electronic Science and Technology of China National Key Laboratory of Automotive Chassis Integration and Bionics Jilin University

This paper focuses on the problems of point cloud deep neural networks in classification and segmentation tasks, including losing important information during down-sampling, ignoring relationships among points when extracting features, and network performance being susceptible to the sparsity of point cloud. To begin with, this paper proposes a farthest point sampling-important points sampling method for down-sampling, which can preserve important information of point clouds and maintain the geometry of input data. Then, the local feature relation aggregating method is proposed for feature extraction, improving the network's ability to learn contextual information and extract rich local region features. Based on these methods, the important points feature aggregating net(IPFA-Net) is designed for point cloud classification and segmentation tasks. Furthermore, this paper proposes the multi-scale multi-density feature connecting method to reduce the negative impact of point cloud data sparsity on network performance. Finally, the effectiveness of IPFA-Net is demonstrated through experiments on ModelNet40, ShapeNet part, and ScanNet v2 datasets. IPFA-Net is robust to reducing the number of point clouds, with only a 3.3% decrease in accuracy under a 16-fold reduction of point number. In the part segmentation experiments, our method achieves the best segmentation performance for five objects.

关键词： Point cloud compression Representation learning Geometry Fuses Semantics Artificial neural networks Feature extraction Sampling methods Robustness Data mining

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-yu tong xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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Multiple-event-triggered adaptive fuzzy output-feedback control for MIMO uncertain nonlinear systems

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Science China Technological Sciences 2025年第2期68卷 220-230页

作者： Shuai SUI yu YANG Shaocheng tong C.L.Philip CHEN School of Science Liaoning University of Technology School of Computer Science and Engineering South China University of Technology

The article addresses the output-feedback control issue for a class of multi-input multi-output(MIMO) uncertain nonlinear systems with multiple event-triggered mechanisms(ETM). Compared to previous event-triggering studies, this paper aims to trigger both the output and filtered signals. Unknown nonlinear dynamics are approximated using fuzzy logic systems(FLSs). Then, a novel kind of state observer has been designed to deal with unmeasurable state problems using the triggered output signal. The sampled estimated state, the triggered output signal, and the filtered signal are utilized to propose an event-triggering mechanism that consists of sensor-to-observer(SO) and observer-to-controller(OC). An event-triggered output feedback control approach is given inside backstepping control, whereby the filter may be employed to circumvent the issue of the virtual control function not being differentiable at the trigger time. It is testified that, according to the Lyapunov stability analysis scheme, all closed-loop signals and the system output are ultimately uniformly constrained by our control method. Finally, the simulation examples are performed to confirm the theoretical findings.

关键词： event-triggered control (ETC) dynamic surface control (DSC) output-feedback control fuzzy adaptive control

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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

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Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANG Hui-ping ZHANG Na xia Jia CHEN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

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Magnitude, spatial patterns and drivers of methane fluxes from coastal salt marshes and mangrove forests in China

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Science China Earth Sciences 2025年第3期68卷 850-866页

作者： Yixuan yu Derrick Y.F.LAI Minjie HU Chuan tong Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education Fujian Normal University School of Geographical Sciences Fujian Normal University Department of Geography and Resource Management The Chinese University of Hong Kong

Methane（CH4） is a highly potent greenhouse gas due to its high radiative forcing and global warming *** the magnitude, spatial patterns, and drivers of CH4emission from wetlands at the regional scale is crucial for formulating suitable strategies to mitigate future climate change. In this study, we synthesized the CH4flux data reported for major plant communities in the coastal salt marshes and mangrove forests in China and produced a spatial map of CH4fluxes from the mangrove sediments and salt marshes in China based on the results of machine learning models. Moreover, we examined the main drivers of CH4flux from these coastal wetlands and estimated the annual CH4emissions from the salt marshes and mangrove forests in different coastal provinces of China using a bottom-up approach. Our results showed that the mean CH4fluxes from the salt marsh and mangrove ecosystems in China were 2.22±0.29 and 2.26±0.55 mg m-2h-1, respectively. Across China, the total annual CH4emission from salt marshes was 31,179.75 Mg CH4a-1, while that from mangroves was 5,533.97 Mg CH4a-1with the sediments contributing to 12.7%(701.64 Mg CH4a-1) of the total efflux. The salt marshes and mangroves in China accounted for 2.75% and 0.14%–0.15% of the global annual CH4emissions from these two ecosystems,respectively. Moreover, we found that CH4emissions from the salt marshes and mangroves could offset the cooling impact arising from net carbon dioxide uptake by 88% and 53%, respectively, over a 100-year time scale. Mean annual temperature, soil moisture, and soil organic carbon content were the main factors controlling CH4emissions from these coastal ***, we found that CH4fluxes from the salt marshes in China decreased with latitude, which implied a possible increase in marsh CH4emission in response to global warming that should be considered carefully when developing nature-based climate solutions to achieve national goals for carbon neutrality.

关键词： Salt marsh Mangrove Methane flux Spatial pattern Driving factors China

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Atmospheric reductive catalytic fractionation of lignocellulose integrated with one-pot catalytic conversion of carbohydrate yielding valuable lignin monomers and platform chemicals from corn straw

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Green Energy & Environment 2025年第1期10卷 161-172页

作者： Meng-Ying Liu Zhe-Hui Zhang Xue-Qi Wang Qian Sun Chen Zhang yu Li Zhuohua Sun Katalin Barta Feng Peng tong-Qi yuan State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing100083China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Department of Chemistry Organic and Bioorganic ChemistryUniversity of GrazHeinrichstrasse 28/II8010 GrazAustria

Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent ***,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps *** key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene *** utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling *** the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.

关键词： Atmospheric reductive catalytic fractionation Corn straw Ethylene glycol Raney Ni 5-Methoxymethylfurfural

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General Automatic Solution Generation for Social Problems

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Machine Intelligence Research 2025年第1期22卷 145-159页

作者： tong Niu Haoyu Huang yu Du Weihao Zhang Luping Shi Rong Zhao Center for Brain-Inspired Computing Research(CBICR) Optical Memory National Engineering Research Centerand Department of Precision InstrumentTsinghua UniversityBeijing100084China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing100084China THU-CET HIK Joint Research Center for Brain-Inspired Computing Beijing100084China

Given the escalating intricacy and multifaceted nature of contemporary social systems,manually generating solutions to address pertinent social issues has become a formidable *** response to this challenge,the rapid development of artificial intelligence has spurred the exploration of computational methodologies aimed at automatically generating ***,current methods for the auto-generation of solutions mainly concentrate on local social regulations that pertain to specific ***,we report an automatic social operating system(ASOS)designed for general social solution generation built upon agent-based models that enables both global and local analyses and regulations of social problems across spatial and temporal *** adopts a hypergraph with extensible social semantics for a comprehensive and structured representation of social *** also incorporates a generalized protocol for standardized hypergraph operations and a symbolic hybrid framework that delivers interpretable solutions,yielding a balance between regulatory efficacy and functional *** demonstrate the effectiveness of the ASOS,we apply it to the domain of averting extreme events within international oil futures *** generating a new trading role supplemented by new mechanisms,ASOS can adeptly discern precarious market conditions and make front-running interventions for nonprofit *** study demonstrated that ASOS provides an efficient and systematic approach for generating solutions for enhancing our society.

关键词： General automatic generation global-local regulation hypergraph social representation symbolic hybrid scheme generalized operation protocol

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Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-tong Cui Hua-Ru Xue Dian-Fang Wei xiao-yu Feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

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