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Success of susceptibility-guided eradication of Helicobacter pylori in a region with high secondary clarithromycin and levofloxacin resistance rates

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World Journal of Gastroenterology 2024年第2期30卷 184-195页

作者： Yan-Meng Wang Mo-Ye Chen Jing Chen xin-He Zhang Yan Feng yu-xi han Yi-Ling Li Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department The First Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of Helicobacter pylori(***)is increasing in severity,and successful eradication is ***,the eradication success rate has greatly declined,leaving a large number of patients with previous treatment *** To investigate secondary resistance rates,explore risk factors for antibiotic resistance,and assess the efficacy of susceptibility-guided *** We recruited 154 subjects positive for Urea Breath Test who attended The First Affiliated Hospital of China Medical University between July 2022 and April *** underwent a string test after an overnight *** gastric juice was obtained and transferred to vials containing storage ***,DNA extraction and the specific DNA amplification were performed using quantitative polymerase chain reaction(qPCR).Demographic information was also analyzed as part of the *** on these results,the participants were administered susceptibility-guided *** was compared with that of the empiric treatment *** A total of 132 individuals tested positive for the *** ureA gene by qPCR *** resistance rate reached a high level of 82.6%(n=109),LFX resistance rate was 69.7%(n=92)and dual resistance was 62.1%(n=82).Gastric symptoms[odds ratio(OR)=2.782;95%confidence interval(95%CI):1.076-7.194;P=0.035]and rural residence(OR=5.152;95%CI:1.407-18.861;P=0.013)were independent risk factors for secondary resistance to CLA and LFX,respectively.A total of 102 and 100 individuals received susceptibility-guided therapies and empiric treatment,*** antibiotic susceptibility-guided treatment and empiric treatment groups achieved successful eradication rates of 75.5%(77/102)and 59.0%(59/411)by the intention-to-treat(ITT)analysis and 90.6%(77/85)and 70.2%(59/84)by the per-protocol(PP)analysis,*** eradication rates of these two treatment strategies were significantly

关键词： Helicobacter pylori Antibiotic resistance Clarithromycin Levofloxacin String-test Susceptibility-guided therapy Eradication rate

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某排土场在不同工况下边坡稳定性研究

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价值工程 2024年第4期43卷 140-142页

作者：于韩浠张雄彪武汉轻工大学武汉430000 新洋丰农业科技股份有限公司荆门448000

为研究某排土场边坡稳定性,结合排土场所在位置工程地质概况,利用GeoStudio软件,采用三种不同的极限平衡法对排土场最不利滑动面进行分析,计算其在自然、强降雨及地震工况的最小边坡安全系数,为排土场边坡稳定性提供数据支撑。

关键词：排土场极限平衡法强降雨地震

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A Generalized Blow up Criteria with One Component of Velocity for 3D Incompressible MHD System

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 253-264页

作者： Bin han xi xiONG Department of Mathematics Hangzhou Dianzi UniversityHangzhou 310018China

In this paper,the authors study the global regularity of the 3D magnetohydrodynamics system in terms of one velocity *** particular,they establish a new Prodi-Serrin type regularity criterion in the framework of weak ... 详细信息

关键词： MHD Regularity Blow-up criterion

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Improved nuclear mass formula with an additional term from the Fermi gas model

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Nuclear Science and Techniques 2024年第5期35卷 131-138页

作者： xiao-yu Xu Li Deng Ai-xi Chen hang Yang Amir Jalili han-Kui Wang School of Science Zhejiang Sci-Tech UniversityHangzhou 310018China

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear *** to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding *** this study,the mass formula was improved by considering an additional term from the Fermi gas *** nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear *** RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

关键词： Nuclear mass formula Neutron-rich nuclei Fermi-gas model

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Rapid report of the December 18,2023 M_(S)6.2 Jishishan earthquake,Gansu,China

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Earthquake Research Advances 2024年第2期4卷 14-21页

作者： Guangjie han Danqing Dai yu Li Nan xi Li Sun China Earthquake Networks Center Beijing100045China

On December 18,2023,the Jishishan area in Gansu Province was jolted by a M_(S) 6.2 earthquake,which is the most powerful seismic event that occurred throughout the year in *** earthquake occurred along the NWtrending Lajishan fault(LJSF),a large tectonic transformation *** this event,China Earthquake Networks Center(CENC)has timely published several reports about seismic sources for emergency *** earthquake early warning system issued the first alert 4.9 s after the earthquake occurrence,providing prompt notification that effectively mitigated panics,injuries,and deaths of *** near real-time focal mechanism solution indicates that this earthquake is associated with a thrust *** distribution of aftershocks,the rupture process,and the recorded amplitudes from seismic monitoring and GNSS stations,all suggest that the mainshock rupture predominately propagates to the northwest *** duration of the rupture process is~12 s,and the largest slip is located at approximately 6.3 km to the NNW from the epicenter,with a peak slip of 0.12 m at~8 km *** station N0028 recorded the highest instrumental intensity,which is 9.4 on the Mercalli *** estimated intensity map shows a seismic intensity reaching up to IX near the rupture area,consistent with field survey *** aftershocks(up to December 22,2023)are mostly distributed in the northwest direction within~20 km of the *** earthquake caused serious casualties and house collapses,which requires further investigations into the impact of this earthquake.

关键词： Earthquake early warning Focal mechanism Rupture process Real-time intensity Coseismic deformation

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Corrosion behavior of pure metals(Ni and Ti)and alloys(316H SS and GH3535)in liquid GaInSn

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Nuclear Science and Techniques 2024年第3期35卷 70-83页

作者： Jian-Hui yu Hong-xia Xu xiang-xi Ye Bin Leng han-Xun Qiu xing-Tai Zhou School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

In this study,the interactions between a Ga-based liquid metal,GaInSn,and several metal materials,including pure metals(Ni and Ti)and alloys(316H stainless steel(SS)and GH3535),at 650℃were *** aim was to evaluate the corrosion performance and select a suitable candidate material for use as a molten salt manometer diaphragm in thermal energy storage *** results indicated that the alloys(316H SS and GH3535)exhibited less corrosion than pure metals(Ni and Ti)in liquid ***-rich binary intermetallic compounds were found to form on the surfaces of all the tested metal materials exposed to liquid GaInSn,as a result of the decomposition of liquid GaInSn and its reaction with the constituent elements of the metal *** corrosion mechanism for all the tested materials exposed to liquid GaInSn was also investigated and proposed,which may aid in selecting the optimal candidate material when liquid GaInSn is used as the pressure-sensing medium.

关键词： Metal materials Liquid GaInSn Corrosion Intermetallic compounds Thermal energy storage systems

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Derivative Spectroscopy and its Application at Detecting the Weak Emission/Absorption Lines

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Research in Astronomy and Astrophysics 2024年第3期24卷 205-223页

作者： Lihuan yu Jiangdan Li Jinliang Wang Jiajia Li Jiao Li Qiang xi Zhanwen han yunnan Observatories Chinese Academy of Sciences(CAS)Kunming 650011China Key Lab of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

The development of spectroscopic survey telescopes like Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),Apache Point Observatory Galactic Evolution Experiment and Sloan Digital Sky Survey has opened up unprecedented opportunities for stellar *** types of stars,such as early-type emission-line stars and those with stellar winds,can be distinguished by the profiles of their spectral *** this paper,we introduce a method based on derivative spectroscopy(DS)designed to detect signals within complex backgrounds and provide a preliminary estimation of curve *** method exhibits a unique advantage in identifying weak signals and unusual spectral line profiles when compared to other popular line detection *** validated our approach using synthesis spectra,demonstrating that DS can detect emission signals three times fainter than Gaussian ***,we applied our method to 579,680 co-added spectra from LAMOST Medium-Resolution Spectroscopic Survey,identifying 16,629 spectra with emission peaks around the Hαline from 10,963 *** spectra were classified into three distinct morphological groups,resulting in nine subclasses as follows.(1)Emission peak above the pseudo-continuum line(single peak,double peaks,emission peak situated within an absorption line,P Cygni profile,Inverse P Cygni profile);(2)Emission peak below the pseudo-continuum line(sharp emission peak,double absorption peaks,emission peak shifted to one side of the absorption line);(3)Emission peak between the pseudo-continuum line.

关键词： line identification-line profiles-methods data analysis-techniques spectroscopic-techniques radial velocities

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A Tabletop Nano-CT Image Noise Reduction Network Based on 3-Dimensional Axial Attention Mechanism

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Computers, Materials & Continua 2024年第7期80卷 1711-1725页

作者： Huijuan Fu Linlin Zhu ChunhuiWang xiaoqi xi yu han Lei Li Yanmin Sun Bin Yan Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou450000China

Nano-computed tomography(Nano-CT)is an emerging,high-resolution imaging ***,due to their low-light properties,tabletop Nano-CT has to be scanned under long exposure conditions,which the scanning process is *** 3D reconstruction data,this paper proposed a lightweight 3D noise reduction method for desktop-level Nano-CT called AAD-ResNet(Axial Attention DeNoise ResNet).The network is framed by theU-net *** encoder and decoder are incorporated with the proposed 3D axial attention mechanism and residual dense *** layer of the residual dense block can directly access the features of the previous layer,which reduces the redundancy of parameters and improves the efficiency of network *** 3D axial attention mechanism enhances the correlation between 3D information in the training process and captures the long-distance *** can improve the noise reduction effect and avoid the loss of image structure *** results show that the network can effectively improve the image quality of a 0.1-s exposure scan to a level close to a 3-s exposure,significantly shortening the sample scanning time.

关键词： Deep learning tabletop Nano-CT image denoising 3D axial attention mechanism

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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

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Frontiers of Medicine 2024年第2期18卷 344-356页

作者： Xue han Chune Ren Aifang Jiang Yonghong Sun Jiayi Lu xi Ling Chao Lu Zhenhai yu Department of Reproductive Medicine Affiliated Hospital of Weifang Medical UniversityWeifang261053China Department of Pathology Affiliated Hospital of Weifang Medical UniversityWeifang261053China

ALKBH5 is a master regulator of N6-methyladenosine(m6A)modification,which plays a crucial role in many biological ***,we show that ALKBH5 is required for breast tumor ***,PRMT6 directly methylates ALKBH5 at R283,which subsequently promotes breast tumor ***,arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation,leading to increased aerobic ***,PRMT6-mediated ALKBH5 arginine methylation is confirmed in PRMT6-knockout ***,these findings identify a PRMT6-ALKBH5-LDHA signaling axis as a novel target for the treatment of breast cancer.

关键词： PRMT6 ALKBH5 N6-methyladenosine glycolysis tumor growth

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Capture Efficiency Analysis in the Circular Restricted Three-body Problem

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Research in Astronomy and Astrophysics 2024年第5期24卷 198-210页

作者： yu-Xuan Miao xi-yun Hou Department of Astronomy and Space Science Nanjing UniversityNanjing 210023China Institute of Space Environment and Astrodynamics Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two ***, a non-uniform distribution of test particles around the secondary's orbit is obtained by fully accounting the secondary's gravitational influence. Second, the capture efficiency is computed based on the non-uniform distribution. Several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency(p) and the mass ratio(μ) is established, which is given by p ≈ 0.27 × μ^(0.53), within the range of 3.0035 ×10^(-6)≤ μ ≤ 3.0034 × 10^(-5). Taking the Sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. Our studies find that the secondary's orbit eccentricity has a negative influence on the capture efficiency.

关键词： methods numerical-celestial mechanics-planets and satellites dynamical evolution and stability

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