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Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data

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Cancer Biology & Medicine 2024年第8期21卷 712-723页

作者： yu Zhang Chao sheng Zhangyan Lyu Hongji Dai Fangfang song Fengju song yubei Huang Kexin Chen Department of Epidemiology and Biostatistics Key Laboratory of Molecular Cancer EpidemiologyKey Laboratory of Prevention and Control of Human Major DiseasesMinistry of EducationNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjin 300060China

Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and ***: We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios(HRs) and absolute risk reductions(ARRs) for CRC incidence and mortality according to risk ***: During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases and 1,487 CRC deaths, respectively. CRC incidence and mortality were significantly lower among screened than non-screened participants in both the intermediateand high-risk groups [incidence: HR: 0.87, 95% confidence interval(CI): 0.81±0.94;0.81, 0.73±0.90;mortality: 0.75, 0.64±0.87;0.70, 0.58±0.85], which composed approximately 60% of the study population. The ARRs(95% CI) were 0.17(0.11±0.24) and 0.43(0.24±0.61), respectively, for CRC incidence, and 0.08(0.05±0.11) and 0.24(0.15±0.33), respectively, for mortality. Screening did not significantly reduce the relative or absolute risk of CRC incidence and mortality in the low-risk group. Further analysis revealed that screening was most effective for men and individuals with distal CRC among the intermediate to high-risk ***: After integrating both genetic and non-genetic factors, our findings provided priority evidence of risk-stratified CRC screening and valuable insights for the rational allocation of health resources.

关键词： Colorectal cancer screening polygenic risk score incidence mortality

Demonstration of high-dimensional controlled quantum teleportation for the first time

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 163-164页

作者： yu-Bo sheng Lan Zhou College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

Controlled quantum teleportation(CQT) [1] is the tripartite version of quantum teleportation and it allows the teleportation of an unknown quantum state under the control of a third party. Compared with low-dimensional counterparts,high-dimensional CQT can exhibit larger information transmission capacity and a higher control power [2,3].

关键词： quantum dimensional high

Trial application of the envelope method to the potential ambiguity problem

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Nuclear Science and Techniques 2024年第1期35卷 73-80页

作者： Li-yuan Hu yu-Shou song Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin Engineering UniversityHarbin 150001China College of Nuclear Science and Technology Harbin Engineering UniversityHarbin 150001China Key Laboratory of Nuclear Safety and Advanced Nuclear Energy Technology Ministry of Industry and Information TechnologyHarbin 150001China

The optical potential ambiguity is a long-standing problem in the analysis of elastic scattering *** a specific collid-ing system,ambiguous potential families can lead to different behaviors in the nearside and farside scattering *** contrast,the envelope method can decompose the experimental data into two components with negative and positive deflection angles,***,a question arises as to whether the comparison between the calculated nearside(or farside)component and the derived positive-deflection-angle(or negative-deflection-angle)component can help analyze the potential ambiguity *** this study,we conducted a trial application of the envelope method to the potential ambiguity *** envelope method was improved by including uncertainties in the experimental *** colliding systems of 16O+28Si at 215.2 MeV and 12C+12C at 1016 MeV were considered in the *** each colliding system,the angular distribution experimental data were described nearly equally well by two potential sets,one of which is“surface transpar-ent”and the other is *** calculated angular distributions were decomposed into nearside and farside scattering *** the improved envelope method,the experimental data were decomposed into the positive-deflection-angle and negative-deflection-angle components,which were then compared with the calculated nearside and farside *** capability of the envelope method to analyze the potential ambiguities was also discussed.

关键词： Elastic scattering Optical potential ambiguities Envelope method Nearside/farside decomposition

Combined use of fly ash and silica to prevent the long-term strength retrogression of oil well cement set and cured at HPHT conditions

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Petroleum Science 2024年第2期21卷 1122-1134页

作者： Guo-Dong Cheng Xue-yu Pang Jin-sheng Sun Zheng-song Qiu Chuang-Chuang Wang Jian-Kun Qin Ning Li School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Oil and Gas Engineering Research Institute(Tarim Oilfield Company) China National Petroleum CorporationTarim841000XinjiangChina

The long-term strength retrogression of silica-enriched oil well cement poses a significant threat to wellbore integrity in deep and ultra-deep wells, which is a major obstacle for deep petroleum and geothermal energy development. Previous attempts to address this problem has been unsatisfactory because they can only reduce the strength decline rate. This study presents a new solution to this problem by incorporating fly ash to the traditional silica-cement systems. The influences of fly ash and silica on the strength retrogression behavior of oil well cement systems directly set and cured under the condition of 200°C and 50 MPa are investigated. Test results indicate that the slurries containing only silica or fly ash experience severe strength retrogression from 2 to 30 d curing, while the slurries containing both fly ash and silica experience strength enhancement from 2 to 90 d. The strength test results are corroborated by further evidences from permeability tests as well as microstructure analysis of set cement. Composition of set cement evaluated by quantitative X-ray diffraction analyses with partial or no known crystal structure(PONKCS) method and thermogravimetry analyses revealed that the conversion of amorphous C-(A)-S-H to crystalline phases is the primary cause of long-term strength *** addition of fly ash can reduce the initial amount of C-(A)-S-H in the set cement, and its combined use with silica can prevent the crystallization of C-(A)-S-H, which is believed to be the working mechanism of this new admixture in improving long-term strength stability of oil well cement systems.

关键词： Fly ash Long-term strength retrogression High temperature Quantitative X-ray diffraction(QXRD) Partial or no known crystal structure(PONKCS)

Clinical pathological characteristics of“crawling-type”gastric adenocarcinoma cancer:A case report

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1660-1667页

作者： Yong-Wei Xu Yan song Jun Tian Ba-Cui Zhang yu-sheng Yang Jing Wang Department of Gastroenterology Songjiang HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201600China Department of Pathology Songjiang HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201600China

BACKGROUND Gastric cancer(GC)is a significant health problem worldwide,and early detection and accurate diagnosis are crucial for improving patient ***-type gastric adenocarcinoma is a rare subtype of GC that has unique histopathological and clinical characteristics,and its diagnosis and management can be *** pathological type of GC is also *** SUMMARY Here,we report the case of a patient who underwent ordinary endoscopy,na-rrow-band imaging,and endoscopic ultrasonography intending to determine the extent of tumor invasion and upper abdominal enhanced computed tomography and whether there was tumor ***,endoscopic submucosal dissection was *** pathological and immunohistochemical examination,the pathological diagnosis was crawling-type gastric *** is a very rare and special pathological type of *** case highlights the importance of using advanced endoscopic techniques and pathological examination in diagnosing and managing gastric crawling-type ***,the findings underscore the need for continued research and clinical experience in this rare subtype of GC to improve patient *** The“crawling-type”GC is a rare and specific tumor *** is difficult to identify and diagnose gliomas via *** tumor is ill-defined,with a flat appearance and indistinct borders due to the lack of contrast against the background *** revealed that the tumor cells were hand-like,so the patient has diagnosed with“crawling-type”gastric adenocarcinoma.

关键词： Clinicopathological Crawling-type gastric Pathology Gastric cancer Gastric adenocarcinoma cancer Case report

Nonlinear metamaterial enabled aeroelastic vibration reduction of a supersonic cantilever wing plate

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1749-1772页

作者： Peng sheng Xin FANG Dianlong yu Jihong WEN Laboratory of Science and Technology on Integrated Logistics Support College of Intelligence Science and TechnologyNational University of Defense TechnologyChangsha 410073China

The violent vibration of supersonic wings threatens aircraft *** paper proposes the strongly nonlinear acoustic metamaterial(NAM)method to mitigate aeroelastic vibration in supersonic wing *** employ the cantilever plate to simulate the practical behavior of a *** aeroelastic vibration model of the NAM cantilever plate is established based on the mode superposition method and a modified third-order piston *** aerodynamic properties are systematically studied using both the timedomain integration and frequency-domain harmonic balance *** presenting the flutter and post-flutter behaviors of the NAM wing,we emphasize more on the preflutter broadband vibration that is prevalent in *** results show that the NAM method can reduce the low-frequency and broadband pre-flutter steady vibration by 50%-90%,while the post-flutter vibration is reduced by over 95%,and the critical flutter velocity is also slightly *** clarified,the significant reduction arises from the bandgap,chaotic band,and nonlinear resonances of the NAM *** reduction effect is robust across a broad range of parameters,with optimal performance achieved with only 10%attached *** work offers a novel approach for reducing aeroelastic vibration in aircraft,and it expands the study of nonlinear acoustic/elastic metamaterials.

关键词： nonlinear acoustic metamaterial(NAM) hypersonic aeroelastic vibration vibration reduction fluid-structure interaction

Electrolytes additives for Zn metal anodes:regulation mechanism and current perspectives

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Rare Metals 2024年第9期43卷 4162-4197页

作者： yu-Zhe Zhang Huai-sheng Ao Qi Dong Shao-Jie Zhang Zhi-Guo Hou Na-Na Wang Xue-song Xie Jian Rong Zhong-yu Li School of Environmental Science and Engineering Changzhou UniversityChangzhou 213164China School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China Hefei National Laboratory for Physical Science at Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsInnovation CampusUniversity of WollongongNorth WollongongNSW 2500Australia Department of Chemical and Materials Engineering University of AlbertaEdmonton AB T6G 1H9Canada

With distinct advantages such as high gravimetric and volumetric capacity(5855 mAh·cm^(-3)and 820mAh·g^(-1)),low redox potential(-0.762 V *** hydrogen electrode(SHE)),high abundance,low toxicity and intrinsic safety of Zn metal anode,Zn-ion batteries have become a potential alternative to Li-ion ***,several challenges still need to be addressed prior to the practical applications of Zn-ion batteries,such as dendrite growth during Zn plating/stripping and interfacial side reactions on the Zn *** issues can be addressed by introducing additives to regulate the components and structures of the *** this review,we systematically discussed the core issues of metallic Zn anodes and comprehensively summarized a novel perspective of the regulation mechanism of inhibiting dendrite growth or interfacial side reactions in Zn anodes by introducing additives into aqueous ***,some discussions and prospects for aqueous Zn ion batteries(AZIBs)are presented for future research.

关键词： Electrolyte additives Zn metal anode Regulation mechanism Current perspectives AZIBs

Type I interferon pathway in pediatric systemic lupus erythematosus

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World Journal of Pediatrics 2024年第7期20卷 653-668页

作者： yu Zhou Hong‑Mei song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalBeijingChina

Background The role of type I interferon(IFN-I)signaling in systemic lupus erythematosus(SLE)has been well ***,unanswered questions remain regarding the applicability of these findings to pediatric-onset *** aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset *** sources A literature search was conducted in the PubMed database using the following keywords:“pediatric systemic lupus erythematosus”and“type I interferon”.Results IFN-I signaling is increased in pediatric SLE,largely due to the presence of plasmacytoid dendritic cells and pathways such as cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase 1 and Toll-like receptor(TLR)4/*** extracellular traps and oxidative DNA damage further stimulate IFN-I *** variants in IFN-I-related genes,such as IFN-regulatory factor 5 and tyrosine kinase 2,are linked to SLE susceptibility in pediatric *** addition,type I interferonopathies,characterized by sustained IFN-I activation,can mimic SLE symptoms and are thus important to *** on interferonopathies also contribute to exploring the pathogenesis of *** IFN-I activation is crucial for SLE diagnosis and *** IFNstimulated gene expression and serum IFN-α2 levels are common *** cytometry markers such as CD169 and galectin-9 are promising ***-IFN therapies,such as sifalimumab and anifrolumab,show promise in adult patients with SLE,but their efficacy in pediatric patients requires further *** kinase inhibitors are another treatment option for severe pediatric SLE *** This review presents an overview of the IFN-I pathway in pediatric *** the intricate relationship between IFN-I and pediatric SLE may help to identify potential diagnostic markers and targeted therapies,paving the way for improved patient care and outcomes.

关键词： Interferonopathies Pediatric systemic lupus erythematosus Type I interferon

Full waveform inversion based on hybrid gradient

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Petroleum Science 2024年第3期21卷 1660-1670页

作者： Chuang Xie Zhi-Liang Qin Jian-Hua Wang Peng song Heng-Guang Shen sheng-Qi yu Ben-Jun Ma Xue-Qin Liu Qingdao Innovation and Development Base Harbin Engineering UniversityQingdao266000ShandongChina Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao266000ShandongChina CNOOC Research Institute Co. Ltd.Beijing100028China College of Marine Geoscience Ocean University of ChinaQingdao266100ShandongChina Weihai Sunfull Geophysical Exploration Equipment Co. Ltd.Weihai264209ShandongChina

The low-wavenumber components in the gradient of full waveform inversion(FWI)play a vital role in the stability of the ***,when FWI is implemented in some high frequencies and current models are not far away from the real velocity model,an excessive number of low-wavenumber components in the gradient will also reduce the convergence rate and inversion *** solve this problem,this paper firstly derives a formula of scattering angle weighted gradient in FWI,then proposes a hybrid *** hybrid gradient combines the conventional gradient of FWI with the scattering angle weighted gradient in each inversion frequency band based on an empirical formula derived *** weighted hybrid mode,we can retain some low-wavenumber components in the initial lowfrequency inversion to ensure the stability of the inversion,and use more high-wavenumber components in the high-frequency inversion to improve the convergence *** results of synthetic data experiment demonstrate that compared to the conventional FWI,the FWI based on the proposed hybrid gradient can effectively reduce the low-wavenumber components in the gradient under the premise of ensuring inversion *** also greatly enhances the convergence rate and inversion accuracy,especially in the deep part of the *** the field marine seismic data experiment also illustrates that the FWI based on hybrid gradient(HGFWI)has good stability and adaptability.

关键词： Full waveform inversion Hybrid gradient Scattering angle weighted Low-wavenumber component