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鼠诺如病毒在新生小鼠坏死性小肠结肠炎模型中的保护作用

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第三军医大学学报 2018年第10期40卷 898-903页

作者：胡坤余加林艾青程晨李秋平贺雨肖洒侯婷重庆医科大学附属儿童医院新生儿科儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室儿童发育重大疾病国家国际科技合作基地重庆400014

目的探讨鼠诺如病毒(murine norovirus,MNV)在新生小鼠坏死性小肠结肠炎(necrotizing enterocolitis,NEC)模型中的作用,并分析其可能的作用机制。方法将75只新生1 d的C57BL/6J小鼠按随机数字表法分为3组(n=25):正常对照组、给予PBS的NE... 详细信息

目的探讨鼠诺如病毒(murine norovirus,MNV)在新生小鼠坏死性小肠结肠炎(necrotizing enterocolitis,NEC)模型中的作用,并分析其可能的作用机制。方法将75只新生1 d的C57BL/6J小鼠按随机数字表法分为3组(n=25):正常对照组、给予PBS的NEC模型组(PBS+NEC组)和给予MNV干预的NEC模型组(MNV+NEC组)。正常对照组与母鼠同笼,不予任何处理;其余两组进行NEC动物模型构建。新生小鼠于生后1 d给予联合抗生素,连续灌胃10 d模拟无菌后,行NEC建模3 d,建模前后固定时间点称量体质量,第14天处死小鼠,HE染色观察回盲部肠组织病理学变化;qPCR法检测TLR-3、MDA-5、IL-6、IL-10、IL-1β、IL-22基因表达水平;流式细胞仪检测3型天然淋巴样细胞(type 3 innate lymphoid cells,ILC3)数量;ELISA法检测肠组织匀浆IL-10水平。结果与正常对照组相比,PBS+NEC组、MNV+NEC组小鼠体质量明显降低(P0.05)、MDA-5(0.98±0.35 vs 0.67±0.39,P>0.05)、IL-10(1.22±0.36 vs 0.60±0.31,P0.05],但其分泌的IL-22表达升高。结论 MNV在新生小鼠NEC模型肠道损伤中起保护作用,可能与MNV下调炎症因子IL-6、IL-1β,上调抑炎因子IL-10及分泌IL-22的ILC3的功能有关。

关键词：鼠诺如病毒坏死性小肠结肠炎 3型天然淋巴样细胞白介素22

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li qing-Fang Guan Shu-Hong yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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正交设计法优选岗梅中总皂苷的提取工艺研究

海峡药学 2016年第4期28卷 74-77页

作者：周惠卿余澄清陈冰冰广东省开平市中心医院药剂科开平529300 广东省开平市中心医院党委办开平529300

目的利用正交设计法对岗梅总皂苷的提取工艺进行研究。方法以齐墩果酸为对照,香草醛-高氯酸法显色,用紫外-可见分光光度法在550nm处测定岗梅总皂苷的含量。采用L9(34)正交试验设计,考察乙醇浓度、料液比、提取时间、提取次数4个因素对... 详细信息

目的利用正交设计法对岗梅总皂苷的提取工艺进行研究。方法以齐墩果酸为对照,香草醛-高氯酸法显色,用紫外-可见分光光度法在550nm处测定岗梅总皂苷的含量。采用L9(34)正交试验设计,考察乙醇浓度、料液比、提取时间、提取次数4个因素对岗梅总皂苷提取的影响,以岗梅中总皂苷的含量为考察指标。结果最佳的提取工艺为40%乙醇,乙醇用量为90倍量,回流提取3次,1.5h·次^(-1)。结论该含量测定方法简便、准确、重复性好,提取工艺经济、合理,值得进一步推广,对工艺开发有较好的参考价值。

关键词：岗梅总皂苷正交试验紫外-可见分光光度法

开喉剑喷雾剂治疗急性化脓性扁桃体炎患者的临床效果分析

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中国实用医药 2019年第29期14卷 65-67页

作者：余成清徐建乐西南医科大学附属医院耳鼻咽喉头颈外科

目的探究开喉剑喷雾剂治疗急性化脓性扁桃体炎患者的临床效果.方法 140例急性化脓性偏桃体炎患者作为研究对象,随机分为对照组和观察组,各70例.对照组采用西瓜霜治疗,观察组采用开喉剑喷雾剂治疗.比较两组患者的治疗效果、满意度、起效... 详细信息

目的探究开喉剑喷雾剂治疗急性化脓性扁桃体炎患者的临床效果.方法 140例急性化脓性偏桃体炎患者作为研究对象,随机分为对照组和观察组,各70例.对照组采用西瓜霜治疗,观察组采用开喉剑喷雾剂治疗.比较两组患者的治疗效果、满意度、起效时间.结果观察组显效48例、有效18例,无效4例,总有效率为94.3%;对照组显效26例、有效28例,无效16例,总有效率为77.1%;观察组总有效率高于对照组,差异具有统计学意义(P<0.05).观察组满意度为92.9%,高于对照组的75.7%,差异具有统计学意义(P<0.05).观察组患者的起效时间为(2.5±2.8)d,早于对照组的(4.3±2.4)d,差异具有统计学意义(P<0.05).结论开喉剑喷雾剂治疗急性化脓性扁桃体炎患者的临床效果显著,具有疗效快、使用简便等特点,值得临床推广.

关键词：开喉剑喷雾剂急性化脓性扁桃体炎西瓜霜

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-yue Shang Ying Chen Meng Tian cheng-yu Jin Xin Lu Bing-Chun Yan Han-qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen Heng Xiao Hai-Yang Hu Xing-yu Chen cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

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海口邮储手机银行校园推广策划

企业技术开发 2015年第5期34卷 42-43页

作者：李小玲于澄清海南经贸职业技术学院海南海口571127

随着手机移动市场的不断扩大,各大手机银行纷纷抢滩校园这块市场。为了更好地进入并服务于学生市场,海口邮储银行在校园调研的基础上,设计了线上和线下多种校园推广方案,以期能够充分利用校园资源,提高手机银行业务的推广效果。

关键词：手机银行校园推广推广策划校园营销

碳硫比和硝酸根投加量对DS-EBPR工艺的影响研究

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水处理技术 2016年第10期42卷 71-75页

作者：赵晴余美程娜邱林清孟了吕慧广州大学土木工程学院广东广州510006 中山大学环境科学与工程学院广东省环境污染控制与修复重点实验室广东广州510275 深圳市下坪固体废弃物填埋场广东深圳518047

为获得适宜的硫循环协同反硝化生物除磷工艺(DS-EBPR)运行条件,采用批次实验研究了进水m(C)/m(S)和NO_3^--N投加量对DS-EBPR的影响,同时对工艺代谢机理进行初步研究。结果表明,m(C)/m(S)为150/200时有最大吸磷速度2.4 mg/(g·h),而PHA... 详细信息

为获得适宜的硫循环协同反硝化生物除磷工艺(DS-EBPR)运行条件,采用批次实验研究了进水m(C)/m(S)和NO_3^--N投加量对DS-EBPR的影响,同时对工艺代谢机理进行初步研究。结果表明,m(C)/m(S)为150/200时有最大吸磷速度2.4 mg/(g·h),而PHA的储存和消耗速度却最低,同时poly-S的储存和消耗速度却最大。DS-EBPR释磷段和吸磷段的反应进行能量平衡分析,说明poly-S在DS-EBPR工艺运行中可作为潜在的能量来源。poly-S在吸磷段可调节NO_3^--N的反硝化作用,可减少NO_3^--N对下一周期释磷段的影响,以达到良好的释磷效果。DS-EBPR工艺的反应机理明显不同于传统的EBPR工艺。

关键词：硫循环协同反硝化生物除磷(DS-EBPR) 碳硫质量比 NO_3^--N投加量 poly-S

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu yu-Fan Yang Zhi-cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin