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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu qi Li Ruihua Li qingwen Li Kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui yuan Xin cao Liang Chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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荧光标记法评价医院环境卫生清洁效果

中国感染控制杂志 2017年第1期16卷 84-86页

作者：卞雪莲郁世芳徐春芬虞正琪曹成刚上海利康消毒高科技有限公司上海200444

目的采用荧光标记法评价医院环境卫生清洁效果。方法 2015年1—2月选择7所医院312间病房高频接触面进行荧光标记,保洁员清洁后,计算荧光标记清除率(作为基线调查资料),对保洁员进行培训和现场指导(干预措施),比较干预前后的清除效果。... 详细信息

目的采用荧光标记法评价医院环境卫生清洁效果。方法 2015年1—2月选择7所医院312间病房高频接触面进行荧光标记,保洁员清洁后,计算荧光标记清除率(作为基线调查资料),对保洁员进行培训和现场指导(干预措施),比较干预前后的清除效果。结果共对110间病房进行基线调查,2 856个接触清洁面的清除率仅为50.81%,量化评估值为45.70;干预后,202间病房3 992个接触清洁面的清除率提高至79.23%,量化评估值为76.30;干预前后清除率比较,差异有统计学意义(χ2=612.14,P75%。结论荧光标记法可直观反映保洁员操作的质量,又可改善病房环境清洁水平,是一种国际流行的简捷、低廉、客观的医院环境清洁水平评估方法。

关键词：医院环境清洁客观评价荧光标记法清除率

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving cao bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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去亚甲基小檗碱的药理作用研究进展

中国药理学通报 2025年第1期41卷 7-12页

作者：李靖琪张琪陈雨桐仝永斌鲁澄宇广东医科大学药学院广东东莞523808

去亚甲基小檗碱(demethyleneberberine,DMB)是小檗碱在体内的主要代谢产物之一,其具有广泛的药理特性。大量研究表明其具有改善感染、抗炎、抗纤维化、抑制癌细胞、调节血脂等多种生物活性,而且在神经退行性疾病治疗领域有巨大潜力。该... 详细信息

去亚甲基小檗碱(demethyleneberberine,DMB)是小檗碱在体内的主要代谢产物之一,其具有广泛的药理特性。大量研究表明其具有改善感染、抗炎、抗纤维化、抑制癌细胞、调节血脂等多种生物活性,而且在神经退行性疾病治疗领域有巨大潜力。该文通过对DMB药理作用及其机制进行系统概述,以期为深入理解其药理作用及合理开发提供科学依据。

关键词：去亚甲基小檗碱药理作用抗感染抗炎肝保护神经保护

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信息茧房对大学生信息素养的影响机制研究

高校教育管理 2025年第1期19卷 113-124页

作者：于文卿宋宪萍曹宇驰北京理工大学教育学院北京理工大学马克思主义学院北京102488

探究算法时代如何打破信息茧房,进而提高大学生的信息素养已成为高等教育领域亟待解决的关键课题。本研究通过扎根理论对不同教育背景的30位大学生进行半结构化访谈,系统探究信息茧房对大学生信息素养的影响机制。结果发现,当大学生困... 详细信息

探究算法时代如何打破信息茧房,进而提高大学生的信息素养已成为高等教育领域亟待解决的关键课题。本研究通过扎根理论对不同教育背景的30位大学生进行半结构化访谈,系统探究信息茧房对大学生信息素养的影响机制。结果发现,当大学生困于信息茧房之中时,其信息素养的各个维度都会受到不同程度的影响;信息茧房通过信息技术这一载体,对大学生信息素养产生直接影响;被信息技术“装备”的信息茧房经由信息驱动力这一中介,对大学生信息素养产生间接影响,在此过程中,主体内驱力和信息情境分别通过改变个体动机强度和环境感知强度,进一步调节信息茧房对大学生信息素养的影响。政府、社会、高校等主体应通过多种举措帮助大学生在信息知识层面下拓展信息视野、在信息意识层面下锐化信息敏感度、在信息能力层面下优化数字技能、在信息道德层面下规范信息行为,从而全面提升大学生的信息素养。

关键词：信息茧房大学生信息素养影响机制扎根理论质性研究

CHAUS:Scalable VM-Based Channels for Unbounded Streaming

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Journal of Computer Science & Technology 2017年第6期32卷 1288-1304页

作者： yu Zhang yu-Fen yu Hui-Fang cao Jian-Kang Chen qi-Liang Zhang School of Computer Science and Technology University of Science and Technology of China Hefei 230027 China

Stream processing is a special form of the dataflow execution model that offers extensive opportunities for optimization and automatic parallelism. A streaming application is represented by a graph of computation stages that communicate with each other via FIFO channels. In shared-memory environment, an FIFO channel is classically a com- mon, fixed-size synchronized buffer shared between the producer and the consumer. As the number of concurrent stage workers increases, the synchronization overheads, such as contention and waiting times, rise sharply and severely impair application performance. In this paper, we present a novel multithreaded model which isolates memory between threads by default and provides a higher level abstraction for scalable unicast or multicast communication between threads -- CHAUS （Channel for Unbounded Streaming）. The CHAUS model hides the underlying synchronization details, but requires the user to declare producer-consumer relationship of a channel in advance. It is the duty of the runtime system to ensure reliable data transmission at data item granularity as declared. To achieve unbounded buffer for streaming and reduce the synchronization overheads, we propose a virtual memory based solution to implement a scalable CHAUS channel. We check the programmability of CHAUS by successfully porting dedup and ferret from PARSEC as well as implementing MapReduce library with Phoenix-like API. The experimental results show that workloads built with CHAUS run faster than those with Pthreads, and CHAUS has the best scalability compared with two Pthread versions. There are three workloads whose CHAUS versions only spend no more than 0.17x runtime of Pthreads on both 16 and 32 cores.

关键词： streaming thread model pipeline parallelism unbounded channel virtual memory

Selective parsing to enhance SIP performance

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The Journal of China Universities of Posts and Telecommunications 2009年第5期16卷 50-55页

作者： cao yu-fei LIAO Jian-xin qi qi ZHU Xiao-min State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China EB Information Technology Ltd. Beijing 100190 China

The session initiation protocol （SIP） is used as the signaling protocol in the IP multimedia subsystem （IMS） and the signaling is becoming computing intensive comparing to the current telecommunication network. The SIP is a text-based protocol with characteristics of unordered and verbose headers, variable-size message, and case-insensitive keyword. It imposes challenges for an efficient message processing. The property of SIP elements being able to process SIP messages quickly is critical for the performance of IMS networks. This article investigates the performance of SIP message processed in SIP servers, mainly focusing on improving message parsing by introducing a method named selective parsing for SIP message （SP4SIP）. By modeling and analyzing a SIP server with a tandem Jackson network, it is concluded that parsing messages is the bottleneck of a SIP server performance, i.e., it is the most processing intensive activity in the system. To validate the approach, it has been implemented in a high-performance SIP server in the authors＇ lab. The results show that selective parsing for SIP message can indeed reduce processing time.

关键词： SP4SIP signaling performance SIP

Distributed location model and algorithm with position uncertainty

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The Journal of China Universities of Posts and Telecommunications 2014年第2期21卷 48-56页

作者： SHI yu-long CUI qi-me cao Si-qi TAO Xiao-feng Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications

The localization of multiple mobile terminals （MTs） is an encouraging paradigm of applications in wireless networks. Peer-to-peer communication between MTs facilitates the cooperative localization of multiple MTs. For sake of low complexity and high robustness, investigations often focus on the distributed algorithm in cooperative localization. However, the impact from position uncertainty of cooperative MT lacks of analysis in related works. A new distributed location model, as well as corresponding algorithm, is devised when considering both the distance measurement error and the position uncertainty of MTs, which is more judicious than the traditional model for distributed cooperative localization scenario. In addition, the performance of proposed algorithm is analyzed through Cramér-Rao lower bound （CRLB）. Simulations indicate that the algorithm outperforms traditional methods in terms of accuracy and robustness.

关键词： distributed algorithm cooperative localization position tmcertainty