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Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin

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Journal of Ocean University of China 2024年第3期23卷 643-653页

作者： guo Kun ZHAI Shikui FAN Di ZHANG Xia ZHANG yu ZHU Zhimin Laoshan Laboratory Qingdao 266237China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental *** clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and *** clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the *** calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 *** geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of *** with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust.

关键词： trace elements clinopyroxenes southern Okinawa Trough seafloor spreading back-arc basin

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EvolveKG:a general framework to learn evolving knowledge graphs

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Frontiers of Computer Science 2024年第3期18卷 43-59页

作者： Jiaqi LIU Zhiwen yu Bin guo Cheng DENG Luoyi FU Xinbing WANG Chenghu ZHOU School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China Department of Computer Science Shanghai Jiao Tong UniversityShanghai 200240China Institute of Geographical Science and Natural Resources Research Chinese Academy of SciencesBejjing 100864China

A great many practical applications have observed knowledge evolution,i.e.,continuous born of new knowledge,with its formation influenced by the structure of historical *** observation gives rise to evolving knowledge graphs whose structure temporally grows over ***,both the modal characterization and the algorithmic implementation of evolving knowledge graphs remain *** this end,we propose EvolveKG–a general framework that enables algorithms in the static knowledge graphs to learn the evolving *** quantifies the influence of a historical fact on a current one,called the effectiveness of the fact,and makes knowledge prediction by leveraging all the cross-time knowledge *** novelty of EvolveKG lies in Derivative Graph–a weighted snapshot of evolution at a certain ***,each weight quantifies knowledge effectiveness through a temporarily decaying function of consistency and attenuation,two proposed factors depicting whether or not the effectiveness of a fact fades away with ***,considering both knowledge creation and loss,we obtain higher prediction accuracy when the effectiveness of all the facts increases with time or remains *** four real datasets,the superiority of EvolveKG is confirmed in prediction accuracy.

关键词： knowledge graph evolution modal characterization algorithmic implementation

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Carbon dots-derived three-dimensional-ordered macroporous host with high penetrability and catalytic activity for LSBs under lean electrolyte

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Rare Metals 2024年第6期43卷 2560-2573页

作者： Jiao-Zi Duan Hua-yu Pei Quan Yang Xue Li Xin Ba Xue Yong Jun-Ling guo Si-yu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Country State Center for International Cooperation On Designer Low-Carbon&Environmental Materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Hubei Institute of Quality Supervision Inspection Wuhan 430061China Department of Chemistry University of SheffieldSheffeld S37HFUK

The practical energy density of lithium-sulfur batteries(LSBs)is seriously limited by the high electrolyte-to-sulfur ratios(E/S).The E/S can be reduced by employing hosts with easy-to-infiltrate structure that ensures the uniform distribution of a lean electrolyte and high catalytic activity that can suppress"shuttle effect"via accelerating the slow conversion of soluble poly sulfides to insoluble *** the easy-to-infiltrate structures,the three-dimensional-ordered macroporous(3DOM)structure is easier to scale preparation and more suitable for the existing industrial ***,it is difficult to obtain the 3DOM with(1)high penetrability due to the high viscosity of frequently-used organic polymer precursors and(2)high catalytic activity due to the low confinement effect,meaning that uniformly dispersed small-sized catalytic materials are difficult to load on ***,using carbon dots(CDs)with both organic and inorganic properties as a precursor and aggregation limiting agent,a 3DOM host with high penetrability and homodispersed Ni particles of small sizes(Ni-CDs-3DOM)was *** this host:(1)CDs precursor with suitable viscosity can improve the penetrability.(2)CDs can effectively inhibit the agglomeration of Ni particles.(3)Uniformly dispersed small-size Ni particles offer high-efficiency catalytic activity toward sulfur ***,the Ni-CDs-3DOM/sulfur cathode exhibits high sulfur utilization and stable cycling performance even under high sulfur loading(5.5 mg·cm^(-2))and low E/S(6.5μl·mg^(-1)).This work indicates the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： Lithium-sulfur batteries Carbon dots Catalytic action Easy-to-infiltrate structure Lean electrolyte

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The behaviors of gas-liquid two-phase flow under gas kick during horizontal drilling with oil-based muds

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Petroleum 2024年第1期10卷 49-67页

作者： yu Su Huiyun Ma Jianhua guo Xinyu Shen Zhaoliang Yang Jie Wu Engineering Technology Research Institute PetroChina Southwest Oil & Gas Field Company

Natural gas is easily soluble in oil-based muds(OBM), leading to complex flow behavior in wellbores,especially in horizontal wells. In this study, a new transient flow model considering wellbore-formation coupling and gas solubility on flow behavior is developed to simulate gas kicks during horizontal drilling with OBM. Furthermore, the effect of gas solubility on parameters such as bottom-hole pressure(BHP),gas void fraction and mixture velocity in the flow behavior is analyzed. Finally, several critical factors affecting flow behavior are investigated and compared to gas kicks in water-based muds(WBM) where the effect of solubility is neglected. The results show that the invading gas exists as dissolved gas in the OBM and as free gas in the WBM. Before the gas escapes from the OBM, the pit gain is zero and there is barely any change in the BHP, annulus return flow rate and mixture velocity, which means that detecting gas kicks through these warning signs can be challenging until they get very close to the surface and develop rapidly. However, in WBM drilling, these parameters change quickly with the increasing gas kick time. Additionally, for both cases, the longer the horizontal length and the greater reservoir permeability,the greater the decrease in BHP, and the shorter the time for gas to migrate from the bottom-hole to the wellhead. A larger flow rate contributes to a greater initial BHP and a lesser BHP reduction. This research is of value in characterizing gas kick behavior and identifying novel ways for early gas kick detection during horizontal drilling with OBM.

关键词： Flow behavior Gas solubility Gas kick Horizontal drilling Oil-based muds Water-based muds

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Review on dietary supplements as an effective improvement of Alzheimer's disease:focus on structures and mechanisms

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Food Science and Human Wellness 2024年第4期13卷 1787-1805页

作者： Sheng Li Yinling Wei Zhenzhen Liang Lingli guo Xiaojiang Hao yu Zhang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China

Alzheimer’s disease(AD),the major form of neurodegenerative diseases that can severely impede normal cognitive function,makes it one of the most common fatal *** are currently over 50 million AD patients *** neuropathology of AD is perplexing and there is a scarcity of disease-modifying ***,early diagnosis of AD has been made possible with the discovery of biological markers associated with pathology,providing strong support for the improvement of the disease *** search for inhibitors of AD markers from dietary supplements(DSs)has become a major hot *** with the widespread use of DSs,DSs containing polyphenols,alkaloids,terpenes,polysaccharides and other bioactive components can prevent AD by reducing Aβdeposition,inhibiting tau protein hyperphosphorylation,reconstructing synaptic dysfunction,weakening cholinesterase activity,regulating mitochondrial oxidative stress,neuronal inflammation and *** review summarizes the anti-AD effects of the main DSs and their bioactive constituents,as well as the potential molecular mechanisms covers from 2017 to ***,we discussed the opportunities and challenges faced by DSs in the process of AD prevention and treatment,aiming to further provide new perspectives for functional food development.

关键词： Dietary supplements Bioactive ingredients Alzheimer’s disease Mechanism of action

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A Novel Analysis Approach of Uniform Persistence for an Epidemic Model with Quarantine and Standard Incidence Rate

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 695-707页

作者： Song-bai guo yu-ling XUE Xi-liang LI Zuo-huan ZHENG School of Science Beijing University of Civil Engineering and ArchitectureBeijing 102616China School of Mathematics and Statistics Hainan Normal UniversityHaikou 571158China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematics and Information Science Shandong Technology and Business UniversityYantai 264005China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Inspired by the transmission characteristics of the coronavirus disease 2019(COVID-19),an epidemic model with quarantine and standard incidence rate is first developed,then a novel analysis approach is proposed for finding the ultimate lower bound of the number of infected individuals,which means that the epidemic is uniformly persistent if the control reproduction number R_(c)>*** approach can be applied to the related biomat hem at ical models,and some existing works can be improved by using *** addition,the infection-free equilibrium V^(0)of the model is locally asymptotically stable(LAS)if R_(c)1.

关键词： uniform persistence epidemic model control reproduction number quarantine standard incidence rate

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Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： Qian-yun guo Jia-Qi Yang Xun-Xun Feng yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

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Research Progress and Challenges on Persistent Organic Pollutants in Lakes

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Journal of Earth Science 2024年第2期35卷 729-736页

作者： Wei guo Xiaoyu Ji Zhengfei yu Hongchen Jiang Xiangyu Guan School of Ocean Sciences China University of GeosciencesBeijing 100083China State Key Lab of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and *** in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,which are constrained and regulated by various physical,chemical and biological *** can affect ecological conditions,chemical properties of water and sedi ments,and biodiversity of the lake ***,it is important to study the sources,migration,transformation,environmental behavior and ecological impacts of POPs in lake *** re view summarizes research progress on detection technologies,diversity and origins,historical records,migration and transformation,distribution patterns,degradation and toxic effects of POPs in *** nally,future directions related to POPs in lakes were summarized.

关键词： persistent organic pollutants(POPs) lakes transformation degradation microbes environment geolgogy

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On the Intelligent Optimization of the Crevice Structure in a Rapid Compression Machine

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Journal of Thermal Science 2024年第3期33卷 1200-1215页

作者： guo Qiang LIU Jie WU Yingtao WANG Hewu TANG Chenglong yu Ruiguang Department of Power Mechanical Engineering Beijing Jiaotong UniversityBeijing100044China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing100084China Beijing Key Laboratory of New Energy Vehicle Powertrain Technology Beijing100044China National International Science and Technology Cooperation Base Beijing Jiaotong UniversityBeijing100044China

In this study,the multi-objective intelligent optimization of the crevice structure in a rapid compression machine(RCM)is carried out based on the RCM simulation model modified with the KIVA-3V program.A multi-objective optimization simulation model of the crevice structure based on the large eddy simulation model coupled with the genetic algorithm NSGA-Ⅲis *** optimization parameters and seven optimization objectives are selected in the optimization *** results show that the genetic algorithm can quickly find the values of the optimized *** crevice volume ratio shows a trade-off relationship with the dimensionless temperature ratio T_(max)/T_(aver)and the tumble ratio.A larger crevice volume can reduce the flow of boundary layer cryogenic gas into the combustion chamber,thus improving the temperature *** addition,the crevice entrance width and the connecting channel length should be smaller,while the volume of the crevice main chamber should be larger,so as to sufficiently introduce the low-temperature gas of the boundary layer into the crevice and reduce their influence on the temperature field of the combustion *** the crevice volume accounts for10%of the total volume,the temperature uniformity of the combustor is significantly enhanced,and when the crevice volume accounts for 30.4%,there is almost no low-temperature vortex in the combustion chamber.

关键词： rapid compression machine adiabatic core area ignition delay period crevice structure

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Functional analysis of the novel mitochondrial tRNA^(Trp)and tRNA^(Ser(AGY))variants associated with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第8期15卷 1753-1763页

作者： yu Ding Xue-Jiao yu Qin-Xian guo Jian-Hang Leng Central Laboratory Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Clinical Laboratory Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Mutations in mitochondrial tRNA(mt-tRNA)genes that result in mitochondrial dysfunction play important roles in type 2 diabetes mellitus(T2DM).We previously reported a large Chinese pedigree with maternally inherited T2DM that harbors novel mt-tRNA^(Trp)A5514G and tRNA^(Ser(AGY))C12237T variants,however,the effects of these mt-tRNA variants on T2DM progression are largely *** To assess the potential pathogenicity of T2DM-associated m.A5514G and m.C12237T variants at genetic,molecular,and biochemical *** Cytoplasmic hybrid(cybrid)cells carrying both m.A5514G and m.C12237T variants,and healthy control cells without these mitochondrial DNA(mtDNA)variants were generated using trans-mitochondrial *** features,including mt-tRNA steady-state level,levels of adenosine triphosphate(ATP),mitochondrial membrane potential(MMP),reactive oxygen species(ROS),mtDNA copy number,nicotinamide adenine dinucleotide(NAD+)/NADH ratio,enzymatic activities of respiratory chain complexes(RCCs),8-hydroxy-deoxyguanine(8-OhdG),malondialdehyde(MDA),and superoxide dismutase(SOD)were examined in cell lines with and without these mt-tRNA *** Compared with control cells,the m.A5514G variant caused an approximately 35%reduction in the steady-state level of mt-tRNA^(Trp)(P<0.0001);however,the m.C12237T variant did not affect the mt-tRNA^(Ser(AGY))steady-state level(P=0.5849).Biochemical analysis revealed that cells with both m.A5514G and m.C12237T variants exhibited more severe mitochondrial dysfunctions and elevated oxidative stress than control cells:ATP,MMP,NAD+/NADH ratio,enzyme activities of RCCs and SOD levels were markedly decreased in mutant cells(P<0.05 for all measures).By contrast,the levels of ROS,8-OhdG and MDA were significantly increased(P<0.05 for all measures),but mtDNA copy number was not affected by m.A5514G and m.C12237T variants(P=0.5942).CONCLUSION The m.A5514G variant impaired mt-tRNA^(Trp)metabolism,which subsequent

关键词： Type 2 diabetes mellitus Mitochondrial tRNA genes Novel variants Oxidative stress Mitochondrial dysfunctions

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