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Preparation, characterization and evaluation of kaempferol phospholipid complex: Improvement of its solubility and biological effect

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Journal of Polyphenols 2024年第2期6卷 56-64页

作者： Dezhi gao Honghui Zhao Fengmao Zou Ming Yang Jing Wang lina Fang Xu Zhao Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Material Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Pharmacy Shenyang Medical CollegeShenyang 110034China

Kaempferol(KA),as one of the flavonoids,has extensive pharmacological ***,the poor solubility of KA severely limits its clinical *** our study,the kaempferol phospholipid complex(KA-PC)has been prepared by solvent evaporation for the enhancement of the bioavailability of ***-PC was verified by scanning electron microscope characterization *** loading,solubility and long-term stability were *** characterization results showed that KA-PC was formed through the intermolecular interaction between KA and *** solubility of KA-PC in water was 189 times higher than that of KA,and the solubility in n-octanol was also significantly ***,pharmacodynamic studies showed that KA-PC can significantly reduce the level of serum uric acid in mice without causing renal *** study expanded the clinical application of KA by preparing KA-PC.

关键词： kaempferol phospholipid complex solubility uric acid-lowering effect

An Intelligent Fault Diagnosis Method of Multi-Scale Deep Feature Fusion Based on Information Entropy

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Chinese Journal of Mechanical Engineering 2021年第4期34卷 121-136页

作者： Zhiwu Shang Wanxiang Li Maosheng gao Xia Liu Yan yu School of Mechanical Engineering Tiangong UniversityTianjin 300387China Tianjin Modern Electromechanical Equipment Technology Key Laboratory Tianjin 300387China

For a single-structure deep learning fault diagnosis model,its disadvantages are an insufficient feature extraction and weak fault classification *** paper proposes a multi-scale deep feature fusion intelligent fault diagnosis method based on information ***,a normal autoencoder,denoising autoencoder,sparse autoencoder,and contractive autoencoder are used in parallel to construct a multi-scale deep neural network feature extraction structure.A deep feature fusion strategy based on information entropy is proposed to obtain low-dimensional features and ensure the robustness of the model and the quality of deep ***,the advantage of the deep belief network probability model is used as the fault classifier to identify the *** effectiveness of the proposed method was verified by a gearbox *** results show that,compared with traditional and existing intelligent fault diagnosis methods,the proposed method can obtain representative information and features from the raw data with higher classification accuracy.

关键词： Fault diagnosis Feature fusion Information entropy Deep autoencoder Deep belief network

基于ICEEMDAN和CNN的水电机组故障诊断

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中国农村水利水电 2024年第8期 216-221页

作者：高金林伍盛金赖兴全王卫玉魏加达马泽宁陈启卷国家电投集团重庆江口水电有限责任公司重庆408506 湖南五凌电力科技有限公司湖南长沙410007 武汉大学动力与机械学院湖北武汉430072

为实现水电机组故障的准确识别,首先结合改进的自适应白噪声完全集合经验模态分解模型(ICEEMDAN)和相关性分析方法对振动信号进行分解及重构处理;接着,为解决因卷积神经网络(CNN)输入具有多样性问题,比较分析了3种不同输入信号构造方式... 详细信息

为实现水电机组故障的准确识别,首先结合改进的自适应白噪声完全集合经验模态分解模型(ICEEMDAN)和相关性分析方法对振动信号进行分解及重构处理;接着,为解决因卷积神经网络(CNN)输入具有多样性问题,比较分析了3种不同输入信号构造方式对CNN模型故障诊断识别准确率的影响;最终选定了一维重构信号的方形矩阵形式作为CNN的输入方式,通过某电厂转轮室碰摩故障实测数据验证该方法能有效提高水电机组故障诊断精度。

关键词：水电机组 ICEEMDAN 卷积神经网络故障诊断

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烟叶精益生产模式的建设路径及实践成效探析——以普洱市景东县为例

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安徽农业科学 2024年第15期52卷 256-260页

作者：余琳李谨成高仁吉谢晋黄浩王维温润豪李福君广东中烟工业有限责任公司广东广州510310 华南农业大学广东广州510642

近年来精益生产正逐步向农业生产领域渗透,为农业生产的结构转型提供了良好契机。为推动景东产区烟草农业的现代化建设,解除烟叶发展中不平衡、不协调、不可持续等因素的制约,实现烟叶生产降工减本、提质增效、可持续发展的核心目标,以... 详细信息

近年来精益生产正逐步向农业生产领域渗透,为农业生产的结构转型提供了良好契机。为推动景东产区烟草农业的现代化建设,解除烟叶发展中不平衡、不协调、不可持续等因素的制约,实现烟叶生产降工减本、提质增效、可持续发展的核心目标,以广东中烟优质基地单元建设为载体,通过对景东产区烟叶生产现状的分析,结合实际探索烟叶精益生产模式的建设路径,以及对其实践成效进行评价分析。通过实践建设,初步建立了良性发展的管理机制,取得了良好的经济效益,逐步完善了广东中烟普洱基地单元高端烟叶原料定制化生产技术体系,提升了烟农收益水平以及基地原料保障水平,并对于持续推进景东县烟叶精益生产模式建设的思考进行了进一步的探析。

关键词：烟叶生产精益生产路径探析实践成效

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生物与仿生微结构复合材料的断裂力学研究进展

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中国科学：物理学、力学、天文学 2024年第5期54卷 74-96页

作者：韦小丁刘俊杰於中良朱文清高洋丛超男北京大学工学院力学与工程科学系湍流与复杂系统国家重点实验室北京100871 北京工业大学材料与制造学部北京100124 扬州大学机械工程学院扬州225127 中国农业大学理学院北京100083

亿万年的“物竞天择”促进自然界生物进化出精妙绝伦的微观结构,生物材料的力学性能因此得以突破传统结构材料著名的“强度-韧性”倒置关系,这为未来先进工程结构材料的研发提供了新的思路.但复杂的微结构也使生物材料的宏观断裂行为呈... 详细信息

亿万年的“物竞天择”促进自然界生物进化出精妙绝伦的微观结构,生物材料的力学性能因此得以突破传统结构材料著名的“强度-韧性”倒置关系,这为未来先进工程结构材料的研发提供了新的思路.但复杂的微结构也使生物材料的宏观断裂行为呈现出多尺度、多过程、多介质耦合的复杂特征,为建立基于均匀性假设的经典断裂力学理论方法带来新的挑战.对含有微结构的生物复合材料的断裂力学行为进行深入研究,对拓宽断裂力学的研究范畴,推动断裂力学理论的发展,启发新一代先进结构材料的优化设计具有重要的科学意义和潜在应用前景.本文试从理论分析、数值模拟、实验手段三个方面回顾近年来关于含有精细微结构的生物及仿生复合材料断裂力学的研究进展,重点介绍新方法与新思想,为非均质材料断裂力学的发展和先进材料的强韧化设计提供借鉴.

关键词：断裂力学微结构复合材料非均质材料强韧化

碱性条件下Cr(Ⅵ)和腐殖酸对赤铁矿胶体在多孔介质中迁移过程的机理研究

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环境科学研究 2024年第4期37卷 901-907页

作者：高羽卢合峰秦雪芬吕媛杨潇商建英阎秀兰中国科学院地理科学与资源研究所陆地表层格局与模拟院重点实验室北京100101 中国科学院大学北京100049 邢台市生态环境局邢东新区分局河北邢台054001 中国农业大学土地科学与技术学院北京100193

赤铁矿胶体是一种广泛存在于土壤中的活性组分,可与重金属Cr(Ⅵ)发生吸附、沉淀、络合等多种化学作用,从而影响Cr(Ⅵ)在土壤中的迁移富集.探究赤铁矿胶体-Cr(Ⅵ)-腐殖酸(HA)三元体系在多孔介质中的共迁移过程,对于深入理解Cr(Ⅵ)污染过... 详细信息

赤铁矿胶体是一种广泛存在于土壤中的活性组分,可与重金属Cr(Ⅵ)发生吸附、沉淀、络合等多种化学作用,从而影响Cr(Ⅵ)在土壤中的迁移富集.探究赤铁矿胶体-Cr(Ⅵ)-腐殖酸(HA)三元体系在多孔介质中的共迁移过程,对于深入理解Cr(Ⅵ)污染过程和防控原理具有重要意义.该研究通过吸附、聚集和柱迁移实验,探究了碱性条件下Cr(Ⅵ)和HA对赤铁矿胶体的聚集动力学和迁移能力的影响.结果表明:与不加Cr(Ⅵ)相比,加入0.25~10 mg/L Cr(Ⅵ)会提高赤铁矿胶体的ζ电势,降低胶体与石英砂之间的最大排斥势垒,阻滞赤铁矿胶体在砂柱中迁移,穿透峰值从61%降至50%左右.引入HA会增加赤铁矿胶体表面负电荷,增强Cr(Ⅵ)与赤铁矿胶体之间的静电斥力,且与Cr(Ⅵ)竞争吸附赤铁矿胶体表面的结合位点,抑制Cr(Ⅵ)在赤铁矿胶体上的吸附,导致胶体与石英砂之间的最大排斥势垒升高.Cr(Ⅵ)和HA的吸附先后顺序对赤铁矿胶体稳定性和迁移性有显著影响.赤铁矿胶体在HA-Cr(Ⅵ)体系中的ζ电势和水合粒径(分别为−30 mV和200~300 nm)比Cr(Ⅵ)-HA体系(分别为−28 mV和400~500 nm)要小,且在HA-Cr(Ⅵ)体系中穿透峰值更高.研究显示,在碱性条件下,尽管HA会抑制Cr(Ⅵ)在赤铁矿胶体表面上的吸附,但会增加赤铁矿胶体在环境中的稳定性和迁移性,使得吸附在赤铁矿胶体表面的Cr(Ⅵ)随胶体发生共迁移的可能性增加,具有潜在的环境风险.

关键词：赤铁矿胶体腐殖酸 Cr(Ⅵ) 稳定性迁移

Proteomic Analysis of Stichopus japonicus and Evaluation of the Antiaging Properties of Its Peptide

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Agricultural Biotechnology 2024年第4期13卷 31-37页

作者： Le WANG Jiao CHEN Jiali WENG Jinxing FU Wenqin SU Bingmiao gao Qin CHEN Department of Food and Pharmacy Hainan Health Management CollegeChengmai 571999China School of Pharmacy Hainan Medical UniversityHaikou 571199China Hainan Open University Haikou 570208China

The sea cucumber Stichopus japonicus is one of the"Eight Treasures of Seafood"and contains a number of bioactive components involved in multiple physiological and pharmacological *** and peptides are generally considered to be responsible for these beneficial *** this study,a total of 3478 proteins and 17390 peptides were identified in Stichopus japonicus by proteomics *** them,4 proteins were involved in 8 metabolic pathways,especially oxidative phosphorylation and cell ***,lifespan assay and oxidative stress test were performed to investigate the peptides prepared from sea cucumber protein hydrolyzate using the aging model of Caenorhabditis *** results of the anti-aging experiment demonstrated that high-dose peptides significantly prolonged the lifespan of nematodes(30.50%),and improved their capacity to inhibit oxidative *** results provide evidence supporting the development of bioactive proteins and peptides derived from Stichopus japonicus as functional foods and lay the foundation for the research of an anti-aging drug.

关键词： Stichopus japonicus Proteomics Protein extraction Caenorhabditis elegans Anti-aging

Current status and prospects of research on safety situation awareness of high speed railway operation environment

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Railway Sciences 2024年第4期3卷 453-468页

作者： Tianyun Shi Zhoulong Wang Jia You Pengyue Guo Lili Jiang Huijin Fu Xu gao Department of Science and Information Technology China Academy of Railway Sciences Corporation LimitedBeijingChina Signal&Communication Research Institute China Academy of Railway Sciences Corporation LimitedBeijingChina Institute of Computing Technology China Academy of Railway Sciences Corporation LimitedBeijingChina Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijingChina

Purpose–The safety of high-speed rail operation environments is an important guarantee for the safe operation of high-speed *** operating environment of the high-speed rail is complex,and the main factors affecting the safety of high-speed rail operating environment include meteorological disasters,perimeter intrusion and external environmental *** purpose of the paper is to elaborate on the current research status and team research progress on the perception of safety situation in high-speed rail operation environment and to propose directions for further research in the ***/methodology/approach–In terms of the mechanism and spatio-temporal evolution law of the main influencing factors on the safety of high-speed rail operation environments,the research status is elaborated,and the latest research progress and achievements of the team are *** paper elaborates on the research status and introduces the latest research progress and achievements of the team in terms of meteorological,perimeter and external environmental situation perception methods for high-speed rail ***–Based on the technical route of“situational awareness evaluation warning active control,”a technical system for monitoring the safety of high-speed train operation environments has been *** theoretical and technical research and application have been carried out around the impact of meteorological disasters,perimeter intrusion and the external environment on high-speed rail *** works strongly support the improvement of China’s railway environmental safety guarantee ***/value–With the operation of CR450 high-speed trains with a speed of 400 kmper hour and the application of high-speed train autonomous driving technology in the future,new and higher requirements have been put forward for the safety of high-speed rail operation *** following five aspects of work are urgently needed:(1)Research the singl

关键词： High-speed rail operating environment Situation awareness Meteorological disasters Perimeter invasion External environment

蛋白酶抑制剂DUBs-IN-1抑制马立克病病毒在鸡细胞内的增殖

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中国兽医学报 2024年第8期44卷 1622-1628页

作者：艾馨许家翠谢佳良马浩原于凯刘洺丞王馨悦林俊彦高旭延边大学农学院吉林延吉133400 吉林大学动物科学学院吉林长春130062

接种疫苗是防御鸡马立克病的主要手段,但疫苗不能扼制马立克病病毒(MDV)的感染、增殖、传播以及毒力增强,因此,抑制MDV在鸡细胞内的增殖是增强疫苗防御效果的重要手段。本研究以MDV编码的大被膜蛋白MDV049为靶点,应用泛素探针从蛋白酶... 详细信息

接种疫苗是防御鸡马立克病的主要手段,但疫苗不能扼制马立克病病毒(MDV)的感染、增殖、传播以及毒力增强,因此,抑制MDV在鸡细胞内的增殖是增强疫苗防御效果的重要手段。本研究以MDV编码的大被膜蛋白MDV049为靶点,应用泛素探针从蛋白酶抑制剂库中筛选出一种化合物DUBs-IN-1,可抑制MDV049的酶活性。分子对接分析发现,DUBs-IN-1可以与MDV049的催化活性中心袋口处的7个残基互作,阻止泛素底物与活性中心的CYS98结合,进而抑制MDV049酶的活性。应用CEF细胞病变(CPE)模型研究发现,0.35、0.70μmol/L的DUBs-IN-1可显著抑制MDV所致的CPE,定量分析揭示DUBs-IN-1可显著抑制MDV在CEF细胞内的增殖(P<0.01)。应用感染MDV的鸡进行动物水平的研究发现,使用80和150μg/kg的DUBs-IN-1每日给药处理,DUBs-IN-1可显著抑制MDV在鸡T细胞内的增殖(P<0.01)。总之,本研究发现蛋白酶抑制剂DUBs-IN-1通过竞争性抑制方式抑制MDV049酶活性,并有效抑制MDV在鸡细胞内增殖,这一发现为研发抗MDV的药物奠定了理论基础。

关键词：马立克病病毒蛋白酶抑制剂 DUBs-IN-1 CEF MDV049