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Global trend of nondrug and nonsedativehypnotic treatment forinsomnia: a bibliometric study

Journal of Traditional Chinese Medicine 2024年第3期44卷 595-608页

作者： lei Hanzhou XU Guixing WEI Zepeng ZHAO Ling LIANG Fanrong Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Haematology Royal North Shore HospitalSydney2065Australia

OBJECTIVE: To present a bibliometric analysis of global scientific publications on the nondrug and nonsedative hypnotic treatment of insomnia with regard to influential institutions, publications, countries, research hotspots,trends, and frontiers. METHODS: A literature review was conducted by searching the Web of Science Core Collection(Wo SCC) and China National Knowledge Infrastructure(CNKI) databases to identify all publications related to the nondrug and nonsedative hypnotic treatment of insomnia from 2000 to 2021. Eligible publications were reviewed, including annual publication increments, citation analyses, international collaborations, and keyword analyses. The data were analysed using Cite Space(vers5.8.R3, 6.1.R2 and 6.1.6, College of Computing and Informatics, Philadelphia, PA, USA) and virtualized by knowledge maps. RESULTS:In total, 9832 publications were included in this analysis. The results from the WoSCC showed that the United States of America(Count = 2268, 40.33%), Stanford University(Count = 141, 2.51%), and the United States Department of Health and Human Services were the leading country, institute, and funding agency regarding the number of publications, respectively. “Cognitive-behavioural therapy” was the most popular research topic generated from the cocited reference. The most frequently co-occurring keywords were insomnia, cognitive behavioural therapy, disorder, depression, quality of life, Meta-analysis, older adult, sleep, prevalence and efficacy, while keywords including clinical practice guideline, guideline, and tai Chi remained popular after 2021. Circadian rhythm was the strongest research frontier for 2000-2021. In China, Chengdu University of Traditional Chinese Medicine(Count = 69, 4.79%) was the most productive institute in this field. The most frequently co-occurring keywords from Chinese literature were sleep disorder, sleep quality, acupuncture and moxibustion, Parkinson's disease, transcranial magnetic stimulation, health

关键词： hypnotics and sedatives cognitive behavioral therapy complementary therapies bibliometrics CiteSpace visualization analysis scientometrics

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Structural insight into palladium-nickel clusters over mordenite zeolite for carbene-insertion reaction

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 89-99页

作者： Guangchao Li Ping-Luen Baron Ho Bryan Kit yue Ng tai-Sing Wu Pawel Rymarz Shik Chi Edman Tsang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Chemistry University of OxfordOxford OX13QRUK Synchrotron Radiation Research Center Hsinchu 30076China

The advancement of heterogeneous catalysts incorporating metal clusters in the nanometric size range has garnered significant attention due to their extraordinary catalytic activity and *** detailed characterization and understanding of the atomic structure of these metal clusters within catalysts is crucial for elucidating the underlying reaction *** the present study,a distinctive three-atom PdNi cluster,characterized by two Pd atoms at terminal positions and a central Ni atom,was synthesized over mordenite *** presence of atomic PdNi clusters within the eight-membered ring side pocket area was confirmed by multiple advanced analytical techniques,including magic-angle spinning nuclear magnetic resonance spectroscopy,synchrotron X-ray powder diffraction,extended X-ray absorption fine structure spectroscopy,and high-angle annular dark-field scanning transmission electron *** catalytic activity of the confined active species was examined by the carbene-mediated reactions of ethyl-2-diazoacetate to ethyl-2-methoxyacetate as a model *** to the Pd-mordenite and Ni-mordenite,the PdNi-mordenite catalyst incorporates a PdNi cluster,which demonstrates a superior performance,achieving 100%conversion and high selectivity under the same reaction *** study elucidates the potential of constructing bimetallic clusters in zeolites,providing valuable insights for developing new heterogeneous catalysts applicable to a wide range of catalytic processes.

关键词： zeolite metal cluster synchrotron X-ray diffraction carbene-mediated reaction

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Spatial Differentiation and Convergence Trend of High-quality Development Level of China’s Tourism Economy

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Chinese Geographical Science 2024年第2期34卷 230-249页

作者： CAO Shanshan HE Zhaoli NIU Jinlan WANG Songmao ZHAO lei School of Geography and Ocean Science Nanjing UniversityNanjing 210046China School of Business Administration Nanjing University of Finance and EconomicsNanjing 210046China School of Economics and Management Shandong Agricultural Uni-versityTai’an 271018China School of Hotel Management Shanghai Business SchoolShanghai 201400China School of Man-agement Zhejiang University of TechnologyHangzhou 310014China

This paper aims to interpret the connotation of high-quality development of tourism economy(HQTE)from the perspective of the new development concepts of innovation,coordination,green,openness and sharing,and then to evaluate the spatial differenti-ation of China’s HQTE based on provincial panel data from 2009 to ***,we employ the spatial convergence model to ex-plore the absolute and conditionalβconvergence trends of HQTE in the whole country and the eastern,central and western regions of *** empirical results reveal that:1)within the decade,from 2009 to 2018,regions of China with the highest HQTE index is its eastern region followed by the central region and then the western region,but the fastest growing one is the western region of China fol-lowed by the central region and then the eastern region.2)Whether or not the spatial effect is included,there are absolute and condition-alβconvergence in HQTE in the whole country and aforementioned three regions.3)The degree of government attention as well as the level of economic development and location accessibility are the positive driving factors for the convergence of HQTE in the whole country and the three *** degree of marketization and human capital have not passed the significance test either in the whole country or in the three *** above conclusions could deepen the understanding of the regional imbalance and spatial conver-gence characteristics of HQTE,clarify the primary development objects,and accomplish the goal of China’s HQTE.

关键词： new development concepts high-quality development of tourism economy(HQTE) spatial convergence China

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Prediction of hepatic artery occlusion after liver transplantation by ultrasound characteristics and clinical risk factors

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World Journal of Radiology 2024年第6期16卷 196-202页

作者： yu-Ting Lai Yi Chen tai-Shi Fang Zhi-Yan Li Ning-Bo Zhao Department of Ultrasound National Clinical Research Centre for Infectious DiseasesThe Third People’s Hospital of ShenzhenThe Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina Department of Liver Surgery National Clinical Research Centre for Infectious DiseasesThe Third People’s Hospital of ShenzhenThe Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Hepatic artery occlusion(HAO)after liver transplantation(LT)is a devastating complication,resulting in early graft loss and reduced overall ***-sound is an established assessment method for HAO in patients following LT,especially those with complex hepatic artery *** We retrospectively analyzed the ultrasound characteristics and the clinic risk factors associated with HAO in 400 adult LT patients who were enrolled and treated at the Third People's Hospital of Shenzhen between November 2016 and July *** patients diagnosed with acute HAO(A-HAO)by surgery and fifteen diagnosed with chronic HAO(C-HAO)were included.A control group of 33 patients without HAO complications during the same period were randomly selected using a random number *** patients underwent an ultrasono-graphy *** including resistance index(RI),peak systolic velocity(PSV),and portal vein velocity(PVV)were compared across the ***,basic clinical data were collected for all patients,including gender,age,primary diagnosis,D-dimer concentration,total operation time,cold ischemia time,hot ischemia time,intraoperative blood loss and transfusion,intraoperative urine volume,infusion,model for end-stage liver disease(MELD)score,and whether complex hepatic artery reconstructions were ***,risk factors influencing HAO formation after LT were *** Compared to the non-HAO group,PVV and RI were higher in the A-HAO group,while PSV was ***,both PSV and RI were lower in the C-HAO group compared to the non-HAO *** proportion of patients undergoing complex hepatic artery reconstructions and the gamma-glutamyltransferase(GGT)level before occlusion were significantly higher in the A-HAO group compared to the non-HAO ***,there were no distinct differences between the two groups in D-dimer,MELD score,pre-occlusion alanine transaminase and aspartate transaminase levels,or intrao

关键词： Hepatic artery occlusion Ultrasonography Diagnostic performance Risk factors Liver transplantation

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A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

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Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： Ting-Ting Huang Jin-Fa Chen Juan Liu tai-Bao Wei Hong Yao Bingbing Shi Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect

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Optimized Phishing Detection with Recurrent Neural Network and Whale Optimizer Algorithm

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Computers, Materials & Continua 2024年第9期80卷 4895-4916页

作者： Brij Bhooshan Gupta Akshat Gaurav Razaz Waheeb Attar Varsha Arya Ahmed Alhomoud Kwok tai Chui Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPuneMaharashtra411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Ronin Institute MontclairNJ 07043USA Management Department College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Business Administration Asia UniversityTaichung413Taiwan Department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon Department of Computer Sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia Department of Electronic Engineering and Computer Science Hong Kong Metropolitan University(HKMU)HomantinHong KongChina

Phishing attacks present a persistent and evolving threat in the cybersecurity land-scape,necessitating the development of more sophisticated detection *** machine learning approaches to phishing detection have relied heavily on feature engineering and have often fallen short in adapting to the dynamically changing patterns of phishingUniformResource Locator(URLs).Addressing these challenge,we introduce a framework that integrates the sequential data processing strengths of a Recurrent Neural Network(RNN)with the hyperparameter optimization prowess of theWhale Optimization Algorithm(WOA).Ourmodel capitalizes on an extensive Kaggle dataset,featuring over 11,000 URLs,each delineated by 30 *** WOA’s hyperparameter optimization enhances the RNN’s performance,evidenced by a meticulous validation *** results,encapsulated in precision,recall,and F1-score metrics,surpass baseline models,achieving an overall accuracy of 92%.This study not only demonstrates the RNN’s proficiency in learning complex patterns but also underscores the WOA’s effectiveness in refining machine learning models for the critical task of phishing detection.

关键词： Phishing detection Recurrent Neural Network(RNN) Whale Optimization Algorithm(WOA) cybersecurity machine learning optimization

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Tuning hot carrier transfer dynamics by perovskite surface modification

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Chinese Chemical Letters 2024年第10期35卷 483-486页

作者： Chenghao Ge Peng Wang Pei yuan tai Wu Rongjun Zhao Rong Huang Lin Xie Yong Hua School of Materials and Energy Yunnan University Department of Physics Center for Optoelectronics Engineering Research Yunnan University

Understanding the role of perovskite surface passivators in hot carriers transfer dynamics is important to develop highly efficient perovskite solar cells(PSCs). In this work, we have designed and synthesized a naphthalimide-based organic small molecule(NCN) for perovskite surface defect passivator. We reveal that the introduction of NCN not only reduces the density of perovskite defect-state, but also promotes hot carriers(HCs) cooling in perovskite through the transient absorption spectroscopy measurements. Fast HCs cooling permits HCs transfer from perovskite layer into NCN layer, thus resulting in the decreased charge-carrier recombination in NCN-treated device. As expected, the power conversion efficiency(PCE)of PSCs with NCN is enhanced to 22.02% from 19.95% for the control device. The findings are relevant for developing highly efficient PSCs.

关键词： Charge recombination Hot carrier Interface passivation Naphthalimide Perovskite solar cells Stability

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Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3980-3993页

作者： He Jiang Guo-tai Wang Zheng Wang Qing-Yong Ma Zhen-Hua Ma Department of Hepatobiliary Surgery The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina

BACKGROUND Pancreatic cancer,a formidable gastrointestinal neoplasm,is characterized by its insidious onset,rapid progression,and resistance to treatment,which often lead to a grim *** the complex pathogenesis of pancreatic cancer is well recognized,recent attention has focused on the oncogenic roles of senescent tumor-associated ***,their precise role in pancreatic cancer remains *** is a natural polyphenol known for its multifaceted biological actions,including antioxidative and neuroprotective properties,as well as its potential to inhibit tumor proliferation and *** current investigation builds on prior research and reveals the remarkable ability of resveratrol to inhibit pancreatic cancer proliferation and *** To explore the potential of resveratrol in inhibiting pancreatic cancer by targeting senescent tumor-associated *** Immunofluorescence staining of pancreatic cancer tissues revealed prominent coexpression ofα-SMA and ***-1 expression was determined using *** were treated with the senescence-inducing factors known as ***-term growth assays confirmed that 3CKs significantly decreased the CAF growth *** blotting was conducted to assess the expression levels of p16 and *** was performed to assess LaminB1 *** real-time polymerase chain reaction was used to measure the levels of several senescence-associated secretory phenotype factors,including IL-4,IL-6,IL-8,IL-13,MMP-2,MMP-9,CXCL1,and CXCL12.A scratch assay was used to assess the migratory capacity of the cells,whereas Transwell assays were used to evaluate their invasive *** Specifically,we identified the presence of senescent tumor-associated fibroblasts within pancreatic cancer tissues,linking their abundance to cancer ***,Resveratrol effectively eradicated these fibroblasts and hindered their senescence,which co

关键词： Resveratrol Pancreatic Cancer Proliferation Metastasis Senescent Fibroblasts

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Oncology Research 2024年第2期32卷 421-432页

作者： SEUNG-HEE GWAK JUHyuN LEE EUNJI OH DOHyuN LEE WONSHIK HAN JONGMIN KIM KYONG-tai KIM Department of Life Sciences Pohang University of Science and TechnologyPohang37673Korea R&D Center NovMetaPharma Co.Ltd.Pohang37668Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoul03080Korea Generative Genomics Research Center Global Green Research&Development CenterHandong Global UniversityPohang37554Korea

Genetic information is transcribed from genomic DNA to mRNA,which is then translated into threedimensional *** can undergo various post-transcriptional modifications,including RNA editing that alters mRNA sequences,ultimately affecting protein *** this study,RNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VRK2).This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2,which leads to an increase in tumor cell *** we reported that VRK2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its ***,we demonstrate that isoleucine-containing VRK2 decreases the level of dysbindin than valinecontaining *** interacts with cyclin D and thereby regulates its expression and *** reduction in the level of dysbindin by isoleucine-containing VRK2 further enhances the cyclin D expression,resulting in increased tumor growth and reduction in survival *** has also been observed that in patient samples,VRK2 level was elevated in breast cancer tissue compared to normal breast ***,the isoleucine form of VRK2 exhibited a greater increase in breast cancer ***,it is concluded that VRK2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation.

关键词： VRK2 Kinase activity Breast cancer Tumor RNA editing Cell proliferation Cell growth

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The possible K■ and D■ bound and resonance states by solving the Schrodinger equation

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Communications in Theoretical Physics 2024年第10期 87-93页

作者： Bao-Xi Sun Qin-Qin Cao Ying-tai Sun School of Physics and Optoelectronic Engineering Beijing University of Technology School of Mechanical and Materials Engineering North China University of Technology

The Schrodinger equation with a yukawa type of potential is solved *** different boundary conditions are taken into account,a series of solutions are indicated as a Bessel function,the first kind of Hankel function and the second kind of Hankel function,***,the scattering processes of K■ and D■ are *** the K■ sector,the f1（1285） particle is treated as a K■ bound state,therefore,the coupling constant in the K■ yukawa potential can be fixed according to the binding energy of the f1（1285） ***,a K■ resonance state is generated by solving the Schrodinger equation with the outgoing wave condition,which lies at 1417-i18 MeV on the complex energy *** is reasonable to assume that the K■ resonance state at 1417-i18 MeV might correspond to the f1（1420） particle in the review of the Particle Data *** the D■ sector,since the X（3872）particle is almost located at the D■ threshold,its binding energy is approximately equal to ***,the coupling constant in the D■ yukawa potential is determined,which is related to the first zero point of the zero-order Bessel *** to the K■ case,four resonance states are produced as solutions of the Schrodinger equation with the outgoing wave *** is assumed that the resonance states at 3885～i1 MeV,4029-i108 MeV,4328-i191 MeV and 4772-i267 MeV might be associated with the Zc（3900）,the X（3940）,the χc1（4274） andχc1（4685） particles,*** is noted that all solutions are isospin degenerate.

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