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Assessment and control of the mine tremor disaster induced by the energy accumulation and dispersion of thick-hard roofs

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International Journal of Mining Science and Technology 2024年第7期34卷 925-941页

作者： Bin yu Mingxian Peng Yang tai Shuai Guo State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China School of Mines China University of Mining and TechnologyXuzhou 221116China

In order to solve the problem that current theory models cannot accurately describe thick-hard roof(THR)elastic energy and assess the mine tremor disasters,a theoretical method,a Timoshenko beam theory on Winkler foundation was adopted to establish the THR’s periodic breaking *** superposition principle was used for this complex model to derive the calculation formulas of the elastic energy and impact load on hydraulic ***,the influence of roof thickness h,cantilever length L_(1),and load q on THR’s elastic energy and impact load was ***,the effect of mine tremor disasters was ***,it is revealed that:(1)The THR’s elastic energy U exhibits power-law variations,with the fitted relationships U=0.0096L_(1)^(3.5866^),U=5943.9h^(-1.935),and U=21.049q^(2).(2)The impact load on hydraulic supports F_(ZJ) increases linearly with an increase in the cantilever length,thickness,and applied *** fitted relationships are F_(ZJ)=1067.3L_(1)+6361.1,F_(ZJ)=125.89h+15100,and F_(ZJ)=10420q+3912.6.(3)Ground hydraulic fracturing and liquid explosive deep-hole blasting techniques effectively reduce the THR’s cantilever length at periodic breakages,thus eliminating mine tremor disasters.

关键词： Dynamic disaster Energy Hard and thick roof Timoshenko beam

NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： yu-Jie Xu Ya-Chang Huo Qi-tai Zhao Jin-Yan Liu Yi-Jun Tian lei-lei Yang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using Gene Ontology and Kyoto Encyclopedia of Genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

De-biased knowledge distillation framework based on knowledge infusion and label de-biasing techniques

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Journal of Electronic Science and Technology 2024年第3期22卷 57-68页

作者： Yan Li tai-Kang Tian Meng-yu Zhuang yu-Ting Sun School of Economics and Management University of Electronic Science and Technology of ChinaChengdu611731China School of Economics and Management Beijing University of Posts and TelecommunicationBeijing100876China School of Electrical Engineering and Computer Science The University of QueenslandBrisbane4072Australia

Knowledge distillation,as a pivotal technique in the field of model compression,has been widely applied across various ***,the problem of student model performance being limited due to inherent biases in the teacher model during the distillation process still *** address the inherent biases in knowledge distillation,we propose a de-biased knowledge distillation framework tailored for binary classification *** the pre-trained teacher model,biases in the soft labels are mitigated through knowledge infusion and label de-biasing *** on this,a de-biased distillation loss is introduced,allowing the de-biased labels to replace the soft labels as the fitting target for the student *** approach enables the student model to learn from the corrected model information,achieving high-performance deployment on lightweight student *** conducted on multiple real-world datasets demonstrate that deep learning models compressed under the de-biased knowledge distillation framework significantly outperform traditional response-based and feature-based knowledge distillation models across various evaluation metrics,highlighting the effectiveness and superiority of the de-biased knowledge distillation framework in model compression.

关键词： De-biasing Deep learning Knowledge distillation Model compression

Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 484-492页

作者： Jun Xie yu-long Ma Ming-tai Gui lei Yao Jian-hua Li Ming-zhu Wang Xun-jie Zhou Yi-fan Wang Ming-yi Zhao Hui Cao Bo Lu De-yu Fu Department of Cardiology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai University of Traditional Chinese Medicine Shanghai 200120China

Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart *** Qianyang Qutan Recipe (HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several ***:This study assesses HQQR’s efficacy for controlling blood pressure among patients with hypertension related to blood stasis,yang hyperactivity and ***,setting,participants and interventions:A randomized controlled trial was conducted at the yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June *** components of HQQR were identified using thin-layer chromatography and high-performance liquid *** aged18–80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two *** intervention group was given HQQR granules alongside conventional hypertension treatment,while the control group was given placebo granules in addition to conventional treatment for 12 *** outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices (e.g.,homeostasis model assessment of insulin resistance[HOMA-IR],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices (left ventricular mass index and urinary albumin creatinine ratio[UACR]) and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR’s primary components were identified as salvianolic acid B,emodin and ferulic *** the 216 participants (108 in each group),compared to the control,the intervention group exhibited significant improvements (P<0.001) in clinic systolic blood pressure ([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure ([84.34±8.72]vs[80.46±6.05]mmHg),home systol

关键词： Huoxue Qianyang Qutan Recipe Hypertension Target organ damage Glycolipid metabolism Inflammatory Chinese herbal compound

Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis

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Food Science and Human Wellness 2024年第1期13卷 482-493页

作者： Zhihui yu Lingyu Fan Fei tai Lixin Zhang Xiaoyu Zhang Yisheng Chen College of Food Science and Engineering Shanxi Agricultural UniversityTaigu 030801China Insitute of Food Nutrition and Safety Shanxi Agricultural UniversityTaiyuan 030031China Shanxi Key Laboratory of Edible Fungi for Loess Plateau Taigu 030801China

In this study,the impacts of egg consumption on mice model of metabolic syndrome(Met S)were comparatively *** were divided into five groups(n=8):normal diet group(ND),high-fat diet group(HFD),HFD with whole egg group(WE),HFD with free-yolk egg substitute group(YFES),and HFD with lovastatin group(Lov).Main biochemical indexes and a non-targeted lipidomic analysis were employed to insight the lipid profile changes in *** was revealed that WE could significantly improve serum biochemical indexes by reducing body weight,low-density lipoprotein cholesterol(LDL-C)and total cholesterol(TC),while increasing high-density lipoprotein *** exhibited remarkably better performance in increasing phosphatidylglycerol and phosphatidic acids,while decreasing phosphatidylinositol than WE.A total of 50 differential lipids biomarkers tightly related to glycerophospholipids metabolism were screened *** C18:2 and C12:1,SM(d18:0/12:0),and SM(d18:1/14:1)were significantly upregulated in YFES compared to *** reduced expression of SREBP-1c and Cpt1a,while did not affect the expression of PPAR-α.Sphingomyelin biomarkers were positively related to the TC(|r|>0.6),while PPAR-αwas negatively correlated with triglyceride and LDL-C *** sum up,YFES attenuated HFD-induced Met S by improving the serum phospholipids,which account for its modulation of glycerophospholipid metabolism.

关键词： Metabolic syndrome Whole egg Yolk free egg substitute Serum Lipidomics

Air pressure law of a reservoir constructed in karst sinkholes

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Journal of Mountain Science 2024年第3期21卷 1048-1057页

作者： yu Bo tai Shengping ZHENG Kexun CHEN Shiwan HAN Xiao WANG Senlin ZUO Shuangying Power China Guiyang Engineering Corporation Limited Guiyang 550081China College of Resources and Environmental Engineering Key Laboratory of Karst Georesources and EnvironmentMinistry of EducationGuizhou UniversityGuiyang 550025China

Karst sinkholes with natural negative landform provide favorable conditions for the pumped storage reservoir construction for less excavation ***,the construction of the reservoir would plug the natural karst channels for water and air,which would cause remarkable air pressure in karst channels when the groundwater level fluctuates.A large laboratory simulation test was carried out to study the air pressure variation of a reservoir built on the karst *** air pressure in the karst channel and inside the model was monitored during the groundwater rising and falling *** showed that the variation of air pressure in the karst channel and the surrounding rock exhibited a high degree of *** air pressure increased rapidly at the initial stage of water level rising,followed by a slight decrease,then the air pressure increased sharply when the water level approached the top of the karst *** initial peak of air pressure and the final peak of air pressure were defined,and both air pressure peaks were linearly increasing with the water level rising *** negative air pressure was also analyzed during the drainage process,which was linearly correlated with the water level falling *** causes of air pressure variation in karst channels of a pumped storage reservoir built on the karst sinkhole were *** initial rapid increase,then slight decrease and final sudden increase of air pressure were controlled by the combined effects of air compression in karst channel and air seepage into the surrounding *** the drainage process,the instant negative air pressure and gradual recovering of air pressure were controlled by the combined effects of negative air pressure induced by water level falling and air supply from surrounding *** work could provide valuable reference for the reservoir construction in karst area.

关键词： Simulation test Karst sinkhole Pumped storage reservoir Air pressure Flow rate

Corrosion behavior of pure metals(Ni and Ti)and alloys(316H SS and GH3535)in liquid GaInSn

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Nuclear Science and Techniques 2024年第3期35卷 70-83页

作者： Jian-Hui yu Hong-Xia Xu Xiang-Xi Ye Bin Leng Han-Xun Qiu Xing-tai Zhou School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

In this study,the interactions between a Ga-based liquid metal,GaInSn,and several metal materials,including pure metals(Ni and Ti)and alloys(316H stainless steel(SS)and GH3535),at 650℃were *** aim was to evaluate the corrosion performance and select a suitable candidate material for use as a molten salt manometer diaphragm in thermal energy storage *** results indicated that the alloys(316H SS and GH3535)exhibited less corrosion than pure metals(Ni and Ti)in liquid ***-rich binary intermetallic compounds were found to form on the surfaces of all the tested metal materials exposed to liquid GaInSn,as a result of the decomposition of liquid GaInSn and its reaction with the constituent elements of the metal *** corrosion mechanism for all the tested materials exposed to liquid GaInSn was also investigated and proposed,which may aid in selecting the optimal candidate material when liquid GaInSn is used as the pressure-sensing medium.

关键词： Metal materials Liquid GaInSn Corrosion Intermetallic compounds Thermal energy storage systems

Capacity Allocation of Renewable Energy Sources Considering Complementarity

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1415-1426页

作者： Yinzhe Hu Kaigui Xie Bo Hu Hengming tai Changzheng Shao Chunyan Li Xueying yu State Key Laboratory of Power Transmission Equipment and System Security at the Chongqing University Chongqing 400030China Department of Electrical and Computer Engineering University of TulsaTulsaOK 74104USA

The outputs of renewable energy sources(RESs)are inherently variable and uncertain,such as wind power(WP)and photovoltaic(PV).However,the outputs of various types of RESs in different regions are *** the capacity of RESs could be properly allocated during system planning,variability of the total output could be ***,system reliability and renewable energy(RE)consumption could be *** paper proposes an analytical model for optimal complementary capacity allocation of RESs to decrease variability of the total *** model considers the capacity ratio of RESs as decision variables and the coefficient of variation(CV)of the total output as the objective *** proposed approach transforms the single-level optimization model into a bilevel optimization model and derives an analytical equation that can directly calculate the optimal complementary capacity ratio(OCCR)of system *** studies on wind and solar farms in Xinjiang and Qinghai,China,are performed to verify the effectiveness of the proposed analytical allocation method.

关键词： Analytical equation capacity allocation complementary optimization renewable energy variability

Bilayer Compounded Polytetrafluoroethylene Membrane for Enhanced Oil-Water Emulsion Separation

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Chinese Journal of Polymer Science 2024年第6期42卷 838-850页

作者： yu-Liang Yang tai-Ran Zhang Yan-Ting Han Shao-yun Guo Qin-Gong Rong Jia-Bin Shen State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversitySichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyChengdu610065China West China Hospital/West China School of Nursing Sichuan UniversityChengdu610041China Shandong Senrong New Materials Co. Ltd.Zibo256401China

In order to achieve efficient and durable oil-water emulsion separation,the membranes possessing high separation efficiency and mechanical strength attract extensive attention and are in great *** present study,a kind of polytetrafluoroethylene(PTFE)-based bilayer membrane was fabricated by electrospinning fibrous PTFE(fPTFE)on an expanded PTFE(ePTFE)*** morphological observation revealed that the fibrous structure of the fPTFE layer could be tailored by controlling the formulation of spinning *** addition of appropriate polyoxyethylene(PEO)would make the fibers in the fPTFE layer finer and more *** a result,the compounded membrane exhibited a small pore size of approximately 1.25µm and a substantial porosity nearing 80%.This led to super-hydrophobicity,characterized by a high water contact angle(WCA)of 149.8°,and facilitated rapid oil *** water-in-oil emulsion separation experiment further confirmed that the compounded membrane not only had a high separation efficiency closing 100%,but such an outstanding separation capacity could be largely retained,either through multiple cycles of use or through strong acid(pH=1),strong alkali(pH=12),or high-temperature(100°C)***,the mechanical behavior of the bilayer membrane was basically contributed by that of each layer in terms of their volume *** significantly,the poor creep resistance of fPTFE layer was suppressed by compounding with ePTFE ***,this study has laid the groundwork for a novel approach to create PTFE-based compounded membranes with exceptional overall characteristics,showing promise for applications in the realm of emulsion separation.

关键词： ePTFE Electrospinning membrane Bilayer compounding Emulsion separation