检索结果-南通市图书馆

Asian Journal of Andrology 2024年第2期26卷 195-204页

作者： Zhao Yang Jia-Qi chen Tian-Jie Liu yu-le chen Zhen-Kun Ma Yi-Zeng Fan Zi-Xi Wang Shan Xu Ke Wang Xin-Yang Wang lei Li Hong-Jun Xie Department of Urology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)*** is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment,even bone metastases,through ***,we found that exosomes isolated from PCa cells after knocking down androgen receptor(AR)or enzalutamide treatment can facilitate the migration of prostate cancer cells to *** addition,AR silencing or treatment with the AR antagonist enzalutamide may increase the expression of circular RNA-deoxyhypusine synthase(circ-DHPS)in PCa cells,which can be transported to osteoblasts by ***-DHPS acts as a competitive endogenous RNA(ceRNA)against endogenous miR-214-3p to promote C-C chemokine ligand 5(CCL5)levels in *** the level of CCL5 in osteoblasts could recruit more PCa cells into the bone ***,blocking the circ-DHPS/miR-214-3p/CCL5 signal may decrease exosome-mediated migration of prostate cancer cells to osteoblasts.

关键词： androgen receptor circRNA exosome prostate cancer

CHD1 deletion stabilizes HIF1α to promote angiogenesis and glycolysis in prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第2期25卷 152-157页

作者： yu-Zhao Wang yu-chen Qian Wen-Jie Yang lei-Hong Ye Guo-Dong Guo Wei Lv Meng-Xi Huan Xiao-yu Feng Ke Wang Zhao Yang Yang Gao lei Li yu-le chen Department of Urology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Oncology Research Laboratory Key Laboratory of Environment and Genes Related to DiseasesMinistry of EducationXi’an 710061China

Chromodomain-helicase-DNA-binding protein 1(CHD1)deletion is among the most common mutations in prostate cancer(PCa),but its role remains *** this study,RNA sequencing was conducted in PCa cells after clustered regularly interspaced palindromic repeat(CRISPR)/CRISPR-associated protein 9(Cas9)-based CHD1 *** set enrichment analysis(GSEA)indicated upregulation of hypoxia-related pathways.A subsequent study confirmed that CHD1 deletion significantly upregulated hypoxia-inducible factor 1α(HIF1α)*** investigation revealed that CHD1 deletion upregulated HIF1αby transcriptionally downregulating prolyl hydroxylase domain protein 2(PHD2),a prolyl hydroxylase catalyzing the hydroxylation of HIF1αand thus promoting its degradation by the E3 ligase von Hippel–Lindau tumor suppressor(VHL).Functional analysis showed that CHD1 deletion promoted angiogenesis and glycolysis,possibly through HIF1αtarget *** together,these findings indicate that CHD1 deletion enhances HIF1αexpression through PHD2 downregulation and therefore promotes angiogenesis and metabolic reprogramming in PCa.

关键词： angiogenesis CHD1 HIF1α metabolism prostate cancer

Sensitivity impacts owing to the variations in the type of zero-range pairing forces on the fission properties using the density functional theory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 198-207页

作者： Yang Su Ze-yu Li Li-le Liu Guo-Xiang Dong Xiao-Bao Wang Yong-Jing chen China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China School of Science Huzhou UniversityHuzhou 313000China

Using the Skyrme density functional theory,potential energy surfaces of^(240)Pu with constraints on the axial quadrupole and octupole deformations(q_(20)and q_(30))were *** volume-like and surface-like pairing forces,as well as a combination of these two forces,were used for the Hartree–Fock–Bogoliubov *** in the least-energy fission path,fission barrier,pairing energy,total kinetic energy,scission line,and mass distribution of the fission fragments based on the different forms of the pairing forces were analyzed and *** fission dynamics were studied based on the timedependent generator coordinate method plus the Gaussian overlap *** results demonstrated a sensitivity of the mass and charge distributions of the fission fragments on the form of the pairing *** on the investigation of the neutron-induced fission of^(239)Pu,among the volume,mixed,and surface pairing forces,the mixed pairing force presented a good reproduction of the experimental data.

关键词： Nuclear fission Density functional theory Pairing force Potential energy surfaces Fission fragment distribution

Abnormal Innervation,Demyelination,and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第8期40卷 1093-1103页

作者： yue Qiu le Xie Xiaohui Wang Kai Xu Xue Bai Sen chen yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Otolaryngology Nanchang UniversityNanchang 330006China

GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary *** individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sole remedy for auditory *** previous studies have highlighted the crucial role of preserving cochlear neural components in achieving favorable outcomes after cochlear ***,we generated a conditional knockout mouse model(Cx26-CKO)in which Cx26 was completely deleted in the cochlear supporting cells driven by the Sox2 *** Cx26-CKO mice showed severe hearing loss and massive loss of hair cells and Deiter’s cells,which represented the extreme form of human deafness caused by GJB2 gene *** addition,multiple pathological changes in the peripheral auditory nervous system were found,including abnormal innervation,demyelination,and degeneration of spiral ganglion neurons as well as disruption of heminodes in Cx26-CKO *** findings provide invaluable insights into the deafness mechanism and the treatment for severe deafness in Cx26-null mice.

关键词： Spiral ganglion neurons Gjb2 Heminode Hearing loss

A memory-friendly class-incremental learning method for hand gesture recognition using HD-sEMG

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medicine in Novel Technology and Devices 2024年第2期22卷 124-132页

作者： yu Bai le Wu Shengcai Duan Xun chen The School of Information Science and Technology University of Science and Technology of ChinaHefei230027China

Hand gesture recognition(HGR)plays a vital role in human-computer *** integration of high-density surface electromyography(HD-sEMG)and deep neural networks(DNNs)has significantly improved the robustness and accuracy of HGR *** methods are typically effective for a fixed set of trained ***,the need for new gesture classes over time poses a *** new classes to DNNs can lead to a substantial decrease in accuracy for previously learned tasks,a phenomenon known as“catastrophic forgetting,”especially when the training data for earlier tasks is not retained and *** issue is exacerbated in embedded devices with limited storage,which struggle to store the large-scale data of ***incremental learning(CIL)is an effective method to reduce catastrophic ***,existing CIL methods for HGR rarely focus on reducing memory *** address this,we propose a memory-friendly CIL method for HGR using *** approach includes a lightweight convolutional neural network,named SeparaNet,for feature representation learning,coupled with a nearest-mean-of-exemplars classifier for *** introduce a priority exemplar selection algorithm inspired by the herding effect to maintain a manageable set of exemplars during ***,a task-equal-weight exemplar sampling strategy is proposed to effectively reduce memory load while preserving high recognition *** results on two datasets demonstrate that our method significantly reduces the number of retained exemplars to only a quarter of that required by other CIL methods,accounting for less than 5%of the total samples,while still achieving comparable average accuracy.

关键词： Myoelectric pattern recognition Memory-friendly Class-incremental learning

Nitrogen-doped titanium dioxide/schwertmannite nanocomposites as heterogeneous photo-Fenton catalysts with enhanced efficiency for the degradation of bisphenol A

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第9期143卷 1-11页

作者： Xing-Xing Qiao yu-Hang Xu Xiang-Ji Liu Sai-le chen Zhou Zhong Ya-Feng Li Jian Lü Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

Potential health risks related to environmental endocrine disruptors(EEDs)have aroused research hotspots at the forefront of water treatment ***,nitrogen-doped titanium dioxide/schwertmannite nanocomposites(N-TiO_(2)/SCH)have been successfully developed as heterogeneous catalysts for the degradation of typical EEDs via photo-Fenton *** to the sustainable Fe(Ⅲ)/Fe(Ⅱ)conversion induced by photoelectrons,as-prepared N-TiO_(2)/SCH nanocomposites exhibit much enhanced efficiency for the degradation of bisphenol A(BPA;ca.100% within 60 min under visible irradiation)in a wide pH range of 3.0-7.8,which is significantly higher than that of the pristine schwertmannite(ca.74.5%)or N-TiO_(2)(ca.10.8%).In this photo-Fenton system,the efficient degradation of BPA is mainly attributed to the oxidation by hydroxyl radical(·OH)and singlet oxygen(^(1)O_(2)).Moreover,the possible catalytic mechanisms and reaction pathway of BPA degradation are systematically investigated based on analytical and photoelectrochemical *** work not only provides a feasible means for the development of novel heterogeneous photo-Fenton catalysts,but also lays a theoretical foundation for the potential application of mineral-based materials in wastewater treatment.

关键词： Titanium dioxide Schwertmannite Fenton reaction Environmental endocrine disruptors Photocatalysis

Heat Transfer Characteristics of a Microchannel Heat Sink with Highly-Dense Micro-Jet Arrays

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第3期33卷 1148-1160页

作者： ZHANG yu chen Xiaoyan MIAO Lin chen Liang HOU yu State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China Beijing Aerospace Technology Institute Beijing100083China

This paper proposed a new structure of highly-dense micro-jet arrays for hybrid jet-impingement/microchannel heat sinks(~120 jet per cm^(2) with jet width of 0.35 mm).Parametric study is performed to investigate the influence of structure and flow parameters on the convective heat transfer of water jet cooling in confined *** simulation results show that the optimal jet width,jet spacing and impingement distance are around 0.2 mm,0.2 mm and 0.3 mm,respectively,which can achieve a low thermal resistance as well as a relatively low pressure *** analysis of the heat transfer pathways shows that the micro-fin jet structures can extend the impinging heat transfer area and conduct a considerable proportion of heat,which can reach up to 38.9%with the Reynolds number ranging from 797.1 to *** heat transfer characteristics in the heat sink will shift from impingement dominated heat transfer to the channel-convection dominated heat transfer as the jet impingement distance increases.A correlation is proposed to predict the average Nusselt number on the stagnation area for the heat sink with different structure parameters,and the deviations of predictions from the numerical results are less than 10%.

关键词： hybrid heat sink impingement microchannel thermal management high heat flux

Approximate analytical solutions for threedimensional ascent trajectory of a solid-fuel launch vehicle with time-varying mass flow rate

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第10期37卷 275-293页

作者： Qi yu Wanchun chen Wenbin yu School of Astronautics Beihang UniversityBeijing 102206China

In the scenario that a solid-fuel launch vehicle maneuvers in outer space at high angles of attack and sideslip for energy management,Approximate Analytical Solutions(AAS)for the threedimensional(3D)ascent flight states are derived,which are the only solutions capable of considering time-varying Mass Flow Rate(MFR)at *** uneven MFR makes the thrust vary nonlinearly and thus increases the difficulty of the problem *** AAS are derived based on a 3D Generalized Ascent Dynamics Model(GADM)with a normalized mass as the independent *** simplify some highly nonlinear terms in the GADM,several approximate functions are introduced carefully,while the errors of the approximations relative to the original terms are regarded as minor ***,a finite series with positive and negative exponents,called Exponent-Symmetry Series(ESS),is proposed for function approximation to decrease the highest exponent in the AAS so as to reduce computer round-off *** calculate the ESS coefficients,a method of seeking the Optimal Interpolation Points(OIP)is proposed using the leastsquares-approximation *** to the artful design of the approximations,the GADM can be decomposed into two analytically solvable subsystems by a perturbation method,and thus the AAS are obtained ***,to help implement the AAS,two indirect methods for measuring the remaining mass and predicting the burnout time in flight are put forward using information from *** results verify the superiority of the AAS under the condition of time-varying MFR.

关键词： Approximate analytical solutions 3D ascent trajectory Solid-fuel launch vehicle Uneven thrust Energy management

Low-melting mixture solvents: extension of deep eutectic solvents and ionic liquids for broadening green solvents and green chemistry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Chemical Engineering 2024年第4期5卷 409-417页

作者： yu chen Zhiwu yu MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Department of ChemistryTsinghua University

Green solvents such as water and ionic liquids(ILs) are pillars of the great mansion of green chemistry and green processing. Initially proposed as a new family of ILs,deep eutectic solvents(DESs) have received fast development in the past two decades. In this contribution,DESs are reviewed critically and the concept is extended to lowmelting mixture solvents(Lo MMSs),which cover all kinds of materials including ionic compounds,molecular compounds,and metals. Six classes of Lo MMSs are proposed as the new classification system and examples are given. Finally,several thermodynamic issues concerning Lo MMSs are discussed. Two new concepts,robustness of Lo MMSs and high-entropy Lo MMSs,are proposed.

关键词： Green solvents Deep eutectic solvents Low transition temperature mixture solvents Phase diagram EGaIn

A Skin-Inspired Self-Adaptive System for Temperature Control During Dynamic Wound Healing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro letters 2024年第8期16卷 211-224页

作者： Yaqi Geng Guoyin chen Ran Cao Hongmei Dai Zexu Hu Senlong yu le Wang Liping Zhu Hengxue Xiang Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620People’s Republic of China

The thermoregulating function of skin that is capable of maintaining body temperature within a thermostatic state is ***,patients suffering from skin damage are struggling with the surrounding scene and situational ***,we report an interactive self-regulation electronic system by mimicking the human thermos-reception *** skin-inspired self-adaptive system is composed of two highly sensitive thermistors(thermal-response composite materials),and a low-power temperature control unit(Laserinduced graphene array).The biomimetic skin can realize self-adjusting in the range of 35–42℃,which is around physiological *** thermoregulation system also contributed to skin barrier formation and wound *** wound models,the treatment group healed~10%more rapidly compared with the control group,and showed reduced inflammation,thus enhancing skin tissue *** skin-inspired self-adaptive system holds substantial promise for nextgeneration robotic and medical devices.

关键词： Thermo-reception Self-regulation Flexible electronic system Wound healing