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Association between acute mountain sickness(AMS) and age: a meta-analysis

Military Medical Research 2019年第1期6卷 31-38页

作者： yu wu Chi Zhang yu Chen Yong-jun Luo Department of Military Medical Geography Army Medical Service Training Base Army Medical University Battalion 5 of Cadet Brigade Army Medical University Key Laboratory of High Altitude Environmental Medicine of PLA Army Medical University

Background: Acute mountain sickness(AMS) is a potentially lethal condition caused by acute hypoxia after ascending to altitudes higher than 2500 m in a short time. The main symptom of AMS is headache. Numerous risk factors of AMS have been examined, including gender, obesity, ascent rate, age and individual susceptibility. In previous studies, age was considered a predisposing factor for AMS. However, different opinions have been raised in recent years. To clarify the association between AMS and age, we conducted this ***: We obtained observational studies that explored risk factors for AMS by searching PubMed, Embase, China National Knowledge Internet(CNKI), the Wanfang database and CQVIP for articles published before March *** studies included were required to provide the mean age and its standard deviation for subjects with and without AMS, the maximum altitude attained and the mode of ascent. The Lake Louse Score(LLS) or the Chinese AMS score(CAS) was used to judge the severity of AMS symptoms and incidence. Studies were pooled for the analysis by using a random effects model in RevMan 5.0. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity using Stata 14.2 and RevMan ***: In total, 17 studies were included, and the overall number of subjects with and without AMS was 1810 and3014, respectively. The age ranged from 10 to 76 years. Analysis of the 17 included studies showed that age was not associated with AMS(mean difference(MD)=0.10; 95%CI: —0.38-0.58; P=0.69).Conclusions: This meta-analysis suggests that there is no association between age and the risk of AMS. Race, age,and ascent mode are common sources of heterogeneity, which may provide an analytical orientation for future heterogeneity analyses.

关键词： Meta-analysis Age Acute mountain sickness Individual susceptibility

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Study of spatial resolution of the associated alpha particle imaging–time-of-flight method

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Nuclear Science and Techniques 2019年第4期30卷 105-113页

作者： Meng Huang Jian-yu Zhu jun wu Center for Strategic Studies China Academy of Engineering Physics

Associated alpha particle imaging based on the time-of-flight(API-TOF) technique is an advanced neutron analysis method, which is capable of discriminating material nuclides and three-dimensional imaging of the spatial distribution of material nuclei. In this paper, the spatial resolution of API-TOF and its effects are studied using mathematical analysis and Monte Carlo numerical simulation. The results can provide guidance and assist in designing of API-TOF detection devices. First, a mathematical analysis of the imaging principles of the API-TOF was carried out, and the calculation formulas of the spatial resolution of API-TOF were deduced. Next, the relationship between the device layout and the spatial resolution of the API-TOF detection device was studied. The concept of a typical API-TOF detection device with an optimized structure was proposed. Then, the spatial distribution of the spatial resolution of the typical API-TOF detection device was analyzed, and the effects of the time resolution and the neutron emission angle resolution on the spatial resolution were studied. The results show that spatial resolutions better than 1 cm can be achieved by improving the time resolution and the neutron emission angle resolution to appropriate levels. Finally, a Monte Carlo numerical simulation program was developed for the study of the APITOF and was used to calculate the spatial resolutions of the API-TOF. The comparison of the results shows that thespatial resolutions calculated based on the Monte Carlo numerical simulation are in good agreement with those calculated based on the mathematical analysis. This verifies the mathematical analysis and the evaluation of the effects of the spatial resolution of the API-TOF in this study.

关键词： API-TOF Spatial resolution Mathematical analysis Monte Carlo numerical simulation

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Approximate Maximum Likelihood Algorithm for Moving Source Localization Using TDOA and FDOA Measurements

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Chinese Journal of Aeronautics 2012年第4期25卷 593-597页

作者： yu Huagang HUANG Gaoming GAO jun wu Xinhui College of Electronic Engineering Naval University of Engineering Wuhan 430033 China Marine Communication Technology Institute Beijing 100841 China

A closed-form approximate maximum likelihood（AML） algorithm for estimating the position and velocity of a moving source is proposed by utilizing the time difference of arrival（TDOA） and frequency difference of arrival（FDOA） measurements of a signal received at a number of *** maximum likelihood（ML） technique is a powerful tool to solve this *** a direct approach that uses the ML estimator to solve the localization problem is exhaustive search in the solution space,and it is very computationally expensive,and prohibits real-time *** the basis of ML function,a closed-form approximate solution to the ML equations can be obtained,which can allow real-time implementation as well as global *** results show that the proposed estimator achieves better performance than the two-step weighted least squares（WLS） approach,which makes it possible to attain the Cramér-Rao lower bound（CRLB） at a sufficiently high noise level before the threshold effect occurs.

关键词： approximate maximum likelihood(AML) maximum likelihood(ML) source localization time differences of arrival(TDOA) frequency differences of arrival(FDOA)

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang wu Hao Kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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Industry characteristics,court location,and bankruptcy resolution

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Journal of Management Analytics 2020年第3期7卷 389-423页

作者： Dongwei He Kai yu jun wu Antai College of Economics and Management Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China Research Center of Finance Shanghai Business SchoolShanghaiPeople’s Republic of China Department of International Finance School of FinanceShanghai Lixin University of Accounting and FinanceShanghaiPeople’s Republic of China

Insolvent firms usually file for formal bankruptcy protection under either liquidation or *** aims to save viable failing firms whereas liquidation focuses on filtering out unviable failing *** paper theoretically and empirically investigates the determinants of formal bankruptcy *** present a concise theory to reveal the theoretical boundary between liquidation and reorganization,which reflects how industry characteristics,judicial bias,and firm characteristics affect the outcome of bankruptcy *** using the commercial bankruptcy data on US courts(2000–2016),we validate the proposed *** empirical tests,we deploy discrete-choice models to address the main predictions derived from theory and conduct robustness checks(*** test).We document that firms are more likely to be reorganized when their industry is experiencing *** in asset-heavy industries(***,mining,and oil)tend to be *** resolution of bankruptcy cases handled by courts in Alaska and Hawaii are more likely to be reorganization than is the case in other states;however,firms that file bankruptcy petitions in California courts are more likely to face ***,larger and more transparent firms are more likely to be reorganized.

关键词： court location firm bankruptcy formal bankruptcy resolution industry characteristics liquidation or reorganization

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Dense molecular gas tracers in high mass star formation regions

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Research in Astronomy and Astrophysics 2016年第2期16卷 33-44页

作者： Hong-jun Ma yu Gao Jing-Wen wu Purple Mountain Observatory/Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China

We report the FCRAO observations that mapped HCN （1-0）, CS （2-1）, HNC （1-0） and HCO＋（1-0） in ten high-mass star forming cores associated with water masers. We present velocity integrated intensity maps of the four lines for these dense cores, compare their line profiles, and derive physical properties of these cores. We find that these four tracers identify areas with similar properties in these massive dense cores, and in most cases, the emissions of HCN and HCO＋ are stronger than those of HNC and CS. We also use the line ratios of HCO＋/HCN, HNC/HCN and HNC/HCO＋ as the diagnostics to explore the environment of these high-mass star forming regions, and find that most of the cores agree with the model that photodominated regions dominate the radiation field, except for W44, for which the radiation field is similar to an X-ray dominated region.

关键词： ISM clouds -- ISM molecules -- stars formation

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Efficient degradation of aqueous dichloromethane by an enhanced microbial electrolysis cell:Degradation kinetics,microbial community and metabolic mechanisms

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Journal of Environmental Sciences 2024年第5期139卷 150-159页

作者： Meng wu Di Zhao Bing Gu ZiruWang jun Hu Zhiliang yu Jianming yu College of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)Co.Ltd. Hangzhou 311121China Zhejiang Tianyi Environmental Co.Ltd. Hangzhou 310000China

Dichloromethane(DCM)has been listed as a toxic and harmful water pollutant,and its re moval needs *** electrolysis cells(MECs)are viewed as a promising alterna tive for pollutant removal,which can be strengthened from two aspects:microbial inocula tion and *** this study,the MEC for DCM degradation was inoculated with the ac tive sludge enhanced by Methylobacterium rhodesianum H13(strain H13)and then acclimated in the form of a microbial fuel cell(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantly promoted DCM *** degradation kinetics were fitted by the Haldane model,with V_(max),K_(h),K_(i)and v_(max)values of 103.2 mg/L/hr,97.8 mg/L268.3 mg/L and 44.7 mg/L/hr/cm^(2),*** cyclic voltammogram implies that DCM redox reactions became easier with the setup of MEC,and the electrochemical impedance spectrogram shows that the acclimated and enriched microbes reduced the charge transfe resistance from the electrode to the *** the biofilm,the dominant genera shifted from Geobacter to Hyphomicrobium in acclimation ***,Methylobacterium played an increasingly important *** metabolism mainly occurred through the hydrolytic glutathione S-transferase pathway,given that the gene dcmA was identified rather than the dhlA and P450/*** exogenous electrons facilitated the reduction of GSSG,directly o indirectly accelerating the GSH-catalyzed *** study provides support fo the construction of an efficient and stable MEC for DCM removal in water environment.

关键词： Dichloromethane Microbial electrolysis cells Metabolic pathways Electron transfer Degradation kinetics

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A new species of the genus Amolops(Anura:Ranidae)from yunnan,China

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Zoological Research 2020年第2期41卷 188-193页

作者： yu-Lu Gan Guo-Hua yu Zheng-jun wu Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilinGuangxi 541004China Guangxi Key Laboratory of Rare and Endangered Animal Ecology College of Life ScienceGuangxi Normal UniversityGuilinGuangxi 541004China

DEAR EDITOR,A new species of the genus Amolops,Amolops tuanjieensis ***.,is described from yunnan,*** new species can be distinguished by the following characters:dorsolateral folds present;dorsal and ventral surfaces smooth;top of head and dorsum brown-red with irregular gray and dark spots;flank green;side of head black,from tip of snout,diffusing posteriorly to axilla,continuing as black streak below edge of dorsolateral fold;SVL 39.5-40.4 mm in males,56.8-60.7 mm in females;tympanum distinct;supratympanic fold indistinct;vomerine teeth in two oblique rows between choanae,closer to each other than choanae;vocal sacs present;nuptial pads present;outer metatarsal tubercle absent,supernumerary tubercles absent;all fingertips expanded into discs;limbs dorsally brown with dark brown bars and irregular dark brown blotches.

关键词： black closer brown

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CDP-GAN:Near-Infrared and Visible Image Fusion Via Color Distribution Preserved GAN

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IEEE/CAA Journal of Automatica Sinica 2022年第9期9卷 1698-1701页

作者： jun Chen Kangle wu Yang yu Linbo Luo the School of Automation Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex SystemsEngineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationChina University of GeosciencesWuhan 430074China the Shanghai Institute of Technical Physics Key Laboratory of Infrared System Detecting and Imaging TechnologyChinese Academy of SciencesShanghai 200083China the School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China

Dear Editor,This letter is concerned with dealing with the great discrepancy between near-infrared(NIR)and visible(VS)image fusion via color distribution preserved generative adversarial network(CDP-GAN).Different from the global discriminator in prior GAN,conflict of preserving NIR details and VS color is resolved by introducing an attention guidance mechanism into the ***。

关键词： details dealing preserving

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