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Inflammatory biomarkers and cerebral small vessel disease:a community-based cohort study

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Stroke & Vascular Neurology 2022年第4期7卷 302-309,I0009-I0014页

作者： Ding-Ding Zhang yuan Cao jing-yu mu Yi-Ming Liu Feng Gao Fei Han Fei-Fei Zhai Li-Xin Zhou Jun Ni Ming Yao Ming-Li Li Zheng-yu Jin Shu-Yang Zhang Li-Ying Cui Yong Shen Yi-Cheng Zhu Central Research Laboratory State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of Life Sciences and Medicine Institute on Aging and Brain DisordersThe First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefeiChina Department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease(CSVD),previous findings remain largely inconclusive and vary according to disease status and study *** present study aimed to investigate possible associations between inflammatory biomarkers and MRI markers of *** A group of 15 serum inflammatory biomarkers representing a variety of those putatively involved in the inflammatory cascade was grouped and assessed in a cross-sectional study involving 960 stroke-free *** biomarker panel was grouped as follows:systemic inflammation(high-sensitivity C reactive protein(hsCRP),interleukin 6 and tumour necrosis factorα),endothelial-related inflammation(E-selectin,P-selectin,intercellular adhesion molecule 1,vascular cell adhesion molecule 1(VCAM-1),CD40 ligand,lipoprotein-associated phospholipase A2,chitinase-3-like 1 protein and total homocysteine(tHCY))and media-related inflammation(matrix metalloproteinases 2,3 and 9,and osteopontin).The association(s)between different inflammatory groups and white matter hyperintensity(WMH),lacunes,cerebral microbleeds(CMBs),enlarged perivascular space(PVS)and the number of deep medullary veins(DMVs)were *** High levels of serum endothelial-related inflammatory biomarkers were associated with both increased WMH volume(R^(2)=0.435,p=0.015)and the presence of lacunes(R^(2)=0.254,p=0.027).Backward stepwise elimination of individual inflammatory biomarkers for endothelial-related biomarkers revealed that VCAM-1 was significant for WMH(β=0.063,p=0.005)and tHCY was significant for lacunes(β=0.069,p<0.001).There was no association between any group of inflammatory biomarkers and CMBs or *** inflammatory biomarkers were associated with fewer DMVs(R^(2)=0.032,p=0.006),and backward stepwise elimination of individual systemic-related inflammatory biomarkers revealed that hsCRP(β=−0.162,p=0.007)was *** WM

关键词： inflammation cerebral stepwise

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing Li Zixuan He Weitai Chai Meng Tian Huali yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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近视的病因研究新进展

国际眼科杂志 2021年第10期21卷 1746-1750页

作者：慕璟玉王雁浏梦张芮高云仙新疆医科大学第四临床医学院中国新疆维吾尔自治区乌鲁木齐市830000 新疆医科大学附属中医医院眼科中国新疆维吾尔自治区乌鲁木齐市830000 新疆维吾尔自治区中医药研究院中国新疆维吾尔自治区乌鲁木齐市830000

近年来,随着社会经济的发展、科技的进步及生活方式的改变,近视发病率逐年提高且有低龄化趋势。且随着新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的爆发,儿童青少年长时间近距离地网络上课加速了近视发生发展的速度。近视... 详细信息

近年来,随着社会经济的发展、科技的进步及生活方式的改变,近视发病率逐年提高且有低龄化趋势。且随着新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的爆发,儿童青少年长时间近距离地网络上课加速了近视发生发展的速度。近视所导致的视力障碍以及高度近视引起的严重并发症已经严重影响到人们的生活、学习和工作质量。因此,世界卫生组织与国际防盲协会及我国卫生部门已将儿童青少年近视的防控工作提上日程。然而其病因复杂,现多认为与遗传、环境等因素有关,本文就此展开简要论述。

关键词：近视病因遗传环境综述

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： jing Yao yuan Li Xi Liu Wenping Liang yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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新疆部分地区7~19岁儿童青少年散光现况

国际眼科杂志 2022年第2期22卷 298-303页

作者：慕璟玉高云仙王雁杨依宁赵勇新疆医科大学第四临床医学院中国新疆维吾尔自治区乌鲁木齐市830000 新疆医科大学附属中医医院眼科中国新疆维吾尔自治区乌鲁木齐市830000 新疆维吾尔自治区中医药研究院中国新疆维吾尔自治区乌鲁木齐市830000

目的:调查中国新疆部分地区7~19岁儿童青少年散光现况,分析新疆儿童青少年散光的分布规律。方法:横断面研究。2019-05/12在新疆部分地区采取立意抽样调查41所学校,其中20所小学、21所中学,最终共纳入71838名儿童青少年作为调查对象进行... 详细信息

目的:调查中国新疆部分地区7~19岁儿童青少年散光现况,分析新疆儿童青少年散光的分布规律。方法:横断面研究。2019-05/12在新疆部分地区采取立意抽样调查41所学校,其中20所小学、21所中学,最终共纳入71838名儿童青少年作为调查对象进行相关眼部检查。结果:71838名学生检出散光(柱镜度≤-0.50D)35888名,散光检出率49.96%,其中在不同年龄、性别、教育程度、地区及民族之间散光检出率比较有差异(均P<0.001)。7~16岁之间随着年龄的增加散光检出率呈上升趋势,16岁达到最高为57.60%,16~19岁散光检出率呈下降趋势,散光检出率总体随着年龄增长呈上升趋势;随着教育程度的增加散光检出率呈上升趋势,且男生散光检出率(51.25%)高于女生(48.62%),省会城市散光检出率(50.99%)高于非省会城市(48.05%);汉族散光检出率(53.41%)高于维吾尔族(40.17%)、哈萨克族(48.23%)、柯尔克孜族(45.56%)、回族(48.87%)等;散光类型主要以顺规散光为主(74.53%),且随着年龄的增加顺规散光构成比呈下降趋势,而逆规散光及斜向散光构成比呈上升趋势。Logistic回归分析最终结果显示年龄、性别、民族、地区及教育程度均是散光的影响因素。结论:中国新疆部分地区7~19岁儿童青少年散光检出率49.96%,且以顺规散光(74.53%)为主。年龄、性别、民族、地区及教育程度均是散光的影响因素。

关键词：新疆儿童青少年散光散光轴向民族

乌鲁木齐市中小学生近视与眼部生物学参数调查分析

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国际眼科杂志 2023年第3期23卷 471-476页

作者：高云仙李小龙马晓玲王雁慕璟玉赵勇新疆医科大学附属中医医院眼科新疆维吾尔自治区乌鲁木齐市830000 新疆维吾尔自治区中医药研究院新疆维吾尔自治区乌鲁木齐市830000

目的:调查研究乌鲁木齐市中小学生近视与眼部生物学参数差异。方法:横断面调查。于2021-09/11采取立意抽样的方法选取乌鲁木齐市4所学校7~18岁中小学生2 495人进行相关眼部检查。比较不同年龄段、性别、民族学生眼部生物学参数和屈光状... 详细信息

目的:调查研究乌鲁木齐市中小学生近视与眼部生物学参数差异。方法:横断面调查。于2021-09/11采取立意抽样的方法选取乌鲁木齐市4所学校7~18岁中小学生2 495人进行相关眼部检查。比较不同年龄段、性别、民族学生眼部生物学参数和屈光状态的差异,并分析纳入学生等效球镜度(SE)与眼部生物学参数的相关性。结果:纳入学生视力不良检出率为80.36%,近视检出率为55.91%,散光检出率为42.96%,其中低度近视检出率为63.80%,中度近视检出率为27.60%,高度近视检出率为8.60%。不同年龄、民族学生视力不良、近视及散光检出率、SE及部分眼部生物学参数均有差异(均P<0.05),其中维吾尔族、哈萨克族学生视力不良、近视及散光检出率明显低于汉族学生。男生视力不良、近视检出率均低于女生,散光检出率高于女生。Spearman相关分析显示,眼轴长度、轴向长度与轴率比、前房深度、瞳孔直径与SE呈负相关(r_(s)=-0.664、-0.724、-0.320、-0.086,均P<0.001);晶状体厚度与SE呈正相关(r_(s)=0.147,P<0.001)。结论:乌鲁木齐市中小学生近视患病率较高,不同年龄、民族儿童青少年眼球生物学参数存在差异性。

关键词：屈光不正近视眼部生物学参数乌鲁木齐民族

水源性高碘地区健康人群甲状腺自身抗体阳性筛查分析

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中国免疫学杂志 2017年第3期33卷 401-406页

作者：侯振江张靖宇牟兆新范洪王华新沧州医学高等专科学校甲状腺疾病研究所沧州061001 河北省沧州中西医结合医院实验诊断科沧州061001 河北省黄骅开发区博爱医院黄骅061100

目的:探讨沧州市健康体检人群甲状腺自身抗体的阳性率及其与甲状腺功能异常的相关性。方法:采用电化学发光免疫分析技术测定沧州市3 218名健康体检人群血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧... 详细信息

目的:探讨沧州市健康体检人群甲状腺自身抗体的阳性率及其与甲状腺功能异常的相关性。方法:采用电化学发光免疫分析技术测定沧州市3 218名健康体检人群血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(Tg Ab),分别以TPOAb>34 U/ml和Tg Ab>115 U/ml为阳性,对检测结果进行统计分析。结果:健康人群甲状腺自身抗体的总阳性率为16.19%,且随年份增加呈明显的增高趋势,不同性别之间的阳性检出率有显著性差异(P<0.001),其中TPOAb、Tg Ab、TPOAb和Tg Ab同时阳性的检出率分别为14.57%、12.74%和11.12%,1 686名女性的阳性检出率(21.53%、19.16%、16.67%)显著高于男性(6.92%、5.68%、5.03%),差异有统计学意义(P均<0.001),且随年龄增加阳性检出率逐渐升高,女性阳性率高峰在≥70岁年龄组,男性阳性率高峰在50~59岁年龄组。甲亢和亚甲亢、甲减和亚甲减甲状腺自身抗体的阳性检出率和OR均有显著性差异(P<0.001)。结论:沧州市健康体检人群甲状腺自身抗体的阳性率较高,对甲状腺功能正常而自身抗体阳性者进行动态监测、随访或早期干预,有利于甲状腺疾病的早期诊断、鉴别诊断及其防治。

关键词：健康人群甲状腺过氧化物酶抗体甲状腺球蛋白抗体电化学发光免疫分析法