检索结果-南通市图书馆

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第17期29卷 3537-3547页

作者： yu Yangyi song Zhuoyue Lian Qiang Ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of Orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin O and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

Parallel Incremental Frequent Itemset Mining for Large Data

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2017年第2期32卷 368-385页

作者： yu-Geng song Hui-Min Cui Xiao-Bing feng State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Frequent itemset mining （FIM） is a popular data mining issue adopted in many fields, such as commodity recommendation in the retail industry, log analysis in web searching, and query recommendation （or related search）. A large number of FIM algorithms have been proposed to obtain better performance, including parallelized algorithms for processing large data volumes. Besides, incremental FIM algorithms are also proposed to deal with incremental database updates. However, most of these incremental algorithms have low parallelism, causing low efficiency on huge databases. This paper presents two parallel incremental FIM algorithms called IncMiningPFP and IncBuildingPFP, implemented on the MapReduce framework. IncMiningPFP preserves the FP-tree mining results of the original pass, and utilizes them for incremental calculations. In particular, we propose a method to generate a partial FP-tree in the incremental pass, in order to avoid unnecessary mining work. Further, some of the incremental parallel tasks can be omitted when the inserted transactions include fewer items. IncbuildingPFP preserves the CanTrees built in the original pass, and then adds new transactions to them during the incremental passes. Our experimental results show that IncMiningPFP can achieve significant speedup over PFP （Parallel FPGrowth） and a sequential incremental algorithm （CanTree） in most cases of incremental input database, and in other cases IncBuildingPFP can achieve it.

关键词： incremental parallel FPGrowth data mining frequent itemset mining MapReduce

Application of Fractal Contact Model in Dynamic Performance Analysis of Gas Face Seals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2018年第2期31卷 137-147页

作者： song-Tao Hu Wei-feng Huang Xiang-feng Liu yu-Ming Wang State Key Laboratory of Tribology Tsinghua University State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University

Fractal theory provides scale?independent asperity contact loads and assumes variable curvature radii in the contact analyses of rough surfaces, the current research for which mainly focuses on the mechanism study. The present study introduces the fractal theory into the dynamic research of gas face seals under face?contacting conditions. Structure?Function method is adopted to handle the surface profiles of typical carbon?graphite rings, proving the fractal con?tact model can be used in the field of gas face seals. Using a numerical model established for the dynamic analyses of a spiral groove gas face seal with a flexibly mounted stator, a comparison of dynamic performance between the Majumdar?Bhushan(MB) fractal model and the Chang?Etsion?Bogy(CEB) statistical model is performed. The result shows that the two approaches induce differences in terms of the occurrence and the level of face contact. Although the approach distinctions in film thickness and leakage rate can be tiny, the distinctions in contact mechanism and end face damage are obvious. An investigation of fractal parameters D and G shows that a proper D(nearly 1.5) and a small G are helpful in raising the proportion of elastic deformation to weaken the adhesive wear in the sealing dynamic performance. The proposed research provides a fractal approach to design gas face seals.

关键词： Fractal theory Asperity contact Gas face seal Dynamic performance

Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah song Jian Muhammad Naeem Ul Hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

NEW PROOF OF DIMENSION FORMULA OF SPLINE SPACES OVER T-MESHES VIA SMOOTHING COFACTORS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2006年第4期24卷 501-514页

作者： Zhang-jin Huang Jian-song Deng yu-yu feng Fa-lai Chen Department of Mathematics University of Science and Technology of China Hefei 230026 China

A T-mesh is basically a rectangular grid that allows T-junctions. Recently, Deng etal introduced splines over T-meshes, which are generalizations of T-splines invented by Sederberg etal, and proposed a dimension formula based on the B-net method. In this paper, we derive an equivalent dimension formula in a different form with the smoothing cofactor method.

关键词： Spline space T-mesh Smoothing cofactors.

Machine learning classification of Gaia Data Release 2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2018年第10期18卷 1-4页

作者： yu Bai Ji-feng Liu song Wang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences College of Astronomy and Space Sciences University of Chinese Academy of Sciences

Machine learning has increasingly gained more popularity with its incredibly powerful ability to make predictions or calculate suggestions for large amounts of data. We apply machine learning clas-sification to 85 613 922 objects in the Gala Data Release 2, based on a combination of Pan-STARRS I and AI1WISE data. The classification results are cross-matched with the Simbad database, and the to-tal accuracy is 91.9%. Our sample is dominated by stars, ~98%, and galaxies make up 2%. For the objects with negative parallaxes, about 2.5% are galaxies and QSOs, while about 99.9% are stars if the relative parallax uncertainties are smaller than 0.2. Our result implies that using the threshold of 0 〈 σπ/π 〈 0.2 could yield a very clean stellar sample.

关键词： methods data analysis - stars general - Gaia catalog

Metal-Free 12-Catalyzed Highly Selective Dehydrogenative Coupling of Alcohols and Cyclohexenones

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2018年第3期36卷 233-240页

作者： yu-feng Liang Yizhi yuan Tao Shen song song Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Rd. 38 Beijing 100191 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Weijin Road 94 Tianjin 300071 China

The l2 catalyzed highly selective oxidatve condensation of cydohexenones and alcohols for the synthesis of aryl atkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.

关键词： metal-free dehydrogenative coupling oxidation selectivity alcohols

Laparoscopic anatomical liver resection of segment 7 using a sandwich approach to the right hepatic vein (with video)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 217-220页

作者： song-feng yu Wei-Chen Zhang Jun yu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Full laparoscopic liver resection has been performed widely since it was introduced in the early *** has been expanded from initial for partial resection of the anterolateral segments to non-restriction of area of the liver[1–3].Anatomical liver resec-tion is considered to have potential superiority than non-anatomic resection in terms of tumor prognosis,thus it is more often rec-ommended in the treatment of hepatocellular carcinoma[4,5].Recently,laparoscopic segmental liver resection according to the Couinaud classification has been widely performed due to its ad-vantages in minimal invasiveness and tumor prognosis.

关键词： resection liver hepatic

Exit options sustain altruistic punishment and decrease the second-order free-riders, but it is not a panacea

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年第1期68卷 278-291页

作者： Chen SHEN Zhao song Lei SHI Jun TANIMOTO Zhen WANG Faculty of Engineering Sciences Kyushu University School of Statistics and Mathematics Yunnan University of Finance and Economics School of Computing Engineering and Digital Technologies Teesside University School of Artificial Intelligence OPtics and Electro Nics (iOPEN) Northwestern Polytechnical University

Why do humans punish free riders at their own expense? This behavior represents an evolutionary puzzle in human societies. This study explores the role of exit strategies in fostering altruistic punishment within evolutionary game theory. We extend the traditional prisoner's dilemma model by incorporating exiters, players who opt out for a small payoff while nullifying their opponent's payoff, and altruistic punishers who cooperate and punish non-cooperators. Our findings indicate that in well-mixed populations, exiters destabilize defection but do not promote altruistic punishment. In social networks, however,exiters enable altruistic punishment via cyclic dominance among altruistic punishers, defectors, and exiters. Notably, this cyclic dominance is sensitive to exit payoffs; adjustments can lead to cyclic dominance of non-punishing cooperators, defectors, and exiters, or to a bi-stable state between these two types of cyclic dominance. These results highlight the nuanced impact of exiters on altruistic punishment, emphasizing the need for careful incentivization of exit behavior. While exiters can support altruistic punishment in networked populations, their effectiveness is not a panacea and is highly sensitive to exit payoffs, indicating limits to the voluntary participation mechanism.

关键词： evolutionary game theory altruistic punishment coexistence cyclic dominance bi-stable