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Comparison of visual acuity of the patients on the first day after sub-Bowman keratomileusis or laser in situ keratomileusis

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 448-452页

作者： Wei Zhao Ting Wu Ze-Hong Dong Jie feng yu-feng ren yu-Sheng Wang Department of Ophthalmology Xijing Hospitalthe Fourth Military Medical University Out-patient Department the Second Artillery Engineering University

AIM：To compare recovery of the visual acuity in patients one day after sub-Bowman keratomileusis（SBK）or laser in situ keratomileusis（LASIK）.· METHODS：Data from 5923 eyes in 2968 patients that received LASIK（2755 eyes） or SBK（3168 eyes） were retrospectively *** eyes were divided into 4groups according to preoperative spherical equivalent：between-12.00 to-9.00 D,extremely high myopia（n =396,including 192 and 204 in SBK and LASIK groups,respectively）;-9.00 to-6.00 D,high myopia（n=1822,including 991 and 831 in SBK and LASIK groups,respectively）,-6.00 to-3.00 D,moderate myopia（n=3071,including 1658 and 1413 in SBK and LASIK groups,respectively）,and-3.00 to 0.00 D,low myopia（n =634,including 327 and 307 in SBK and LASIK groups,respectively）.Uncorrected logMAR visual acuity values of patients were assessed under standard natural *** of variance was used for comparisons among different groups.· RESULTS：Uncorrected visual acuity values were0.0115±0.1051 and 0.0466±0.1477 at day 1 after operation for patients receiving SBK and LASIK,respectively（P〈0.01）;visual acuity values of 0.1854±0.1842,0.0615±0.1326,-0.0033±0.0978,and-0.0164±0.0972 were obtained for patients in the extremely high,high,moderate,and low myopia groups,respectively（P〈0.01）.In addition,significant differences in visual acuity at day 1 after operation were found between patients receiving SBK and LASIK in each myopia subgroup.· CONCLUSION：Compared with LASIK,SBK is safer and more effective,with faster ***,SBK is more likely to be accepted by patients than LASIK for better uncorrected visual acuity the day following operation.

关键词： sub-Bowman keratomileusis laser in situ keratomileusis visual acuity myopia recovery

Clinical Effect Observation of Constructing PERMA Model in Psychological Intervention for Patients with Chronic Cancer Pain

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Psycho-Oncologie 2024年第4期18卷 329-336页

作者： yu-feng ren Dong-Li Ji yu Wu Ru-Qin Ben Hai-Xia Wei Integrated Traditional Chinese and Western Medicine Department Nantong Tumor HospitalNantong226361China

Background:The constructing PERMA model in psychological intervention was applied to patients with chronic cancer pain to provide data reference for reducing pain,fear of cancer recurrence,and improving the level of psychological ***:To explore the clinical effects of constructing PERMA model in psychological intervention for patients with chronic cancer ***:A total of 98 patients with chronic cancer pain admitted to our hospital from March 2021 to March 2023 were randomly divided into two groups,49 cases in each *** control group received routine intervention,while the research group constructed PERMA model based on the routine intervention for psychological *** pain severity,fear of cancer recurrence,psychological capital and quality of life before and after intervention were compared between the two ***:After two months of intervention,the pain in the research group was milder than that in the control group(prence in the research group were lower than those in the control group(prence,increase the level of psychological capital,and thus improve quality of life.

关键词： Chronic cancer pain psychological intervention PERMA model degree of pain fear of cancer recurrence psychological capital quality of life

Dose-volume parameters and clinical outcome of CT-guided free-hand high-dose-rate interstitial brachytherapy for cervical cancer

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Chinese Journal of Cancer 2012年第12期31卷 598-604页

作者： Yi Wang Wei-Jun Ye Le-Hui Du Ai-Ju Li yu-feng ren Xin-Ping Cao State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat-sen University Cancer Center

Currently, image-based 3-dimentional (3D) planning brachytherapy allows for a better assessment of gross tumor volume (GTV) and the definition and delineation of target volume in cervix cancer. In this study, we investigated the feasibility of our novel computed tomography (CT)-guided free-hand high-dose- rate interstitial brachytherapy (HDRISBT) technique for cervical cancer by evaluating the dosimetry and preliminary clinical outcome of this approach. Dose-volume histogram (DVH) parameters were analyzed according to the Gynecological GEC-ESTRO Working Group recommendations for image-based 3D treatment in cervical cancer. Twenty cervical cancer patients who underwent CT-guided free-hand HDRISBT between March 2009 and June 2010 were studied. With a median of 5 (range, 4-7) implanted needles for each patient, the median dose of brachytherapy alone delivered to 90% of the target volume (D90 ) was 45 (range, 33-54) Gyα/β10 for high-risk clinical target volume (HR-CTV) and 30 (range, 20-36) Gyα/β10 for intermediate-risk clinical target volume (IR-CTV). The percentage of the CTV covered by the prescribed dose (V100 ) of HR-CTV with brachytherapy alone was 81.9%-99.2% (median, 96.7%). With an additional dose of external beam radiotherapy (EBRT), the median D90 was 94 (range, 83-104) Gyα/β10 for HR-CTV and 77 (range, 70 -87) Gyα/β10 for IR-CTV; the median dose delivered to 100% of the target volume (D100 ) was 75 (range, 66-84) Gyα/β10 for HR-CTV and 65 (range, 57-73) Gyα/β10 for IR-CTV. The minimum dose to the most irradiated 2 cc volume (D2cc ) was 73-96 (median, 83) Gyα/β3 for the bladder, 64-98 (median, 73) Gyα/β3 for the rectum, and 52-69 (median, 61) Gyα/β3 for the sigmoid colon. After a median follow-up of 15 months (range, 3 -24 months), two patients experienced local failure, and 1 showed internal iliac nodal metastasis. Despite the relatively small number of needles used, CT-guided HDRISBT for cervical cancer showed favorable DVH parameters and clinical outcome.

关键词：子宫颈癌放射治疗体积参数剂量率 CTV 近距离临床引导

Spontaneous healing after conservative treatment of isolated grade IV pancreatic duct disruption caused by trauma:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6319-6324页

作者： Ming-Zhen Mei yu-feng ren Yi-Ping Mou yuan-yu Wang Wei-Wei Jin Chao Lu Qi-Cong Zhu Departments of General Surgery Tiantai Campus of Zhejiang Provincial People’s HospitalTaizhou 317200Zhejiang ProvinceChina Department of General Surgery Cancer CenterDivision of Gastrointestinal and Pancreatic SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Key Laboratory of Gastroenterology of Zhejiang Province Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND Trauma is a common cause of pancreatic duct *** treatment is recommended in current clinical guidelines for adult pancreatic injury because non-surgical treatments have higher risks of serious complications or even death compared with surgical *** SUMMARY A 22-year-old woman was admitted to Tiantai People’s Hospital of Zhejiang Province after 1-h duration of abdominal pain and distension following *** diagnosis was“traumatic pancreatic rupture”.The patient’s symptoms were not severe,her vital signs were stable,and signs of peritonitis were not ***,conservative treatment could be considered,with the possibility of emergency surgery if *** 2 mo of conservative treatment with duct drainage,the pancreatic duct healed spontaneously with no significant *** We report a case of pancreatic duct disruption in the head and neck caused by trauma that was treated conservatively and healed spontaneously,providing a new choice for clinical *** isolated pancreatic injury with rupture of the pancreatic duct in the head and neck,conservative treatment under close observation is feasible.

关键词： Trauma Pancreatic ducts Conservative treatment Drainage Case report

Cloning and Characterization of Adinbitor,a Novel Disintegrin from the Snake Venom of Agkistrodon halys brevicaudus stejneger

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Acta Biochimica et Biophysica Sinica 2004年第6期36卷 425-429页

作者： Ji-Hong WANG, yu WU, feng ren, Li Lü, and Bao-Chang ZHAO*Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116027, China Department of Biochemistry and Molecular Biology Dalian Medical UniversityDalian 116027 China

Adinbitor was cloned from Agkistrodon halys brevicaudus stejneger and characterized as a novel disintegrin. In this study, total RNA was extracted from venom gland and used in RT-PCR to generate a cDNA which is 219 bp long. The sequence encoded a polypeptide composed of 73 amino acids, including 12 cysteines, an RGD motif, and the signature motif of disintergrin. Recombinant Adinbitor (rAdinbitor) was expressed in E. coli and purified by using the His?Bind affinity chromatography. The IC50 for inhibiting human platelet aggregation and bFGF-induced proliferation of ECV304 cells was 6 μΜ and 0.89 μΜ respectively. Furthermore, Adinbitor significantly inhibited angiogenesis both in vivo and in vitro. Taken together, these results suggested that Adinbitor had typical functions of disintegrins.

关键词： cloning Adinbitor disintegrin platelet aggregation angiogenesis

Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae

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Chinese Journal of Cancer 2017年第1期36卷 26-33页

作者： Li Ma Guang-yu Luo yu-feng ren Bo Qiu Hong Yang Chun-Xia Xie Song-Ran Liu Shi-Liang Liu Zhao-Lin Chen Qun Li Jian-Hua Fu Meng-Zhong Liu Yong-Hong Hu Wen-feng Ye Hui Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Research Institute Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Endoscopy Sun Yat-sen University Cancer Center Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-sen University Department of Thoracic Surgery Sun Yat-sen University Cancer Center Department of Clinical Nutrition Sun Yat-sen University Cancer Center

Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term ***: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of ***: With a median follow?up of 18 months(range, 3–39 months), patients' 1?year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P < 0.001) were sig= 0.003), increase i= 0.024), fistula closure(P = 0.011), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 11 patients(27.5%), and grade 3 cough was observed in 13 patients(32.5%); 2 patients(5.0%) died of massive bleeding during ***: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be

关键词： Esophageal squamous cell carcinoma Malignant istula Radiotherapy Concurrent chemotherapy Enteral nutrition support

基于混合遗传算法的多约束组播路由问题的求解

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中山大学学报（自然科学版） 2005年第2期44卷 45-48页

作者：谢黎明余丰人丘海明广东轻工职业技术学院广东广州510300 中山大学电子与通信工程系广东广州510275

研究了延时、延时抖动约束的最小费用组播路由问题,并且提出了一种混合遗传算法。遗传算法是一种模拟生物进化过程的并行最优算法,适合在大型、复杂的空间中寻找最优解。遗传算法并不需要求解问题具有连续性,因而适宜于约束组播路由问... 详细信息

研究了延时、延时抖动约束的最小费用组播路由问题,并且提出了一种混合遗传算法。遗传算法是一种模拟生物进化过程的并行最优算法,适合在大型、复杂的空间中寻找最优解。遗传算法并不需要求解问题具有连续性,因而适宜于约束组播路由问题的求解。此外,遗传算法的并行分布式处理实现简单,因而用遗传算法解决约束组播路由问题十分有效。并通过计算分析,表明本算法能够快速有效的构造出所要求的满足延时、延时抖动约束的最优组播树。

关键词：组播路由多约束延时抖动并行混合遗传算法分布式处理组播树求解最优解最优算法

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关于合取范式可满足性问题的复杂性分析

中山大学学报（自然科学版） 2006年第2期45卷 121-122页

作者：余丰人丘海明中山大学电子与通信工程系广东广州510275

合取范式可满足性问题(简称SAT问题)是典型的NP完全问题,本文引入了一个饱和子句集的新概念,利用饱和子句集的特性,研究了SAT问题的复杂性,证明了SAT问题复杂性为多项式的一个充分条件,并揭示了二元可满足性问题与三元可满足性问题的本... 详细信息

合取范式可满足性问题(简称SAT问题)是典型的NP完全问题,本文引入了一个饱和子句集的新概念,利用饱和子句集的特性,研究了SAT问题的复杂性,证明了SAT问题复杂性为多项式的一个充分条件,并揭示了二元可满足性问题与三元可满足性问题的本质差别。因此,通过变换来提炼出SAT问题的复杂性的本质特征,并加以研究的方法,是SAT问题的复杂性研究的一种有效方法。

关键词：合取范式 SAT问题复杂性分析

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近代西方社会契约论之演变及逻辑反思

许昌学院学报 2013年第6期32卷 113-115页

作者：余仁峰河南大学哲学与公共管理学院河南开封475004

社会契约论的核心概念是权利的合法性:一切权利——个人权利和最高权力都具有合法性。社会契约论代表了启蒙时期西方政治思想的最高成就,但霍布斯、洛克和卢梭的理论观点有着明显差异,由此反映出这一理论的演进轨迹。其理论逻辑和人类... 详细信息

社会契约论的核心概念是权利的合法性:一切权利——个人权利和最高权力都具有合法性。社会契约论代表了启蒙时期西方政治思想的最高成就,但霍布斯、洛克和卢梭的理论观点有着明显差异,由此反映出这一理论的演进轨迹。其理论逻辑和人类社会的历史发展密切相关,依次沿着"生命-自由-平等"这种思路进行。但社会契约论只是对国家起源、性质和基本原理的一种理论论证,并非是对国家产生过程的真实描述。以其检验人类社会的价值得失,往往会陷入一定困境而凸显出难以克服的缺陷。

关键词：社会契约论自然状态权利转让契约