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ON IMPROVING AN INTEGRATED INVENTORY MODEL FOR A SINGLE VENDOR AND MULTIPLE BUYERS WITH A RELAXED MATERIAL ORDERING CYCLE POLICY

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Journal of Systems Science and Systems Engineering 2006年第3期15卷 298-313页

作者： yugang yu feng CHU Haoxun chen FRE CNRS 2732 ISTIT-OSI University of Technology of Troyes 10010 Troyes France

In this paper, we propose a new model for improving the lot size obtained with the model of Woo, Hsu, and Wu （2001） proposed in their paper ＂An integrated inventory model for a single vendor and multiple buyers with ordering cost reduction＂（Int. J. Production Economics 73 203-215）. The new model can provide a lower or equal joint total cost as compared to Woo, Hsu, and Wu＇s model due to the relaxation of their integral multiple material ordering cycle policy to a fractional-integral multiple material ordering cycle policy. The proposed model is analyzed and an algorithm for calculating the optimal lot size of the model is developed. A numerical study based on the example used by Woo, Hsu, and Wu is presented.

关键词： Inventory integrated model raw materials single vendor multiple buyers

Mechanism of selective laser trabeculoplasty:a systemic review

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 963-968页

作者： yu-feng chen Wen Zeng Department of Ophthalmology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Although selective laser trabeculoplasty(SLT)is a recognized method for the treatment of glaucoma,the exact changes in the target tissue and mechanism for its intraocular pressure lowing effect are still *** purpose of this review is to summarize the potential mechanisms of SLT on trabecular meshwork both in vivo and in vitro,so as to reveal the potential mechanism of *** may induce immune or inflammatory response in trabecular meshwork(TM)induced by possible oxidative damage etc,and remodel extracellular *** may also induce monocytes to aggregate in TM tissue,increase Schlemm’s canal(SC)cell conductivity,disintegrate cell junction and promote permeability through autocrine and paracrine *** provides a theoretical basis for SLT treatment in glaucoma.

关键词： mechanisms selective laser trabeculoplasty glaucoma trabecular meshwork

NEW PROOF OF DIMENSION FORMULA OF SPLINE SPACES OVER T-MESHES VIA SMOOTHING COFACTORS

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Journal of Computational Mathematics 2006年第4期24卷 501-514页

作者： Zhang-jin Huang Jian-song Deng yu-yu feng Fa-lai chen Department of Mathematics University of Science and Technology of China Hefei 230026 China

A T-mesh is basically a rectangular grid that allows T-junctions. Recently, Deng etal introduced splines over T-meshes, which are generalizations of T-splines invented by Sederberg etal, and proposed a dimension formula based on the B-net method. In this paper, we derive an equivalent dimension formula in a different form with the smoothing cofactor method.

关键词： Spline space T-mesh Smoothing cofactors.

Enhanced oxidation resistance of low-carbon MgO-C refractories with ternary carbides:a review

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Journal of Iron and Steel Research International 2022年第7期29卷 1052-1062页

作者： Chao yu Bo Dong yu-feng chen Bei-yue Ma Jun Ding cheng-ji Deng Hong-xi Zhu Jing-hui Di The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The demand for low-carbon MgO–C refractories is ever growing to meet the development of advanced steelmaking technologies and efficient energy ***,to improve the oxidation resistance and inhibit the weakness of low-carbon MgO–C refractories,antioxidants are *** application of ternary carbides that focused on improving the oxidation performance of MgO–C refractories has been explored,and the ternary carbides including Al_(4)O_(4)C,Al8B_(4)C_(7),Al_(4)SiC_(4),Ti_(2)AlC,Ti_(3)AlC_(2),and Ti_(3)SiC_(2)have been proved *** crystal structure,physical properties,oxidation behavior,and synthesis of these ternary carbides were summarized,and their oxidation mechanism in assisting antioxidation of MgO–C refractories was *** addition,the potential aspects related to the usage and development of ternary carbides in low-carbon MgO–C refractories were proposed.

关键词： Low-carbon MgO–C refractory Ternary carbide MAX phase Oxidation mechanism Oxidation resistance

Novel transmitter of dark RZ signal based on external modulator

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Optoelectronics Letters 2007年第2期3卷 109-111页

作者： SHAO yu-feng chen Lin WEN Shuang-chun School of Computer and Communication Hunan University Changsha 410082 China

A novel transmitter to generate a dark RZ signal with tunable duty cycle and extinction ratio is proposed, by modifying the process of preceding, modulating and coding, A dark RZ signal is generated simply by using one dual-arm Mach-Zehnder LiNbO3 modulator. We demonstrate experimentally that this optical dark RZ signal can be directly measured by a conventional binary intensity modulation direct detection （IM-DD） receiver. When different values of duty cycles at 2.5 Gbit/s are adjusted, the experimental results show different BER curves and eye diagrams of the optical dark RZ signal.

关键词：外调制器光暗RZ信号发射机直接检测式光接收机

Noninvasive Detection and Imaging of Matrix Metalloproteinases for Cancer Diagnosis

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Journal of Analysis and Testing 2017年第3期1卷 203-212页

作者： Jin Hong yu-feng chen Jia-Jia Shen Ya Ding Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical UniversityMinistry of EducationNanjing 21009China Key Laboratory of Biomedical Functional Materials School of SciencesChina Pharmaceutical UniversityMinistry of EducationNanjing 211198China

Matrix metalloproteinases(MMPs)are important cancer biomarkers and the sensitive detection of MMPs is of great importance to improve clinical diagnosis and therapy of cancer at its early *** imaging,including fluorescent optical imaging,radiolabeled imaging,and magnetic resonance imaging,is a powerful tool to visualize and characterize biological processes at the cellular and molecular *** recognition of MMPs via imaging strategies by utilizing MMP-responsive probes has been a hot pursuit in recent *** designed for MMP detection commonly have two features:(1)off-thenon state in detection signal response to the appearance of MMPs,which has been applied in optical imaging and magnetic resonance imaging;(2)specific retention upon sensing MMPs,which has been applied in radiolabeled *** development of theory and technology in the field of biomarker probes will be beneficial to the accurate diagnosis and effective treatment of cancer.

关键词： MMPs Noninvasive detection Optical imaging Radiolabeled imaging Magnetic resonance imaging

Structural characterization of a novel marine polysaccharide from mussel and its antioxidant activity in RAW264.7 cells induced by H_(2)O_(2)

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Food Bioscience 2022年第3期47卷 716-727页

作者： Xing-Wei Xiang Rui Wang Hui chen yu-feng chen Guo-Xin Shen Shu-Lai Liu Pei-Long Sun Lin chen College of Food Science and Technology Zhejiang University of TechnologyHangzhou Zhejiang310014China Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province Hangzhou310014China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian116034China Zhejiang Academy of Agricultural Sciences Hangzhou Zhejiang310014People’s Republic of China

In this study,a new type of water-soluble polysaccharide was extracted and purified from mussels,and its structure and cellular antioxidant levels were *** polysaccharide(MP 4.25×10^(3) Da)is composed mainly of glucose,with a small amount of galactosamine hydrochloride,glucosamine hydrochloride,and *** shows characteristic polysaccharide bands in Fourier transform NMR and infrared *** main chain connection mode of MP is the glycosidic bond of→4)-α-D-Glcp-(1→,and the end groupα-D-Glcp-(1→andα-D-Glcp-(1→6)-α-D-Glcp-(1→pass→4,6)-α-D-Glcp-(1→.The O-6 bond is connected to the main ***,MP could protect RAW264.7 cells against H_(2)O_(2)-induced oxidative stress by increasing catalase(CAT),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD)activities and reducing the content of malondialdehyde(MDA).This is expected to make MP an important member of the antioxidant family.

关键词： Mussel polysaccharide Structural characterization Antioxidant activity

Acupoint Selection Standards of Auricular Therapy in the Treatment of Maintenance Hemodialysis Insomnia Based on Data Mining

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 53-64页

作者： Jun-Xin Wang Bing-Qian Zou yu-feng chen cheng-Long Wang Wei-Hong Li Xue-Ling Ma Xiang-Di Liu Department of TCM Nursing School of NursingBeijing University of Chinese MedicineBeijingChina Department of Healthcare Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesP.R.China Pharmacology of Integrated Chinese and Western Medicine School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Beijing Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineMinistry of EducationBeijingChina

Background:Insomnia is a high-incidence complication in patients undergoing maintenance hemodialysis(MHD).Auricular therapy can effectively improve sleep with few adverse *** selection affects the impact of auricular ***,there is currently a lack of analysis on the standards of acupoint *** study used data mining technology to investigate the acupoint selection principles and characteristics of auricular therapy for the treatment of MHD-related ***:The objective of the study is to explore the standards of acupoint selection in auricular therapy for the treatment of MHD-related insomnia through data mining *** and Methods:We searched three English(PubMed,WOS,and Embase)and four Chinese(CNKI,VIP,Wangfang,and CBM)databases for studies on auricular therapy for MHD-related insomnia from self-establishment to November 14,***:Eighty-one publications were involved,which included 33 *** most common auricular points in patients with MHD-related insomnia were the Shenmen,heart,and kidney *** applications involved the visceral,nervous system,and specific *** effective clusters and two clusters were obtained through cluster analysis,including specific auricular points for insomnia,such as the multi-dream area,neurasthenia area,deep sleep point,and anterior ear *** network analysis showed that the core auricular acupoint combinations for the intervention of MHD-related insomnia were Shenmen with kidney,Shenmen with heart,heart with kidney,heart with Shenmen,and heart and Shenmen with ***:The selection of auricular points for the treatment of MHD-related insomnia was guided by the heart theory of traditional Chinese *** treatment attaches importance to the use of the multi-dream area,neurasthenia area,and other acupoints.

关键词： Acupoint selection standards auricular therapy data mining insomnia maintenance hemodialysis

Erlotinib as a salvage treatment for patients with advanced non-small cell lung cancer after failure of gefitinib treatment

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Chinese Medical Journal 2011年第15期124卷 2279-2283页

作者： SONG Zheng-bo yu Yong-feng chen Zhi-wei LU Shun Shanghai Lung Tumor Clinical Medical Center Chest Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Background Several clinical trials showed that erlotinib was effective after the failure of gefitinib in advanced non-small cell lung cancer （NSCLC）. The aim of this study was to evaluate the feasibility of erlotinib treatment after the failure of gefitinib based on the data from our hospital. Methods The clinical data of 20 patients with advanced NSCLC who were admitted to Shanghai Chest Hospital from August 2007 to December 2008 were retrospectively analyzed. All of the patients were given erlotinib treatment after the failure of gefitinib. Survival analysis was made by Kaplan-Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the erlotinib progression-free survival （PFS）. Results Five patients had a partial response （PR）, nine patients had stable disease （SD） and six patients had progressive disease （PD） with gefitinib treatment. The median PFS was 277 days （95% CI 0-566）. No patient had a PR, seven had SD and fourteen PD with the erlotinib therapy. The median PFS was 31 days （95% CI 9.1-52.9）. The response rate （RR） was 0, and the disease control rate （DCR） was 35% （7/20）. Cox regression analysis demonstrated that sex （P=0.96）, age （P=0.89）, smoking history （P=0.78）, performance status （PS）（P=0.98）, gefitinib efficacy （P=-0.90） and whether chemotherapy was applied between using the two drugs （P=-0.45） had no significant correlation with erlotinib PFS. Fifteen patients had epidermal growth factor receptor （EGFR） mutation status determined. There were five cases got SD with the erlotinib treatment in ten mutation negative （wild-type） patients. No SD was recorded in the five mutation positive patients. Conclusions The efficacy of erlotinib treatment after gefitinib failure was limited. However, the patients who are EGFR mutation negative can probably benefit from erlotinib treatment after gefitinib failure.

关键词： non-small cell lung cancer erlotinib gefitinib efficacy epidermal growth factor receptor mutation