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Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： yu-fan yang Hai-Lu Ma Xi Wang Min Nie Jiang-Feng Mao Xue-Yan Wu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

Fibroblast growth factor receptor 1(FGFR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at Peking Union Medical College Hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with FGFR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366L *** majority of FGFR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(LH)levels were 0.5 IU l−1,follicle-stimulating hormone(FSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had LH levels of 0.2 IU l−1,FSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited FGFR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of FGFR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo FGFR1 inherited

Preoperative prediction of hepatocellular carcinoma microvascular invasion based on magnetic resonance imaging feature extraction artificial neural network

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2546-2554页

作者： Jing-Yi Xu yu-fan yang Zhong-yue Huang Xin-Ye Qian fan-Hua Meng Center of Hepatobiliary Pancreatic Disease Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Surgical Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Anesthesiology Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Hepatocellular carcinoma(HCC)recurrence is highly correlated with increased *** invasion(MVI)is indicative of aggressive tumor biology in *** To construct an artificial neural network(ANN)capable of accurately predicting MVI presence in HCC using magnetic resonance *** This study included 255 patients with HCC with tumors<3 *** annotated the tumors on the T1-weighted plain MR ***,a three-layer ANN was constructed using image features as inputs to predict MVI status in patients with *** pathological examination is considered the gold standard for determining *** operating characteristic analysis was used to evaluate the effectiveness of the *** Using the bagging strategy to vote for 50 classifier classification results,a prediction model yielded an area under the curve(AUC)of ***,correlation analysis revealed that alpha-fetoprotein values and tumor volume were not significantly correlated with the occurrence of MVI,whereas tumor sphericity was significantly correlated with MVI(P<0.01).CONCLUSION Analysis of variable correlations regarding MVI in tumors with diameters<3 cm should prioritize tumor *** ANN model demonstrated strong predictive MVI for patients with HCC(AUC=0.79).

关键词： Hepatocellular carcinoma Microvascular invasion Artificial neural network Magnetic resonance imaging Tumor sphericity Area under the curve

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适应于硬件部署的神经网络剪枝量化算法

计算机工程与科学 2024年第9期46卷 1547-1553页

作者：王鹏张嘉诚范毓洋中国民航大学民航航空器适航审定技术重点实验室天津300399 中国民航大学安全科学与工程学院天津300399

深度神经网络由于性能优异已经在图像识别、目标检测等领域广泛应用,然而其包含大量参数和巨大计算量,导致在需要低延时和低功耗的移动边缘端部署时困难。针对该问题,提出一种用移位加法代替乘法运算的压缩算法,通过对神经网络进行剪枝... 详细信息

深度神经网络由于性能优异已经在图像识别、目标检测等领域广泛应用,然而其包含大量参数和巨大计算量,导致在需要低延时和低功耗的移动边缘端部署时困难。针对该问题,提出一种用移位加法代替乘法运算的压缩算法,通过对神经网络进行剪枝和量化将参数压缩至低比特。该算法在乘法资源有限的情况下降低了硬件部署难度,可满足移动边缘端低延时和低功耗的要求,提高运行效率。对ImageNet数据集经典神经网络进行了实验,结果表明神经网络的参数在压缩到4 bit的情况下,其准确率与全精度神经网络的基本一致,甚至在ResNet18、ResNet50和GoogleNet网络上的Top-1/Top-5准确率还分别提升了0.38%/0.22%,0.35%/0.21%和1.14%/0.57%。对VGG16第8层卷积层进行实验,将其部署在Zynq7035上,结果表明,压缩后的网络在使用的DSP资源减少43%的情况下缩短了51.1%的推理时间,并且减少了46.7%的功耗。

关键词：深度神经网络硬件剪枝量化 FPGA

维普期刊数据库博看期刊

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基于多特征融合的藏文命名实体识别方法研究

计算机仿真 2024年第6期41卷 396-400,502页

作者：索朗次仁杨宇帆高定国西藏大学信息科学技术学院西藏拉萨850000

藏文命名实体识别是藏文信息处理必须解决的关键问题之一,针对以往命名实体识别中特征提取较为单一的问题,提出基于多特征融合的IDCNN-BiGRU-CRF模型,将藏文分词与藏文实体联合训练,并融合双向门限循环单元网络(BiGRU)和迭代膨胀卷积网... 详细信息

藏文命名实体识别是藏文信息处理必须解决的关键问题之一,针对以往命名实体识别中特征提取较为单一的问题,提出基于多特征融合的IDCNN-BiGRU-CRF模型,将藏文分词与藏文实体联合训练,并融合双向门限循环单元网络(BiGRU)和迭代膨胀卷积网络(IDCNN),分别提取上下文特征和局部特征,融合两种特征信息以提升实体识别效果。实验证明,对比目前主流的藏文命名实体识别方法BiLSTM-CRF、BiGRU-CRF、IDCNN-BiLSTM-CRF,该模型的F1分别提升了0.51%、0.47%、0.14%,验证了上述模型在藏文命名实体识别任务中的有效性。

关键词：多特征融合藏文命名实体识别

Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： yu-Zhao yang Cheng Xu Li-Xia fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

Microstructure evolution,mechanical properties and fracture behavior of Al-xSi/AZ91D bimetallic composites prepared by a compound casting

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Journal of Magnesium and Alloys 2024年第5期12卷 1944-1964页

作者： Guangyu Li Wenming Jiang Feng Guan Junwen Zhu yang yu Zitian fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this paper,the effect of the Si content on microstructure evolution,mechanical properties,and fracture behavior of the Al-xSi/AZ91D bimetallic composites prepared by compound casting was investigated *** obtained results showed that all the Al-xSi/AZ91D bimetallic composites had a metallurgical reaction layer(MRL),whose thickness increased with increasing Si content for the hypoeutectic Al-Si/AZ91D composites,while the hypereutectic Al-Si/AZ91D composites were *** MRL included eutectic layer(E layer),intermetallic compound layer(IMC layer)and transition region layer(T layer).In the IMC layer,the hypereutectic Al-Si/AZ91D composites contained some Si solid solution and flocculent Mg_(2)Si+Al-Mg IMCs phases not presented in the hypoeutectic Al-Si/AZ91D ***,increasing Si content,the thickness proportion of the T layer increased,forming an inconsistent preferred orientation of the *** shear strengths of the Al-xSi/AZ91D bimetallic composites enhanced with increasing Si content,and the Al-15Si/AZ91D composite obtained a maximum shear strength of 58.6 MPa,which was 73.4% higher than the Al-6Si/AZ91D *** fractures of the Al-xSi/AZ91D bimetallic composites transformed from the T layer into the E layer with the increase of the Si *** improvement of the shear strength of the Al-xSi/AZ91D bimetallic composites was attributed to the synergistic action of the Mg_(2)Si particle reinforcement,the reduction of oxidizing inclusions and the ratio of Al-Mg IMCs as well as the orientation change of the MRL.

关键词： Al/Mg bimetallic composites Si content Mg_(2)Si reinforcement Microstructure Mechanical properties Fracture behavior

Biomimetic porous silicon oxycarbide ceramics with improved specific strength and efficient thermal insulation

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Journal of Materials Science & Technology 2024年第1期168卷 185-193页

作者： Zhuoqing Zhang Jinghan Li Lei Cao yu Shi Huajie yang Rui yang fan Xie Xing Zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Shenyang Aircraft Design and Research Institute Shenyang 110035China

Considering the challenge of aerodynamic heating,the development of high-performance insulating ce-ramic materials with lightweight and low thermal conductivity is crucially important for aerospace vehi-cles to achieve flight at high speed for a long *** this work,macro-porous silicon oxycarbide(SiOC)ceramics with directional pores(DP-SiOC)(mean pore size of 88.1μm)were prepared using polysiloxane precursors via freeze casting and photocrosslinking,followed by *** DP-SiOC samples were lightweight(density∼0.135 g cm^(-3))with a porosity of 90.4%,which showed good shapability through the molding of polysiloxane *** DP-SiOC samples also exhibited an ultra-low thermal con-ductivity of 0.048 W(m K)^(-1)at room temperature,which can also withstand heat treatment at 1200°C for 1 *** addition,scaffolds with triply periodic minimal surfaces(TPMS)were fabricated using digital light processing(DLP)printing,which was further filled with polysiloxane precursors for increasing the strength of *** TPMS scaffolds filled with macro-porous SiOC ceramics(TPMS-DP-SiOC)showed good integration between TPMS and macro-pore structures,which had a porosity∼75%and high specific strength of 9.73×10^(3)N m kg^(-1).The thermal conductivity of TPMS-DP-SiOC samples was 0.255 W(m K)^(-1)at room *** biomimetic TPMS-DP-SiOC ceramics developed in this study are likely used for thermal protection systems.

关键词： Thermal insulation Light weight Macro-porous ceramics SiOC

Improving photochemical indicators for attributing ozone sensitivities in source apportionment analysis

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Journal of Environmental Sciences 2024年第9期143卷 235-246页

作者： Xiaohui Du Wei Tang Zhongzhi Zhang yang yu yang Li Ling Huang Greg Yarwood fan Meng Atmospheric Environment Institute Chinese Research Academy of Environmental SciencesBeijing 100012China College of Water Sciences Beijing Normal UniversityBeijing 100857China Asia Center for Air Pollution Research United Nations Environment Programme Asia and the Pacific OfficeNishi-kuNiigata-shi 9502144Japan School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Ramboll NovatoCalifornia 94945USA

Comprehensive Air Quality Model with extensions(CAMx)-Decoupled Direct Method(DDM)simulations of first-order ozone(O_(3))sensitivity to nitrogen oxides(NO_(x))and volatile organic compounds(VOCs)emissions were performed and combined with modelled P_(H_(2)O_(2))/P_(HNO_(3))ratios to obtain a range of thresholds for determining O_(3)-sensitivity regimes for different areas of *** the new threshold ranges for photochemical indicators,the method for determining O_(3)formation in the Ozone Source Apportionment Technology(OSAT)module within CAMx was improved by a dynamically varied threshold of P_(H_(2)O_(2))/P_(HNO_(3))*** O_(3)concentration contributions in the newly added transition regime were apportioned to NO_(x)and VOCs emissions in proportion to the relationship between the P_(H_(2)O_(2))/P_(HNO_(3))ratio and first-order O_(3)*** source contributions of O_(3)concentrations from different emission sectors from June to September 2019 were compared using the original and improved *** results showed that the O_(3)concentration contributions changed significantly in the NO_(x)-limited regime,with a maximum decrease of 21.89%,while the contributions increased by up to 7.57%in the VOC-limited regime,and were within 15μg/m^(3)in the transition *** modified OSAT module enabled a more sophisticated attribution of O_(3)to precursor emissions and may have far-reaching implications for informing O_(3)pollution control policy.

关键词： O_(3) modeling O_(3)-sensitivity regimes Ozone source apportionment technology Photochemical indicators

Ultra-high sensitivity fiber optic microphone with corrugated graphene-oxide diaphragm for voice recognition

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Nano Research 2024年第8期17卷 7593-7602页

作者： yang Liu Cheng Li Lingxiao yu Zhengwei Wu Shangchun fan Ruitao Lv School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Shenzhen Institute of Beihang University Shenzhen 518063China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100190China

To avoid interference from unexpected background noises and obtain high fidelity voice signal,acoustic sensors with high sensitivity,flat frequency response,and high signal-to-noise ratio(SNR)are urgently needed for voice ***(GO)has received extensive attention due to its advantages of controllable thickness and high fracture ***,low mechanical sensitivity(SM)introduced by undesirable initial stress limits the performance of GO material in the field of voice *** alleviate the aforementioned issue,GO diaphragm with annular corrugations is *** means of the reusable copper mold machined by picosecond laser,the fabrication and transfer of corrugated GO diaphragm are realized,thus achieving a Fabry–Perot(F–P)acoustic *** from the structural advantage of the corrugated GO diaphragm,our F–P acoustic sensor exhibits high S_(M)(43.70 nm/Pa@17 kHz),flat frequency response(−3.2 to 3.7 dB within 300–3500 Hz),and high SNR(76.66 dB@1 kHz).In addition,further acoustic measurements also demonstrate other merits,including an excellent frequency detection resolution(0.01 Hz)and high time stability(output relative variation less than 6.7% for 90 min).Given the merits presented before,the fabricated F–P acoustic sensor with corrugated GO diaphragm can serve as a high-fidelity platform for acoustic detection and voice *** conjunction with the deep residual learning framework,high recognition accuracy of 98.4%is achieved by training and testing the data recorded by the fabricated F–P acoustic sensor.

关键词： corrugated graphene-oxide(GO)diaphragm Fabry-Perot(F-P)acoustic sensor mechanical sensitivity voice recognition