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Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： Lan zhou yu Huang yuzhang wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 448-457页

作者： wu Peng zHANG yu-huai WANG Ling School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China School of Humanities and Management Zhejiang Chinese Medical UniversityHangzhou 311402China Public Foundational Courses Department Nanjing Vocational University of Industry TechnologyNanjing 210023China

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be *** this paper,we establish an HIV infection model with nonlocal dispersal and infection ***,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and *** well-posedness,positivity,and boundedness of the solution for the model are studied.

关键词： HIV model nonlocal dispersal time delay general incidences

A novel and promising engineering application of carbon dots:Enhancing the chloride binding performance of cement

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Chinese Chemical Letters 2024年第6期35卷 409-416页

作者： wu-Jian Long Yang yu Chuang He Guangdong Provincial Key Laboratory of Durability for Marine Civil Engineering Key Lab of Coastal Urban Resilient InfrastructureMOECollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China

Corrosion of reinforcement induced by chloride invasion is extensively considered as the dominating deterioration mechanism of reinforced concrete(RC)structures,leading to serious safety hazards and tremendous economic ***,it still lacks well dispersive and cost-efficient nanomaterials to improve the anti-chloride-corrosion ability of RC ***,specific carbon dots(CDs)with high dispersity and low cost are deliberately designed,successfully prepared by hydrothermal processing,and then firstly applied to immensely enhance chloride binding performance of cement,thereby contributing to suppressing the corrosion of ***,the tailored CDs are composed of the carbon core with highly crystalline sp^(2.C structures and oxygen-containing groups connecting on the carbon core;The typical equilibrium test confirms that with respect to that of the blank cement paste,the chloride binding capacity of cement paste involving 0.2.wt%(by weight of cement)CDs is increased by 109% after 14-day exposure to 3 mol/L Na Cl solution;according to comprehensive analyses of phase compositions,the chloride binding mechanism of CDs-modified cement is rationally attributed to the fact that the incorporation of CDs advances the formation of calcium silicate hydrate(C-S-H)gels and Friedel's salt(Fs),thus enormously enhancing the physically adsorbed and chemically bound chloride ions of cement *** work not only firstly provides a novel high-dispersity and low-cost nanomaterial toward the durability enhancement of RC structures,but also broadens the application of CDs in the field of engineering,conducing to stimulating their industrialization development.

关键词： Carbon dots Chloride binding Cement Chloride binding mechanism Friedel’s salt

Recent advances in post-chiroptical manipulation of supramolecular aggregates assembled with molecular modules

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Science China Chemistry 2024年第9期67卷 2842-2863页

作者： Yanling Shen Wanhua wu zhipeng yu Cheng Yang Key Laboratory of Green Chemistry&Technology of Ministry of Education College of Chemistry InstitutionSichuan UniversityChengdu 610064China

Recently,various supramolecular assembly systems have been identified where the pre-existing chiral supramolecular structure can be manipulated through environmental adjustments,such as temperature,solvent,and *** changes result in diverse microscopic morphologies during the assembly process and induce chiroptical variations,particularly in circular dichroism(CD)and circularly polarized luminescence(CPL)*** chiroptical properties serve as direct indicators of the chiral supramolecular structure and hold promise for applications in sensing,molecular recognition,asymmetric synthesis,and material *** review focuses on research published in the last five years,highlighting instances where assembled structures aggregated by small organic molecular modules demonstrate in-situ chiroptical changes through external condition *** categorizes and discusses different modes of regulation,aiming to offer insights and guidelines for exploring dynamic changes in assembly processes and designing in-situ adjustable structures of assembly modules.

关键词： supramolecular assemblies post-chiroptical manipulation in-situ structural changes

Optical detection method of discharge mode transition of inductively coupled plasma in an atmosphere-breathing electric propulsion system

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Chinese Journal of Aeronautics 2024年第10期37卷 172-183页

作者： yuxuan zHONG yu zHANG Jianjun wu Peng zHENG College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Plasma discharge stability is an important problem in atmosphere-breathing electric propulsion system when maintaining long-term missions at ultra-low earth *** paper designed an inductively coupled plasma source to imitate the ionization *** effect of inflow rate and Radio Frequency(RF)power on the plasma discharge mode transition is experimentally studied.A discharge mode detection method is proposed,which determines the discharge mode by identifying the morphology of the plasma *** using the method,the discharge mode transition is quantified and a control model based on the parameter sensitivity is *** verify the method,the spectra are measured and the electron temperature spatial distribution is *** the method has been proven *** results show that the inductively coupled discharge contains capacitive components affected by the mass flow rate and the radio frequency *** plasma characteristics can be maintained stably by controlling the radio frequency power when the mass flow rate randomly changes in a certain *** is demonstrated that the application of detection method effectively identifies the discharge mode,which is a promising active control method for the plasma discharge mode.

关键词： Atmosphere-breathing electric propulsion Inductively coupled plasma Discharge mode transition Optical diagnosis Ultra-low earth orbit

Parameter-Free Shifted Laplacian Reconstruction for Multiple Kernel Clustering

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1072-1074页

作者： Xi wu zhenwen Ren F.Richard yu the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010China the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010 the Guangxi Key Laboratory of Machine Vision and Intelligent Control Wuzhou UniversityWuzhou 543002 the Guangdong Laboratory of Artificial Intelligence and Digital Economy(Sz) Shenzhen 518060China

Dear Editor,This letter proposes a parameter-free multiple kernel clustering(MKC)method by using shifted Laplacian *** MKC can effectively cluster nonlinear data,but it faces two main challenges:1)As an unsupervised method,it is up against parameter problems which makes the parameters intractable to tune and is unfeasible in real-life applications;2.Only considers the clustering information,but ignores the interference of noise within Laplacian.

关键词： parameter letter Parameter

Efficient degradation of aqueous dichloromethane by an enhanced microbial electrolysis cell:Degradation kinetics,microbial community and metabolic mechanisms

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Journal of Environmental Sciences 2024年第5期139卷 150-159页

作者： Meng wu Di zhao Bing Gu ziruWang Jun Hu zhiliang yu Jianming yu College of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)Co.Ltd. Hangzhou 311121China zhejiang Tianyi Environmental Co.Ltd. Hangzhou 310000China

Dichloromethane(DCM)has been listed as a toxic and harmful water pollutant,and its re moval needs *** electrolysis cells(MECs)are viewed as a promising alterna tive for pollutant removal,which can be strengthened from two aspects:microbial inocula tion and *** this study,the MEC for DCM degradation was inoculated with the ac tive sludge enhanced by Methylobacterium rhodesianum H13(strain H13)and then acclimated in the form of a microbial fuel cell(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantly promoted DCM *** degradation kinetics were fitted by the Haldane model,with V_(max),K_(h),K_(i)and v_(max)values of 103.2.mg/L/hr,97.8 mg/L2.8.3 mg/L and 44.7 mg/L/hr/cm^(2.,*** cyclic voltammogram implies that DCM redox reactions became easier with the setup of MEC,and the electrochemical impedance spectrogram shows that the acclimated and enriched microbes reduced the charge transfe resistance from the electrode to the *** the biofilm,the dominant genera shifted from Geobacter to Hyphomicrobium in acclimation ***,Methylobacterium played an increasingly important *** metabolism mainly occurred through the hydrolytic glutathione S-transferase pathway,given that the gene dcmA was identified rather than the dhlA and P450/*** exogenous electrons facilitated the reduction of GSSG,directly o indirectly accelerating the GSH-catalyzed *** study provides support fo the construction of an efficient and stable MEC for DCM removal in water environment.

关键词： Dichloromethane Microbial electrolysis cells Metabolic pathways Electron transfer Degradation kinetics

Solvent-Resistant Wearable Triboelectric Nanogenerator for Energy-Harvesting and Self-Powered Sensors

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Energy & Environmental Materials 2024年第5期7卷 380-390页

作者： Yongtao yu yuelin yu Hongyi wu Tianshuo Gao Yi zhang Jiajia wu Jiawei Yan Jian Shi Hideaki Morikawa Chunhong zhu Graduate School of Medicine Science and Technology Shinshu University Institute for Fiber Engineering (IFES) Interdisciplinary Cluster for Cutting Edge Research (ICCER) Shinshu University Faculty of Textile Science and Technology Shinshu University

Wearable triboelectric nanogenerators （TENGs） have attracted attention owing to their ability to harvest energy from the surrounding environment without maintenance. Herein, polyetherimide–Al2.3（PAl） and polyvinylidene fluoride-co-hexafluoropropylene （PVDF-HFP, PH） nanofiber membranes were used as tribo-positive and tribo-negative materials, respectively. Phytic aciddoped polyaniline （PANI）/cotton fabric （PPCF） and ethylenediamine （EDA）-crosslinked PAl （EPAl） nanofiber membranes were used as triboelectrode and triboencapsulation materials, respectively. The result showed that when the PAl–PH-based TENG was shaped as a circle with a radius of 1 cm, under the pressure of 50 N, and the frequency of 0.5 Hz, the open-circuit voltage (Voc)and short-circuit current (Isc) reached the highest value of 66.6 V and-93.4to 110.1 nA, respectively. Moreover, the PH-based TENG could be used as a fabric sensor to detect fabric composition and as a sensor-inductive switch for light bulbs or beeping warning devices. When the PAl–PH-based TENG was shaped as a 5×5 cm2.ectangle, a 33μF capacitor could be charged to15 V in 2. s. Interestingly, compared to PAl nanofiber membranes, EPAl nanofiber membranes exhibited good dyeing properties and excellent solvent resistance. The PPCF exhibited <5%resistance change after washing,bending, and stretching.

关键词： energy-harvesting power supply sensors solvent-resistant wearable triboelectric nanogenerator

Opportunities and challenges in studies of mammalian hybrid speciation

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Science China(Life Sciences) 2024年第3期67卷 614-617页

作者： Hong wu yuxing zhang Li yu State Key Laboratory for Conservation and Utilization of Bio-Resource in yunnan School of Life SciencesYunnan UniversityKunming 650091China

Revealing the mechanisms of speciation remains one of the most attractive and challenging issues in the field of evolutionary biology, and is also key to understanding the biodiversity present in nature.

关键词： biodiversity attractive evolutionary