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Comparative Evaluation of Antitumor Chinese Patent Medicine Injections Based on Evidence-Based Medicine and Markov Model

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 220-229页

作者： Jing Yang Yan-Peng Wang Wen-Gong yu yu-yao guan Prince Emmanuel Opoku Amponsah Xian-Shuai Tang Ying-Zi Sun Lei Zheng School of Medicine and Pharmacy Ocean University of ChinaQingdaoChina Department of Pharmacy Shandong Medical CollegeJinanChina Department of Pharmacy Cheeloo College of MedicineShandong Provincial Third HospitalShandong UniversityJinanChina Biomedical Engineering Graduate School University of ArizonaTucsonAZUSA

Objective: The objective of this study was to explore the safety, efficacy, economy, and other aspects of frequently-used antitumor Chinese patent medicine injections through a comprehensive evaluation of evidence-based medical research to provide scientific information and decision-making basis for drug selection, rational drug use, public awareness of safe drug use, and medical insurance. Materials and Methods: The names of five frequently used antitumor Chinese patent medicine injections were used as search terms, including the compound Sophora flavescens injection, Kangai injection, Aidi injection, Kanglaite injection, and Brucea javanica oil emulsion injection. Relevant evidence-based medical research was extracted from the databases. A descriptive evaluation was conducted, and the Markov model was used for the cost-benefit analysis. Finally, the above injections are ranked by comprehensive scores using the multi-criteria decision analysis and Delphi method. Results: The five injections had their own advantages in enhancing the effectiveness of anti-tumor treatments, improving the quality of life for cancer patients, and reducing the incidence of adverse reactions. From the perspective of economy and other attributes, compound S. flavescens was superior to B. javanica oil, Aidi, Kangai, and Kanglaite. After a comprehensive evaluation of the above five injections, the compound S. flavescens injection received the highest score. Conclusions: Compound S. flavescens, Kangai, Aidi, B. javanica oil, and Kanglaite have their own advantages in effectiveness and no significant difference in safety. Compound S. flavescens injection has the highest comprehensive score. Clinical attention should be paid to monitoring the initial stage of medication and special groups.

关键词： Anti-tumor Chinese patent medicine comprehensive evaluation medication safety pharmacoeconomics rational drug use

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Investigation of Planar Shock Reflection on a Wedged Surface Loaded with Low Temperature Plasmas

Investigation of Planar Shock Reflection on a Wedged Surface...

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The 4th Across-strait Workshop on Shock Wave/Vortex Interaction

作者： Fan-Ming yu~*,guan-yao Huang Institute of Aeronautics and Astronautics,National Cheng Kung University Tainan,701,Taiwan

The directly energy addition in front of a moving object had been proposed to reduce the aerodynamics drag in supersonic *** former experiments demonstrated that with a direct energy addition in the shock wave the original strong bow shock wave produced by blunt body can be reduced to a weaker benign conical shock *** has been examined that a proper gas energy arrangement between body and the shock wave would offer a major effect on the decreasing of strength of the detached *** on this consideration,it is proposed to load a wedged model surface with an extra high voltage(200KV) in a shock tube facility and to examine the shock reflection over the surface loaded with low temperature plasma on *** observation of the planar shock reflection of Mach number of 1.35-1.68 for models with

关键词： Color schlieren Plasma Regular reflection Mach reflection

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen yu Han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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基因工程人表皮生长因子的分离纯化及其浓度的在线检测

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分析测试学报 2004年第6期23卷 22-24,28页

作者：童望宇姚善泾关怡新朱自强浙江大学化学工程与生物工程学系浙江杭州310027

在分离纯化快速开拓系统 ( KTAexplorer100)中用凝胶 (SephadexG_50superfine)纯化人表皮生长因子 ,并在优化的条件下对人表皮生长因子 (hEGF)进行定量测定。与经离子交换柱、SDS -PAGE及凝胶图象扫描分析系统的人表皮生长因子标准品间... 详细信息

在分离纯化快速开拓系统 ( KTAexplorer100)中用凝胶 (SephadexG_50superfine)纯化人表皮生长因子 ,并在优化的条件下对人表皮生长因子 (hEGF)进行定量测定。与经离子交换柱、SDS -PAGE及凝胶图象扫描分析系统的人表皮生长因子标准品间相互印证。结果表明在优化条件下 ,在SDS -PAGE上可得到与标准样品hEGF一样清晰的单条带 ,其产品纯度高于94 %,检出限可达1μg/mL。该法不仅对人表皮生长因子的在线检测行之有效。

关键词：基因工程人表皮生长因子分离纯化浓度在线检测多肽生长因子

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Regulating Ni site in NiV LDH for efficient electrocatalytic production of formate and hydrogen by glycerol electrolysis

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Rare Metals 2022年第5期41卷 1583-1594页

作者： Lin Dong guan-Ru Chang Yi Feng Xian-Zhi yao Xin-yao yu Key Laboratory of Structure and Functional Regulation of Hybrid Materials Institutes of Physical Science and Information TechnologyAnhui UniversityMinistry of Education.Hefei 230601China School of Chemistry and Chemical Engineering Huangshan UniversityHuangshan 245041China Department of Polymer Materials and Engineering Academy of Chemical EngineeringHebei University of TechnologyTianjin 300130China Ningbo Research Institute of Ecological and Environmental Sciences Ningbo 315000China Energy Materials and Devices Key Laboratory of Anhui Province for Photoelectric Conversion Anhui UniversityHefei 230601China

Energy-saving glycerol electrolysis with lower potential than water spitting endows a promising way for the concurrent production of value-added formate and high-purity hydrogen. However, there is still lack of efficient electrocatalysts at both anode and cathode for glycerol electrolysis. Herein, we report the activation of Ni site in NiV layered double hydroxide(LDH) by electrochemical and N_(2)/H_(2) plasma regulations for boosting the activity of glycerol oxidation reaction(GOR) and hydrogen evolution reaction(HER), respectively. Specifically, boosted GOR performance with a low overpotential(1.23 V at 10 mA·cm^(-2)) and a high Faradic efficiency(94%) is demonstrated by electrochemically regulated NiV LDH(ENiV LDH) with elevated valence state of Ni site. In situ Raman spectrum reveals the generation of Ni(Ⅲ) species by electrochemical regulation, and the highly active Ni(Ⅲ)can be regenerated with the process of electrochemical oxidation. Additionally, the possible reaction pathway is speculated based on the in situ Fourier transform infrared spectroscopy(FTIR) and high-performance liquid chromatography results. The plasma-regulated NiV LDH(PNiV LDH) with lower valence state of Ni site exhibits outstanding HER activity, displaying a low overpotential of 45 m V to deliver 10 mA·cm^(-2).When employing E-NiV LDH and P-NiV LDH as anode and cathode electrocatalyst, respectively, the assembled electrolyzer merely needs 1.25 V to achieve 10 m A·cm^(-2) for simultaneous production of formate and hydrogen, demonstrating remarkable 320 mV of lower potential than water electrolysis.

关键词： Glycerol electrolysis Glycerol oxidation reaction Hydrogen evolution reaction NiV LDH Formate

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-Fang guan Shu-Hong yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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A Novel PLL Structure for Dynamic Stability Improvement of DFIG-based Wind Energy Generation Systems During Asymmetric LVRT

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1149-1164页

作者： Lei guan Jun yao State Key Laboratory of Power Transmission Equipment&System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqing 400044China

The dynamic coupling effect,which is introduced by the dual-sequence phase-locked loops(PLLs)used in doublyfed induction generator(DFIG)based wind energy generation systems(WEGSs)during asymmetric low voltage ride-through(LVRT)in weak grid,needs *** order to study this new dynamic coupling effect,an equivalent two-degree-of-freedom(2-DOF)spring damper particle model is used in this paper to develop a small-signal model for the dual-sequence *** dynamic interaction between the positive-sequence(PS)and negative-sequence(NS)PLLs is ***,the impact of the dynamic coupling between the dual-sequence PLLs on the dynamic stability during the steady-state stage of an asymmetric fault is *** analysis results show that the dynamic coupling between the dual-sequence PLLs will cause drift in the frequency and damping for the PS and NS PLL *** will change the instability modal of the system and introduce the risk of dynamic ***,the effectiveness of existing control strategies for enhancing the dynamic stability will be ***,a novel PLL structure is designed to improve the dynamic stability of the system during the steady-state stage of an asymmetric *** effectiveness of the proposed strategy is verified by simulations and experiments.

关键词： Doubly-fed induction generator(DFIG) phaselocked loop(PLL) dynamic stability dynamic coupling weak grid asymmetric low-voltage ride through(LVRT)

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人椎间盘软骨细胞外基质小分子蛋白的双向电泳和质谱鉴定

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苏州大学学报（医学版） 2006年第1期26卷 17-20,26页

作者：冯皓宇郝跃峰关海山李承罡唐天驷苏州大学附属第一医院骨科江苏苏州215006

目的初步研究双向电泳和质谱鉴定在人椎间盘的蛋白质组特性研究中的价值和作用．为进一步研究椎间盘疾病寻找有效途径。方法取人的正常椎间盘组织（包括纤维环和髓核），针对细胞外基厦分子蛋白进行蛋白萃取，通过氯化铯梯度离心去除蛋... 详细信息

目的初步研究双向电泳和质谱鉴定在人椎间盘的蛋白质组特性研究中的价值和作用．为进一步研究椎间盘疾病寻找有效途径。方法取人的正常椎间盘组织（包括纤维环和髓核），针对细胞外基厦分子蛋白进行蛋白萃取，通过氯化铯梯度离心去除蛋白多糖，通过固相pH梯度（IPG）等电聚焦和梯度聚丙烯酰胺双向电泳分别分离纤维环和髓核的蛋白质．分析电泳图像．使用基质辅助激光解吸附飞行时间质谱仪对蛋白质点进行分析鉴定。结果双向电泳显示。纤维环和髓核的细胞外基质小分子蛋白无明显差异．纤维环和髓核中的小分子蛋白在pH3～10、分子量16～250kd范围内能被很好地分离。对各蛋白质点行质谱仪鉴定．分别确定了萁中相同的19种蛋白质。结论双向电泳可有效地分离准间盘组织中细胞外基质小分子蛋白，通过质谱仪鉴定可以确定其组成成分，为进一步研究椎间盘软骨细胞外基质小分子蛋白的功能及在准间盘病变中的改变和所起的作用打下基础。

关键词：椎间盘纤维环髓核蛋白质组双向电泳质谱仪基质辅助激光解吸附飞行时间质谱仪

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A Photoacoustic Imaging System with Optimized Real-Time Parallel Reconstruction

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Chinese Physics Letters 2013年第10期30卷 46-49页

作者： FENG Ting yuAN Jie yu yao ZHOU yu XU guan School of Electronic Science and Engineering Nanjing UniversityNanjing 210093 Department of Radiology University of MichiganAnn ArborMI 48109USA

Biomedical photoacoustic tomography(PAT)provides anatomical,functional,metabolic,molecular,and genetic contrasts of vasculature,hemodynamics,oxygen metabolism,biomarkers,and gene *** attributes bring PAT to a wide variety of applications in clinical medicine and preclinical *** report the development of a real-time PAT imaging system,which integrates signal scanning,image reconstruction and displaying photoacoustic images in real *** optimized back projection algorithm for PAT imaging is proposed and tested on a latest graphics process unit based *** whole system is built and tested in an experiment for monitoring moving blood events to validate the real-time performance of this system to image moving events.

关键词： expression graphics system

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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua guan Jing Dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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