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World Journal of Clinical Cases 2022年第20期10卷 7163-7170页

作者： Fang He ling-ling Xu yu-xiu li Ya-xiu Dong Department of Endocrinology Peking Union Medical College HospitalBeijing 100730China

BACKGROUND Latent autoimmune diabetes in adults(LADA)is a special type of type 1 diabetes *** the early stages,patients with LADA are treated with oral ***,insulin treatment is still required as islet function gradually *** patients have developed insulin allergy,clinical treatment and nursing care become very *** SUMMARY Here,we report a case of LADA with insulin-related lipodystrophy,allergy,and exogenous insulin autoimmune syndrome during insulin treatment,thus making it very difficult to effectively control glucose levels with *** attempted subcutaneous injection and an insulin pump to desensitize the patient’s response to insulin,and finally assisted the doctor to select the appropriate insulin treatment for the *** describe the management of this patient from a nursing *** We summarize the nursing experience of a case with complex insulin allergy requiring desensitization *** approach is very practical and can be applied to similar patients needing insulin desensitization.

关键词： Insulin allergy Desensitization lipodystrophy Exogenous insulin autoimmune syndrome Skin test Nursing Case report

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv Shu-Meng Han li-yun He Zi-Yi li yu-Cheng Yang Fan Ping ling-ling Xu Wei li Hua-Bing Zhang yu-xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(Plinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

Phosphatase and Tension Homolog Overexpression in Insulin Resistant Diabetic Adipose Tissue

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Chinese Medical Sciences Journal 2014年第3期29卷 167-173页

作者： Jing-bo Zeng yun Zhang Qi Sun yu-xiu li Department of Endocrinology Key Laboratory of Endocrinology of the Ministry of Health Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Endocrinology Fuxing Hospital Affiliated to Capital University of Medical Sciences

Objective To investigate the expression of phosphatase and tension homolog(PTEN) in adipose tissue of KKAy diabetic mice, a mouse model of type 2 diabetes. Methods KKAy diabetic mice were fed with high fat diet for 4 weeks. After blood glucose met the criteria of diabetes(over 16.7 mmol/L), mice were randomly divided into 3 groups: a control group(without any treatment), a rosiglitazone group(treated with rosiglitazone 12.5 mg/kg·d once per day), and a metformin group(treated with metformin 3 g/kg·d twice daily). After 4 weeks, we then determined the expression of PTEN and phosphoserine 473-Akt(pS473-Akt) in the epididymal adipose tissue with Western blots. The mice in each group were further divided into the insulin(-) subgroup and insulin(+) subgroup, which were intraperitoneally injected with saline and insulin(5 mU/g body weight), respectively. Results The expression of PTEN was elevated in the epididymal adipose tissue obtained from KKAy diabetic mice compared with that from the C57BL/6J mice(Plin was decreased in the adipose tissue of KKAy mice compared to the C57BL/6J mice(Plin-sensitizing agents, rosiglitazone and metformin did not inhibit the elevated expression of PTEN in adipose tissue of KKAy diabetic mice. Conclusion PTEN may play an important role in the development of insulin resistance in adipose tissue of type 2 diabetes mice model.

关键词： insulin resistance phosphatase and tension homolog adipose tissue

Heteroplasmy Level of the Mitochondrial tRNA^(Leu(UUR)) A3243G Mutation in a Chinese Family Is Positively Associated with Earlier Age-of-onset and Increasing Severity of Diabetes

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Chinese Medical Sciences Journal 2009年第1期24卷 20-25页

作者： Shi Zhang An-li Tong yun Zhang Min Nie yu-xiu li Heng Wang Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthPeking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. Methods Genomic DNA was isolated from blood leucocytes of each member of the pedigree. The mitochondrial genome was amplified with 24-pair primers that could cover the entire mitochondrial DNA. Direct sequencing of PCR products was used to identify any mitochondrial DNA mutations. Results Family members on the maternal side all harbored the tRNA^Lcu（UUR） A3243G mutation. The paternal side family members did not have the mutation. The age-of-onset of diabetes of the 4 maternal side family members was 15, 41, 44, and 65 years old, and their corresponding heteroplasmy level of the mutation was 34.5%, 14.9%, 14.6%, and 5.9%, respectively. The age-of-onset of diabetes and heteroplasmy level of A3243G mutation were negatively correlated with a correlation coefficient of -0.980（P=0.02）. Meanwhile, patient with high heteroplasmy level of A3243G mutation had relatively low severity of disease. Moreover, 6 reported polymorphisms and 2 new variants were found. Conclusions The main cause of diabetes in this pedigree is the tRNA^Lcu（UUR） A3243G mutation. However, other gene variants may contribute to its pathogenicity. The heteroplasmy level of the tRNA^Lcu（UUR） A3243G mutation is positively associated with earlier age-of-onset and increasing severity of diabetes.

关键词： maternally inherited diabetes and deafness tRNA^Lcu(UUR) A3243G mutation beteroplasmy

A new route to prepare the mixed oxo-ethylidynecapped trinuclear tungsten(Ⅳ)cluster and the crystal structure of H_2Na_3[W_3O(CCH_3)(O_2CCH_3)_6(H_2O)_3][H_2W_(12)O_(40)]·13.5H_2O

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Chinese Journal of Chemistry 1992年第2期10卷 130-137页

作者： yu,xiu-Fen XU,li Department of Chemitsry,Fuzhou University,Fuzhou,Fujian 350002 Department of Chemistry Fuzhou University Fuzhou Fujian 350002

The synthesis and the structural characterization of the title compound HNa[WO（CCH）-（OCCH）（HO）][HWO]·13.5 HO are *** is known that the mixed oxo-ethylidyne-capped tritungsten cluster can be obtained by Zn dust reduction of NaWO·2HO in acetic *** title compound has been characterized by X-ray diffraction,UV/VIS andH NMR *** tungsten atoms in the cluster cation and anion are in the oxidation states of W（IV）and W（VI）*** crystal is rhombohedral with the space group R32,a=17.058（3）,c=49.665（9）,γ=120°,V=12516（9）,Z=6,final R=0.037 for 2071 reflections with I≥3σ（I）.Boththe cluster cation and anion have a *** important interatomic distances in angstroms forthe cluster cation are:W—W,2.730（2）;W—μ-O,2.00;W—O（carboxyl）,2.12;W—O,2.18（2）.

关键词： A new route to prepare the mixed oxo-ethylidynecapped trinuclear tungsten H2O H2W O2CCH3 cluster and the crystal structure of H2Na3[W3O CCH3 Na

Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding:A case report

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World Journal of Clinical Cases 2021年第8期9卷 1976-1982页

作者： Na Yang Hui-Juan Zhu Yong Yao li-yun He yu-xiu li Hui You Hua-Bing Zhang Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Germinoma is a type of germ cell tumor that most frequently arises in the midline axis of the *** vision is a clinical manifestation of *** rare,intracranial germinoma seeding to the perioptic arachnoid space is one cause of visual acuity *** SUMMARY An 11yearold girl who presented with polyuria and polydipsia and subsequently developed diminution of *** showed bilateral heterogeneous enhancement of the optic nerve sheaths and atrophy of the optic nerve,and transsphenoidal biopsy revealed a *** patient experienced poor visual recovery following chemotherapy and *** are rare and they are mostly identified in children and *** manifestations include diabetes insipidus,pituitary dysfunction,visual complaints,*** mechanisms that lead to visual loss include intracranial hypertension,compression of optic chiasma,and tumor invasion.A literature review was performed to summarize the cases with a tumor infiltrating the optic *** of the reported patients were adolescents and presented with anterior pituitary hormone *** of optic nerve sheaths and optic disc pallor could be identified in most of the *** purpose of this report is to provide awareness that in cases where a germinoma is associated with visual loss,though rare,perioptic meningeal seeding should be taken into *** The case report suggests that children with diabetes insipidus need a complete differential diagnosis.

关键词： Germinoma Visual acuity decrease Central diabetes insipidus Perioptic meningeal seeding Intracranial tumor Case report

Triceps skinfold thickness trajectories and the risk of all-cause mortality:A prospective cohort study

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World Journal of Clinical Cases 2024年第15期12卷 2568-2577页

作者： Na Yang li-yun He Zi-Yi li yu-Cheng Yang Fan Ping ling-ling Xu Wei li Hua-Bing Zhang yu-xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat *** its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly *** To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause *** This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition *** class trajectory modeling was employed to identify distinct trajectories of TSF *** were classified into subgroups reflective of their respective TSF thickness *** utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory *** Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’*** the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and *** females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly *** In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.

关键词： Triceps skinfold thickness Trajectory All-cause mortality Body mass index Geriatric Nutritional Risk Index

Dipeptidyl peptidase-4 inhibitors and the risk of infection: A systematic review and meta-analysis of cardiovascular outcome trials

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World Journal of Diabetes 2024年第5期15卷 1011-1020页

作者： Na Yang li-yun He Peng liu Zi-Yi li yu-Cheng Yang Fan Ping ling-ling Xu Wei li Hua-Bing Zhang yu-xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Endocrinology The First Affiliated Hospitaland College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina

BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)*** To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)*** Electronic databases were *** selection criteria included randomized controlled trials focused on cardiovascular *** these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or *** trials involving 53616 patients were deemed *** calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the *** The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts.

关键词： T2DM drugs treatment

Hypercalcemia Appeared in a Patient with Glucagonoma Treated with Octreotide Acetate Long-acting Release

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Chinese Medical Sciences Journal 2012年第3期27卷 182-184页

作者： Rui Min Mei li Jiang-feng Mao Feng Gu Hui-juan Zhu Wen-hui li yu-xiu li Department of Endocrinology Key Laboratory of Endocrinology of the Ministry of HealthPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

PABCREATIC neuroendocrine tumours are uncommon neoplasms of the *** may cause a clinical syndrome due to hormone *** is a rare kind of pancreatic tumors. Here we report a case of glucagonoma. Hypercalcemia occurred wh... 详细信息

关键词： octreotide acetate long-acting release glucagonoma hypercalcemia

Low complexity SEU mitigation technique for SRAM-based FPGAs

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Journal of Beijing Institute of Technology 2016年第3期25卷 403-412页

作者： JIANG Run-zhen WANG Yong-qing FENG Zhi-qiang yu xiu-li School of Information and Electronics Beijing Institute of Technology Beijing 100081 China Beijing Institute of Astronautical Systems Engineering Beijing 100076 China

An internal single event upset（SEU）mitigation technique is proposed,which reads back the configuration frames from the static random access memory（SRAM）-based field programmable gate array（FPGA）through an internal port and compares them with those stored in the radiationhardened memory to detect and correct *** modular redundancy（TMR）,which triplicates the circuit of the technique and uses majority voters to isolate any single upset within it,is used to enhance the *** analysis shows that the proposed technique can satisfy the requirement of ordinary aerospace missions with less power dissipation,size and *** fault injection experiment validates that the proposed technique is capable of correcting most errors to protect spaceborne facilities from SEUs.

关键词： static random access memory (SRAM) field programmable gate array (FPGA) single event upset (SEU) low complexity triple modular redundancy scrubbing