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Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

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Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min ZHANG yu Lan ZHANG Kai Li LI Ping Ping Lyu yu Han LIANG Ya xin yu yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

Coping strategy of independent directors for job-fulfillment risk under different ownership types and enforced legal environments

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China Journal of Accounting Research 2024年第4期17卷 112-142页

作者： yu xin Ying xin xinyi Huang Liping Xu School of Business Sun Yat-sen UniversityGuangzhouChina School of Accounting Guangdong University of Foreign StudiesGuangzhouChina

Ownership type,legal system evolution and their interaction significantly affect the incentives and behaviors of independent *** use the 2019 Securities Law revision as an exogenous shock to examine how state-owned enterprises(SOEs)versus non-SOEs and their independent directors respond to variations in regulatory compliance *** the revision,SOEs are more likely to purchase directors’and officers’liability insurance to provide job security for independent ***-SOEs are more likely to compensate for independent directors’fulfillment risk by increasing salaries and their independent directors are more likely to resign to avoid litigation *** coping strategies for SOEs,non-SOEs and independent directors are dynamic under different compliance risk stages and are affected by firm-level and director-level characteristics.

关键词： New Securities Law Ownership type Regulatory compliance risk Independent directors Job-fulfillment risk

Graphitic carbons:preparation,characterization,and application on K-ion batteries

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Rare Metals 2024年第9期43卷 4056-4075页

作者： Kang-Zhe Cao Jia-Hui Ma yu-Lian Dong yu duan Run-Tian Zheng Dharani Bundhooa Hui-Qiao Liu Yong Lei College of Chemistry and Chemical Engineering Xinyang Normal UniversityXinyang 464000China xinyang Key Laboratory of Low-Carbon Energy Materials Xinyang 464000China Fachgebiet Angewandte Nanophysik Institut fur Physik&IMN MacroNanoTechnische Universitat Ilmenau98693 IlmenauGermany Laboratory of Inorganic Materials Chemistry(CMI) University of NamurB-5000 NamurBelgium

K-ion batteries(KIBs)have drawn much attention due to the abundant potassium reserves and wide accessibility as well as high energy density,which can be designed for large-scale energy storage *** the most promising anode materials for KIBs,graphitic carbons,especially those with an intermediate structure between the crystalline graphite and amorphous carbons become a hot research focus because of the improved rate capability and enhanced diffusion-controlled capacity at low voltage ***,we first review the structures of graphitic carbons in the view of graphitic domains and the structure changes in their K-ion intercalation ***,we summarize the preparation mechanisms and characterizations of graphitic carbons and the influence factors in their degree of ***,we illustrate the strategies to optimize their K-ion storage properties from four aspects,namely graphitic domain design,microstructure engineering,electrochemical active component regulation,and defect ***,we propose the issues that urgently need to be solved in graphitic carbons and the possible *** hope that this view could offer some inspiration for the further designing and optimizing of graphitic carbons for practical KIBs.

关键词： Graphitic carbon K-ion battery Anode Graphite Structure design

Spherical Polyelectrolyte Brush Nanoreactor:Preparation of Hollow TiO_(2) Nanospheres and Characterization by Small Angle X-Ray Scattering

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Chinese Journal of Polymer Science 2024年第9期42卷 1393-1400,I0009页

作者： yu-Hua Zhang Zi-yu Zhang xin Liu En-Guang Ma Jiang-Tao Guo Li Li Xu-Hong Guo State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou253023China Institute of Bast Fiber Crops&Center of Southern Economic Crops Chinese Academy of Agricultural SciencesChangsha410205China

Titanium dioxide(TiO_(2))hollow nanoparticles present significant potential for photocatalytic applications while their straightforward preparation with precise structure control is still *** work reports the approach to preparing tunable hollow TiO_(2) nanospheres by utilization of spherical polyelectrolyte brushes(SPB)as nanoreactors and *** the preparation,the evolution of the structure was characterized by small angle X-ray scattering(SAXS),and in combination with dynamic light scattering and transmission electron *** formation of TiO_(2) shell within the brush(SPB@TiO_(2))is confirmed by the significant increase of the electron density,and its internal structure has been analyzed by fitting SAXS data,which can be influenced by Titanium precursors and ammonia *** calcining SPB@TiO_(2) in a muffle furnace,hollow TiO_(2) nanospheres are produced,and their transition to the anatase crystal form is triggered,as confirmed by X-ray diffraction *** the advantages of their hollow structure,these TiO_(2) nanospheres exhibit exceptional catalytic degradation efficiency of methylene blue(MB),tetracycline(TC),and 2,4-dichlorophenoxyacetic acid(2,4-D),and also demonstrate excellent recyclability.

关键词： Spherical polyelectrolyte brush Nanoreactor Hollow titanium dioxide X-ray scattering

Steam disinfection enhances bioaccessibility of metallic nanoparticles in nano-enabled silicone-rubber baby bottle teats,pacifiers,and teethers

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Journal of Environmental Sciences 2024年第2期136卷 161-171页

作者： yu Su BinWang xin Tong Shuchuan Peng Sijin Liu Baoshan xing Rong Ji State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Stockbridge School of Agriculture University of MassachusettsAmherstMA 01003USA

Nano-enabled silicone-rubber articles for feeding or chewing could be a source of metallic nanoparticles(NPs)directly exposed to infants and young ***,the impact of steam disinfection on release of NPs and the related potential risks to children's health are ***,we investigated contents and form of Ag and Zn in 57 nano-enabled silicone-rubber baby bottle teats,pacifiers,and teethers of seven countries and examined the impacts of steam disinfection on in vitro bioaccessibility(IVBA)of Ag and Zn in the *** 89%articles had a mixture of Ag-and Zn-containing NPs and the teethers had relatively high Ag and Zn contents(up to 501 and 254μg/g,respectively).Steam disinfection caused rubber decomposition into micro(nano)plastics(0.54-15.7μm)and NP release from the interior of bulk rubber and micro-sized plastics,thus enhancing the IVBA of Ag and Zn by up to 5.5 *** findings provide insights into mechanisms for NP release by steam *** oral exposure risk assessment suggested low health concerns on individual metal release,our study points out the need to assess the potential health risks of child co-exposure to metallic NPs and micro(nano)plastics.

关键词： Silicone rubber Metallic nanoparticles Micro(nano)plastics Bioaccessibility Children's health

Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets

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Animal Nutrition 2024年第1期16卷 409-421页

作者： xin Lai Aimin Wu Bing yu Hui Yan Junqiu Luo Ping Zheng Jie yu Daiwen Chen Institute of Animal Nutrition Sichuan Agricultural University Key Laboratory for Animal Disease-resistance Nutrition of China Ministry of Education Sichuan Agricultural University

Rotaviruses(RV) are a major cause of severe gastroenteritis, particularly in neonatal piglets. Despite the availability of effective vaccines, the development of antiviral therapies for RV remains an ongoing challenge. Retinoic acid(RA), a metabolite of vitamin A, has been shown to have anti-oxidative and antiviral properties. However, the mechanism by which RA exerts its intestinal-protective and antiviral effects on RV infection is not fully understood. The study investigates the effects of RA supplementation in Duroc × Landrace × Yorkshire(DLY) piglets challenged with RV. Thirty-six DLY piglets were assigned into six treatments, including a control group, RA treatment group with two concentration gradients(5and 15 mg/d), RV treatment group, and RV treatment group with the addition of different concentration gradients of RA(5 and 15 mg/d). Our study revealed that RV infection led to extensive intestinal architecture damage, which was mitigated by RA treatment at lower concentrations by increasing the villus height and villus height/crypt depth ratio(P < 0.05), enhancing intestinal stem cell signaling and promoting intestinal barrier functions. In addition, 15 mg/d RA supplementation significantly increased NRF2 and HO-1 protein expression(P < 0.05) and GSH content(P < 0.05), indicating that RA supplementation can enhance anti-oxidative signaling and redox homeostasis after RV challenge. Additionally,the research demonstrated that RA exerts a dual impact on the regulation of autophagy, both stimulating the initiation of autophagy and hindering the flow of autophagic flux. Through the modulation of autophagic flux, RA influence the progression of RV infection. These findings provide new insights into the regulation of redox hemostasis and autophagy by RA and its potential therapeutic application in RV infection.

关键词： Rotavirus Piglet Retinoic acid Intestinal barrier Redox hemostasis Autophagic flux

Cooperative Rate Splitting Transmit Design for Full-Duplex-Enabled Multiple Multicast Communication Systems

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工程与科学中的计算机建模(英文) 2024年第1期138卷 619-638页

作者： Siyi duan Mingsheng Wei Shidang Li Weiqiang Tan Bencheng yu School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou221116China School of Computer Science and Cyber Engineering Guangzhou UniversityGuangzhou510006China School of Information Engineering Xuzhou Vocational College of Industrial TechnologyXuzhou221140China

This paper examines the performance of Full-Duplex Cooperative Rate Splitting(FD-CRS)with Simultaneous Wireless Information and Power Transfer(SWIPT)support in Multiple Input Single Output(MISO)*** a Rate Splitting Multiple Access(RSMA)multicast system with two local users and one remote user,the common data stream contains the needs of all users,and all users can decode the common data ***,each user can receive some information that other users need,and local users with better channel conditions can use this information to further enhance the reception reliability and data rate of users with poor channel *** using Cell-Center-Users(CCUs)as a cooperative relay to assist the transmission of common data can improve the average system *** maximize the minimum achievable rate,we optimize the beamforming vector of Base Station(BS),the common streamsplitting vector,the cooperative distributed beamvector and the strong user transmission power under the power budget constraints of BS and relay devices and the service quality requirements constraints of *** the whole problem is not convex,we cannot solve it ***,we propose a low complexity algorithm based on Successive Convex Approximation(SCA)technology to find the optimal solution to the problemunder *** simulation results show that FD C-RSMA has better gain andmore powerful than FD C-NOMA,HD C-RSMA,RSMA and NOMA.

关键词： Full-duplex cooperative rate segmentation SWIPT RSMA power control

A memory-friendly class-incremental learning method for hand gesture recognition using HD-sEMG

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Medicine in Novel Technology and Devices 2024年第2期22卷 124-132页

作者： yu Bai Le Wu Shengcai duan Xun Chen The School of Information Science and Technology University of Science and Technology of ChinaHefei230027China

Hand gesture recognition(HGR)plays a vital role in human-computer *** integration of high-density surface electromyography(HD-sEMG)and deep neural networks(DNNs)has significantly improved the robustness and accuracy of HGR *** methods are typically effective for a fixed set of trained ***,the need for new gesture classes over time poses a *** new classes to DNNs can lead to a substantial decrease in accuracy for previously learned tasks,a phenomenon known as“catastrophic forgetting,”especially when the training data for earlier tasks is not retained and *** issue is exacerbated in embedded devices with limited storage,which struggle to store the large-scale data of ***incremental learning(CIL)is an effective method to reduce catastrophic ***,existing CIL methods for HGR rarely focus on reducing memory *** address this,we propose a memory-friendly CIL method for HGR using *** approach includes a lightweight convolutional neural network,named SeparaNet,for feature representation learning,coupled with a nearest-mean-of-exemplars classifier for *** introduce a priority exemplar selection algorithm inspired by the herding effect to maintain a manageable set of exemplars during ***,a task-equal-weight exemplar sampling strategy is proposed to effectively reduce memory load while preserving high recognition *** results on two datasets demonstrate that our method significantly reduces the number of retained exemplars to only a quarter of that required by other CIL methods,accounting for less than 5%of the total samples,while still achieving comparable average accuracy.

关键词： Myoelectric pattern recognition Memory-friendly Class-incremental learning

BIO-inspired intelligent navigation: from methodology, system theory, to behavioural science

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Science China(Information Sciences) 2024年第9期67卷 333-335页

作者： Wenshuo LI xin LIU Pengwei HU Jian YANG Xiang yu Lei GUO Hangzhou Innovation Institute of Beihang University School of Automation Science and Electrical Engineering Beihang University School of Instrumentation and Optoelectronic Engineering Beihang University

It is crucial for unmanned systems to determine their motion information accurately, reliably, and in real time. This function is accomplished by the autonomous navigation module of the unmanned systems. By analogy to the animals,the autonomous navigation module can be regarded as the“sensory nerve center” of an unmanned system.

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