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Geo-engineered buffer capacity of two-layered absorbing system under the impact of rock avalanches based on Discrete Element Method

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Journal of Mountain Science 2016年第5期13卷 917-929页

作者： BI yu-zhang HE Si-ming LI xin-po WU Yong XU Qiang OUYANG Chao-jun SU Li-Jun WANG Hao Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of Sciences Institute of Mountain Hazards and Environment Chinese Academy of Sciences & Water Resources Ministry Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences State Key Laboratory of Geo-Hazard Prevention and Geo-Environment Protection Chengdu University of Technology College of Environment and Resources Fuzhou University

Many rock avalanches were triggered by the Wenchuan earthquake on May 12, 2008 in southwest China. Protection galleries covered with a single soil layer are usually used to protect against rockfall. Since one-layer protection galleries do not have sufficient buffer capacity, a two-layered absorbing system has been designed. This study aims to find whether an expanded poly-styrol （EPS） cushion, which is used in the soil-covered protection galleries for shock absorption, could be positioned under dynamic loadings. The dynamic impacts of the two-layered absorbing system under the conditions of rock avalanches are numerically simulated through a 2D discrete dement method. By selecting reasonable parameters, a series of numerical experiments were conducted to find the best combination for the two- layered absorbing system. The values of the EPS layer area as a percentage of the total area were set as 0% （Sl）, 22~ （S2）, and 70% （$3）. 22~ of the area of the EPS layer was found to be a reasonable value, and experiments were conducted to find the best position of the EPS layer in the two-layered absorbing system. The numerical results yield useful conclusions regarding the interaction between the impacting avalanches and the two-layered absorbing system. The soil layer can absorb the shock energy effectively and S2 （0.4-m thick EPS cushion covered with soil layer） is the most efficient combination, which can reduce the impact force, compared with the other combinations.

关键词： Discrete element method Buffer capacity Dynamic simulation Impact force Two-layered absorbing system

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Evaluation of heavy roller compaction on a large-thickness layer of subgrade with full-scale field experiments

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第11期23卷 933-944页

作者： Shu-jian WANG Hong-guang JIANG Zong-bao WANG yu-jie WANG Yi-xin LI Xue-yu GENG xin-yu WANG Kai WANG Yi-yi LIU Yan-kun GONG School of Qilu Transportation Shandong UniversityJinan 250002China Shandong Hi-Speed Engineering Test Co. Ltd.Jinan 250002China Shandong High-Speed Jiqing Middle Line Highway Co. Ltd.Weifang 261599China School of Engineering University of WarwickCoventry CV48UWUK Shandong Hi-Speed Group Co. Ltd.Jinan 250002China

Subgrade construction is frequently interrupted due to precipitation,soil shortage,and environmental ***,increasing the thickness layer is required to reduce construction costs and to allow highways to be placed into service *** paper presents a series of full-scale field experiments evaluating the compaction quality of gravel subgrade with large-thickness layers of 65 cm and 80 cm using heavy vibratory *** improved sand cone method was first proposed and calibrated to investigate the distribution of soil compaction degree across the full subgrade *** showed that dynamic soil stresses caused by the heavy vibratory rollers were 2.4–5.9 times larger than those of traditional rollers,especially at deeper depths,which were large enough to densify the soils to the full depth.A unified empirical formula was proposed to determine the vertical distribution of dynamic soil stresses caused by roller *** was demonstrated that soils were effectively compacted in a uniform fashion with respect to the full depth to 96.0%–97.2%and 94.1%–95.4%for the large-thickness layers of 65 cm and 80 cm within 6 or 7 passes,***,linear formulae were finally established between soil compaction degree and the subgrade reaction modulus,dynamic modulus of deformation,dynamic deflection,and relative difference of settlement to conveniently evaluate the compaction *** is demonstrated that increasing the thickness layer by means of heavy rollers can significantly reduce the cost and time burdens involved in construction while ensuring overall subgrade quality.

关键词： Highway subgrade Heavy vibratory roller Thickness layer Dynamic soil stress Compaction degree Compaction quality control

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Gastric foregut cystic developmental malformation: Case series and literature review

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World Journal of Gastroenterology 2015年第2期21卷 432-438页

作者： Yan-Hua Geng chang-xing Wang Jiang-Tao Li Qing-yu Chen Xiu-Zhen Li Hao Pan Department of Pathology Second Affiliated Hospital of Zhejiang University College of Medicine Department of Osteology Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine Department of Surgery Second Affiliated Hospital of Zhejiang University College of Medicine Department of Gastroenterology Second Affiliated Hospital of Zhejiang University College of Medicine

Foregut cystic developmental malformation(FCDM) is a very rare lesion of the alimentary tract, especially in the stomach. We discuss the concepts of gastric duplication cyst, bronchogenic cysts, and FCDM. Nomenclature has been inconsistent and confusing, but, by some definitions, gastric duplication cysts involve gastric mucosa and submucosal glands, bronchogenic cysts involve respiratory mucosa with underlying cartilage and glands, and FCDM lacks gastric mucosa or underlying glands or cartilage but has pseudostratified ciliated columnar epithelium(PCCE). We searched our departmental case files from the past 15 years and identified 12 cases of FCDM in the alimentary tract. We summarize the features of these 12 cases including a report in detail on a 52-year-old man with a submucosal cyst lined with simple PCCE and irregular and stratified circular muscle layers that merged with gastric smooth muscle bundles near the lesser curvature of the gastric cardia. A literature review of cases with this histology yielded 25 cases. We propose the term gastric-FCDM for such cases. Our own series of 12 cases confirms that preoperative recognition of the entity is infrequent and problematic. The rarity of this developmental disorder, as well as a lack of understanding of its embryologic origins, may contribute to missing the diagnosis. Not appreciating the diagnosis preoperatively can lead to an inappropriate surgical approach. In contrast, presurgical recognition of the entity will contribute to a good outcome and reduced risk of complications.

关键词： Endoscopic ultrasound-guided fine-needle aspiratio

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How modern teaching technology affects the transmission of traditional Chinese medicine knowledge: reflections from educators in clinical Chinese pharmaceutical education

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History & Philosophy of Medicine 2023年第2期5卷 26-29页

作者： yu-Qi Bu Fang-Xiang yu Zi-chang Liu Bo-Han Liu Wen-Shu Xue xin-Ju Li School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Traditional Chinese medicine(TCM)education plays a crucial role in cultivating TCM talents and preserving the profound cultural heritage of the Chinese *** paper explores the current situation and problems of TCM education and proposes philosophical reflections on this *** analysis shows that the current TCM education faces various challenges,including an unbalanced curriculum,a narrow teaching approach,a lack of practical experience,and an insufficient number of qualified *** enhance the teaching effectiveness and foster a new generation of high-quality Chinese medicine professionals,it is necessary to reform the teaching methods of TCM and integrate the depth of humanities into the teaching *** paper argues that a philosophical perspective can provide a more comprehensive understanding of TCM education and its role in the development of Chinese medicine.

关键词： Chinese medicine education teaching reform practical exploration humanities education TCM cultural heritage

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Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz

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Natural Products and Bioprospecting 2021年第4期11卷 421-429页

作者： Na Zhang Fan Xia Song-yu Li Yin Nian Li-xin Wei Gang Xu State Key Laboratory of Phytochemistry and Plant Resources in West China and yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Tibetan Medicine Research and Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningQinghaiChina

Sixteen diterpenoid alkaloids(DAs),including six aconitine-type alkaloids(5 and 9−13),seven 7,17-seco-aconitine-type alkaloids(1−4,6−8),two napelline-type alkaloids(14 and 15)as well as one veatchine-type alkaloid(16),were isolated from the aerial parts of Aconitum flavum Hand.-*** which,flavumolines A−D(1−4)were four new ones,and flavu-moline E(5)was reported as natural compound for the first *** chemical structures were elucidated by the analysis of extensive spectroscopic *** inhibitory activities of these isolates on Cav3.1 low voltage-gated Ca^(2+)channel,NO production in LPS-activated RAW264.7cells,five human tumor cell lines,as well as acetylcholinesterase(AChE)were tested.

关键词： Aconitum flavum Hand.-Mazz Diterpenoid alkaloids Bioactivity

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Point-of-care ultrasound for the early diagnosis of emphysematous pyelonephritis: A case report and literature review

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World Journal of Clinical Cases 2021年第11期9卷 2584-2594页

作者： Zhou-Xiong xing Hang Yang Wen Zhang yu Wang chang-Sheng Wang Tao Chen Hua-Jun Chen Department of Critical Care Medicine Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Emphysematous pyelonephritis(EPN)is a rare but fatal necrotic infection of the kidney,which usually leads to septic ***,early diagnosis and optimized therapy are of paramount *** the past two decades,pointof-care ultrasound(POCUS)has been widely used in clinical practice,especially in emergency and critical care settings,and helps to rapidly identify the source of infection in *** report a rare case in which a“falls”sign on POCUS played a pivotal role in the early diagnosis of *** SUMMARY A 57-year-old man presented with fever and lumbago for 3 d prior to *** went to the emergency room,and the initial POCUS detected gas bubbles in the hepatorenal space showing a hyperechoic focus with dirty shadowing and comet-tail *** imaging feature was like a mini *** blood and urine culture demonstrated Escherichia coli bacteremia,and EPN associated with septic shock was *** patient did not respond to broad-spectrum antibiotic treatment and a perirenal abscess *** subsequently underwent computed tomography-guided percutaneous catheter drainage,and fully *** also review the literature on the sonographic features of POCUS in *** This case indicates that a“falls”sign on POCUS facilitates the rapid diagnosis of severe EPN at the bedside.

关键词： Emphysematous pyelonephritis Point-of-care ultrasound Ultrasound Urinary

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High-strength and self-degradable sodium alginate/polyacrylamide preformed particle gels for conformance control to enhance oil recovery

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Petroleum Science 2022年第6期19卷 3149-3158页

作者： Xiao Zhang Jia-Nan Deng Kai Yang Qian Li Sen-Yao Meng Xiu-Xia Sun Zhao-Zheng Song Yong-Dong Tian Sui-An Zhang xin-Jia Liu Zhan-Yi Wang xin-yu Liu Gui-Wu Lu Zi-Long Liu Coalbed Methane Research Center Beijing Key Laboratory of Optical Detection Technology for Oil and GasCollege of ScienceChina University of Petroleum-BeijingBeijing102249China Shanxi Lanyan Coalbed Methane Group Co. LtdJinchengShanxi048012China State Key Laboratory of Coal and CBM Co-Mining in Nancun Town JinchengShanxi048012China Institute of Oil and Gas Technology Research Changqing OilfieldCNPCXi’anShaanxi710021China

Excess water production has become an important issue in the oil and gas extraction *** particle gels(PPGs),show the capability to control the conformance and reduce excess water ***,conventional PPGs have poor mechanical properties and their swollen particles are easily damaged by shearing force when passing through the fractures in formations,meanwhile PPGs can be also degraded into various byproducts,leading to permanent damage to the reservoir permeability after temporary ***,a novel type of dual cross-linked PPGs(dPPGs)was designed and synthesized using sodium alginate(SA)and acrylamide(AAm),cross-linked with N,N’-methylenebisacrylamide(MBA)and Fe^(3+).Results show that dPPGs have excellent mechanical properties with a storage modulus up to 86,445 Pa,which is almost 20 times higher than other reported ***,dPPGs can be completely degraded into liquid without any solid residues or byproducts and the viscosity of dPPGs degraded liquid was found to be lower than 5 mPa·s.A laboratory coreflooding test showed that the plugging efficiency of dPPGs was up to 99.83%on open *** obtained results demonstrated that dPPGs could be used as economical and environment-friendly temporary plugging agent with high-strength,self-degradation,thermal stability,and salt stability,thus making it applicable to a wide range of conformance control to enhance oil recovery.

关键词： Conformance control Sodium alginate Dual cross-linked Temporary plugging agent High-strength Self-degradation

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Phasic study of intestinal homeostasis disruption in experimental intestinal obstruction

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World Journal of Gastroenterology 2014年第25期20卷 8130-8138页

作者： Xiang-Yang yu chang-Lin Zou Zhen-Li Zhou Tao Shan Dong-Hua Li Nai-Qiang Cui Department of Gastrointestinal Surgery Nankai Hospital Graduate School of Tianjin Medical University Tianjin Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine Department of Hepatopancreatobiliary Surgery Nankai Hospital

AIM: To investigate the phasic alteration of intestinal homeostasis in an experimental model of intestinal obstruction.

关键词： Intestinal obstruction Rabbit model Homeostasis disruption Intestinal epithelial cells Intestinal microorganisms Intestinal immune system

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Effect of Acupuncture on the Notch Signaling Pathway in Rats with Brain Injury

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Chinese Journal of Integrative Medicine 2018年第7期24卷 537-544页

作者： ZHANG Yi-min CHEN Sheng-xin DAI Qiu-fu JIANG Shu-ting CHEN Ai-lian TANG Chun-zhi ZHANG yu-qing Department of Traditional Chinese Medicine School of MedicineJinan University Clinical Medical School of Acupuncture Rehabilitation Guangzhou University of Traditional Chinese Medicine

Objective： To observe the effect of acupuncture on the Notch signaling pathway in rats with traumatic brain injury and to explore the pathogenesis of acupuncture intervention on traumatic brain injury. Methods： Feeney＇s freefall epidural impact method was used to establish a traumatic brain injury model in rats; the rats were randomly divided into a normal group, sham operation group, model group and acupuncture group. Acupuncture was performed in the Baihui（DU 20）, Shuigou（DU 26）, Fengfu（DU 16）, Yamen（DU 15） and Hegu（LI 4） acupoints in the rat, and Yamen was punctured via Fengfu. Then, the rats in each group were randomly divided into three subgroups, namely the day 3 subgroup, day 7 subgroup and day 14 subgroup according to treatment duration. The modified neurological severity scores（m Nss） method was used to perform neurobehavioral scoring for evaluating the degree of injury in the rats. The hematoxylin-eosin（HE） staining method was used to observe the pathological change in the brain tissue of rats in each group. Real-time fluorescent quantitative polymerase chain reaction（Q-PCR） technology was used to detect changes in the Notch1, Hes1 and Hes5 gene expression levels in the cortex on the injured side. Western blot was used to detect the protein expression changes. Results： One day after modeling, the m Nss scores in the model group and in the acupuncture group were significantly higher than those in the normal and sham operation groups（P〈0.01）; there was no statistically significant difference between the normal group and the sham operation group. The scores decreased with increased treatment time, and the scores in the acupuncture group decreased more significantly than those in the model group（P〈0.01）. The pathological examination by the HE staining method demonstrated that the brain tissue of the rats in the acupuncture and model groups relatively significantly changed. The Notch1 gene expression level in the acupuncture group was significantly higher than

关键词： brain injury Notch Hes1 Hes5 acupuncture

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Time series analysis-based seasonal autoregressive fractionally integrated moving average to estimate hepatitis B and C epidemics in China

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World Journal of Gastroenterology 2023年第42期29卷 5716-5727页

作者： Yong-Bin Wang Si-yu Qing Zi-yue Liang chang Ma Yi-Chun Bai Chun-Jie Xu Department of Epidemiology and Health Statistics School of Public HealthXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmacology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100010China

BACKGROUND Hepatitis B(HB)and hepatitis C(HC)place the largest burden in China,and a goal of eliminating them as a major public health threat by 2030 has been *** more informed and accurate forecasts of their spread is essential for developing effective strategies,heightening the requirement for early warning to deal with such a major public health *** To monitor HB and HC epidemics by the design of a paradigmatic seasonal autoregressive fractionally integrated moving average(SARFIMA)for projections into 2030,and to compare the effectiveness with the seasonal autoregressive integrated moving average(SARIMA).METHODS Monthly HB and HC incidence cases in China were obtained from January 2004 to June *** analysis and the Hodrick-Prescott method were employed to identify trends and *** periods(from January 2004 to June 2022 and from January 2004 to December 2015,respectively)were used as the training sets to develop both models,while the remaining periods served as the test sets to evaluate the forecasting *** There were incidents of 23400874 HB cases and 3590867 HC cases from January 2004 to June ***,HB remained steady[average annual percentage change(AAPC)=0.44,95%confidence interval(95%CI):-0.94-1.84]while HC was increasing(AAPC=8.91,95%CI:6.98-10.88),and both had a peak in March and a trough in *** the 12-step-ahead HB forecast,the mean absolute deviation(15211.94),root mean square error(18762.94),mean absolute percentage error(0.17),mean error rate(0.15),and root mean square percentage error(0.25)under the best SARFIMA(3,0,0)(0,0.449,2)12 were smaller than those under the best SARIMA(3,0,0)(0,1,2)12(16867.71,20775.12,0.19,0.17,and 0.27,respectively).Similar results were also observed for the 90-step-ahead HB,12-step-ahead HC,and 90-step-ahead HC *** predicted HB incidents totaled 9865400(95%CI:7508093-12222709)cases and HC totaled 1659485(95%CI:856681-2462290)cases during ***

关键词： Hepatitis Seasonal autoregressive fractionally integrated moving average Seasonal autoregressive integrated moving average Prediction Epidemic Time series analysis

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