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World Journal of Clinical Oncology 2025年第2期16卷 165-172页

作者： Xuan Guo Yan Liu yu-ting wang Kan Liu Hui Ding Department of Pulmonary and Critical Care Medicine Yixing People’s Hospital of Jiangsu UniversityYixing 214200Jiangsu ProvinceChina

BACKGROUND Through deeper understanding of targetable driver mutations in non-small-cell lung cancer(NSCLC)over the past years,some patients with driver mutations have benefited from the targeted molecular *** the anaplastic lymphoma kinase and BRAF mutations are not frequent subtypes in NSCLC,the availability of several targeted-drugs has been confirmed through a series of clinical *** little is clear about the proper strategy in rare BRAF G469A mutation,not to mention co-exhibition of anaplastic lymphoma kinase and BRAF G469A mutations,which is extremely rare in *** SUMMARY We present a patient to stage IVA lung adenocarcinoma with coexisting echinoderm microtubule associated protein like-4 rearrangement and BRAF G469A *** received several targeted drugs with unintended resistance and suffered from unbearable adverse *** Due to the rarity of co-mutations,the case not only enriches the limited literature on NSCLC harbouring BRAF G469A and echinoderm microtubule associated protein like-4 mutations,but also suggests the efficacy and safety of specific multiple-drug therapy in such patients.

关键词： Non-small-cell lung cancer Driver mutation Rearrangement Resistance Case report

Synthesis and properties of electrodeposited Ni-CeO_2 nano-composite coatings

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Rare Metals 2018年第2期37卷 148-153页

作者： Hui Jin Yi-Yong wang yu-ting wang Hong-Bing Yang School of Materials and Metallurgy University of Science and Technology Liaoning School of Material Science and Engineering Shenyang University of Technology Laser Advanced Manufacturing Technology Center University of Science and Technology Liaoning

Current machinery requires metallic materials to have better surface properties. Based on an orthogonal experimental design and analysis method, the CeO2-rein- forced nickel nano-composite coatings were prepared by direct current electrodeposition in a nickel sulfate bath containing CeO2 nanoparticles. Statistical results indicate that current density is the most significant variable in the electrodeposition processing, while temperature is the least important factor. The microstructure of Ni and Ni-CeO2 nano-composite coatings was characterized by scanning electron microscopy （SEM） equipped with energy-disper- sive spectroscopy （EDS）, and X-ray diffraction （XRD）. The microhardness of the Ni coating is enhanced by the incorporation of CeO2 nanoparticles. Potentiodynamic polarization and electrochemical impedance spectroscopy （EIS） were used to characterize the corrosion behavior of Ni and Ni-CeO2 coatings. These studies show that Ni- CeOz coating has better corrosion resistance compared to Ni coating.

关键词： Electrodeposition Nano-composite coatings Ce02 nanoparticles Corrosion resistance

Endoscopic polidocanol foam sclerobanding for treatment of internal hemorrhoids:A novel outpatient procedure

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World Journal of Gastroenterology 2024年第42期30卷 4583-4586页

作者： An-Na Mou yu-ting wang Department of Radiology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

In the study,we comment on the article by Qu et *** hemorrhoids are the most common anorectal disorders worldwide with bleeding,prolapse,and difficulty in *** rubber band ligation(ERBL)is a safe,convenient,quick,and economical outpatient *** main goal of ERBL is to alleviate prolapse,but the high incidence of recurrence and post-procedural pain are of clinical *** foam as a local hemostatic and anesthetic agent could reduce the rates of post-procedural pain and *** polidocanol foam sclerobanding(EFSB)is a novel approach that could lift the mucosa for easy ligation and promote increased scarring in the submucosal tissue which translates into long-term relief from prolapse recurrence and reduced 24-h postprocedural *** study by Qu et al is a novel multi-center prospective randomized study to compare ERBL and EFSB in patients with grades II and III internal hemorrhoids with one-year *** showed that EFSB is a novel therapy for internal hemorrhoids,but future studies with a larger sample,multiple treatment sessions,and long-term follow-up are required to confirm these findings.

关键词： Internal hemorrhoids Goligher classification Rubber band ligation Sclerotherapy Polidocanol foam

Non-frozen process of heavy-ion fusion reactions at deep sub-barrier energies

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Nuclear Science and Techniques 2022年第10期33卷 117-125页

作者： Kai-Xuan Cheng Jie Pu yu-ting wang Ya-Fei Guo Chun-wang Ma School of Physics Henan Normal UniversityXinxiang 453007China

The hindrance in heavy-ion fusion reactions a deep sub-barrier energies is investigated using the double folding model with a hybrid method between the frozen and adiabatic density *** this method,the density distributions of the projectile and the target depend closely on the distance between *** the distance decreased,the half-density radii of the colliding nucle gradually increased to the half-density radius of the compound *** total potential based on this non-frozen approximation generates a slightly shallower pocket and becomes more attractive inside the pocket compared to that obtained from the frozen approximation.A damping factor was used to simulate the decline of the coupled channel effects owing to the density rearrangement of the two colliding *** calculated fusion cross-sections and astrophysical S factors at the deep sub-barrier energies are both in good agreement with the experimental data for the medium-heavyNi+Ni and medium-lightMg+Si mass *** addition,it was concluded that the apparent maximum of the S factors most likely appears in fusion systems with strong coupling effects.

关键词： Adiabatic approximation Double folding model Fusion hindrance

A Simple-Prepared and Multi-Reusable Adhesive Based on Epoxy Vitrimer

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Chinese Journal of Polymer Science 2024年第10期42卷 1589-1594,I0015页

作者： yu-ting wang Huan Liang Yen Wei Jian-Long wang Xiang-Ming He Yang Yang Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China

Adhesives play an important role in modern society's production and daily *** robust and sustainable adhesives remains a great *** we report a sustainable epoxy-vitrimer adhesive with high adhesive strength(about 10 MPa)and reusability(82%strength after 3 times).This adhesive can be fabricated from commercially available products through a straightforward hot-pressing method without the need of *** adhesive process is also simple,requiring only 30 min at 180℃.In addition,the vitrimer adhesive has the advantages of both erasability for reuse and excellent water *** work provides a facile strategy to fabricate high-strength adhesive that ensures reusability,recyclability,low cost of raw materials,and simple processing ***,it expands the range of potential applications for epoxy vitrimers.

关键词： Epoxy Vitrimer Adhesive Reusable Sustainable

Nitric Oxide Mediates Cytokinin Functions in Cell Proliferation and Meristem Maintenance in Arabidopsis

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Molecular Plant 2013年第4期6卷 1214-1225页

作者： Qi Shen yu-ting wang Hua Tian Fang-Qing Guo The National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research (Shanghai) Institute of Plant Physiology andEcology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China

Cytokinin and nitric oxide （NO） have been characterized as signaling molecules to trigger cell division in tissue culture. Here, we show that the hypocotyl and root explants of Arabidopsis NO-deficient mutant nosl/noal exhibit severe defects in callus induction and shoot regeneration in response to cytokinin. Accordingly, depletion of NO caused by a NO scavenger leads to a severe inhibitory effect on callus induction. Moreover, cytokinin-induced NO production is impaired in nosl/noal in which cytokinin-triggered activation of cell cycle gene CYCD3;1 is inhibited, indicating that NO may act downstream of cytokinin in the control of cell proliferation through CYCD3;1. This hypothesis is further con- firmed by the genetic evidence that constitutive expression of CYCD3;1 complements the defects of nosl/noal mutant in meristematic activity in shoot, root, and floral tissues as well as in cytokinin-induced callus initiation and shoot regen- eration. Furthermore, we show that NO deficiency caused by loss of NOSl/NOA1 impairs cellular development such as the duration of the mitotic phase and timing of the transition to endocycles in nosl/noal mutant leaves, which can be reverted by constitutive expression of CYCD3;1. Taken together, these results demonstrate that NO mediates transcrip- tional activation of CYCD3,1 in regulating the mitotic cycles in response to cytokinins.

关键词： nitric oxide cytokinins cell proliferation CYCD3 1 shoot regeneration endocycles.

Reconstructing the temporal evolution of the speed of light in a flat FRW Universe

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Research in Astronomy and Astrophysics 2019年第10期19卷 138-144页

作者： Dan-Dan wang Han-yu Zhang Jing-Lan Zheng yu-ting wang Gong-Bo Zhao National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Department of Physics Kansas State University116 Cardwell HallManhattanKS 66506USA School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing 100049 China Institute of Cosmology and Gravitation University of Portsmouth Portsmouth POl 3FX UK

We present a novel method to reconstruct the temporal evolution of the speed of light c(z) in a flat Friedmann-Robertson-Walker(FRW) Universe using astronomical observations. After validating our pipeline with mock datasets, we apply our method to the latest baryon acoustic oscillations(BAO) and supernovae observations, and reconstruct c(z) in the redshift range of z ∈[0, 1.5]. We find no evidence of a varying speed of light, although we see some interesting features of △c(z), the fractional difference between c(z) and c0(the speed of light in the International System of Units), e.g.,△c(z) 0 at 0.2≤z≤0.5 and 0.8≤z≤1.3, respectively, although the significance of these features is currently far below statistical importance.

关键词： cosmology-dark energy-large scale structure

Probing dynamics of dark energy with latest observations

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Research in Astronomy and Astrophysics 2017年第6期17卷 5-10页

作者： yue-Cheng Zhang Han-yu Zhang Dan-Dan wang Yang-Han Qi yu-ting wang Gong-Bo Zhao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China University of Chinese Academy of Sciences Beijing 100049 China Department of Physics & Astronomy Swarthmore College Swarthmore PA 19081 USA Institute of Cosmology and Gravitation University of Portsmouth Portsmouth PO1 3FX UK

We examine the validity of the ACDM model and probe the dynamics of dark energy with the latest astronomical observations. Using the Ore（z） diagnosis, we find that various kinds of observational data are in tension within the ACDM framework. We then allow for dynamics of dark energy and investigate the constraint on dark energy parameters. We find that for two different kinds of parametri- sations of the equation of state parameter w, a combination of current data mildly favours an evolving w, although the significance is not sufficient for it to be supported by Bayesian evidence. A forecast of the DESI survey shows that the dynamics of dark energy could be detected at the 7σ confidence level and would be decisively supported by Bayesian evidence, if the best-fit model of w derived from current data is the true model.

关键词： cosmology - dark energy - large scale structure

Research on the influences of confining pressure and strain rate on NEPE propellant:Experimental assessment and constitutive model

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Defence Technology（防务技术） 2021年第5期17卷 1764-1774页

作者： Hui Li Jin-sheng Xu Jia-ming Liu ting-yu wang Xiong Chen Hong-wen Li School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China Technology Center Jinxi Industries Group CorporationTaiyuan030027China

In order to study the influences of confining pressure and strain rate on the mechanical properties of the Nitrate Ester Plasticized Polyether(NEPE)propellant,uniaxial tensile tests were conducted using the selfmade confining pressure system and material testing *** stress-strain responses of the NEPE propellant under different confining pressure conditions and strain rates were obtained and *** results show that confining pressure and strain rate have a remarkably influence on the mechanical responses of the NEPE *** confining pressure increases(from 0 to 5.4 MPa),the maximum tensile stress and ultimate strain increase *** the coupled effects of confining pressure and strain rate,the value of the maximum tensile stress and ultimate strain at 5.4 MPa and 0.0667 s^(-1)is 2.03 times and 2.19 times of their values under 0 MPa and 0.00333 s^(-1),***,the influence mechanism of confining pressure on the NEPE propellant was ***,based on the viscoelastic theory and continuous damage theory,a nonlinear constitutive model considering confining pressure and strain rate was *** damage was considered to be rate-dependent and *** constitutive model was validated by comparing experimental data with predictions of the constitutive *** whole maximum stress errors of the model predictions are lower than 4%and the corresponding strain errors are lower than 7%.The results show that confining pressure can suppress the damage initiation and evolution of the NEPE propellant and the nonlinear constitutive model can describe the mechanical responses of the NEPE propellant under various confining pressure conditions and strain *** research can lay a theoretical foundation for analyzing the structural integrity of propellant grain accurately under working pressure loading.

关键词： Confining pressure Strain rate NEPE propellant Constitutive model Damage

Mechanical characteristic and failure mechanism of joint with composite sucker rod

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Petroleum Science 2023年第5期20卷 3172-3183页

作者： Yan-Wen Zhang Jia-Qi Che Han-Xiang wang Jin Zhang Feng Li Ming-Chao Du yu-ting wang College of Mechanical and Electronic Engineering China University of Petroleum(East China)Qingdao266580ShandongChina National Petroleum Corporation Offshore Engineering(Qingdao)Company Limited Qingdao266520ShandongChina Technical Testing Center of SINOPEC Shengli Oilfield Co.Dongying257088ShandongChina College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao266590ShandongChina

Composite sucker rods are widely used in oil fields because of light weight,high strength,and corrosion *** technology becomes the primary connection method of ***,the joints with composite sucker rods are prone to debone and *** connected characteristics are less considered,so the failure mechanism of the joint is still *** on the cohesive zone model(CZM)and the Johnson-Cook constitutive model,a novel full-scale numerical model of the joint with composite sucker rod was established,and verified by pull-out *** mechanical properties and slip characteristics of the joint were studied,and the damaged procession of the joint was *** results showed that:a)the numerical model was in good agreement with the experimental results,and the error is within 5%;b)the von Mises stress,shear stress,and interface stress distributed symmetrically along the circumferential path increased gradually from the fixed end to the loading end;c)the first-bonded interface near the loading end was damaged at first,followed by debonding of the second-bonded interface,leading to the complete shear fracture of the epoxy,and resulted in the debonding of the joint with composite sucker rod,which can provide a theoretical basis for the structural design and optimization of the joint.

关键词： Joint with composite sucker rod Numerical model Connected characteristics Failure mechanism Tensile tests