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Factors and Their Impact on Treatment Effect of Acupuncture in Different Outcomes:A Meta-Regression of Acupuncture Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2024年第3期30卷 260-266页

作者： XIU Wen-cui GANG Wei-juan ZHOU Qi shi Lan-jun HU Xiang-yu MING Tian-yu luo Zhen ZHANG yu-qing JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing100700China China Center for Evidence-Based Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonOntarioL8S 4L8Canada Center for Evidence-Based Integrative Medicine-Clarity Collaboration Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China

Background:The effects of acupuncture have varied in different randomized controlled trials(RCTs),and there are many factors that influence treatment effect of acupuncture in different outcomes,with conflicting results.Objective:To identify factors and their impact on the treatment effect of acupuncture in different outcomes.Methods:Acupuncture RCTs were searched from 7 databases including Medline(Pub Med),Embase,Cochrane Central Register of Controlled Trials,China National Knowledge Infrastructure,Wanfang Database,VIP Database,and China Biology Medicine disc between January 1st,2015 and December 31st,2019.Eligible studies must compare acupuncture to no acupuncture,sham acupuncture,or waiting lists,and report at least 1patient-important outcome.A multi-level meta-regression was conducted using a 3-level robust mixed model and univariate analyses were performed for all independent variables,even those excluded from the multivariable model due to collinearities.We used thresholds of 0.2 and 0.4 for the difference of standardized mean differences(SMDs),categorising them as small(0.4) effects.Results:The pain construct analysis involved 211 effect estimates from 153 studies and 14 independent variables.High-frequency acupuncture treatment sessions produced larger effects compared to low-frequency sessions [large magnitude,the difference of adjusted SMDs 0.46,95% confidence interval(CI) 0.07 to 0.84;P=0.02].The non-pain symptoms construct analysis comprised 323 effect estimates from 231 studies and 15 independent variables.Penetrating acupuncture showed moderately larger effects when compared to non-penetrating acupuncture(0.30,95% CI 0.06 to 0.53;P=0.01).The function construct analysis included 495 effect estimates from 274 studies and 14 independent variables.Penetrating acupuncture and the flexible acupuncture regimen showed moderately larger effects,compared to non-penetrating acupuncture and fixed regimen,respectively(0.40,95% CI 0 to 0.80;P=0.05;0.29,95% CI 0.06 to 0.53;P=0.01).

关键词： acupuncture randomized controlled trial patient-important outcome meta-regression

The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： shi Lin yu Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie groups.Only even quantizations were considered there.In this paper,these results are generalized to the case of general quantizations with arbitrary periods.The key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over X.As an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

The dual role of striatal interneurons: circuit modulation and trophic support for the basal ganglia

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Neural Regeneration Research 2024年第6期19卷 1277-1283页

作者： Elliot Wegman Marlena Wosiski-Kuhn yu luo Department of Molecular and Cellular Biosciences University of Cincinnati 2. Department of Emergency Medicine at the School of Medicine University of Cincinnati Neuroscience Graduate Program University of Cincinnati

Striatal interneurons play a key role in modulating striatal-dependent behaviors, including motor activity and reward and emotional processing. Interneurons not only provide modulation to the basal ganglia circuitry under homeostasis but are also involved in changes to plasticity and adaptation during disease conditions such as Parkinson’s or Huntington’s disease. This review aims to summarize recent findings regarding the role of striatal cholinergic and GABAergic interneurons in providing circuit modulation to the basal ganglia in both homeostatic and disease conditions. In addition to direct circuit modulation, striatal interneurons have also been shown to provide trophic support to maintain neuron populations in adulthood. We discuss this interesting and novel role of striatal interneurons, with a focus on the maintenance of adult dopaminergic neurons from interneuronderived sonic-hedgehog.

关键词： cholinergic dopamine GABAergic interneuron levodopa-induced dyskinesia parvalbumin sonic hedgehog striatum trophic factor

Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： shi-Lin Lv Pei Guo Jun-Rong Zou Ren-Sheng Chen Ling-yu luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis.SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.AIM To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer.METHODS This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April 2007.Patients were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)staining.The expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC patients.Prognosis and survival information of the patients was recorded by Outdo Biotech from May 2007 to July 2015.The relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation coefficient.The relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival analysis.RESULTS TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous tissue.The positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multivariate analysis indicated that high expression of

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1

Alcohol solvent effect on the self-assembly behaviors of lignin oligomers

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Green Energy & Environment 2024年第4期9卷 597-603页

作者： Ya Ma Zhicheng Jiang Yafei luo Xingjie Guo Xudong Liu Yiping luo Bi shi College of Biomass Science and Engineering Sichuan UniversityChengdu610065China National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu610065China College of Pharmacy(International Academy of Targeted Therapeutics and Innovation) Chongqing University of Arts and SciencesChongqing402160China State Key Laboratory of Utilization of Woody Oil Resource Hunan Academy of ForestryChangsha410004China CAS Key Laboratory of Environmental and Applied Microbiology Environmental Microbiology Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu610041China

The interactions between lignin oligomers and solvents determine the behaviors of lignin oligomers self-assembling into uniform lignin nanoparticles(LNPs).Herein,several alcohol solvents,which readily interact with the lignin oligomers,were adopted to study their effects during solvent shifting process for LNPs’production.The lignin oligomers with widely distributed molecular weight and abundant guaiacyl units were extracted from wood waste(mainly consists of pine wood),exerting outstanding self-assembly capability.Uniform and spherical LNPs were generated in H_(2)O-n-propanol cosolvent,whereas irregular LNPs were obtained in H_(2)O-methanol cosolvent.The unsatisfactory self-assembly performance of the lignin oligomers in H_(2)O-methanol cosolvent could be attributed to two aspects.On one hand,for the initial dissolution state,the distinguishing Hansen solubility parameter and polarity between methanol solvent and lignin oligomers resulted in the poor dispersion of the lignin oligomers.On the other hand,strong hydrogen bonds between methanol solvent and lignin oligomers during solvent shifting process,hindered the interactions among the lignin oligomers for self-assembly.

关键词： Lignin oligomers Alcohol solvent Self-assembly LNPs Solvent effects

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li yu-shi Jiang Xue-Ling luo Xuming Ran yuqiang Li Dong Wu Cheng-Xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer catalysis.The reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated manner.The strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and anti-stereoselectivity.Through the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive system.Results revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl radicals.This discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Recent progress in all-inorganic tin-based perovskite solar cells:a review

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Science China Chemistry 2024年第4期67卷 1117-1136页

作者： Minghao Wang yu shi School of Electronics and Information Engineering Wuxi UniversityWuxi 214105China Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China

Recently,power conversion efficiency(PCE)of organic-inorganic hybrid perovskite solar cells(PSCs)has been improved to26.1%.However,the toxicity issue of lead still hinders the large-scale commercial production and application of lead(Pb)-based halide perovskites.Fortunately,environmentally friendly tin(Sn)-based perovskites have recently shown excellent performance.Among them,the all-inorganic Sn-based perovskites,including CsSnX_(3) and Cs_(2)SnX_(6),have better stability,more suitable bandgap,and higher charge mobility,which have attracted more attention from researchers than organic-inorganic Sn-based hybrid perovskites.Herein,we review recent research progress on all-inorganic Sn-based perovskite materials and corresponding solar cell devices.Finally,we also summarize the current challenges and future research directions for this type of PSCs.

关键词： solar cells perovskite all-inorganic CsSnX_(3) Cs_(2)SnX_(6)

Multimodal Fusion of Brain Imaging Data: Methods and Applications

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Machine Intelligence Research 2024年第1期21卷 136-152页

作者： Na luo Weiyang shi Zhengyi Yang Ming Song Tianzi Jiang Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Augmented Intelligence Zhejiang LaboratoryHangzhou 311100China

Neuroimaging data typically include multiple modalities,such as structural or functional magnetic resonance imaging,dif-fusion tensor imaging,and positron emission tomography,which provide multiple views for observing and analyzing the brain.To lever-age the complementary representations of different modalities,multimodal fusion is consequently needed to dig out both inter-modality and intra-modality information.With the exploited rich information,it is becoming popular to combine multiple modality data to ex-plore the structural and functional characteristics of the brain in both health and disease status.In this paper,we first review a wide spectrum of advanced machine learning methodologies for fusing multimodal brain imaging data,broadly categorized into unsupervised and supervised learning strategies.Followed by this,some representative applications are discussed,including how they help to under-stand the brain arealization,how they improve the prediction of behavioral phenotypes and brain aging,and how they accelerate the biomarker exploration of brain diseases.Finally,we discuss some exciting emerging trends and important future directions.Collectively,we intend to offer a comprehensive overview of brain imaging fusion methods and their successful applications,along with the chal-lenges imposed by multi-scale and big data,which arises an urgent demand on developing new models and platforms.

关键词： Multimodal fusion supervised learning unsupervised learning brain atlas cognition brain disorders

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

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Genes & Diseases 2024年第3期11卷 368-384页

作者： yulu shi Quan Kang Hong Zhou Xiaohan yue Yang Bi Qing luo Stem Cell Biology and Therapy Laboratory The Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Pediatric Surgery The Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Osteosarcoma is a differentiation-deficient disease,and despite the unique advan-tages and great potential of differentiation therapy,there are only a few known differentia-tion inducers,and little research has been done on their targets.Cell differentiation is associated with an increase in mitochondrial content and activity.The metabolism of some tu-mor cells is characterized by impaired oxidative phosphorylation,as well as up-regulation of aerobic glycolysis and pentose phosphate pathways.Leucine-containing zipper and EF-hand transmembrane protein 1(LETM1)is involved in the maintenance of mitochondrial morphology and is closely associated with tumorigenesis and progression,as well as cancer cell stemness.We found that MG63 and 143B osteosarcoma cells overexpress LETM1 and exhibit abnormalities in mitochondrial structure and function.Knockdown of LETM1 partially restored the mitochon-drial structure and function,inhibited the pentose phosphate pathway,promoted oxidative phosphorylation,and led to osteogenic differentiation.It also inhibited spheroid cell forma-tion,proliferation,migration,and invasion in an in vitro model.When LETM1 was knocked down in vivo,there was reduced tumor formation and lung metastasis.These data suggest that mitochondria are aberrant in LETM1-overexpressing osteosarcoma cells,and knockdown of LETM1 partially restores the mitochondrial structure and function,inhibits the pentose phosphate pathway,promotes oxidative phosphorylation,and increases osteogenic differentiation,thereby reducing malignant biological behavior of the cells.

关键词： Cancer metabolism Differentiation LETM1 Osteosarcoma Stemness