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Dual energy computed tomography for detection of metastatic lymph nodes in patients with hepatocellular carcinoma

World Journal of Gastroenterology 2019年第16期25卷 1986-1996页

作者： yu-rong zeng Qi-Hua Yang Qing-yu Liu Jun Min Hai-Gang Li Zhi-Feng Liu Ji-Xin Li Department of Radiology Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Hepatobiliary Surgery Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Pathology Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Radiology Zengcheng District People’s Hospital of Guangzhou

BACKGROUND Regional lymph node metastasis in patients with hepatocellular carcinoma(HCC)is not uncommon, and is often under-or misdiagnosed. Regional lymph node metastasis is associated with a negative prognosis in patients with HCC, and surgical resection of lymph node metastasis is considered feasible and efficacious in improving the survival and prognosis. It is critical to characterize lymph node preoperatively. There is currently no consensus regarding the optimal method for the assessment of regional lymph nodes in patients with *** To evaluate the diagnostic value of single source dual energy computed tomography(CT) in regional lymph node assessment for HCC *** Forty-three patients with pathologically confirmed HCC who underwent partial hepatectomy with lymphadenectomy were retrospectively enrolled. All patients underwent dual-energy CT preoperatively. Regional lymph nodes(n = 156) were divided into either a metastatic(group P, n = 52) or a non-metastasis group(group N, n = 104), and further, according to pathology, divided into an active hepatitis(group P1, n = 34; group N1, n = 73) and a non-active hepatitis group(group P2, n = 18; group N2, n = 31). The maximal short axis diameter(MSAD),iodine concentration(IC), normalized IC(NIC), and the slope of the spectralcurve(λ_(HU)) of each group in the arterial phase(AP), portal phase(PP), and delayed phase(DP) were *** Analysis of the MSAD, IC, NIC, and λ_(HU) showed statistical differences between groups P and N(P < 0.05) during all three phases. To distinguish benign from metastatic lymph nodes, the diagnostic efficacy of IC, NIC, and λ_(HU) in the PP was the best among the three phases(AP, PP, and DP), with a sensitivity up to 81.9%,83.9%, and 81.8%, and a specificity up to 82.4%, 84.1% and 84.1%, *** diagnostic value of combined analyses of MSAD with IC, NIC, or λ_(HU) in the PP was superior to the dual energy CT parameters alone, with a sensitivity up to84.5%, 86.9%

关键词： Computed tomography Hepatocellular carcinoma Lymph node Metastasis Hepatitis Dual energy

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前列腺调强放射治疗中摆位对正常组织剂量的影响

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中国医学工程 2005年第1期13卷 49-51,58页

作者：余增荣广东省江门市中心医院肿瘤科广东江门529030

目的量化利用计划危及器官区(PORV)对股骨头的剂量影响,同时评估虽因临床上小的摆位误差但运用计划危及器官区(PORV)却能约束正常组织的剂量。方法首先给十位前列腺癌患者用五野调强计划进行优化,然后用外扩股骨头5mm的计划危及器官区... 详细信息

目的量化利用计划危及器官区(PORV)对股骨头的剂量影响,同时评估虽因临床上小的摆位误差但运用计划危及器官区(PORV)却能约束正常组织的剂量。方法首先给十位前列腺癌患者用五野调强计划进行优化,然后用外扩股骨头5mm的计划危及器官区再优化。模拟治疗最差的情况下,将治疗等中心上下、左右、前后六个方面移动5mm以模拟系统摆位的不确定性,对每一计划不进行优化,剂量分布重新计算,每个病人产生六个不用计划危及器官区(PORV)的计划和六个用计划危及器官区(PORV)的计划。结果增加了计划危及器官区(PORV)及进行再优化并没有很大程度影响PTV、直肠、膀胱及股骨头的受照射剂量,相反,没移动等中心位置,用计划危及器官区(PORV)可限制股骨头的剂量升高,同时减少股骨头毗邻区域的面积。模拟移动等中心位置,对侧股骨头的剂量会因向对侧移动中心位置而提高很多,如右股骨头用计划危及器官区(PORV)其超过50Gy的剂量会从8.07%减少到5.95%。结论运用计划危及器官区(PORV)可以限制正常组织结构的体积及受照射量,如右股骨头,从而减少因摆位误差而造成剂量的改变。

关键词：股骨头剂量正常组织治疗前列腺摆位器官区域限制模拟系统

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一楔合成楔形板的楔形板因子(WF)与射野大小及不规则野的关系

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中国医学工程 2005年第4期13卷 358-359页

作者：余增荣广东省江门市中心医院肿瘤科广东江门529030

目的探讨楔形因子与射野大小及不规则射野之间的关系。方法用PTW剂量仪及电离室对北京医研所BJ-6B直线加速器的一楔合成60°楔形板不同照射野及不规则射野的楔形因子进行测量。结果BJ-6B直线加速器一楔合成楔形板其楔形因子随射大小变... 详细信息

目的探讨楔形因子与射野大小及不规则射野之间的关系。方法用PTW剂量仪及电离室对北京医研所BJ-6B直线加速器的一楔合成60°楔形板不同照射野及不规则射野的楔形因子进行测量。结果BJ-6B直线加速器一楔合成楔形板其楔形因子随射大小变化而变化,并且其楔形因子随不规则射野的变化,X和Y方向上都有变化。结论在放射治疗计算中,一定要重视射野大小及不规则野对楔形因子的影响。

关键词：楔形板一楔合成楔形因子射野大小不规则野

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基因工程表达产物的体外酰胺化加工

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生物化学与生物物理学报 2000年第3期32卷 312-315页

作者：杨宇虹陈虎俞超曾嵘崔大敷吴祥甫李伯良中国科学院上海生物化学研究所!上海200031 中国科学院上海?

以C端为甘氨酸的修饰型人降钙素 (mhCT Gly)的融合蛋白为底物和利用重组酰胺化酶 ,研究建立基因工程表达产物的体外酰胺化加工系统。首先 ,人工合成mhCT Gly基因 ,并构建其融合表达质粒 pGEXCT ,在大肠杆菌中获得了高效表达并通过亲和... 详细信息

以C端为甘氨酸的修饰型人降钙素 (mhCT Gly)的融合蛋白为底物和利用重组酰胺化酶 ,研究建立基因工程表达产物的体外酰胺化加工系统。首先 ,人工合成mhCT Gly基因 ,并构建其融合表达质粒 pGEXCT ,在大肠杆菌中获得了高效表达并通过亲和层析分离纯化获得谷胱甘肽S 转移酶 (GST)融合蛋白 (GST mhCT Gly)。同时 ,从稳定表达大鼠酰胺化酶的CHO细胞株中制备了重组酰胺化酶。然后 ,利用此重组酰胺化酶对GST mhCT Gly进行体外酰胺化加工研究。特异性抗体免疫结合实验和质谱鉴定结果表明 ,融合表达蛋白GST mhCT Gly已被重组酰胺化酶酰胺化加工修饰。

关键词：人降钙素基因工程表达重组酰胺化酶体外酰胺化加工

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu yushan Chen Zhen Wei yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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三维适形半野轮照放疗技术治疗局部晚期原发性肝癌的临床疗效

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中国实用医药 2016年第29期11卷 13-15页

作者：饶建余增容吴庭安广东省江门市中心医院 529070

目的探讨全肝或部分肝的三维适形半野轮照放射治疗(放疗)技术治疗局部晚期原发性肝癌的临床疗效。方法 40例局部晚期肝癌,随机给予三维适形半野轮照放疗技术治疗(放疗组)和最佳支持治疗(对照组),各20例。观察两组中位总生存期(OS)、中... 详细信息

目的探讨全肝或部分肝的三维适形半野轮照放射治疗(放疗)技术治疗局部晚期原发性肝癌的临床疗效。方法 40例局部晚期肝癌,随机给予三维适形半野轮照放疗技术治疗(放疗组)和最佳支持治疗(对照组),各20例。观察两组中位总生存期(OS)、中位无疾病进展时间(DFS),并观察放疗组治疗并发症情况。结果放疗组中位总生存期10.0个月,中位无疾病进展时间(DFS)7.0个月;对照组中位总生存期7.0个月,中位无疾病进展时间3.0个月;放疗组中位总生存期、中位无疾病进展时间均优于对照组(P<0.05)。放疗组未见肝功能进行性恶化、黄疸、腹水等放射性肝炎症状发生。结论根据患者的个体情况采用半野轮照放疗技术作为局部晚期原发性肝癌辅助治疗手段,可获得较好疗效,毒副作用可耐受。

关键词：原发性肝癌适形放疗半野照射

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Interpretable Tourism Demand Forecasting with Two-Stage Decomposition and Temporal Fusion Transformers

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Journal of Systems Science & Complexity 2024年第6期37卷 2654-2679页

作者： WU Binrong WANG Lin zeng yu-rong Business School Hohai UniversityNanjing 211100China School of Management Huazhong University of Science and TechnologyWuhan 430074China School of Information Engineering Hubei University of EconomicsWuhan 430205China

This paper proposes a novel interpretable tourism demand forecasting framework that considers the impact of the COVID-19 pandemic by using multi-source heterogeneous data,namely,historical tourism volume,newly confirmed cases in tourist origins and destinations,and search engine *** paper introduces newly confirmed cases in tourist origins and tourist destinations to forecast tourism demand and proposes a new two-stage decomposition method called ensemble empirical mode decomposition-variational mode decomposition to deal with the tourist arrival *** solve the problem of insufficient interpretability of existing tourism demand forecasting,this paper also proposes a novel interpretable tourism demand forecasting model called JADE-TFT,which utilizes an adaptive differential evolution algorithm with external archiving(JADE)to intelligently and efficiently optimize the hyperparameters of temporal fusion transformers(TFT).The validity of the proposed prediction framework is verified by actual cases based on Hainan and Macao tourism data *** interpretable experimental results show that newly confirmed cases in tourist origins and tourist destinations can better reflect tourists'concerns about travel in the post-pandemic era,and the two-stage decomposition method can effectively identify the inflection point of tourism prediction,thereby increasing the prediction accuracy of tourism demand.

关键词： COVID-19 interpretable deep learning search engine data tourism demand forecasting

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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

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血管内皮生长因子在乳腺癌中的表达及与分子分型的关系

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蚌埠医学院学报 2014年第10期39卷 1333-1336页

作者：袁媛范宏娟于增荣施慧河北省唐山市妇幼保健院普外科 063000 山西省介休市人民医院急诊科 032000

目的：检测血管内皮生长因子（VEGF）在乳腺癌中的表达情况,探讨其与乳腺癌临床病理参数及分子分型之间的关系。方法：采用免疫组织化学法检测乳腺癌标本中VEGF、雌激素受体、孕激素受体、人表皮生长因子受体2（Her-2）及增殖细胞核抗... 详细信息

目的：检测血管内皮生长因子（VEGF）在乳腺癌中的表达情况,探讨其与乳腺癌临床病理参数及分子分型之间的关系。方法：采用免疫组织化学法检测乳腺癌标本中VEGF、雌激素受体、孕激素受体、人表皮生长因子受体2（Her-2）及增殖细胞核抗原67的表达情况。对Her-2（2＋）的组织进行荧光原位杂交检测。根据雌激素受体、孕激素受体、Her-2及增殖细胞核抗原67的表达情况,将乳腺癌标本分为4个亚型,检测VEGF在各分子亚型中的表达情况。结果：VEGF在乳腺癌组织组中的阳性率显著高于良性病变组及癌旁组织组（P〈0.01）。VEGF在淋巴结转移者中的阳性率高于无淋巴结转移者（P〈0.05）。VEGF的阳性率均随着组织学分级、临床分期的升高而升高（P〈0.05-P〈0.01）。在不同乳腺癌分子亚型中,Basal-like型乳腺癌组织中VEGF的阳性率高于Luminal A型（P〈0.05）。结论：VEGF参与乳腺癌的发生、发展及浸润转移过程,有可能成为指导临床治疗的重要靶向指标之一。将乳腺癌中VEGF的表达情况与乳腺癌分子分型相互结合,有助于肿瘤恶性程度及预后的判断,有可能成为指导分子分型的又一重要指标。

关键词：乳腺肿瘤血管内皮生长因子免疫组织化学荧光原位杂交分子分型

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