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Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng Wei yu-qing huang Cheng-Hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

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Causal relationship association of cheese intake with gestational hypertension and diabetes result from a Mendelian randomization study

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World Journal of Clinical Cases 2023年第30期11卷 7318-7328页

作者： Tao Zhong yu-qing huang Gui-Ming Wang Department of Cardiology The First Hospital of NanchangNanchang 330008Jiangxi ProvinceChina Department of Cardiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina

BACKGROUND The evidence from observational studies has been inconclusive on the causal relationship between cheese intake and gestational hypertension or *** To determine whether cheese consumption was causally related to hypertension and diabetes during *** This was a two-sample Mendelian randomized(MR)***-level genetic data for cheese intake was exposure and corresponding outcome data for gestational hypertension and gestational diabetes were extracted from the IEU OpenGWAS *** analysis was conducted using inverse variance *** sensitivity analyses,MR-Egger regression,weighted median,weighted mode,and leave-one-out methods were conducted.A fixed-effect model was used to meta-analyze two sample MR *** traits of gestational hypertension were pregnancy hypertension(123579 individuals)and oedema,proteinuria and hypertensive disorders in pregnancy,childbirth and the puerperium(123579 individuals),and traits of gestational diabetes were gestational diabetes(123579 individuals)and diabetes mellitus in pregnancy(116363 individuals),*** Cheese intake per standard deviation increase has causally reduced the risks of gestational hypertension[odds ratio(OR)=0.60,95%confidence interval(CI):0.47-0.76,P0.05)nor horizontal pleiotropy(all P>0.05)in the relationship between cheese intake and gestational hypertension,but heterogeneity presented(all P<0.05)in relation to gestational diabetes in the two-sample MR *** Cheese intake was inversely associated with gestational hypertension and gestational diabetes in MR analysis,suggesting that cheese consumption may be beneficial in preventing hypertension and diabetes during pregnancy.

关键词： Cheese intake Gestational hypertension Gestational diabetes Mendelian randomization

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Magnetotransport properties of graphene layers decorated with colloid quantum dots

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Chinese Physics B 2019年第6期28卷 361-365页

作者： Ri-Jia Zhu yu-qing huang Jia-yu Li Ning Kang Hong-Qi Xu School of Physics Dalian University of TechnologyDalian 116024China Beijing Key Laboratory of Quantum Devices Key Laboratory for Physics and Chemistry of Nanodevices and Department of ElectronicsPeking UniversityBeijing 100871China Division of Solid State Physics Lund UniversityP.O.Box 118S-22100 LundSweden

The hybrid graphene-quantum dot devices can potentially be used to tailor the electronic, optical, and chemical properties of graphene. Here, the low temperature electronic transport properties of bilayer graphene decorated with PbS colloid quantum dots(CQDs) have been investigated in the weak or strong magnetic fields. The presence of the CQDs introduces additional scattering potentials that alter the magnetotransport properties of the graphene layers, leading to the observation of a new set of magnetoconductance oscillations near zero magnetic field as well as the high-field quantum Hall *** results bring about a new strategy for exploring the quantum interference effects in two-dimensional materials which are sensitive to the surrounding electrostatic environment, and open up a new gateway for exploring the graphene sensing with quantum interference effects.

关键词： graphene colloid quantum dots quantum Hall effect Aharonov–Bohm oscillations

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Origin of dolomite in the Middle Ordovician peritidal platform carbonates in the northern Ordos Basin, western China

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Petroleum Science 2016年第3期13卷 434-449页

作者： Xiao-Liang Bai Shao-Nan Zhang qing-yu huang Xiao-Qi Ding Si-Yang Zhang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University School of Geoscience and Technology Southwest Petroleum University Research Institute of Petroleum Exploration & Development PetroChina College of Energy Chengdu University of Technology Department of Geology University of Regina

The carbonates in the Middle Ordovician Ma_5～5submember of the Majiagou Formation in the northern Ordos Basin are partially to completely *** types of replacive dolomite are distinguished：（1） type 1dolomite,which is primarily characterized by microcrystalline（〈30 urn）,euhedral to subhedral dolomite crystals,and is generally laminated and associated with gypsumbearing microcrystalline dolomite,and（2） type 2 dolomite,which is composed primarily of finely crystalline（30-100 urn）,regular crystal plane,euhedral to subhedral *** type 2 dolomite crystals are truncated by stylolites,indicating that the type 2 dolomite most likely predated or developed simultaneously with the formation of the ***,petrographic,and geochemical data indicate that the type 1 dolomite formed from near-surface,low-temperature,and slightly evaporated seawater and that the dolomitizing fluids may have been driven by density differences and elevation-related hydraulic *** absence of massive depositional evaporites in the dolomitized intervals indicates that dolomitization was driven by the reflux of slightly evaporated *** δ～（18）O values（-7.5 to-6.1 ‰） of type1 dolomite are slightly lower than those of seawaterderived dolomite,suggesting that the dolomite may be related to the recrystallization of dolomite at higher temperatures during *** type 2 dolomite has lowerδ～（18）O values（-8.5 to-6.7 ‰） and Sr～（2＋） concentration and slightly higher Na～＋,Fe～（2＋）,and Mn～（2＋） concentrations and～（87）Sr/～（86）Sr ratios（0.709188-0.709485） than type 1 dolomite,suggesting that the type 2 dolomite precipitated from modified seawater and dolomitic fluids in pore water and that it developed at slightly higher temperatures as a result of shallow burial.

关键词： Carbonate platform Dolomitization Dolomite Middle Ordovician Ma_5~5 submember Dolomitizing fluids

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The Potential Immunomodulatory Properties of Levornidazole Contribute to Improvement in Experimental Ulcerative Colitis

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Current Medical Science 2021年第4期41卷 746-756页

作者： Xing-qi WANG Hao CHEN yu-zhi GAO Yan-xiu huang Rui-juan ZHANG Jun XIE yu LI yu-qing huang Ling-shan GOU Rui-qin YAO School of Life Science Jiangsu Normal UniversityXuzhou221116China The Affiliated Hospital of Xuzhou Medical University Xuzhou Medical UniversityXuzhou221600China Department of Cell Biology Xuzhou Medical UniversityXuzhou221009China Center for Genetic Medicine Xuzhou Maternity and Child Health Care HospitalXuzhou221009China

The use of an antibiotic with immunomodulatory properties could be fascinating in treating multifactorial inflammatory conditions such as ulcerative colitis(UC).We report our investigations into the immunomodulatory properties of levornidazole,the S-enantiomer of ornidazole,which displayed a tremendous therapeutic potential in UC induced by dextran sodium sulfate(DSS).Levornidazole administration to DSS-colitic mice attenuated the intestinal inflammatory process,with an efficacy better than that shown by 5-amino salicylic *** was evidenced by decreased disease activity index,ameliorated macroscopic and microscopic colon damages,and reduced expression of inflammatory ***,levornidazole displayed anti-inflammatory activity through Caveolin-1-dependent reducing IL-1βand IL-18 secretion by macrophages contributing to its improvement of the intestinal inflammation,as confirmed in vitro and in *** conclusion,these results pointed out that the immunomodulatory effects of levornidazole played a vital role in ameliorating the intestinal inflammatory process,which would be crucial for the translation of its use into clinical settings.

关键词： levornidazole immunomodulatory antibiotic ulcerative colitis Caveolin-1 macrophage

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Application of endovascular pure electrocoagulation in the management of coronary artery perforation during percutaneous coronary intervention

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Journal of Geriatric Cardiology 2021年第3期18卷 240-244页

作者： qing-yu huang Bang-Wei WU Bo JIN Wei SHEN Mazin Eisa Xin-Ping LUO Jian LI Department of Cardiology North Huashan HospitalFudan UniversityShanghaiChina Department of Cardiology Huashan HospitalFudan UniversityShanghaiChina Shanghai Medical College of Fudan University ShanghaiChina

Coronary artery perforation(CAP)during percutaneous coronary intervention(PCI)is a serious complication associated with significant morbidity and *** incidence in the general PCI population has been reported to range from 0.50%to 0.58%.Meanwhile,in chronic total occlusion(CTO)PCI procedure,the incidence increased to 1.4%−4.4%.[1]Currently,most of CAPs are distally located and related to guidewire,especially hydrophilic guidewire manipulations.[2]To avoid urgent or emergency cardiac surgery,some commonly used techniques include balloon inflations,covered stents,and coil embolization stand as representative options in the treatment of CAP.[3]Despite the availability of treatment approaches,there is still a lack of a standard consensus about the optimal management of this challenging *** pure electrocoagulation is a new approach that has been reported in the management of small vessel hemorrhage disease in cerebrovascular intervention,it can also provide promising results in CAP management.

关键词： coronary balloon treatment

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Effects of Guideline-based Hypertension Management in Rural Areas of Guangdong Province

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Chinese Medical Journal 2015年第6期128卷 799-803页

作者： Guang Li An-Ping Cai yu-Jin Mo Ji-Yan Chen Rui-Bing Wei yu-qing huang Song-Tao Tang Ying-Ling Zhou Ying-qing Feng Department of Cardiology Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Community Health Services Center of D-onguang Liaobu Donguang Guangdong 523000 China

Background:Despite the improvement in the health care industry,the rates of undetected,untreated,and uncontrolled hypertension (HTN)are still very high,especially in rural areas of *** aim of this study was to investigate the efficacy and efficiency of a guideline-based HTN management (novel therapy) in population of rural areas of Guangdong ***:Totally,3113 patients with essential HTN in a rural area of Guangdong Province were enrolled and assigned to two groups,named traditional (n =372) and novel therapeutic (n =2741) groups,*** in the traditional group were treated routinely,and patients in the novel group were treated in a novel model characterized by regular educational programs for hypertensive populations,close monitoring of blood pressure in combination with finely tuned antihypertensive medications,strict implementation of lifestyle modification and improving medical knowledge and skill of local medical staff *** 2 years of follow-up,primary endpoints including magnitude of systolic and diastolic blood pressures (SBP and DBP) decrease,treated and controlled rates,as well as secondary endpoints,were evaluated in both ***:Initially,the treated rate was significantly higher in traditional group than that of novel group (71.15％ vs.64.99％,P ＜ 0.05),while the controlled rates were comparable and insignificant difference between baseline BP in both groups (31.07％ vs.26.88％,P ＞ 0.05).Four variables were significantly different,namely smoking rate,daily vegetable consumption (VC),and serum levels of low-density lipoprotein-cholesterol and fasting blood glucose between these two *** 2 years of follow-up,decreases in SBP and DBP were more prominent in the novel group (P ＜ 0.001).Treated and controlled rates in both groups were both ***,in comparison to the traditional group,controlled rate increased more significantly in the novel group (64.31％ vs.37.85％,P ＜ 0.001).Variables ind

关键词： Hypertension Management Population Rural Areas

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Anomalous Hall effect in ferromagnetic LaCo_(2)As_(2) and ferrimagnetic NdCo_(2)As_(2)

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Chinese Physics B 2023年第10期32卷 641-648页

作者：黄雨晴郑鹏宇刘瑞许锡童吴紫阳董超王俊峰殷志平贾爽 International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100081China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200China Department of Physics and Center for Advanced Quantum Studies Beijing Normal UniversityBeijing 100875China Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074China Kunshan Innovation Institute of Nanjing University Kunshan 215347China

We conducted a comparative study of the magnetic and transport properties of single-crystalline LaCo_(2)As_(2) and NdCo_(2)As_(2).LaCo_(2)As_(2) is a soft metallic ferromagnet which exhibits purely intrinsic anomalous Hall effect(AHE) due to Co-3d electrons. With Nd-4f electronic magnetism, ferrimagnetic NdCo_(2)As_(2) manifests pronounced sign reversal and multiple hysteresis loops in temperature-and field-dependent magnetization, Hall resistivity, and magnetoresistance, due to complicated magnetic structural changes. We reveal that the AHE for NdCo_(2)As_(2) is stemming from the Co sub-lattice and deduce its phase diagram which includes magnetic compensation and two meta-magnetic phase transitions. The sensitivity of the Hall effect on the details of the magnetic structures in ferrimagnetic NdCo_(2)As_(2) provides a unique opportunity to explore the magnetic interaction between 4f and 3d electrons and its impact on the electronic structure.

关键词： anomalous Hall effect ferrimagnetism magnetic compensation meta-magnetic transitions

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Epidemiologic Survey for Human Sparganosis Infection in Wumeng mountainous area of China during 2011-2015

Epidemiologic Survey for Human Sparganosis Infection in Wume...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Ying Shun Zhou Guang Xi Wang yu qing huang Zhang Hua Tang Rong Li Wang Department of Pathogenic Biology Southwest Medical University Section of Health Southwest Medical University Department of Paediatric Affiliated Hospital of Southwest Medical University Department of Respirotory Affiliated Hospital of Southwest Medical University

Background: Sparganosis is a water and food borne disease caused by the plerocercoid larvae(spargana) of various diphyllobothroid tapeworms of the genus Spirometra. The parasite transmitted to humans by ingesting the meats of snakes or frogs which are raw or undercooked, even by drinking untreated water. Its can invade the brain, eyes, spinal cord and subcutaneous tissues. Objective: In this study, one hundred and twelve patients was suspected of infection of the Sparganum from the Wumeng mountainous area of China who were admitted to our hospital complaining of exertional dyspnea, fever, cough and chest pain. Methods: The clinical symptoms, the past history of drinking and the eating patterns have been investigated. Routine blood cell and X-ray/CT were determined. Multiple-dot ELISA method was performed to detect specific anti-parasite antibody. Results: Results showed that eleven of the one hundred and twelve cases were serum sparganum-mansoni antibody positive. Most of them(10 /11 cases) had a history of drinking untreated water. Conclusion: The results suggest that we should pay more attention to the the origin of Sparganosis infection in moutains area by drinking untreated water.

关键词： Sparganum sparganosis Wumeng mountainous area of China

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氧化应激在糖尿病性角膜病变中的研究进展

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国际眼科杂志 2022年第3期22卷 399-402页

作者：黄钰清杨燕宁武汉大学人民医院眼科中心中国湖北省武汉市430060

据统计,目前约有46%~64%的糖尿病患者罹患糖尿病性角膜病变。随着糖尿病患病率的日益攀升,糖尿病性角膜病变逐渐受到眼科医生的重视,但其发病机制尚未明确。氧化应激是机体内活性氧和活性氮产生过多,从而损害机体组织细胞的一种病理过程... 详细信息

据统计,目前约有46%~64%的糖尿病患者罹患糖尿病性角膜病变。随着糖尿病患病率的日益攀升,糖尿病性角膜病变逐渐受到眼科医生的重视,但其发病机制尚未明确。氧化应激是机体内活性氧和活性氮产生过多,从而损害机体组织细胞的一种病理过程,其参与众多疾病的发生发展,在糖尿病眼部并发症中亦扮演重要角色。本文回顾氧化应激在糖尿病性角膜病变发病机制以及治疗中的研究进展,希望对临床诊疗有所助益。

关键词：糖尿病性角膜病变氧化应激发病机制研究进展

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