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Improving the sulfidation-flotation of fine cuprite by hydrophobic flocculation pretreatment

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International Journal of Minerals,Metallurgy and Materials 2018年第11期25卷 1256-1262页

作者： qian-yu sun Wan-zhong Yin Dong Li Ya-feng Fu Ji-wei Xue Jin Yao College of Resources and Civil Engineering Northeastern University College of Zijin Mining Fuzhou University

Hydrophobic flocculation pretreatment was performed to assess its effect on the recovery of fine cuprite in sulfidation-flotation. The results of the micro-flotation experiment showed that cuprite recovery is related to the particle size, and that an excessive content of fine particles(<18 μm) impacted the recovery of coarse particles. When hydrophobic flocculation pretreatment was used, the recovery of fine cuprite in sulfidation-flotation increased from 60.3% to 86.3% under optimum conditions(pH 9.5; sodium oleate concentration, 2 × 10^(-4) mol×L^(-1); stirring time, 6 min; stirring speed, 1600 r×min^(-1)). The laser particle size analysis and optical microscopy results indicate that hydrophobic flocculation pretreatment effectively reduces the content of fine cuprite, and augments the apparent particle size in the pulp. We performed the Derjaguin–Landau–Verwey–Overbeek(DLVO) theory and extended DLVO theory calculations to further support the interpretation of the results.

关键词： fine cuprite sulfidation-flotation hydrophobic flocculation pretreatment extened DLVO theory calculation

Expanded clinical-grade NK cells exhibit stronger effects than primary NK cells against HCMV infection

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Cellular & Molecular Immunology 2023年第8期20卷 895-907页

作者： qian-Nan Shang Xing-Xing yu Zheng-Li Xu yu-Hong Chen Ting-Ting Han yuan-yuan Zhang Meng Lv yu-qian sun yu Wang Lan-Ping Xu Xiao-Hui Zhang Xiang-yu Zhao Xiao-Jun Huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationPeking UniversityBeijingChina Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina

Cytomegalovirus (CMV) reactivation remains a common complication and leads to high mortality in patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). Early natural killer (NK) cell reconstitution may protect against the development of human CMV (HCMV) infection post-HSCT. Our previous data showed that ex vivo mbIL21/4-1BBL-expanded NK cells exhibited high cytotoxicity against leukemia cells. Nevertheless, whether expanded NK cells have stronger anti-HCMV function is unknown. Herein, we compared the anti-HCMV functions of ex vivo expanded NK cells and primary NK cells. Expanded NK cells showed higher expression of activating receptors, chemokine receptors and adhesion molecules;stronger cytotoxicity against HCMV-infected fibroblasts;and better inhibition of HCMV propagation in vitro than primary NK cells. In HCMV-infected humanized mice, expanded NK cell infusion resulted in higher NK cell persistence and more effective tissue HCMV elimination than primary NK cell infusion. A clinical cohort of 20 post-HSCT patients who underwent adoptive NK cell infusion had a significantly lower cumulative incidence of HCMV infection (HR = 0.54, 95% CI = 0.32–0.93, p = 0.042) and refractory HCMV infection (HR = 0.34, 95% CI = 0.18–0.65, p = 0.009) than controls and better NK cell reconstitution on day 30 post NK cell infusion. In conclusion, expanded NK cells exhibit stronger effects than primary NK cells against HCMV infection both in vivo and in vitro.

关键词： Allogeneic haematopoietic stem cell transplantation Natural killer cells Human cytomegalovirus infection Adoptive infusion

Proanthocyanidin B2 attenuates high-glucose-induced neurotoxicity of dorsal root ganglion neurons through the PI3K/Akt signaling pathway

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Neural Regeneration Research 2018年第9期13卷 1628-1636页

作者： yuan-Pin Zhang Si-Yan Liu qian-yu sun Jing Ren Hua-Xiang Liu Hao Li Department of Rheumatology Shandong University Qilu Hospital Department of Endocrinology and Metabolism Fudan University Huashan Hospital Department of Orthopedics Shandong University Qilu Hospital

High glucose affects primary afferent neurons in dorsal root ganglia by inhibiting neurite elongation,causing oxidative stress,and inducing neuronal apoptosis and mitochondrial dysfunction,which finally result in neuronal ***,a potent antioxidant,has been shown to have neuroprotective *** B2 is a common dimer of oligomeric *** date,no studies have reported the neuroprotective effects of proanthocyanidin B2 against high-glucose-related neurotoxicity in dorsal root ganglion *** this study,10 μg/m L proanthocyanidin B2 was used to investigate its effect on 45 m M high-glucose-cultured dorsal root ganglion *** observed that challenge with high levels of glucose increased neuronal reactive oxygen species and promoted apoptosis,decreased cell viability,inhibited outgrowth of neurites,and decreased growth-associated protein 43 protein and m RNA *** B2 administration reversed the neurotoxic effects caused by glucose *** of the phosphatidylinositol 3 kinase/Akt signaling pathway with 10 μM LY294002 eliminated the protective effects of proanthocyanidin ***,proanthocyanidin B2 might be a potential novel agent for the treatment of peripheral diabetic neuropathy.

关键词： nerve regeneration high glucose diabetes neurons neuropathy reactive oxygen species apoptosis growth-associated protein 43 cell viability neural regeneration

Comparable anti-CMV responses of transplant donor and third-party CMV-specific T cells for treatment of CMV infection after allogeneic stem cell transplantation

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Cellular & Molecular Immunology 2022年第4期19卷 482-491页

作者： Xu-Ying Pei Xue-Fei Liu Xiang-yu Zhao Meng Lv Xiao-Dong Mo Ying-Jun Chang qian-Nan Shang yu-qian sun yu-Hong Chen Lan-Ping Xu yu Wang Xiao-Hui Zhang Kai-Yan Liu Xiao-Jun Huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing100044China Peking-Tsinghua Center for Life Sciences Beijing100871China

Adoptive transfer of cytomegalovirus(CMV)-specific cytotoxic T lymphocytes(CMV-CTLs)from original transplant donors or third-party donors was effective for the treatment of CMV infection after allogenic stem cell transplantation(allo-SCT),but the antiviral activity of CMV-CTL types has not been *** determine whether third-party CMV-CTLs provide comparable long-term antiviral efficacy to transplant donor CMV-CTLs,we first compared the antiviral abilities of transplant donors and third-party CMV-CTLs for treatment of CMV infection in two mouse models,compared the in vivo recovery of CMV-specific immunity,and analyzed the underlying mechanisms driving sustained antiviral *** results showed that both donor and third-party CMV-CTLs effectively combated systemic CMV infection by reducing CMV pathology and tumor burden 28 days *** in vivo recovery of CMV-specific immunity after CMV-CTL infusion was comparable in both groups.A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both *** clinical study,which enrolled 31 patients who received third-party CMV-CTLs and 62 matched pairs of individuals who received transplant donor CMV-CTLs for refractory CMV infection,further showed that adoptive therapy with donor or third-party CMV-CTLs had comparable clinical responses without significant therapy-related *** observed strong expansion of CD8+tetramer+T cells and proliferation of recipient endogenous CMV-CTLs after CMV-CTL infusion,which were associated with a reduced or cleared viral *** data confirmed that adoptive therapy with third-party or transplant donor CMV-CTLs triggered comparable antiviral responses to CMV infection that might be mediated by restoration of endogenous CMV-specific immunity.

关键词： Allogeneic stem cell transplantation CMV-specific cytotoxic T lymphocytes Transplant donor Third party donor Immunotherapy

Pre-transplantation cytoreduction does not benefit advancedmyelodysplastic syndrome patients after myeloablative transplantation with grafts from family donors

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Cancer Communications 2021年第4期41卷 333-344页

作者： yu-qian sun Lan-Ping Xu Kai-Yan Liu Xiao-Hui Zhang Chen-Hua Yan Jian Jin Xiao-Jun Huang yu Wang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic Disease BeijingKey Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044P.R.China Peking-Tsinghua Center for Life Sciences Beijing 100871P.R.China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100871P.R.China

Background:The role of pre-hematopoietic stem cell transplantation(HSCT)cytoreduction with either induction chemotherapy(IC)or hypomethylating agents(HMAs)in treating advanced myelodysplastic syndrome(MDS)remains *** aimed to evaluate pre-HSCT strategies by comparing the endpoints related to disease control between advanced MDS patients with pre-HSCT cytoreduction and those with best supportive ***:We described 228 consecutive advanced MDS patients who received HSCT from a haploidentical donor(HID,n=162)or matched related donor(MSD,n=66)with uniform myeloablative conditioning regimens between January 2015 and December *** these 228 patients,131(57.5%)were treated exclusively with pre-HSCT best supportive care(BSC),49(22.5%)were given HMA,and 48(21.1%)received both IC and *** score-matching analysis,multivariate analyses,and subgroup analyses were performed to elucidate the impact of pre-HSCT strategies on transplant ***:The 3-year relapse-free survival(RFS)rates were 78.2% and 70.0% for the BSC and cytoreduction cohorts(P=0.189)and were 78.2%,66.7%,and 73.2% for the BSC,HMA,and HMA+IC groups,respectively(P=0.269).A propensity score-matching analysis confirmed that the 3-year RFS rates were 81.9%,87.5%,and 66.9% for BSC,cytoreduction complete remission(CR),and cytoreduction non-CRgroups,respectively(P=0.051).Multivariate analyses demonstrated that pre-HSCT cytoreduction,older patient age,monosomal karyotype,and interval between diagnosis and HSCT were poor prognostic factors for *** the subgroup analyses,BSC was associated with longer RFS compared to cytoreduction among the younger patients,those with international prognostic scoring system intermediate-2/high risk at diagnosis,and those with intermediate/poor ***:Different pre-HSCT therapies did not yield discrepant post-HSCT *** benefit in terms of post-HSCT outcomes were correlated with pre-HSCT cytoreduction in advanced MDS even for cyt

关键词： myelodysplastic syndrome cytoreduction hypomethylating agent induction chemotherapy hematopoietic stem cell transplantation best supportive care

Haploidentical stem cell transplantation in patients with chronic myelomonocytic leukemia

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Science China(Life Sciences) 2020年第8期63卷 1261-1264页

作者： yu-qian sun Chen Zhao yu Wang Chen-Hua Yan Xiao-Hui Zhang Lan-Ping Xu Kai-Yan Liu Xiao-Jun Huang Peking University People’s Hospital Peking University Institute of HaematologyNational Clinical Research Center for Hematologic diseaseBeijing Key Laboratory of Haematopoietic Stem Cell TransplantationBeijing 100044China Peking-Tsinghua Centre for Life Sciences Beijing 100871China

Dear Editor,Chronic myelomonocytic leukemia (CMML) is a rare clonal hematological malignancy with both myelodysplastic and myeloproliferative features. Patients with CMML have a very poor prognosis。

关键词： leukemia prognosis patients

Atmospheric reductive catalytic fractionation of lignocellulose integrated with one-pot catalytic conversion of carbohydrate yielding valuable lignin monomers and platform chemicals from corn straw

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Green Energy & Environment 2025年第1期10卷 161-172页

作者： Meng-Ying Liu Zhe-Hui Zhang Xue-Qi Wang qian sun Chen Zhang yu Li Zhuohua sun Katalin Barta Feng Peng Tong-Qi yuan State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing100083China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Department of Chemistry Organic and Bioorganic ChemistryUniversity of GrazHeinrichstrasse 28/II8010 GrazAustria

Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent ***,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps *** key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene *** utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling *** the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.

关键词： Atmospheric reductive catalytic fractionation Corn straw Ethylene glycol Raney Ni 5-Methoxymethylfurfural

Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation

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Cellular & Molecular Immunology 2021年第5期18卷 1172-1185页

作者： Huidong Guo Ying-Jun Chang Yan Hong Lan-Ping Xu yu Wang Xiao-Hui Zhang Ming Wang Huan Chen yu-Hong Chen Feng-Rong Wang Wei-Han yu-qian sun Chen-Hua Yan Fei-Fei Tang Xiao-Dong Mo Kai-Yan Liu Xiao-Jun Huang Peking University People’s Hospital&Peking University Institute of Hematology National Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationNo.11 South Street of XizhimenXicheng District100044BeijingChina Peking-Tsinghua Center for Life Sciences 100871BeijingChina Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences2019RU029BeijingChina

Haploidentical stem cell transplantation(haplo-SCT)achieves superior or at least comparable clinical outcomes to HLA-matched sibling donor transplantation(MSDT)in treating hematological *** define the underlying regulatory dynamics,we analyzed time courses of leukemia burden and immune abundance of haplo-SCT or MSDT from multiple ***,we employed two nonirradiated leukemia mouse models which carried human AML-ETO or MLL-AF9 fusion gene to establish haplo-identical and major histocompatibility(MHC)-matched transplantation models and investigated the immune cell dynamic response during leukemia development in *** found that haplo-matching the MHCs of leukemia cells with recipient mouse T cells prolonged leukemic mice survival and reduced leukemia *** stronger graft-versus-leukemia activity in haplo-SCT group mainly induced by decreased apoptosis and increased cytotoxic cytokine secretion including tumor necrosis factor–α,interferon-γ,pore-forming proteins and CD107a secreted by T cells or natural killer ***,we conducted a prospective clinical trial which enrolled 135 patients with t(8;21)acute myeloid leukemia that displayed minimal residual disease before transplantation and underwent either haplo-SCT or *** results showed that the haplo-SCT slowed the kinetics of the leukemia burden in vivo and reduced the cumulative incidence of relapse compared with *** vivo experiments showed that,1 year after transplantation,cytotoxic T lymphocytes from the haplo-SCT group had higher cytotoxicity than those from the MSDT group during the same *** results unraveled the role of immune cells in superior antileukemia effects of haplo-SCT compared with MSDT.

关键词： Graft-versus-leukemia Haplo-SCT MSDT AML MRD

Optimized therapeutic strategy for patients with refractory or relapsed acutemyeloid leukemia:long-term clinical outcomes and health-related quality of life assessment

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Cancer Communications 2022年第12期42卷 1387-1402页

作者： Chen-hua Yan yu Wang yu-qian sun Yi-fei Cheng Xiao-dong Mo Feng-rong Wang yu-hong Chen yuan-yuan Zhang Ting-ting Han Huan Chen Lan-ping Xu Xiao-hui Zhang Kai-yan Liu Xiao-jun Huang Peking University Peoples Hospital Peking University Institute of HematologyBeijing 100044P.R.China National Clinical Research Center for Hematologic Disease Beijing 100044P.R.China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044P.R.China Peking-Tsinghua Center for Life Science Beijing 100044P.R.China

Background:Patients with refractory or relapsed acute myeloid leukemia(AML)have poor survival,necessitating the exploration of optimized therapeutic ***,we aimed to investigate clinical outcomes and health-related quality of life(HR-QoL)after total therapy,which included allogeneic hematopoietic stem cell transplantation(allo-HSCT),and prophylactic donor lymphocyte infusion(DLI)in the early phase after transplantation,followed bymultiplemeasurable residual disease(MRD)and graft-versus-host disease(GvHD)-guided ***:Consecutive patients who had refractory or relapsed AML and had received non-T-cell-depleted allo-HSCT at Peking University Institute of Hematology were included in the *** the patients achieved complete remission at 30 days after transplantation and had no evidence of relapse,severe infection,organ failure,and active GvHD at the time of planned DLI,prophylactic DLI was administered at 30 days after transplantation for human leukocyte antigen(HLA)-matched related HSCT or at 45-60 days after transplantation for haploidentical or unrelated ***,multiple DLIs were administered based on MRD results and whether they developed GvHD after ***:A total of 105 patients were ***-seven patients received prophylactic DLI(group B),while 18 did not receive prophylactic DLI(group A).Among 105 patients,the cumulative incidence of grade 2-4 acute GvHD and chronic GvHDwas 40.6%(95%confidence interval[CI]=30.6%-50.6%)and 73.3%(95%CI=67.4%-79.2%),*** cumulative incidence of relapse(CIR),transplant-related mortality(TRM),and leukemia-free survival(LFS)at 5 years after transplantation were 31.5%(95%CI=21.9%-41.1%),22.1%(95%CI=11.3%-32.9%),and 46.4%(95%CI=36.8%-56.0%),*** group B,the CIR,TRM,and LFS at 5 years after transplantation were 27.6%(95%CI=17.6%-37.6%),21.6%(95%CI=11.2%-32.0%),and 50.8%(95%CI=40.0%-61.6%),*** the end of follow-up,48 patients survived,and more than 90

关键词： acute myeloid leukemia allogeneic hematopoietic stem cell transplantation refractory relapsed total therapy