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Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： Di Pan Hao-Nan liu Zhi-yuan Yao Xiao-Xiao Chen yu-qi li Jing-Jing Zhu Zheng-Xiang Han Xiao-Bing qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy

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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： yu-qin Wang Di Pan Zhi-yuan Yao yu-qi li Peng-Fei Qu Run-Bang Wang qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First College of Clinical Medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent *** Retrospective data were collected from 126 HCC patients treated with lenvatinib plus *** were divided into two groups based on BMI:The non-overweight group(BMIline graph *** subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** Median progression-free survival was significantly longer in the obese/overweight group compared to the non-overweight ***,the median OS was significantly prolonged in the obese/overweight group than in the non-overweight *** objective remission rate and disease control rate for the two groups of patients were,respectively,objective remission rate(5.88%vs 28.00%)and disease control rate(39.22%vs 62.67%).Fatigue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety

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Environmental effects induced by excavation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 50-57页

作者： yu-qi li Jian ZHOU Kang-he XIE Department of Civil Engineering Shanghai University Shanghai 200072 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China Institute of Geotechnical Engineering Zhejiang University Hangzhou 310027 China

Based on 3D Biot’s consolidation theory and nonlinear Duncan-Chang’s model, a 3D FEM (finite element method) program is developed considering the coupling of groundwater seepage and soil skeleton deformation during excavation. The comparison between the analysis result considering the variation of water head difference and that without considering it shows that the porewater pressure distribution of the former is distinctly different from that of the latter and that the foundation pit de- formations of the former are larger than those of the latter, so that the result without considering the variation of water head dif- ference is unreliable. The distribution rules of soil horizontal and vertical displacements around the pit and excess porewater pressure are analyzed in detail in time and space, which is very significant for guiding underground engineering construction and ensuring environment safety around the pit.

关键词： Environmental effect Excavation Deformation Excess porewater pressure

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Health Effects of Airborne Particulate Matter Trace Elements

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Biomedical and Environmental Sciences 2005年第5期18卷 349-355页

作者： XIANG GAO qi yu li-MIN CHEN Department of Environmental Science and Engineering Fudan University Shanghai 200433 China

The effects of airborne particulate matter （PM） trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses, describes the effects of exposure to PM trace elements on health epidemiological evidence, toxicology findings, and raises some questions for future studies.

关键词： Health effect Particulate matter Trace element

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Chemical additives affect sulfate reducing bacteria biofilm properties adsorbed on stainless steel 316L surface in circulating cooling water system

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 143-156页

作者： yu qi Jin li Rui liang Sitong Ji Jianxiang li Meng liu Research Center for Aqueous Organic Pollutants Control and Water Quality Security Beijing Key Laboratory Beijing Jiaotong University Beijing 100044 China

This paper studied the biofilm properties and corrosion behavior of sulfate reducing bacteria （SRB） on stainless steel 316L （SS316L） surface in circulating cooling water system with and without additives including hydroxy ethyl fork phosphonic acid （HEDP）, dodecyl dimethyl benzyl anunonium chlotide （1227） and NaClO. Biochemical technique, electrochemical technology, X-ray photoelectron spectroscopy （XPS） and scanning electron microscope （SEM） were used. The results show that the extracellular polymeric substance （EPS） in biofilm attached on the SS316L surface mainly contain proteins and polysaccharides, the contents are 98 ***-2 and ***-2, respectively. The polysaccharides were cut by 1227 about 80%, while 55% by NaCIO. The proteins were reduced by NaCIO about 53%, while only 30% by 1227. The potentiodynamic polarization shows that the corrosion potential of SS316L was enhanced from -0.495 V to -0.390 V by the chemical additive delaying the occurrence of the corrosion. And the corrosion rate was also reduced from 5.19 × 10^-3 mm·a^-1 to 2.42 × 10^-3 mm＇a . But NaCIO stdl caused pitting corrosion after stenhzmg the bacteria, while 1227 can form a protective film on the surface of SS316L. Though HEDP contribute to the bacteria activity, it can enhance the breakdown potential. XPS results confirmed that 1227 can change the value of C：O in the biofilm attached on metal surface, and NaCIO can eliminate the existence of amidogen. This study would provide some recommendations for the selection of chemical additives in the thermal power plant.

关键词： Sulfate reducing bacteria (SRB)Chemical additivesBiofilmExtracellular polymeric substance (EPS)Microbe conosion

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AquaSee: Predict Load and Cooling System Faults of Supercomputers Using Chilled Water Data

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Journal of Computer Science & Technology 2020年第1期35卷 221-230页

作者： yu-qi li li-Quan Xiao Jing-Hua Feng Bin Xu Jian Zhang National Supercomputer Center in Tianjin Tianjin 300450China College of Computer National University of Defense TechnologyChangsha 410073China

An analysis of real-world operational data of Tianhe-1A(TH-1A)supercomputer system shows that chilled water data not only can reflect the status of a chiller system but also are related to supercomputer *** study proposes AquaSee,a method that can predict the load and cooling system faults of supercomputers by using chilled water pressure and temperature *** method is validated on the basis of real-world operational data of the TH-1A supercomputer system at the National Supercomputer Center in *** with various compositions are used to construct the prediction model,which is also established using different prediction sequence *** results show that the method that uses a combination of pressure and temperature data performs more effectively than that only consisting of either pressure or temperature *** best inference sequence length is two ***,an anomaly monitoring system is set up by using chilled water data to help engineers detect chiller system anomalies.

关键词： supercomputer chilled water data sensor network load prediction

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Synthesis and antitumor activity of 9-methyl-10-hydroxycamptothecin

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Chinese Chemical Letters 2008年第8期19卷 918-920页

作者： Sheng Wang yu Yan li qi Dong You Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A novel camptothecin analogue, 9-methyl-10-hydroxycamptothecin （4）, was unexpectedly synthesized from 10-hydroxycamptothecin in two steps. The key step included an efficient Mannich-type reaction. The overall yield was 47.2%. An ether analogue of 4, 9-methyl-10-benzylaminomethoxycamptothecin （5）, was also prepared. These new camptothecin analogues were evaluated for in vitro cytotoxicity against four human cancer cell lines, and exhibited more potent antitumor activities than contrals camptothecin and topotecan against several cancer cells.

关键词： Synthesis Camptothecin 10-Hydroxycamptothecin Cytotoxicity

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商业综合体项目建筑给排水设计要点探讨

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工程建设与设计 2024年第3期 52-54页

作者：戚玉丽戚凯锋冯佳颖卢豪嘉兴大学浙江嘉兴314001 绿城房地产建设管理集团有限公司杭州310020 中国建筑第二工程局有限公司杭州310020

阐述建筑给排水系统设计原则,从用水量取值、给水方式、设备房的位置、排水的畅通环保、消防给水安全设计、可再生能源选择等方面进行了设计要点的分析和探究,使商业综合体项目建筑给排水系统设计既能满足功能需求,又能最大限度地满足... 详细信息

阐述建筑给排水系统设计原则,从用水量取值、给水方式、设备房的位置、排水的畅通环保、消防给水安全设计、可再生能源选择等方面进行了设计要点的分析和探究,使商业综合体项目建筑给排水系统设计既能满足功能需求,又能最大限度地满足后期业态调整或维修要求,同时也能满足绿色建筑评价的要求。

关键词：商业综合体给水排水消防可再生能源

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Microsatellite Variation in the Oyster Crassostrea plicatula Along the Coast of China

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Journal of Ocean University of China 2008年第4期7卷 432-438页

作者： yu Hong, li qi yu Ruihai College of Fisheries Ocean University of China Qingdao 266003 P. R. China

Genetic diversity and differentiation of the oyster Crassostrea plicatula populations from China’s coast were studied based on seven microsatellite loci. All loci showed high polymorphism for all five C. plicatula populations,with an average number of allele per locus of 19.3-27.9 and an average expected heterozygosity of 0.889-0.952. Significant departures from Hardy-Weinberg equilib-rium and deficits of heterozygotes were observed over most populations at each locus,which were fully explained by null alleles. Microsatellite analysis revealed significant subdivision in the C. plicatula populations. According to the neighbor-joining tree con-structed on the basis of the DA distance,the five populations fell into three regional groups,showing a relatively homogeneous genetic structure in geographically close populations. Assignation tests correctly assigned high percentages of individuals to their original populations and groups,and also confirmed the existence of genetic differentiation among C. plicatula populations. The results ob-tained in this study will facilitate the formulation of appropriate fisheries management programs,stock identification and conservation of biodiversity for the species.

关键词： Crassostrea plicatula microsatellites genetic diversity population structure

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Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value

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World Journal of Hepatology 2023年第6期15卷 786-796页

作者： yu-qi li Lei Xin yu-Chi Zhao Shang-qi li Ya-Nuo li Department of Pathophysiology School of Basic MedicineBinzhou Medical UniversityYantai 264000Shandong ProvinceChina Department of Gastrointestinal Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina Department of Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina The First School of Clinical Medicine Binzhou Medical UniversityYantai 264000ShandongChinaYantai 264000Shandong ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)refers to fatty liver disease caused by liver injury factors other than *** disease is characterized by diffuse fat infiltration,including simple steatosis(no inflammatory fat deposition),nonalcoholic fatty hepatitis,liver fibrosis,and so on,which may cause liver cirrhosis,liver failure,and even liver cancer in the later stage of disease *** present,the pathogenesis of NAFLD is still being ***"two-hit"theory,represented by lipid metabolism disorder and inflammatory reactions,is gradually enriched by the"multiple-hit"theory,which includes multiple factors,such as insulin resistance and adipocyte *** recent years,vascular endothelial growth factor B(VEGFB)has been reported to have the potential to regulate lipid metabolism and is expected to become a novel target for ameliorating metabolic diseases,such as obesity and type 2 *** review summarizes the regulatory role of VEGFB in the onset and development of NAFLD and illustrates its underlying molecular *** conclusion,the signaling pathway mediated by VEGFB in the liver may provide an innovative approach to the diagnosis and treatment of NAFLD.

关键词： Nonalcoholic fatty liver disease Vascular endothelial growth factor B "Twohit"theory "Multiple-hit"theory Obesity

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