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Xiao Tan San Jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： yu-qi zhou Jun-Fei yuan Hong-Shi Shen Ya-Ping Wang Han-Fei Shi De-Jian Pan Min Ye Department of Hematology and Oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San Jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

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两混合凸体的相对曲率积分不等式

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数学学报（中文版） 2024年第4期67卷 732-742页

作者：董旭王亚玲周玉奇曾春娜重庆师范大学数学科学学院重庆401331

曲率积分不等式在几何不等式中有举足轻重的地位.本文主要利用非对称的Green-Osher不等式,获得了两混合凸体高次幂的相对曲率积分界的估计.这些不等式在Green和Osher工作的基础上去掉了对称性条件,为著名的Green-Osher不等式的改进形式... 详细信息

曲率积分不等式在几何不等式中有举足轻重的地位.本文主要利用非对称的Green-Osher不等式,获得了两混合凸体高次幂的相对曲率积分界的估计.这些不等式在Green和Osher工作的基础上去掉了对称性条件,为著名的Green-Osher不等式的改进形式.特别地,当一个凸体为单位圆时,获得了R^(2)中的Ros不等式、曲率熵不等式,提供了曲率熵不等式新的简化证明.

关键词： Gage等周不等式 Ros不等式 Green-Osher不等式曲率熵不等式

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Influence of different high pressure die casting processes on 3D porosity distribution of Mg-3.0Nd-0.3Zn-0.6Zr alloy

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China Foundry 2021年第6期18卷 521-528页

作者： Yi-hu Ma Wen-bo yu yu-qi zhou Shou-mei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

3D reconstruction was adopted to characterize the microstructural morphologies of Mg-3.0Nd-0.3Zn-0.6Zr alloy castings produced by high pressure die casting(HPDC)processes with different parameters,including low slow-shot speed,solidification pressurization and fast slow-shot *** low slow-shot speeds of 0.1 m·s^(-1),0.2 m·s^(-1) and 0.3 m·s^(-1),the porosity is concentrated in the center of the castings with one spiral staggered shape along the liquid flow *** porosity volume simultaneously decreases with the reduction of quantity and size of externally solidified crystals(ESCs),while the shrinkage pores become more and more dispersed with the increasing low slow-shot *** not only reduces the porosity volume due to the improvement of feeding ability,but also transformes the center gathered porosity into one layer-by-layer distribution *** with the increasing fast slow-shot speed,the central porosity dramatically decreases and transforms into a large-scale spiral staggered shape along the liquid flow ***,the porosity is much more dispersed when the speed is increased from 2 m·s^(-1) to 3 m·s^(-1).

关键词： HPDC parameters porosity volume 3D morphology

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Millimeter-sized few-layer graphene sheets with aligned channels for fast lithium-ion charging kinetics

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Journal of Energy Chemistry 2021年第4期30卷 62-69页

作者： yu-qi zhou Xiao-Ling Dong Wen-Cui Li Guang-Ping Hao Dong Yan An-Hui Lu State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Assembly of the top-down graphene units mostly results in 3D porous structure with randomly organized *** direct bottom-up synthesis of macroscopic 2D graphene sheets with organized pores are long sought in materials chemistry field,but rarely ***,we present a self-catalysisassisted bottom-up route usingL-glutamic acid and iron chloride as starting materials for the fabrication of the millimeter-sized few-layer graphene sheets with aligned porous channels parallel to the 2D *** amino-and carboxyl-functional groups inL-glutamic acid can coordinate with iron cations,thus allowing an atomic dispersion of iron *** pyrolysis thus initiated the growth of graphene catalyzed by in-situ generated iron nanoparticles,and a dynamic flow of iron nanoparticles eventually led to the formation of millimeter-sized few-layer graphene sheets with aligned channels(60-85 nm in diameter).Used as anodes in lithium-ion batteries,these graphene sheets showed a good rate capability(142 m A h g^(-1) at 2 A g^(-1))and high capacity retention of 93%at 2 A g^(-1) after 1200 *** analysis revealed that lithium ions storage was dominated by diffusion behavior and capacitive behavior together,in that graphene sheets with aligned channels could accelerate electron transfer and shorten lithium ions transport *** work provides a novel approach to prepare unique porous graphene materials with specific structure for energy storage.

关键词： Few-layer graphene Aligned channels Catalytic growth Lithium-ion batteries

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Transient stimulated Raman scattering spectroscopy and imaging

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Light(Science & Applications) 2024年第4期13卷 654-663页

作者： qiaozhi yu Zhengjian Yao Jiaqi zhou Wenhao yu Chenjie Zhuang Yafeng qi Hanqing Xiong National Biomedical Imaging Center College of Future TechnologyPeking UniversityBeijing 100871China Biomedical Engineering Department College of Future TechnologyPeking UniversityBeijing 100871China

Stimulated Raman scattering(SRS)has been developed as an essential quantitative contrast for chemical imaging in recent ***,while spectral lines near the natural linewidth limit can be routinely achieved by state-of-the-art spontaneous Raman microscopes,spectral broadening is inevitable for current mainstream SRS imaging *** is because those SRS signals are all measured in the frequency *** is a compromise between sensitivity and spectral resolution:as the nonlinear process benefits from pulsed excitations,the fundamental time-energy uncertainty limits the spectral ***,the spectral range and acquisition speed are mutually *** we report transient stimulated Raman scattering(T-SRS),an alternative time-domain strategy that bypasses all these fundamental conjugations.T-SRS is achieved by quantum coherence manipulation:we encode the vibrational oscillations in the stimulated Raman loss(SRL)signal by femtosecond pulse-pair sequence excited vibrational wave packet *** Raman spectrum was then achieved by Fourier transform of the time-domain SRL *** all Raman modes are impulsively and simultaneously excited,T-SRS features the natural-linewidth-limit spectral line shapes,laser-bandwidth-determined spectral range,and improved ***~150-fs laser pulses,we boost the sensitivity of typical Raman modes to the sub-mM *** all-plane-mirror high-speed time-delay scanning,we further demonstrated hyperspectral SRS imaging of live-cell metabolism and high-density multiplexed imaging with the natural-linewidth-limit spectral resolution.T-SRS shall find valuable applications for advanced Raman imaging.

关键词： scattering excited mutually

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Intracranial electroencephalography study in epileptic patients with dual pathology

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Chinese Medical Journal 2013年第13期126卷 2577-2579页

作者： SHI Yan-fang ZHANG yu-qi zhou Wen-jing SUN Zhao-hui ZU0 Huan-cong Department of Neurosurgery Yuquan Hospital Tsinghua University School of Medicine Beijing 100049 China

Acommon dual pathology observed on presurgical magnetic resonance imaging （MRI） of epilepticpatients is extrahippocampal lesions combined with mesial temporal sclerosis. The hippocampus was highly vulnerable to many types of insults. However, it is difficult to detect subtle hippocampal atrophy in some patients. The most reliable method to confirm epileptogenicity is chronic intracranial electroencephalography （EEG） monitoring. In this study, we recorded intracranial EEG signals in 11 patients with dual *** Patient enrollment We evaluated ! 1 patients with a confirmed diagnosis of dual pathology in yuquan Hospital, China between 2007 and 2010. The patients were satisfied with the following criteria：（1） MRI showed structural lesions in the extrahippocampal lobe; （2） a postoperative follow-up period lasting at least 24 months. For all 11 patients, both seizure frequency and impact on quality of life were judged as severe enough to justify presurgical evaluation using implanted electrodes. Detailed histories of prenatal, neonatal, and early childhood events were systematically reviewed through direct interviews with the patients. Patients were initially evaluated with noninvasive methods, including scalp EEG monitoring to capture spontaneous seizures and MRI. MRI was performed using a 1.5 T scanner and included axial images parallel to the long axis of the hippocampus. Ipsilateral and contralateral hippocampal images were visually compared to confirm mesial temporal sclerosis （MTS）. EEG recording and analysis Noninvasive data （scalp EEG and MRI） identified the mesial temporal region and a neocortical lesion site as the most likely ictal onset zones. Thus, all 11 patients were examined by implanted intracranial electrodes. To investigate the mesial temporal region, we used a stereo- eletroencephalography procedure. Depth electrodes were orthogonally directed through the middle temporal gyrus with the deepest contacts in the amygdala and anterior hippocamp

关键词： intracranial electroencephalography dual pathology, epilepsy surgery

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Assessing target optical camouflage effects using brain functional networks:A feasibility study

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Defence Technology（防务技术） 2024年第4期34卷 69-77页

作者： zhou yu Li Xue Weidong Xu Jun Liu qi Jia Jianghua Hu Jidong Wu National Key Laboratory of Lightning Protection and Electromagnetic Camouflage Army Engineering University Nanjing 210007JiangsuChina Unit 31608 of PLA Xiamen 361000FujianChina School of Biological Sciences&Medical Engineering Southeast UniversityNanjing 210096JiangsuChina

Brain functional networks model the brain's ability to exchange information across different regions,aiding in the understanding of the cognitive process of human visual attention during target searching,thereby contributing to the advancement of camouflage *** this study,images with various camouflage effects were presented to observers to generate electroencephalography(EEG)signals,which were then used to construct a brain functional *** topological parameters of the network were subsequently extracted and input into a machine learning model for *** results indicate that most of the classifiers achieved accuracy rates exceeding 70%.Specifically,the Logistic algorithm achieved an accuracy of 81.67%.Therefore,it is possible to predict target camouflage effectiveness with high accuracy without the need to calculate discovery *** proposed method fully considers the aspects of human visual and cognitive processes,overcomes the subjectivity of human interpretation,and achieves stable and reliable accuracy.

关键词： Camouflage effect evaluation Electroencephalography(EEG) Brain functional networks Machine learning

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Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： qian-yun Guo Jia-qi Yang Xun-Xun Feng yu-Jie zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

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The Diagnosis and Differential Diagnosis of Ureteral Fibroepithelial Polyps

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Chinese Journal of Clinical Oncology 2006年第5期3卷 373-375页

作者： Wanru Geng Ning Li qi yu Huiqin zhou Hongmin Xu Department of Pathology the Second Affiliated Hospital of the General Hospital of the PLA Beijing 100091 China.

OBJECTIVE To study the clinical pathologic characteristics and differential diagnosis of ureteral fibroepithelial polyps. METHODS One case of ureteral fibroepithelial polyps was studied by clinical data analysis and light microscopy. RESULTS The tumor was located in the lower ureter. Histologically, the polyp was composed of expanded blood vessels and fibrous connective tissue under normal or proliferous transitional epithelium. CONCLUSION Benign ureteral fibroepithelial polyps are extremely rare, recognition of it's precise histological features can facilitate its correct diagnosis.

关键词： fibroepithelial polyps ureteral polyps diagnosis differential diagnosis.

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Landscape Changes from 1974 to 1995 in the Upper Minjiang River Basin, China

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Pedosphere 2006年第3期16卷 398-405页

作者： HE Xing-yuan ZHAO Yong-Hua HU yuan-Man CHANG yu zhou qi-Xing Institute of Applied Ecology the Chinese Academy of Sciences Shenyang 110016 （China） College of Earth Science ＆ Land Resources Management Chang＇an University Xi＇an 710054 （China） Graduate School of the Chinese Academy of Sciences Beijing 100039 （China）

Landscape changes were traced over the 20 years from 1974 to 1995 in the upper Minjiang River basin, one of the most important forest regions in China, based on satellite image interpretation to provide basic data for local decision-making as well as sustainable landscape use and management. Results revealed that landscape from 1974 to 1995 changed at the regional scale as the area of forestland decreased, while cropland, shrubland, economic forest, grassland, and built-up land increased. Landscape changes mainly occurred in forestland, shrubland, grassland, economic forest, and built-up land. Moreover, the changes among forestland, shrubland, and grassland were the largest, influencing the whole characteristics of the changes in the basin. Analysis of the changes between 1974 and 1995 in the study area indicated that landscape heterogeneity and fragmentation increased, whereas landscape connectivity decreased. There were multiple reasons for landscape changes. A principal component analysis (PCA) was used to quantitatively study driving forces of landscape changes. The PCA results showed that economic and population factors were the principal driving forces of landscape changes from 1974 to 1995 in the upper Minjiang River basin, and that PCA was a suitable method for investigating driving forces of landscape changes.

关键词： driving forces landscape change satellite image quantification principal component analysis

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