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Increased expression of angiogenin in gastric carcinoma in correlation with tumor angiogenesis and proliferation

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World Journal of Gastroenterology 2006年第32期12卷 5135-5139页

作者： yu chen Sheng Zhang yu-peng chen Jian-Yin Lin Department of Physiology and Pathophysiology Fujian Medical Oniversity Fuzhou 350004 Fujian Province China Department of Pathology The First Affiliated Hospital of Fujian Medical University Fuzhou350004 Fujian Province China Department of Biochemistry and Molecular Biology Fujian Medical University Fuzhou 350004 Fujian ProvinceChina

AIM： To investigate the implication of angiogenin （ANG） in the neovascularizaton and growth of human gastric carcinoma （HGC）. METHODS： ANG mRNA expression in HGC specimens obtained by surgical resection from patients with HGC were examined by RT-PCR. ANG, Ki-67, VEGF protein expression and microvessel density （MVD） in HGC specimens were detected by immunohistochemistry. RESULTS： RT-PCR showed significantly higher ANG mRNA expression （0.482 ± 0.094） in HGC tissues than in the surrounding nontumorous tissues （0.276 ±0.019, P = 0.03）. MVD within tumorous tissues increased significantly with ANG mRNA expression （r = 0.380, P = 0.001） and ANG protein expression （P 〈 0.01）. The ANG expression levels of cancer tissues were positively correlated with VEGF （P 〈 0.01） and the proliferation index of cancer cells （P 〈 0.01）. CONCLUSION： ANG is one of the neovascularization factors of HGC. ANG may work in coordination with VEGF, and promote the proliferation of HGC cells.

关键词： Angiogenin Gastric carcinoma Vascular endothelial growth factor Angiogenesis

Cerebral metastasis from hepatoid adenocarcinoma of the stomach

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World Journal of Gastroenterology 2007年第43期13卷 5787-5793页

作者： Sheng Zhang Mi Wang Yi-Hui Xue yu-peng chen Department of Pathology The First Affiliated Hospital of FujianMedical University Fuzhou 350005 Fujian Province China

We first report a rare case of metastasis from gastric hepatoid adenocarcinoma (HAC) to cerebral parenchyma, in a 50-year-old Chinese patient. He complained of a one-month history of a paroxysm of headache in the left temple and pars parietalis accompanied with binocular caligation caligo, insensible feeling of limbs and transient anepia. Magnetic resonance (MR) imaging revealed a spherical occupying lesion in the left posterior-temple lobe which was clinically diagnosed as a metastatic tumor. Three years ago, the patient accepted total gastrectomy as he was pathologically diagnosed at gastroscopy having an adenocarcinoma. Eight months after gastrectomy, the occupying lesion in liver was detected by ultrasound and CT, and he accepted transcatheter arterial embolization. Before operation of the brain metastasis, no obvious abnormality was found in liver by ultrasound. Histopathological characteristics of the brain tumor were identical to those of stomach tumor. The growth pattern of both tumors showed solid cell nests. The tumor cells were polygonal, and had abundant eosinophilic cytoplasm and round nuclei with obvious nucleoli. Sinusoid-like blood spaces were located between nodular tumor cells. Immunohistochemistry-stained tumor cells were positive for AFP and negative for Hep-Par-1. According to these histopathological findings, both tumors were diagnosed as HAC and metastatic HAC. The patient remained alive 16 mo after tumorectomy of the cerebral metastasis. The differential diagnosis of brain metastasis from metastatic tumors should use a panel of antibodies to avoid confusing with the brain metastasis of hepatocellular carcinoma (HCC). This paper describes this rare case of metastasis from gastric hepatoid adenocarcinoma to cerebral parenchyma, and provides a review of the literature concerning its histopathological and immunohistochemical characteristics.

关键词： Cerebral metastasis Gastric hepatoidadenocarcinoma Immunohistochemistry

A method for automated development of model and fragility inventories of nonductile reinforced concrete buildings

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Resilient Cities and Structures 2023年第3期2卷 87-103页

作者： peng-yu chen Nikolaos Lesgidis Anastasios Sextos Ertugrul Taciroglu National Central University Civil Eng.Dept.TaoyuanTaiwan Deep Excavation LLC New YorkUSA University of Bristol Civil Eng.Dept.BristolUK UCLA Civil&Env.Eng.Dept.Los AngelesCA 90095USA

The nonductile reinforced concrete building(NDRCB)stock-typically,pre-1974 structures in the U.S.-is a well-known high-risk group for seismic *** studies indicate that there are approximately 1500 NDRCBs in Los *** various ordinances,the owners are currently required to choose between demolition and,when appropriate,seismic *** fulfilling these ordinances will take decades,the potential risk of major losses will *** this study,a method for automated development of structural analysis models and damage fragilities for non-ductile moment-resisting frames is *** capability enables seismic risk assessment at a regional scale using relatively limited building metadata and the era-specific seismic design *** approach is used first to develop archetypal models in OpenSees,verified through static pushover and nonlinear time-history analyses against prior detailed *** curves for discrete damage states are developed through a probabilistic seismic demand *** investigations are carried out to consider the influence of soil-structural interaction effects and to determine the most suitable seismic intensity measures to quantify the seismic damage levels of NDRCB *** sensitivity of the proposed modeling method to variations/uncertainties in building configurations and properties is also examined through parametric *** method is limited to a particular subcategory of NDRBCs-namely,moment-resisting frames-but extensions to other types appear straightforward.

关键词： Nonductile reinforced concrete building Fragility curve Optimal intensity measurement Soil-Structure interaction Sensitive analysis

Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion

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World Journal of Gastroenterology 2008年第31期14卷 4943-4948页

作者： Yong-Lian Wu Sheng Zhang Guo-Rong Wang yu-peng chen The Medical College of Putian University Putian 351100 Fujian Province China Department of Pathology the First Affiliated Hospital of Fujian Medical University Fuzhou 350005 Fujian Province China Hanjiang Hospital Putian 351100 Fujian Province China

AIM: To investigate the relation of expression transfor-mation of claudin-1 with invasiveness and metastasis of gastric carcinoma. METHODS: By using immunohistochemistry, expres-sion of claudin-1 in mucosa and invasive front of 136 gastric adenocarcinoma cases and proliferative index (Ki-67) were detected and analyzed. RESULTS: In mucosa, the claudin-1 over-expression rate of mucinous adenocarcinomas (including signet-ring cell carcinomas) was the highest. It was nega-tively related with the differentiation but positively related with the invasiveness and metastasis of gastric cancer. In invasive front, the claudin-1 over-expression rate was positively related with the differentiation, in-vasiveness and metastasis of gastric carcinoma. The expression transformation of claudin-1 was found in gastric carcinoma. The expression of claudin-1 in inva-sive front was transformed in 28/136 gastric carcinoma cases. The transformation rate in highly differentiated tubular adenocarcinomas was the highest (51.5%, 17/33). The deeper was the invasiveness, the higher was the transformation rate. The claudin-1 expression transformation rate in serosa and omenta was signifi -cantly higher (92.9%) than in tunica muscularis of in-vasive gastric cancer cases, as well as in patients withlymph node metastasis than in those without lymph node metastasis. CONCLUSION: Up-regulation of claudin-1 expres-sion and its transformation in invasive and metastatic gastric carcinoma suggest that claudin-1 participates in the transformation of biological behaviors in neo-plasms. Further study is needed to elucidate the pre-cise mechanism and the relation of claudin-1 expres-sion with the neoplasm progress.

关键词： Gastric carcinoma Claudin-1 Expression transformation Invasiveness Metastasis Immunohistochemistry

A diagnostic of the orbital spectrum of LS 5039 with Fermi-LAT

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Research in Astronomy and Astrophysics 2019年第12期19卷 281-286页

作者： Zhi Chang Shu Zhang yu-peng chen Long Ji Ling-Da Kong Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBejjing 100049China University of Chinese Academy of Sciences Beijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls UniversitatSand 172076 TibingenGermany

LS 5039 is a well-known γ-ray binary system which consists of an unknown compact object and a massive companion O star. It shows rather stable emissions at high energies over years and hence serves as an ideal laboratory to investigate the emission mechanism for such peculiar systems which emit prominent γ-rays. To this end, we take the orbital phase resolved energy spectrum as observed by Fermi-LAT over 10 years. We divide the orbit into four orbital phases, each with an orbital phase range of 0.25,centered at 0.00, 0.25, 0.50 and 0.75 respectively, where the phase 0.0 is the periastron and phase 0.5 is the apastron. The phases around 0.25 and 0.75 are symmetric and hence are supposed to have identical local acceleration environment. The spectral analysis shows that the Fermi-LAT spectra are largely different from these two symmetric orbital phases: the emission from orbital phase 0.25 turns out to be significantly stronger than that from 0.75. This result does not fit a scenario that γ-rays are Doppler boosted emission from bow shock tails if LS 5039 has a shock configuration similar to PSR B1259-63, and indicates that the inverse Compton scatterings between the shock accelerated plasma and the stellar particle environment is the underline procedure. We also find that the previous report for a disappearance of the orbital modulation at 3–20 GeV is due to the similar spectral turn-over energies of the different orbital phases. The spectral properties of periastron and apastron regions are addressed in the context of the measurements in phase regions around 0.25 and 0.75.

关键词： binaries:general gamma rays:general

The GeV emission of PSR B1259–63 during its last three periastron passages observed by Fermi-LAT

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Research in Astronomy and Astrophysics 2018年第12期18卷 89-94页

作者： Zhi Chang Shu Zhang yu-peng chen Long Ji Ling-Da Kong Cong-Zhan Liu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls UniversitatSand 172076 TubingenGermany University of Chinese Academy of Sciences Beijing 100049China

PSR B1259–63 is a γ-ray emitting high mass X-ray binary system, in which the compact object is a millisecond *** system has an orbital period of 1236.7 d and shows peculiar γ-ray flares when the neutron star moves out of the stellar disk of the companion *** γ-ray flare events were firstly discovered by using Fermi-LAT around the 2010 periastron passage, which was repeated for the 2014 and 2017 periastron *** analyze the Fermi-LAT data for all the three periastron passages and found that in each flare the energy spectrum can be represented well by a simple power *** γ-ray light curves show that in 2010 and 2014 after each periastron there are two main flares,but in 2017 there are four flares including one precursor about 10 d after the periastron *** first main flares in 2010 and 2014 are located at around 35 d after the periastron passage, and the main flare in 2014 is delayed by roughly 1.7 d with respect to that in *** the 2017 flare, the source shows a precursor about 10 d after the periastron passage, but the following two flares become weaker and lag behind those in 2010 by roughly 5 *** strongest flares in 2017 occurred 58 d and 70 d after the periastron *** results challenge the previous models.

关键词： binaries:general pulsars:general gamma rays:general

NUMERICAL RESEARCH ON WATER GUIDE BEARING OF HYDRO-GENERATOR UNIT USING FINITE VOLUME METHOD

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Journal of Hydrodynamics 2007年第5期19卷 635-642页

作者： peng yu-cheng chen Xi-yang ZHANG Ke-wei HOU Guo-xiang School of Energy and Power. Engineering Huazhong University of Science and Technology Wuhan 430074 China School of Traffic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

With the consideration of the geometry of tilting pad journal bearing, a new form of the Reynolds equation was derived in this article. The film thickness, the squeeze motion of the journal and the rotation motion of the pad were explicitly contained in the equation. Based on this equation, together with the equilibrium equation of pad pivot, the water guide bearing used in the Gezhouba 10 F hydro-generator unit was numerically researched. The new Reynolds equation for the lubricating film was solved using Finite Volume （FV） discretization, Successive Over-Relaxation （SOR） iteration method and C＋＋ code are included. According to the numerical solution, and the stability of the film and the influences of the film thickness, the journal squeeze effect and the pad rotation effect on film force were discussed. The results indicate that the squeeze effect can not be neglected, although the rotation effect is negligible for both low-speed and high-speed bearings, so the computing time could be greatly reduced.

关键词： hydro-generator unit Reynolds equation,tilting pad journal bearing Finite Volume (FV) method

A compact inorganic layer for robust anode protection in lithium-sulfur batteries

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InfoMat 2020年第2期2卷 379-388页

作者： yu-Xing Yao Xue-Qiang Zhang Bo-Quan Li Chong Yan peng-yu chen Jia-Qi Huang Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijingChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina

Lithium-sulfur(Li-S)batteries are one of the most promising candidates for high energy density rechargeable batteries beyond current Li-ion ***,severe corrosion of Li metal anode and low Coulombic efficiency(CE)induced by the unremitting shuttle of Li polysulfides immensely hinder the practical applications of Li-S ***,a compact inorganic layer(CIL)formed by ex situ reactions between Li anode and ionic liquid emerged as an effective strategy to block Li polysulfides and suppress shuttle effect.A CE of 96.7%was achieved in Li-S batteries with CIL protected Li anode in contrast to 82.4%for bare Li anode while no lithium nitrate was ***,the corrosion of Li during cycling was effectively *** applied to working batteries,80.6%of the initial capacity after 100 cycles was retained in Li-S batteries with CIL-protected ultrathin(33μm)Li anode compared with 58.5%for bare Li anode,further demonstrating the potential of this strategy for practical *** study presents a feasible interfacial regulation strategy to protect Li anode with the presence of Li polysulfides and opens avenues for Li anode protection in Li-S batteries under practical conditions.

关键词： electrochemical energy storage lithium metal anode lithium-sulfur batteries rechargeable battery solid electrolyte interphase

NUMERICAL STUDY OF CAVITATION ON THE SURFACE OF THE GUIDE VANE IN THREE GORGES HYDROPOWER UNIT

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Journal of Hydrodynamics 2010年第5期22卷 703-708页

作者： peng yu-cheng chen Xi-yang CAO Yan HOU Guo-xiang School of energy and Power Engineering Huazhong University of Science and Technology Wuhan 430074 China College of Electronic Information Engineering Wuhan Polytechnic Wuhan 430074 China School of Traffic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Large-area erosions such as rust and obvious cavitation were found on the surface of the guide vane in Three Gorges hydropower units. A numerical explanation of the cavitation is given in this article. At first, based on the characteristic performance curves of the prototype hydro-turbine supplied by ALSTOM together with the actual operating conditions, an operating point is chosen for numerical analysis using the Reynolds-Averaged Navier-Stokes （RANS） equations. The flow passages from the inlet of the spiral case to the outlet of the draft tube are included in the computational domain. The results show that the static pressure on the guide vane surface is much higher than the critical pressure of cavitation. Secondly, a tiny protrusion on the guide vane surface is considered and the problem is simplified to a 2-D problem to study the local detailed flow near the guide vane surface. The protrusion is 0.5 mm in height and is 5.0 mm in width. On the basis of the results of RANS simulations, the 2-D problem is studied using the Large Eddy Simulation （LES）. It is shown that there exists a region in which the static pressure reaches a level below the vapor pressure of the water. Thirdly, a cavitation model is included for the 0.5 mm protrusion case and another tiny pit case, with a tiny pit 0.3 mm in depth and 1.0 mm in width. The results show that vapor bubble exists at the protrusion entrance and the pit exit as the low pressure regions.

关键词： cavitation guide vane numerical analysis