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Aquaporin-3 promotes proliferation and inflammation in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 45-48页

作者： Yao Wang Yalan Wu Xueying Li Weiwei song Fengling Zheng Xiaoying mo Yi Luo yun Li song Chen Huanhuan Luo School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China The School of Health Guangzhou Vocational University of Science andTechnologyGuangzhouGuangdong 510555China Zhongshan Hospital of Traditional Chinese Medicine ZhongshanGuangdong 528401China The Journal Center Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China Jiangsu Vocational College of Medicine YanchengJiangsu 224005China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China State Key Laboratory of Dampness Syndrome of Chinese Medicine GuangzhouGuangdong 510006China

Carcinogenesis is closely associated with *** have shown that lipopolysaccharides(LPS)can contribute to hepatocellular carcinoma(HC)development by inducing IL-6 and TNF-αproduction from the hepatic progenitor cells.1 Aquaporin 3(AQP3),a water channel protein,has recently been found to play a critical role in cancer-associated inflammation.

关键词： inflammation. hepatocellular inflammation

Comprehensive treatment of von Hippel-Lindau disease:A case report

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Cancer Innovation 2024年第2期3卷 63-67页

作者： Xuesong Li Zheng mo Zhuo yu School of Clinical Medicine Tsinghua UniversityBeijingChina Department of Oncology Beijing Tsinghua Changgung HospitalBeijingChina

von Hippel-Lindau(VHL)disease is a rare autosomal dominant multiorgan disease characterized by several benign and malignant tumors rich in vascular,as well as cysts in other organs.A great clinical treatment strategy is significantly warranted for good prognosis of patients with VHL ***,we reported a case of a 45-year-old woman diagnosed with VHL disease with spinal hemangioblastoma(HB)and clear cell renal cell carcinoma(ccRCC).Four years after the resection of the right kidney,a recurrent RCC in the right kidney and a malignant lesion in the left kidney were *** patient was started on sorafenib(800 mg,daily)and tislelizumab(200 mg per 3 weeks).After 6 months of treatment,the size of renal cell carcinoma was dramatically reduced and renal function *** importantly,she achieved partial response during the whole ***,intramedullary masses resection was done and the HB in T4-5 thoracic spinal was *** symptoms such as numbness and pain were remarkably ***,tislelizumab-induced elevation in liver transaminase levels and hypothyroidism were revered by hepatoprotector and levothyroxine,*** short,comprehensive treatment strategies may benefit patients with VHL disease,especially with HB and ccRCC.

关键词： sorafenib surgery tislelizumab treatment von Hippel-Lindau disease

Can serum immunoglobulin G4 levels and age serve as reliable predictors of relapse in autoimmune pancreatitis?

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World Journal of Gastroenterology 2024年第5期30卷 512-515页

作者： Jun-Min song Si-yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

We are writing in response to the paper published in the World Journal of Gastroenterology by Zhou et *** authors identified higher serum immunoglobulin(Ig)G4 levels and age over 55 years as independent risk factors for disease *** notable strengths,it is crucial to address potential ***,the cohort study included 189 patients with autoimmune pancreatitis(AIP)type 1(with higher IgG4 seropositivity and higher relapse)and 24 with type 2(with lower IgG4 seropositivity and lower relapse).Consequently,most,if not all,AIP type 2 patients were assigned to the normal group,possibly inflating the association of higher serum IgG4 levels with relapse and potentially exaggerating the association of older age with ***,the authors did not provide sufficient details regarding AIP diagnosis,such as the ratio of definitive vs probable cases and the proportion of *** cases where histological evidence is unavailable or indeterminate,AIP type 2 may be misdiagnosed as definitive type 1,and type 1 may also be misdiagnosed as probable type 2,particularly in cases with normal or mildly elevated serum IgG4 ***,in this retrospective study,approximately one-third of the consecutive patients initially collected were excluded for various ***,the impact of nonrandom exclusion on relapse outcomes should be carefully *** conclusion,the paper by Zhou et al offers plausible,though not entirely compelling,evidence suggesting a predictive role of elevated serum IgG4 levels and advanced age in AIP *** foundation for future investigations lies in ensuring a reliable diagnosis and accurate disease subtyping,heavily dependent on obtaining histological *** this regard,endoscopic ultrasound-guided fine-needle biopsy emerges as a pivotal component of the diagnostic process,contributing to mitigating biases in future explorations of the disease.

关键词： Autoimmune pancreatitis Immunoglobulin Endoscopic ultrasound Relapse Age

Imbalance of Circulating Follicular Regulatory and Follicular Helper T Cell Subpopulations Is Associated with Disease Progression and Serum CYFRA 21-1 Levels in Patients with Non-small Cell Lung Cancer

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Current Medical Science 2024年第1期44卷 102-109页

作者： Tian-ci LIU mo-han ZHENG Xing-yue ZENG Rui KANG Ayibaota Bahabayi Bulidierxin Tuerhanbayi song-song LU Chen LIU Department of Clinical Laboratory Peking University People's HospitalBeijing 100044China School of Basic Medical Sciences Peking University Health Science CenterBeijing 100191China

Objective This study aimed to investigate the changes of follicular helper T(TFH)and follicular regulatory T(TFR)cell subpopulations in patients with non-small cell lung cancer(NSCLC)and their *** Peripheral blood was collected from 58 NSCLC patients at different stages and 38 healthy *** cytometry was used to detect TFH cell subpopulation based on programmed death 1(PD-1)and inducible co-stimulator(ICOS),and TFR cell subpopulation based on cluster determinant 45RA(CD45RA)and forkhead box protein P3(FoxP3).The levels of interleukin-10(IL-10),interleukin-17a(IL-17a),interleukin-21(IL-21),and transforming growth factor-β(TGF-β)in the plasma were measured,and changes in circulating B cell subsets and plasma IgG levels were also *** correlation between serum cytokeratin fragment antigen 21-1(CYFRA 21-1)levels and TFH,TFR,or B cell subpopulations was further *** The TFR/TFH ratio increased significantly in NSCLC *** CD45RA^(+)FoxP3^(int) TFR subsets were increased,with their proportions increasing in stages Ⅱ to Ⅲ and decreasing in stage ***-1^(+)ICOS+TFH cells showed a downward trend with increasing *** IL-21 and TGF-β concentrations were increased in NSCLC patients compared with healthy ***,plasma IgG levels,and CD45RA^(+)FoxP3^(int) TFR cells showed similar *** numbers and plasmablasts were positively correlated with CYFRA 21-1 in stages Ⅰ-Ⅲ and negatively correlated with CYFRA 21-1 in stage *** Circulating TFH and TFR cell subpopulations and plasmablasts dynamically change in different stages of NSCLC,which is associated with serum CYFRA 21-1 levels and reflects disease progression.

关键词： non-small cell lung cancer follicular helper T cells follicular regulatory T cells progression

Uncertainties of landslide susceptibility prediction:influences of different study area scales and mapping unit scales

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International Journal of Coal Science & Technology 2024年第2期11卷 143-172页

作者： Faming Huang yu Cao Wenbin Li Filippo Catani Guquan song Jinsong Huang Changshi yu School of Civil Engineering and Architecture Nanchang UniversityNanchang 330031China Hebei International Joint Research Center for Remote Sensing of Agricultural Drought monitoring/School of Land Science and Space Planning Hebei GEO UniversityShijiazhuang 050031China Department of Geosciences University of PadovaPaduaItaly Discipline of Civil Surveying and Environmental EngineeringPriority Research Centre for Geotechnical Science and EngineeringUniversity of NewcastleCallaghanNSWAustralia School of Information Engineering Nanchang UniversityNanchang 330031China

This study aims to investigate the effects of different mapping unit scales and study area scales on the uncertainty rules of landslide susceptibility prediction(LSP).To illustrate various study area scales,Ganzhou City in China,its eastern region(Ganzhou East),and Ruijin County in Ganzhou East were *** mapping unit scales are represented by grid units with spatial resolution of 30 and 60 m,as well as slope units that were extracted by multi-scale segmentation *** 3855 landslide locations and 21 typical environmental factors in Ganzhou City are first determined to create spatial datasets with ***,landslide susceptibility maps(LSMs)of Ganzhou City,Ganzhou East and Ruijin County are pro-duced using a support vector machine(SVM)and random forest(RF),*** LSMs of the above three regions are then extracted by mask from the LSM of Ganzhou City,along with the LSMs of Ruijin County from Ganzhou ***,LSMs of Ruijin at various mapping unit scales are generated in *** and landslide suscepti-bility indexes(LSIs)distribution are used to express LSP *** LSP uncertainties under grid units significantly decrease as study area scales decrease from Ganzhou City,Ganzhou East to Ruijin County,whereas those under slope units are less affected by study area *** course,attentions should also be paid to the broader representativeness of large study *** LSP accuracy of slope units increases by about 6%–10%compared with those under grid units with 30 m and 60 m resolution in the same study area's *** significance of environmental factors exhibits an averaging trend as study area scale increases from small to *** importance of environmental factors varies greatly with the 60 m grid unit,but it tends to be consistent to some extent in the 30 m grid unit and the slope unit.

关键词： Landslide susceptibility prediction Uncertainty analysis Study areas scales Mapping unit scales Slope units Random forest

Comparison of models to predict air infiltration rate of buildings with different surrounding environments

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Building Simulation 2024年第6期17卷 1007-1021页

作者： Shu Zheng Xiujiao song Lin Duanmu yu Xue Xudong Yang Department of Building Science Tsinghua UniversityBeijing100084China School of Civil Engineering Dalian University of TechnologyDalian116024China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan030032China

The air infiltration rate of buildings strongly influences indoor environment and energy *** this study,several traditional methods for determining the air infiltration rate were compared,and their accuracy in different scenarios was ***,a method combining computational flow dynamics(CFD)with the Swami and Chandra(S-C)model was developed to predict the influence of the surrounding environment on the air infiltration *** buildings in Dalian,China,were selected:one with a simple surrounding environment and the other with a complex surrounding environment;their air infiltration rates were *** test results were used to validate the accuracy of the air infiltration rate solution models in different urban *** the building with a simple environment,the difference between the simulation and experimental results was 0.86%–22.52%.For the building with a complex environment,this difference ranged from 17.42%to 159.28%.We found that most traditional models provide accurate results for buildings with simple surrounding and that the simulation results widely vary for buildings with complex *** results of the method of combining CFD with the S-C model were more accurate,and the relative error between the simulation and test results was 10.61%.The results indicate that the environment around the building should be fully considered when calculating the air infiltration *** results of this study can guide the application of methods of determining air infiltration rate.

关键词： air infiltration rate models CFD simulation building surrounding air infiltration rate test

MXene:Promising materials for magnesium-ion batteries

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Chinese Journal of Chemical Engineering 2024年第5期69卷 199-211页

作者： Liuyu song Haibo Li Pengkai Wang yu Shang yue Yang Zhaoyu Wu School of Resources and Civil Engineering Northeastern UniversityShenyang 110004China

Magnesium-ion batteries(MIBs)have attracted extensive attention due to their high theoretical capacity,superior safety,and low ***,the development of MIBs is hindered by the lack of cathode materials with long cycle life and rate *** stands out as a prime choice for MIB cathode or collector for anode-free magnesium batteries(AFMBs)because of its larger surface area,adjustable surface properties,and good electrical *** this paper,we summarized the preparation and layering methods of MXene and discussed the prospects of MXene as a cathode or collector for *** review will be immensely beneficial in critically analyzing the synthesis techniques and the applications of MXene material as MIB cathode or AFMB *** addition,the challenges of the preparation and layering were concluded,along with raising the research strategies of MXene for storing Mg ions.

关键词： MXene Nanomaterials Electrochemistry Optimization Magnesium-ion batteries(MIBs)

An effective'salt in dimethyl sulfoxide/water'electrolyte enables high-voltage supercapacitor operated at-50℃

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Journal of Energy Chemistry 2024年第6期93卷 361-367,I0009页

作者： Yingbin Liu Chang yu Xuedan song Siyi Hou Shuqin Lan Jinhe yu yuanyang Xie Jieshan Qiu State Key Lab of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina School of Chemistry Frontier Science Center for Smart MaterialsLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina College of Chemical Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Compared with organic electrolytes,aqueous electrolytes exhibit significantly higher ionic conductivity and possess inherent safety features,showcasing unique advantages in ***,challenges remain for low-salt aqueous electrolytes operating at high voltage and low ***,we report a low-salt(0.87 m,m means mol kg^(-1))'salt in dimethyl sulfoxide/water'hybrid electrolyte with non-flammability via hybridizing aqueous electrolyte with an organic co-solvent of dimethyl sulfoxide(hydrogen bond acceptor).As a result,the 0.87 m hybrid electrolyte exhibits enhanced electrochemical stability,a freezing temperature below-50℃,and an outstanding ionic conductivity of 0.52mS cm~(-1)at-50℃.Dimethyl sulfoxide can anchor water molecules through intermolecular hydrogen bond interaction,effectively reinforcing the stability of water in the hybrid ***,the interaction between dimethyl sulfoxide and water molecules diminishes the involvement of water in the generation of ordered ice crystals,finally facilitating the low-temperature performance of the hybrid *** paired with the 0.87 m'salt in dimethyl sulfoxide/water'hybrid electrolyte,the symmetric supercapacitor presents a 2.0 V high operating voltage at 25℃,and can operate stably at-50℃.Importantly,the suppressed electrochemical reaction of water at-50℃further leads to the symmetric supercapacitor operated at a higher voltage of 2.6 *** modification strategy opens an effective avenue to develop low-salt electrolytes for high-voltage and low-temperature aqueous supercapacitors.

关键词： Dimethyl sulfoxide Co-solvent High voltage Low temperature Supercapacitors

Drug delivery systems for colorectal cancer chemotherapy

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Chinese Chemical Letters 2024年第2期35卷 163-175页

作者： Wen Chen Kun Shi Yan yu Peipei Yang Zhongwu Bei Dong mo Liping yuan Meng Pan yu Chen Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Colorectal cancer causes the third most common type of malignant tumors with high morbidity and *** is currently one of the most effective and common treatments for colorectal ***,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the undesirable systemic side effects of conventional treatment remain the major issues for colorectal cancer ***,drug delivery systems(DDS)based on biomaterials have been widely investigated and found to be capable of resolving those issues with good ***,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer *** not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus ***,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also *** provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.

关键词： Colorectal cancer Chemotherapy Drug delivery systems Solubility Targeted Local administration