检索结果-南通市图书馆

Inflammatory Factor IL1αInduces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca^(2+)/CaMK2b Pathway

引用

Neuroscience Bulletin 2024年第4期40卷 421-438页

作者： yu Xia Lu Ding Changlin Zhang Qi Xu ming Shi Tianshun gao Feng-Quan Zhou David Y.B.Deng Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Department of Gynecology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Pelvic Floor Disorders Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Big Data Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310016China Orthopaedic and Neurological Repair Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Spinal cord injury(SCI)is one of the most devastating traumas,and the aberrant proliferation of astrocytes usually causes neurological ***,the mechanism underlying astrocyte over-proliferation after SCI is ***2c(glutamate ionotropic receptor type 2c)plays an essential role in cell *** bioinformatic analysis indicated that Grin2c and Ca^(2+)transport functions were inhibited in astrocytes after *** of Grin2c stimulated astrocyte proliferation by inhibiting the Ca^(2+)/calmodulin-dependent protein kinase 2b(CaMK2b)pathway in *** screening different inflammatory factors,interleukin 1α(IL1α)was further found to inhibit Grin2c/Ca^(2+)/CaMK2b and enhance astrocyte proliferation in an oxidative damage *** of IL1αusing neutralizing antibody resulted in increased Grin2c expression and the inhibition of astrocyte proliferation ***,this study suggests that IL1αpromotes astrocyte proliferation by suppressing the Grin2c/Ca^(2+)/CaMK2b pathway after SCI,revealing a novel pathological mechanism of astrocyte proliferation,and may provide potential targets for SCI repair.

关键词： IL1α Grin2c Astrocyte Spinal cord injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sparse Modal Decomposition Method Addressing Underdetermined Vortex-Induced Vibration Reconstruction Problem for Marine Risers

引用

China Ocean Engineering 2024年第2期38卷 285-296页

作者： DU Zun-feng ZHU Hai-ming yu Jian-xing State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation School of Civil EngineeringTianjin UniversityTianjin 300350China

When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fatigue monitoring of real *** problem is conventionally solved using the modal decomposition method,based on the principle that the response can be approximated by a weighted sum of limited vibration ***,the method is not valid when the problem is underdetermined,i.e.,the number of unknown mode weights is more than the number of known *** study proposed a sparse modal decomposition method based on the compressed sensing theory and the Compressive Sampling Matching Pursuit(Co Sa MP)algorithm,exploiting the sparsity of VIV in the modal *** the validation study based on high-order VIV experiment data,the proposed method successfully reconstructed the response using only seven acceleration measurements when the conventional methods failed.A primary advantage of the proposed method is that it offers a completely data-driven approach for the underdetermined VIV reconstruction problem,which is more favorable than existing model-dependent solutions for many practical applications such as riser structural health monitoring.

关键词： motion reconstruction vortex-induced vibration(VIV) marine riser modal decomposition method compressed sensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

引用

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-yu Chen Xiang-yu Lyu En-Kun Li Yi-ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Homological dimensions of gentle algebras via geometric models

引用

Science China Mathematics 2024年第4期67卷 733-766页

作者： yu-Zhe Liu Hanpeng gao Zhaoyong Huang Department of Mathematics Nanjing UniversityNanjing 210093China School of Mathematical Sciences Anhui UniversityHefei 230601China

Let A=kQ/I be a finite-dimensional basic algebra over an algebraically closed field k,which is a gentle algebra with the marked ribbon surface(SA,MA,ΓA).It is known that SAcan be divided into some elementary polygons{Δi|1≤i≤d}byΓA,which has exactly one side in the boundary of ***■(Δi)be the number of sides ofΔibelonging toΓAif the unmarked boundary component of SAis not a side ofΔi;otherwise,■(Δi)=∞,and let f-Δbe the set of all the non-co-elementary polygons and FA(resp.f-FA)be the set of all the forbidden threads(*** finite length).Then we have(1)the global dimension of A is max1≤i≤d■(Δi)-1=maxΠ∈FAl(Π),where l(Π)is the length ofΠ;(2)the left and right self-injective dimensions of A are 0,if Q is either a point or an oriented cycle with full ***Δi∈f-Δ{1,■(Δi)-1}=max n∈f-F_(A)l(П),otherwise,As a consequence,we get that the finiteness of the global dimension of gentle algebras is invariant under AvellaGeiss(AG)-*** addition,we get that the number of indecomposable non-projective Gorenstein projective modules over gentle algebras is also invariant under AG-equivalence.

关键词： global dimension self-injective dimension gentle algebras marked ribbon surfaces geometric models AG-equivalence

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Triazine-based multicomponent metallacages with tunable structures for SO_(2) selective capture and conversion

Aggregate

引用

Aggregate 2024年第1期5卷 270-279页

作者： Ruoqian Zhang Dingyue Hu yu Fu Qian Feng Chaoqun Mu Kai gao Heping Ma ming Liu mingming Zhang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’anP.R.China Department of Chemistry Hangzhou Global Scientific and Technological Innovation Center(HIC)Zhejiang UniversityHangzhouP.R.China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’anP.R.China

The design of novel materials for sulfur dioxide(SO_(2))capture and conversion with considerable efficiency under mild conditions is of great significance for human health and environmental protection yet highly ***,we report a series of triazine-based multicomponent metallacages via coordination-driven self-assembly of 2,4,6-tri(4-pyridyl)-1,3,5-triazine,cis-Pt(PEt3)2(OTf)2 and different tetracarboxylic *** the increase of the length of the tetracarboxylates,the structures of the metallacages change from pyramids to extended *** to their N-rich structure,these metallacages are further used for selective SO_(2)capture,showing good adsorption capacity and remarkable SO_(2)/CO_(2)selectivity in ambient conditions,suggesting their potential applications toward real flue gas *** metallacages are further employed for the conversion of SO_(2)into value-added compounds,showing exceptional efficiency even dilute SO_(2)is used as the *** study represents a type of structure-tunable triazinebased metallacages for SO_(2)capture and conversion,which will pave the way on the applications of metal-organic complexes for gas adsorption.

关键词： multicomponent metallacages self-assembly SO_(2) adsorption SO_(2) conversion tunable structures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

How the enhanced East Asian summer monsoon regulates total gross primary production in eastern China

引用

Advances in Climate Change Research 2024年第2期15卷 244-252页

作者： ming-yu HAN Yong ZHANG Jing PENG China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China China Meteorological Administration Institute for Development and Programme Design Beijing 100081China CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of Sciences(CAS)Beijing 100029China

Recognizing the relationship between gross primary production(GPP)and precipitation in eastern China,the East Asian Summer Monsoon(EASM)plays a crucial role in shaping *** confirmation of the strong link between EASM and GPP,there remains a notable research gap in understanding the specific impact of the EASM on GPP in different regions of eastern *** we used simulations from Trends in Net Land-Atmosphere Carbon Exchanges(TRENDY)models from 1951 to 2010 and divided eastern China into five subregions for the *** also used the New East Asian Summer Monsoon Index(NEWI)as a quantitative metric to distinguish between periods of strong and weak *** on this,this study aims to investigate the response of GPP in different subregions of eastern ***,under strengthened EASM years(1954,1957,1965,1969,1977,1980,1983,1987,1993 and 1998),East China experienced the most pronounced increase in GPP at 12±21(mean±1 sigma)gC m^(-2) mon^(-1) compared to the weak EASM years(1958,1961,1972,1973,1978,1981,1985,1994,1997 and 2004).In contrast,Southwest China showed a decline in GPP at-4±10 gC m^(-2) mon^(-1).Moreover,GPP also increased in Northeast and North China when EASM strengthened,while South China showed a decline in *** indicated that GPP changed with monsoon *** to the mechanism analysis,during strong EASM,there was intense moisture convergence through alterations in the atmospheric circulation field over East China and abundant precipitation,which further contributed to the increase in *** solar radiation in Southwest China decreased with EASM enhancement,which suppressed GPP and hindered vegetation ***,the results highlight the importance of accurately predicting the impact of different EASM intensities of regional carbon fluxes.

关键词： Gross primary production Surface air temperature Precipitation Solar radiation Eastern China Carbon cycle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国“无废城市”发展水平的空间关联结构与影响机制

引用

环境科学 2024年第8期45卷 4980-4992页

作者：高煜昕高明福州大学经济与管理学院福州350116 福州大学福建绿色发展研究院福州350116

基于熵权TOPSIS法测度2004~2021年中国“无废城市”发展水平,采用社会网络分析法和空间杜宾模型探究“无废城市”发展水平的空间关联网络结构与影响机制.结果表明:①“无废城市”发展水平在全国、东部和中部总体呈下降趋势,在西部总体... 详细信息

基于熵权TOPSIS法测度2004~2021年中国“无废城市”发展水平,采用社会网络分析法和空间杜宾模型探究“无废城市”发展水平的空间关联网络结构与影响机制.结果表明:①“无废城市”发展水平在全国、东部和中部总体呈下降趋势,在西部总体呈上升趋势;②“无废城市”发展水平的空间关联呈现核心-边缘结构,网络密度总体呈上升趋势,网络整体趋于稳定状态;③北京、上海、江苏、浙江、福建和广东处于网络的中心和主导位置;④北京、天津、上海和江苏属于“净受益”板块,浙江、福建和广东属于“经纪人”板块,其余省份属于“净溢出”板块;⑤城镇化水平、经济发展水平、技术创新水平、外商投资水平、环境规制、政府干预和人口规模分别对本地或邻近省份“无废城市”发展水平产生显著影响.研究结果可为各地区“无废城市”建设与协同发展政策的提出提供借鉴.

关键词： “无废城市” 发展水平空间关联结构社会网络分析空间杜宾模型

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global output feedback control of feedforward nonlinear time-delay systems with unknown growth rate and unknown measurement sensitivity

引用

Control Theory and Technology 2024年第1期22卷 122-134页

作者： Weiyong yu Keao gao Hongbing Zhou Qiang Liu Academy of Artificial Intelligence Beijing Institute of Petrochemical TechnologyBeijing102617China School of Mathematics and Statistics Nanyang Normal UniversityNanyang473061HenanChina

This paper discusses the problem of global state regulation via output feedback for a class of feedforward nonlinear time-delay systems with unknown measurement sensitivity. Different from previous works, the nonlinear terms are dominated by upper triangular linear unmeasured (delayed) states multiplied by unknown growth rate. The unknown growth rate is composed of an unknown constant, a power function of output, and an input function. Furthermore, due to the measurement uncertainty of the system output, it is more difficult to solve this problem. It is proved that the presented output feedback controller can globally regulate all states of the nonlinear systems using the dynamic gain scaling technique and choosing the appropriate Lyapunov–Krasovskii functionals.

关键词： Adaptive control Dynamic gain controllers Feedforward time-delay systems Measurement sensitivity Output feedback

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accelerating BERT inference with GPU-efficient exit prediction

引用

Frontiers of Computer Science 2024年第3期18卷 31-42页

作者： Lei LI Chengyu WANG minghui QIU Cen CHEN ming gao Aoying ZHOU Shanghai Engineering Research Center of Big Data Management School of Data Science and EngineeringEast China Normal UniversityShanghai 200062China Alibaba Group Hangzhou 311121China KLATASDS-MOE School of StatisticsEast China Normal UniversityShanghai 200062China

BERT is a representative pre-trained language model that has drawn extensive attention for significant improvements in downstream Natural Language Processing(NLP)*** complex architecture and massive parameters bring BERT competitive performance but also result in slow speed at model inference *** speed up BERT inference,FastBERT realizes adaptive inference with an acceptable drop in accuracy based on knowledge distillation and the early-exit ***,many factors may limit the performance of FastBERT,such as the teacher classifier that is not knowledgeable enough,the batch size shrinkage and the redundant computation of student *** overcome these limitations,we propose a new BERT inference method with GPU-Efficient Exit Prediction(GEEP).GEEP leverages the shared exit loss to simplify the training process of FastBERT from two steps into only one step and makes the teacher classifier more knowledgeable by feeding diverse Transformer outputs to the teacher *** addition,the exit layer prediction technique is proposed to utilize a GPU hash table to handle the token-level exit layer distribution and to sort test samples by predicted exit *** this way,GEEP can avoid batch size shrinkage and redundant computation of student *** results on twelve public English and Chinese NLP datasets prove the effectiveness of the proposed *** source codes of GEEP will be released to the public upon paper acceptance.

关键词： BERT FastBERT inference acceleration model distillation early exit text classification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis

引用

Chinese Journal of Natural Medicines 2024年第6期22卷 554-567页

作者： LI Weiming gao ming XUE Weili LI Xiaoli CHANG yu ZHANG Kaixin WEN Chenyu ZHANG mingzhi Department of Oncology Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China

Diffuse large B-cell lymphoma(DLBCL)is characterized by significant treatment *** acid(PA)has shown promising antitumor *** study aims to elucidate the molecular mechanisms by which PA influences DLBCL *** quantified the expression levels of microRNAs(miRNAs),Forkhead box protein O1(FOXO1),and DNA methyltransferase 3A(DNMT3A)in both untreated and PA-treated DLBCL tumors and cell *** were made of cell viability,apoptosis,and autophagy-related protein expression following PA *** analyses among miR-429,DNMT3A,and FOXO1 were conducted using luciferase reporter assays and methylation-specific(MSP)Polymerase chain reaction(PCR).After transfecting the miR-429 inhibitor,negative control(NC)inhibitor,shRNA against DNMT3A(sh-DNMT3A),shRNA negative control(sh-NC),over-expression vector for DNMT3A(oe-DNMT3A),or overexpression negative control(oe-NC),we evaluated the effects of miR-429 and DNMT3A on cell viability,mortality,and autophagy-related protein expression in PA-treated DLBCL cell *** efficacy of PA was also tested in vivo using DLBCL tumor-bearing mouse ***-429 and FOXO1 expression levels were downregulated,whereas DNMT3A was upregulated in DLBCL compared to the control *** treatment was associated with enhanced autophagy,mediated by the upregulation of miR-429 and downregulation of *** luciferase reporter assay and MSP confirmed that miR-429 directly inhibits DNMT3A,thereby reducing FOXO1 *** experiments demonstrated that PA promotes autophagy and inhibits DLBCL progression by upregulating miR-429 and modulating the DNMT3A/FOXO1 *** vivo PA signific-antly reduced the growth of xenografted tumors through its regulatory impact on the miR-429/DNMT3A/FOXO1 *** acid may modulate autophagy and inhibit DLBCL progression by targeting the miR-429/DNMT3A/FOXO1 signaling pathway,suggesting a novel therapeutic target for DLBCL management.

关键词： Palmitic acid Diffuse large B-cell lymphoma MiR-429 DNMT3A FOXO1 Autophagy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：