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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： Mengyao ZHAO Jie MA Lanlan YANG Chuanqi PAN Denggui WANG Jianjun ZHOU Sheng li Jiaxing WEI long ZHANG Siyang liU Weifeng SUN National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi lin Ruian Xu Lu liu yu Zhang Feng Tian Jiao Jiao li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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The pharmacodynamics experiment of Xinkang injection protect action of ADR-induced toxin myocarditisin mice

The pharmacodynamics experiment of Xinkang injection protect...

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两岸三地药理学与临床药理学术会议

作者： ZHANG Hong DU Jia-lin li Xin-hua XIANG Shao-jie JIA Dong BAO yu-long li Kun (liaoning University of Traditional Chinese Medicine, Shenyang 110034, China)

Objective The experiment is to study the protective effects of Xinkang Injection on ADR-induced toxin myocarditisin *** The test of Xinkang Injection on ADR-induced toxin myocarditisin mice. Firstly,the animal of obnormal,weight and death ***,the influnences of cardiogram of ADR-in- duced toxin myocarditisin ***,the influnences of lactate dehydrogenase (LDH),creatine kinase (CK) and glutamic oxaloacetic transaminasw (GOT) of ADR-induced toxin myocarditisin ***, the influnences of changes of cardioc pathological mechanism of ADR-induced toxin myocarditisin mice. Fifthly,the influnces of the caidioc ultrastructural of ADR-induced toxin myocarditisin *** First- ly,to ADR-induced toxin myocarditisin mice,the weight of middle dose and high dose of Xinkang injection had declined obviosly which contrast with the constraction model mice *** the mean time,the weight of Xinkang injection team had obviosly changde which contrast with contrastion mice team(Plined the activity of LDH and CK (P<0.01).Fouthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team can contrast with injured on toxic my- ocarditisin mice ***,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team have effect of allevite the injection of the cardioc ulteasteuctural of ADR-induced toxin myocarditisin *** Xinkang

关键词： Xinkang injection ADR toxin myocarditisin

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Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI Jianxin WANG Shulin XU Man ZHU li BAI Lei TANG Dandan LEI yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

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Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng li Chunyan Chen Zhenyang li Peng Yi Haihan Zou Gao Deng Ming Fang Junzhe He Xin Sun Ronghai yu Jianglan Shui Caofeng Pan Xiaofang liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam liquid metal Electromagnetic interference shielding

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非均匀网格FDTD分析波导宽边辐射缝隙特性

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通信学报 2004年第5期25卷 143-147页

作者：张玉李龙梁昌洪西安电子科技大学电子工程学院陕西西安710071

波导宽边辐射缝隙被广泛应用于波导缝隙阵列中,为了比较准确地对波导缝隙进行建模,同时考虑到计算资源限制,本文引入一种采用非均匀网格的时域有限差分方法对其S参数特性进行了计算。数值结果表明该方法分析波导辐射缝隙特性问题的有效性。

关键词：波导宽边辐射缝隙非均匀网格时域有限差分方法 S参数

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Fatigue behavior of aluminum stiffened plate subjected to random vibration loading

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Transactions of Nonferrous Metals Society of China 2014年第5期24卷 1331-1336页

作者：胡海涛李玉龙索涛赵峰苗应刚薛璞邓琼西北工业大学航空学院西安710072 顶峰多尺度科学研究所成都610064

Vibration tests were carried out on three types of stiffened aluminum plates with fully clamped boundaries under random base excitation. During the test, the response of the specimens was monitored using strain gauges. Based on the strain history, the accumulation of fatigue damage of the stiffened plates was estimated by means of the rainflow cycle counting technique and the Miner linear damage accumulation model in the time domain. Utilizing the change of natural frequencies, a nonlinear model was fitted for predicting the fatigue damage of plate and then the foregone failure criterion of 5% reduction in natural frequency is improved. The influence of section and spacing of the stiffeners on the vibration fatigue behavior of the aluminum plate was investigated. The results show that the fatigue life of aluminum plate increases with adding either T or L section riveted stiffeners. With the same cross-sectional area of stiffener, the T section stiffened plate shows longer fatigue life than L section stiffened plate. Meanwhile, the vibration fatigue life also shows great sensitivity to the spacing between the stiffeners.

关键词： stiffened plate vibration fatigue vibration test fatigue life natural frequency

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Uniaxial compressive behavior of equal channel angular pressing Al at wide temperature and strain rate range

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Transactions of Nonferrous Metals Society of China 2014年第8期24卷 2447-2452页

作者：汤忠斌索涛张部声李玉龙赵峰范学领西北工业大学航空学院西安710072 西安交通大学航天航空学院西安710049

Uniaxial compressive experiments of ultrafine-grained Al fabricated by equal channel angular pressing(ECAP) method were performed at wide temperature and strain rate range. The influence of temperature on flow stress, strain hardening rate and strain rate sensitivity was investigated experimentally. The results show that both the effect of temperature on flow stress and its strain rate sensitivity of ECAPed Al is much larger than those of the coarse-grained Al. The temperature sensitivity of ultrafine-grained Al is comparatively weaker than that of the coarse-grained Al. Based on the experimental results, the apparent activation volume was estimated at different temperatures and strain rates. The forest dislocation interactions is the dominant thermally activated mechanism for ECAPed Al compressed at quasi-static strain rates, while the viscous drag plays an important role at high strain rates.

关键词： ultrafine-grained materials equal channel angular pressing Al mechanical behavior strain rate sensitivity temperature dependence activation volume

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JAK2/STAT3信号通路介导原花青素抗H9C2细胞缺氧/复氧损伤

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生理学报 2016年第5期68卷 568-574页

作者：俞辰斌赵国龙于立明俞世强段维勋张海锋江苏省中医药研究院急诊科南京210028 第四军医大学教学实验中心西安710032 第四军医大学西京医院心血管外科西安710032

本研究旨在探讨原花青素(proanthocyanidin,Pro)抗H9C2细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的机制,明确蛋白质酪氨酸激酶2/信号传导子与激活子3(Janus kinase 2/signal transducer and activator of transcription 3,JAK2/STAT3)信号通路在此过程中的作用。取对数生长期的H9C2细胞株,随机分为5组:对照组(Con)、H/R损伤组(H/R)、Pro处理组(H/R+Pro)、JAK2小干扰RNA处理组(H/R+Pro+JAK2 si RNA)和JAK2小干扰RNA对照组(H/R+JAK2 si RNA)。Pro(40μmol/L)预处理8 h,H9C2细胞系缺氧2 h、复氧4 h后用MTT和TUNEL法分别检测各组细胞活力和凋亡率,用试剂盒检测超氧化物生成量,用Western blot法检测JAK2/STAT3通路相关分子,氧化应激指标及内质网应激相关蛋白的表达。结果显示,与H/R组相比,Pro处理可显著提高H/R处理的H9C2细胞活力,并降低细胞凋亡率,明显上调p-JAK2及p-STAT3水平,下调氧化应激指标超氧化物生成量及gp91phox蛋白表达量,下调内质网应激标志蛋白葡萄糖调节蛋白78(glucose-regulated protein 78,GRP78)、CCAAT/增强子结合蛋白(CCAAT/enhancer binding protein homologous protein,CHOP)及caspase-12的表达,而Pro以上保护作用均被JAK2 si RNA所抑制。本研究结果表明,Pro可通过JAK2/STAT3信号通路减轻H/R引起的H9C2细胞氧化应激与内质网应激损伤。本研究为阐明Pro的心血管保护作用及相关药物的开发提供了实验依据。

关键词：原花青素缺氧/复氧损伤 JAK2/STAT3 氧化应激内质网应激

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