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Food Bioscience 2022年第1期45卷 266-273页

作者： yu-Hang Jiang lin-yu yang Wei-Gang Xin Qi-lin Zhang Faculty of Life Science and Technology Kunming University of Science and TechnologyYunnan Kunming650500China

This study investigated antibacterial and antibiofilm activity of the combined use of phenyllactic acid(PLA)and bacteriocin XJS01 against Shigella flexneri_*** minimum inhibitory concentration(MIC)of PLA and XJS01 against ***_14 was 2.45 mg/mL and 18.75μg/mL,*** and kill kinetics assays showed that the combined use of 1/2MIC PLA plus 1/2MIC XJS01 had a better activity against planktonic ***_14 compared to treatment with PLA and XJS01 used singly(1/2MIC and 2MIC).Cellular biochemical and morphological analysis revealed the remarkable ability of the combination in disrupting cell appearance and promoting deformation of planktonic ***_14 compared to single ***,***_14 biofilm formation was inhibited and degraded by the combination,which showed a more remarkable antibiofilm activity than PLA and XJS01 when used *** study demonstrates the synergistic antibacterial activity of PLA and XJS01 against ***_14 in either planktonic or biofilm states in foods.

关键词： Foodborne pathogenic bacteria Shigella flexneri Bacteriocin Phenyllactic acid Synergistic antibacterial activity Antibiofilm activity

STRUCTURE PARAMETERS DESIGN AND PERFORMANCE TEST OF FUEL INJECTION SYSTEM

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Chinese Journal of Mechanical Engineering 2006年第3期19卷 407-411页

作者： WU Changshui yu Jinxia yang lin ZHUO Bin Institute of Automotive Electronic Technology Shanghai Jiaotong University Shanghai 200030 China

Based on the numerical simulation analysis, structure parameters of the high pressure fuel pump and common rail as well as flow limiter are designed and the GD-1 high pressure common rail fuel injection system is self-developed. Fuel injection characteristics experiment is performed on the GD-1 system. And double-factor variance analysis is applied to investigate the influence of the rail pressure and injection pulse width on the consistency of fuel injection quantity, thus to test whether the design of structure parameters is sound accordingly. The results of experiment and test show that rail pressure and injection pulse width as well as their mutual-effect have no influence on the injection quantity consistency, which proves that the structure parameters design is successful and performance of GD-1 system is sound.

关键词： High pressure common rail fuel injection system Structure parameters design Variance analysis

APPLICATION OF CIRCUIT SIMULATION IN HARDWARE DESIGN FOR ELECTRONIC CONTROL HIGH PRESSURE COMMON-RAIL FUEL SYSTEM OF DIESEL ENGINE

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 613-616页

作者： Tan Wenchun yu Shitao yang lin Zhuo Bin Institute of Automotive Electronic Technology Shanghai Jiaotong University Shanghai 200030 China

By means of circuit simulation, hardware of electronic control unit （ECU） of high pressure common-rail electronic control fuel system for diesel engine is designed. According to the system requirements for hardware of ECU, signal-processing circuit of variable reluctance （VR） sensor, filter circuit for input signal, high voltage power circuit and driver and protection circuit of solenoid are simulated as emphases. Difficulties of wide scope of VR sensor output signal, efficiency of high voltage power and reliable and swift driver of solenoid are solved. The results of simulation show that the hardware meets the requirement of the fuel system. At the same time, circuit simulation can greatly increase quality of the design, alleviate design labor and shorten design time.

关键词： Diesel engine Electronic control unit (ECU) Circuit simulation.

Thermal Error Compensation of the Wear-Depth Real-Time Detecting of Self-Lubricating Spherical Plain Bearings

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 35-47页

作者： Zhan-Qi Hu Wei Li yu-lin yang Bing-Li Fan Hai-Li Zhou Aviation Key Laboratory of Science and Technology on Generic Technology of Aviation Self-Lubricating Spherical Plain Bearing Yanshan University

The spherical plain bearing test bench is a necessary detecting equipment in the research process of self?lubricating spherical plain bearings. The varying environmental temperatures cause the thermal deformation of the wear?depth detecting system of bearing test benches and then a ect the accuracy of the wear?depth detecting data. However, few researches about the spherical plain bearing test benches can be found with the implementation of the detect?ing error compensation. Based on the self?made modular spherical plain bearing test bench, two main causes of ther?mal errors, the friction heat of bearings and the environmental temperature variation, are analysed. The thermal errors caused by the friction heat of bearings are calculated, and the thermal deformation of the wear?depth detecting sys?tem caused by the varying environmental temperatures is detected. In view of the above results, the environmental temperature variation is the main cause of the two error factors. When the environmental temperatures rise is 10.3 °C, the thermal deformation is approximately 0.01 mm. In addition, the comprehensive compensating model of the thermal error of the wear?depth detecting system is built by multiple linear regression(MLR) and time series analysis. Compared with the detecting data of the thermal errors, the comprehensive compensating model has higher fitting precision, and the maximum residual is only 1 μm. A comprehensive compensating model of the thermal error of the wear?depth detecting system is proposed, which provides a theoretical basis for the improvement of the real?time wear?depth detecting precision of the spherical plain bearing test bench.

关键词： Self?lubricating spherical plain bearing Wear depth Bearing test bench Thermal error Error compensation

Enhanced performance of ruthenium dye-sensitized solar cell by employing an organic co-adsorbent of N,N'-bis((pyridin-2-yl)(methyl)methylene)-o-phenylenediamine

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Chinese Chemical Letters 2016年第1期27卷 127-134页

作者： yang Xu Liang-Sheng Qiang yu-lin yang Li-Guo Wei Ping Wang Rui-Qing Fan Department of Chemistry Harbin Institute of Technology College of Environmental and Chemical Engineering Heilongjiang University of Science and Technology

A pyridine-anchor co-adsorbent of N,N＇-bis（（pyridin-2-yl）（methyl） methylene）-o-phenylenediamine（named BPPI） is prepared and employed as co-adsorbent in dye-sensitized solar cells（DSSCs）. The prepared co-adsorbent could overcome the deficiency of N719 absorption in the low wavelength region of visible spectrum, offset competitive visible light absorption of I_3^-, enhance the spectral responses of the co-adsorbed TiO_2 film in region from 300 nm to 750 nm, suppress charge recombination, prolong electron lifetime, and decrease the total resistance of DSSCs. The optimized cell device co-sensitized by BPPI/N719 dye gives a short circuit current density of 12.98 m A cm^（-2）, an open circuit voltage of 0.73 V,and a fill factor of 0.66 corresponding to an overall conversion efficiency of 6.22% under standard global AM 1.5 solar irradiation, which is much higher than that of device solely sensitized by N719（5.29%）under the same conditions. Mechanistic investigations are carried out by various spectral and electrochemical characterizations.

关键词： Dye-sensitized solar cells Co-adsorbent Enhanced performance Co-sensitization

CdS quantum dot sensitized p-type NiO as photocathode with integrated cobaloxime in photoelectrochemical cell for water splitting

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Chinese Chemical Letters 2015年第1期26卷 141-144页

作者： Yong Na Bo Hu Qiu-ling yang Jian Liu Li Zhou Rui-Qing Fan yu-lin yang Department of Chemistry Harbin Institute of Technology Center of Ultra-Precision Optoelectronic Instrument Engineering Harbin Institute of Technology

CdS sensitized NiO electrode was used as the photoactive cathode in a photoelectrochemical cell for water splitting,avoiding the use of a sacrificial electron *** increment under visible light irradiation was observed after integration of[Co（dmgH）_2（4-Me-py）Cl]（1） to the photocathode,suggesting 1 could accept electrons from photoexcited CdS for water reduction and NiO could move the holes in the valence band of CdS to anode for water oxidation.

关键词： Quantum dot Photocathode Cobaloxime Photoelectrochemical cell Water splitting

VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release

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Cellular & Molecular Immunology 2021年第5期18卷 1186-1196页

作者： Wen-Rui He Li-Bo Cao yu-lin yang Duo Hua Ming-Ming Hu Hong-Bing Shu Department of Infectious Diseases Frontier Science Center for Immunology and MetabolismMedical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanChina Research Unit of Innate Immune and Inflammatory Diseases Chinese Academy of Medical SciencesWuhanChina

Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated vaccinia virus-related kinase 2 (VRK2) as a key regulator of this process. VRK2 deficiency inhibited the induction of antiviral genes and caused earlier and higher mortality in mice after viral infection. Upon viral infection, VRK2 associated with voltage-dependent anion channel 1 (VDAC1) and promoted VDAC1 oligomerization and mtDNA release, leading to the cGAS-mediated innate immune response. VRK2 was also required for mtDNA release and cGAS-mediated innate immunity triggered by nonviral factors that cause Ca^(2+) overload but was not required for the cytosolic nucleic acid-triggered innate immune response. Thus, VRK2 plays a crucial role in the mtDNA-triggered innate immune response and may be a potential therapeutic target for infectious and autoimmune diseases associated with mtDNA release.

关键词： cGAS Mita/Sting mitostress innate immune response mitochondrial DNA

Inhibitory effect of H_(3+x)PMo_(12-x)V_xO_(40)-Ton the self-polymerization of methyl methacrylate

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Chinese Chemical Letters 2016年第4期27卷 613-618页

作者： Yan-Bing Yin Hui-Song Wang yu-lin yang Rui-Qing Fan Guo-Hua Dong Li-Guo Wei College of Chemistry and Chemical Engineering Qiqihar University Qiqihar 161006 China Department of Chemistry Harbin Institute of Technology Harbin 150001 China College of Environmental and Chemical Engineering Heilongjiang University of Science and Technology Harbin 150022 China

In this work,a series of molybdovanadophosphoric heteropoly acid quaternary ammonium salts H_（3＋x）PMo_（12 -x）V_xO40-T were synthesized and employed as a reaction inhibitor in the selfpolymerization of methyl methacrylate（MMA）.The polymerization inhibition effect of H_（3＋x）PMoPMo_（12 -x）V_xO40-T）with different number of vanadium atoms and reaction dosages was investigated using differential scanning calorimetry（DSC）.It shows that the inhibitory effect was improved with the increasing dosages of H_（3＋x）PMoPMo_（12 -x）V_xO40-T）,and the polymerization inhibition was also affected by the number of vanadium atoms in the H_（3＋x）PMo_（12 -x）V_xO40-T .Furthermore,cyclic voltammograms（CV）was used to probe the mechanism of the inhibition reaction with H3＋*** result of CV indicates that the inhibition reaction is an oxidation–reduction reaction.H_（3＋x）PMo_（12 -x）V_xO40-T can react directly with the MMA monomer radicals,which eliminated the MMA monomers,and therefore the self-polymerization of the MMA can be effectively inhibited by H_（3＋x）PMo_（12 -x）V_xO40-T.

关键词： Molybdovanadophosphoric heteropoly acid Quaternary ammonium salt Methyl methacrylate Differential scanning calorimetry Cyclic voltammograms Inhibition effect

Studies on the Surface Interaction Between MoO_3 and ZSM-11 Zeolite

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Chemical Research in Chinese Universities 1993年第1期9卷 53-58页

作者： DONG yu-lin LIU Jing and yang Kong-zhang (Institute of Colloid and Interface Chemistry, Shandong University, Jinan, 250100)

A series of Mo-containing ZSM-11 zeolite catalysts has been prepared by calcining mixtures of MoO3 and ZSM-11 zeolite, and studied by using X-ray diffraction and infrared spectroscopy. It has been found that MoO3 can be well dispersed on ZSM-11 zeolite as a surface molybdenum species, and mostly within the zeolite cavities. With increasing the amount of dispersed MoO3, the zeolite framework is destroyed, and the crystallinity of the zeolite decreases. It seems that this perturbation is due to the strong interaction between dispersed MoO3 and zeolite framework.

关键词： MoO_3 ZSM-11 Surface dispersion

Estrogen receptorα-mediated signaling inhibits type Ⅰ interferon response to promote breast carcinogenesis

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Journal of Molecular Cell Biology 2023年第7期15卷 59-72页

作者： Li-Bo Cao Zi-Lun Ruan yu-lin yang Nian-Chao Zhang Chuan Gao Cheguo Cai Jing Zhang Ming-Ming Hu Hong-Bing Shu Department of Infectious Diseases Medical Research InstituteZhongnan Hospital of Wuhan UniversityCollege of Life SciencesWuhan UniversityWuhan 430072China Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical SciencesWuhan UniversityWuhan 430072China Research Unit of Innate Immune and Inflammatory Diseases Chinese Academy of Medical SciencesWuhan 430072China

Estrogen receptorα(ERα)is an important driver and therapeutic target in∼70%of breast *** ERαdrives breast carcinogenesis is not fully *** this study,we show that ERαis a negative regulator of type I interferon(IFN)*** of ERαby its natural ligand estradiol inhibits IFN-β-induced transcription of downstream IFN-stimulated genes(ISGs),whereas ERαdeficiency or the stimulation with its antagonist fulvestrant has opposite ***,ERαinduces the expression of the histone 2A variant H2A.Z to restrict the engagement of the IFN-stimulated gene factor 3(ISGF3)complex to the promoters of ISGs and also interacts with STAT2 to disrupt the assembly of the ISGF3 *** two events mutually lead to the inhibition of ISG transcription induced by type I *** a xenograft mouse model,fulvestrant enhances the ability of IFN-βto suppress ERα^(+)breast tumor ***,clinical data analysis reveals that ERα^(+)breast cancer patients with higher levels of ISGs exhibit higher long-term survival *** together,our findings suggest that ERαinhibits type I IFN response via two distinct mechanisms to promote breast carcinogenesis.

关键词： estrogen receptor type I interferon breast cancer