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Spatial compartmentalization and temporal stability of associated microbiota in Pacific oyster Crassostrea gigas

Journal of Oceanology and Limnology 2024年第4期42卷 1348-1358页

作者： Qiang fu Zichao yu Junyan ZHAO Lei GAO Ning KONG Lingling WANG Linsheng SONG Liaoning Key Laboratory of Marine Animal Immunology and Disease Control Dalian Ocean UniversityDalian 116023China functional Laboratory of Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control Dalian Ocean UniversityDalian 116023China

The Pacific oyster Crassostrea gigas,one of the most exploited molluscs in the world,has suffered from massive mortality in recent decades,and the occurrence mechanisms have not been well *** this study,to reveal the relationship of associated microbiota to the fitness of oysters,temporal dynamics of microbiota in the gill,hemolymph,and hepatopancreas of *** during April 2018-January 2019 were investigated by 16 S rRNA gene *** microbiota in *** exhibited tissue heterogeneity,of which Spirochaetaceae was dominant in the gill and hemolymph while Mycoplasmataceae enriched in the ***-occurrence network demonstrated that the gill microbiota exhibited higher inter-taxon connectivity while the hemolymph microbiota had more *** richness(Chao 1 index)and diversity(Shannon index)of microbial community in each tissue showed no significant seasonal variations,except for the hepatopancreas having a higher richness in the ***,beta diversity analysis indicated a relatively stable microbiota in each tissue during the sampling period,showing relative abundance of the dominant taxa exhibiting temporal *** indicate that the microbial community in *** showed a tissue-specific stability with temporal dynamics in the composition,which might be essential for the tissue functioning and environmental adaption in *** work provides a baseline microbiota in *** and is helpful for the understanding of host-microbiota interaction in oysters.

关键词： Pacific oyster associated microbiota spatial compartmentalization temporal stability

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High-throughput screening system of citrus bacterial cankerassociated transcription factors and its application to the regulation of citrus canker resistance

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Journal of Integrative Agriculture 2024年第1期23卷 155-165页

作者： Jia fu Jie Fan Chenxi Zhang Yongyao fu Baohang Xian Qiyuan yu Xin Huang Wen Yang Shanchun Chen Yongrui He Qiang Li Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China School of Advanced Agriculture and Bioengineering Yangtze Normal UniversityChongqing 408100China National Citrus Engineering Research Center Chongqing 400712China

One of the main diseases that adversely impacts the global citrus industry is citrus bacterial canker(CBC),caused by the bacteria Xanthomonas citri ***(Xcc).Response to CBC is a complex process,with both proteinDNA as well as protein–protein interactions for the regulatory *** detect such interactions in CBC resistant regulation,a citrus high-throughput screening system with 203 CBC-inducible transcription factors(TFs),were *** the upstream regulators of target by yeast-one hybrid(Y1H)methods was also performed.A regulatory module of CBC resistance was identified based on this *** TF(CsDOF5.8)was explored due to its interactions with the 1-kb promoter fragment of CsPrx25,a resistant gene of CBC involved in reactive oxygen species(ROS)homeostasis *** mobility shift assay(EMSA),dual-LUC assays,as well as transient overexpression of CsDOF5.8,further validated the interactions and transcriptional *** CsDOF5.8–CsPrx25 promoter interaction revealed a complex pathway that governs the regulation of CBC resistance via *** high-throughput Y1H/Y2H screening system could be an efficient tool for studying regulatory pathways or network of CBC resistance *** addition,it could highlight the potential of these candidate genes as targets for efforts to breed CBC-resistant citrus varieties.

关键词： citrus bacterial canker(CBC) high-throughput screening system transcription factor(TF) yeast-one hybrid(Y1H) CsPrx25

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Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： ZUO Qian XU Ding-qiao yuE Shi-jun fu Rui-jia TANG yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole *** further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune *** this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are ***,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further ***,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

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Synthesis of carbon quantum dots decorating Bi_(2)MoO_(6) microspherical heterostructure and its efficient photocatalytic degradation of antibiotic norfloxacin

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Chinese Chemical Letters 2024年第8期35卷 373-378页

作者： Meijuan Chen Liyun Zhao Xianjin Shi Wei Wang yu Huang Lijuan fu Lijun Ma School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China Key Lab of Aerosol Chemistry and Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China

In this study,three-dimensional microspherical CQDs/Bi_(2)MoO_(6)heterostructures were synthesized using a simple alcohol-thermal *** was found that the CQDs/Bi_(2)MoO_(6)had a large specific surface area of 56.0 m^(2)/g,and the introduction of CQDs extended the light absorption spectrum from 480 nm to 496 *** utilizing the synthesized CQDs/Bi_(2)MoO_(6)composite for photocatalytic degradation of antibiotic nor-floxacin in a water environment,complete decay of norfloxacin and effective removal of total organic car-bon(TOC)were achieved within 30 *** the optimization of material synthesis and experimen-tal conditions,the optimal CQDs loading amount was determined as 200μL,the optimal CQDs/Bi_(2)MoO_(6)dosage was 0.8 g/***,the CQDs/Bi_(2)MoO_(6)worked well under a wide pH range of *** co-existence of HCO_(3)−enhanced the norfloxacin decay,while the presence of Cl^(−),NO_(3)^(−),and SO_(4)^(2−)slightly retarded *** synthesized CQDs/Bi_(2)MoO_(6)had the great potential in removing and mineralizing nor-floxacin in real aquatic environments.

关键词： Bi_(2)MoO_(6) CQDs Heterojunction Norfloxacin Photocatalysis

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Decreased eggshell strength caused by impairment of uterine calcium transport coincide with higher bone minerals and quality in aged laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1258-1277页

作者： yu fu Jianmin Zhou Martine Schroyen Haijun Zhang Shugeng Wu Guanghai Qi Jing Wang Key Laboratory of Feed Biotechnology Ministry of Agriculture and Rural AffairsInstitute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Precision Livestock and Nutrition Laboratory Gembloux Agro‑Bio TechTERRA Teaching and Research CentreUniversity of LiegeGembloux B‑5030Belgium

Background Deteriorations in eggshell and bone quality are major challenges in aged laying *** study compared the differences of eggshell quality,bone parameters and their correlations as well as uterine physiologi-cal characteristics and the bone remodeling processes of hens laying eggs of different eggshell breaking strength to explore the mechanism of eggshell and bone quality reduction and their interaction.A total of 24074-week-old Hy-line Brown laying hens were selected and allocated to a high(HBS,44.83±1.31 N)or low(LBS,24.43±0.57 N)eggshell breaking strength *** A decreased thickness,weight and weight ratio of eggshells were observed in the LBS,accompanied with ultrastructural deterioration and total Ca *** quality was negatively correlated with eggshell quality,marked with enhanced structures and increased components in the *** the LBS,the mammillary knobs and effective layer grew *** the initiation stage of eggshell calcification,a total of 130 differentially expressed genes(DEGs,122 upregulated and 8 downregulated)were identified in the uterus of hens in the LBS relative to those in the *** DEGs were relevant to apoptosis due to the cellular Ca *** values of p62 protein level,caspase-8 activity,Bax protein expression and lower values of Bcl protein expression and Bcl/Bax ratio were seen in the *** assay and hematoxylin-eosin staining showed a significant increase in TUNEL-positive cells and tissue damages in the uterus of the *** few DEGs were identified at the growth stage,similar uterine tissue damages were also observed in the *** expressions of runt-related transcription factor 2 and osteocal-cin were upregulated in humeri of the *** diameter and more structural damages of endocortical bones and decreased ash were observed in femurs of the *** The lower eggshell breaking strength may be attributed to a declined Ca transport due to uterine tissue damages,which

关键词： Bone parameter Calcium transport Eggshell quality Laying hen Tissue damage

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The carrying capacity for vegetation of forest land across China:Near real-time monitoring and short-term forecasting based on satellite observation

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Geography and Sustainability 2024年第3期5卷 415-429页

作者： Huiqian yu Nan Lu Bojie fu Lu Zhang Shufen Pan State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China College of Forestry Wildlife and EnvironmentAuburn UniversityAL 36849USA Department of Engineering Boston CollegeChestnut HillMA 02467USA

Ecological restoration projects implemented over the past 20 years have substantially increased forest coverage in China,but the high tree mortality of new afforestation forest remains a challenging but unsolved *** is still not clear how much vegetation can be sustained by the forest lands with given water,energy and soil conditions,i.e.,the carrying capacity for vegetation(CCV)of forest lands,which is the prerequisite for planning and implementing forest restoration ***,we used a simplified method to evaluate the CCV across forest lands ***,based on leaf area index(LAI)dataset,we use boosted regression tree and multiple linear regression model to analyze the CCV during 2001-2020 and 2021-2030 and explore the contribution of environmental *** find that there are three typical regions with lower CCV located in the Loess Plateau and the southern region of the Inner Mongolia Plateau,the Hengduan Mountain region,and the Tianshan *** importantly,the vegetation in the regions near the dry-wet climate transition zone show excess local carrying capacity for vegetation over the past two decades and they are more susceptible to potential climatic *** comparison,in the Greater Khingan Mountains and Hengduan Mountains,there is high potential to improve the forest ***,precipitation and soil affects the CCV by shaping the vegetation in the optimal *** indicates that more consideration should be given to restrictions of regional environmental constraints when planning afforestation and forest *** study has important implications for guiding future forest scheme in China.

关键词： Carrying capacity for vegetation Leaf area index Ecosystem restoration Forest management

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Molecular docking-aided AIEgen design: concept, synthesis and applications

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Science China Chemistry 2024年第8期67卷 2614-2628页

作者： Jian-Qing Zhang Xiao-yu Xu fu-Sheng Liu Shu-Qiang Cao yu-Xin Gui Yi-Wen Su Xiao-yu He Ji-yuan Liang You-Quan Zou Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationWuhan UniversityWuhan 430071China Tai kang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China Department of Hepatobiliary Pancreatic SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China

Aggregate-induced emission luminogens(AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable research interests during the last few years. Herein, molecular docking-aided AIEgen design has been reasonably proposed and AIEgen TBQZY with excellent ~1O_(2) generation ability has been synthesized. The newly developed TBQZY could efficiently kill S. epidermidis and methicillinresistant S. epidermidis(MRSE) by tightly binding to bacteria and triggering the accumulation of ~1O_(2) in bacteria. TBQZY specifically regulated the immune system and polarized macrophages from M1 to M2 to accelerate the elimination of biofilm in vivo. In addition, healing acceleration was observed in chronic wounds treated with TBQZY, and side effects were ***, TBQZY had extraordinary potential for combating drug-resistant bacteria in the clinical setting. This research not only provided new concepts for the design of AIEgens, but also shed some lights on the discovery of drugs against drug-resistant bacteria.

关键词： AIEgen molecular docking drug-resistant bacteria biofilm chronic wounds healing

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Segregation of Mg-6Gd alloy under natural convection:From macro solute distribution to micro dendrite growth

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China Foundry 2024年第5期21卷 613-624页

作者： Hong-xu Chen Ang Zhang Hao Li yu Gao yu-hong Cui Guang-sheng Huang Bin Jiang fu-sheng Pan National Engineering Research Center for Magnesium Alloys National Key Laboratory of Advanced Casting TechnologiesCollege of Materials Science and EngineeringChongqing UniversityChongqing 400044China

Segregation is a serious defect in alloy ingots which severely deteriorates materials *** segregation defect in Mg-6Gd alloy is studied by coupling macro thermal-solutal-convection transport and micro dendrite *** macroscopic fluid dynamics and mass transfer equations are resolved to forecast the segregation behavior under conditions of continuous temperature variation during the solidification *** numerical model is validated by testing double-diffusive natural convection in a closed square cavity.A phase field model is then applied to simulate the micro dendrite growth,using macro undercooling and liquid flow velocity as boundary *** show that the multiscale segregation behavior,including macro solute distribution and micro dendritic morphology,is strongly dependent on the temperature condition and the liquid convection,which provides guidance for reducing and eliminating the segregation defect.

关键词： magnesium alloy segregation numerical simulation phase-field simulation multiscale

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Application of a concrete thermal pile in cooling the warming permafrost under climate change

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Advances in Climate Change Research 2024年第1期15卷 170-183页

作者： yun-Hu SHANG fu-Jun NIU Guo-yu LI Jian-Hong FANG Ze-Yong GAO State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Da Xing'anling Observation and Research Station of Frozen-Ground Engineering and Environment Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesJagdaqi 165000China Qinghai Research Institute of Transportation Xining 810008China

Permafrost degradation caused by climate warming is posing a serious threat to the stability of cast-in-place pile foundations in warm permafrost *** cold energy can be effectively utilized by two-phase closed thermosyphons(TPCTs)to cool the ***,we installed TPCTs in a cast-in-place pile foundation to create a unique structure called a thermal pile,which effectively utilizes the TPCTs to regulate ground *** we conducted a case study and numerical simulation to exhibit the cooling performance,and optimize the structure of the thermal *** purpose of this study is to promote the application of thermal piles in unstable permafrost *** on the findings,the thermal pile operated for approximately 53%of the entire year and effectively reduced the deep ground temperature at a rate of at least-0.1℃per ***,it successfully raised the permafrost table that is 0.35 m shallower than the natural ground *** characteristics prove highly beneficial in mitigating the adverse effects of permafrost degradation and enhancing infrastructure *** the length of the condenser section and the diameter of the TPCT in a suitable manner can effectively enhance the cooling capability of the thermal pile and ensure the long-term mechanical stability of the pile foundation even under climate warming.

关键词： Heat transfer Cold energy Warm permafrost Two-phase closed thermosyphons Cast-in-place pile foundation

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Morphological and molecular evidence for natural hybridization between Sorbus pohuashanensis and S. discolor (Rosaceae)

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Journal of Forestry Research 2024年第4期35卷 189-201页

作者： yuxia Wu Xuedan yu Wei Tang Wenhua Yang Qidi fu Yongqi Zheng Chuanhong Zhang State Key Laboratory of Tree Genetics and Breeding Research Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Beijing Waiyan Online Digital Technology Co. LtdBeijing 100081People’s Republic of China Huabanlv Nature Enlightenment Education Technology Co. LtdBeijing 100010People’s Republic of China

In overlapping distribution areas of Sorbus pohuashanensis and *** in North China(Mount Tuoliang,Mount Xiling and Mount Baihua),Sorbus indi-viduals were found with pink fruit,which have never been recorded for the flora of *** morphological characters combined with four chloroplast DNA markers and internal transcribed spacer(ITS)were used to analyze the origin of the Sorbus individuals with pink fruits and their relationship to *** and ***,SDA and one-way(taxon)ANOVA of morphological characters provided convincing evidence of the hybrid ori-gin of Sorbus individuals with pink fruits based on a novel morphological character and many intermediate *** analysis based on four cpDNA markers showed that either *** or *** were maternal parents of Sorbus individuals with pink ***-ence of the position of Sorbus individuals with pink fruits between cpDNA and ITS in cluster trees supported by DNA sequence comparative analysis,implying former hybridiza-tion events between *** and ***-tiple hybridization events between *** and *** might have contributed to the generation of Sorbus individuals with pink *** study has provided insights into hybridization between species of the same genus in sympatric areas,which is of great significance for the study of interspecific hybridization.

关键词： Hybridization ITS Chloroplast DNA Morphological characters Sorbus

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