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Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation

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Infectious Disease Modelling 2024年第2期9卷 618-633页

作者： Xin-Chen Li Hao-Ran Qian Yan-Yan Zhang Qi-yu Zhang Jing-Shu Liu hong-yu lai Wei-Guo Zheng Jian Sun Bo Fu Xiao-Nong Zhou Xiao-Xi Zhang School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople's Republic of China School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China School of Data Science Fudan UniversityShanghaiPeople's Republic of China

The rapid acceleration of global warming has led to an increased burden of high temperature-related diseases(HTDs),highlighting the need for advanced evidence-based management *** have developed a conceptual framework aimed at alleviating the global burden of HTDs,grounded in the One Health *** framework refines the impact pathway and establishes systematic data-driven models to inform the adoption of evidence-based decision-making,tailored to distinct *** collected extensive national-level data from authoritative public databases for the years 2010–*** burdens of five categories of disease causes–cardiovascular diseases,infectious respiratory diseases,injuries,metabolic diseases,and non-infectious respiratory diseases–were designated as intermediate outcome *** cumulative burden of these five categories,referred to as the total HTD burden,was the final outcome *** evaluated the predictive performance of eight models and subsequently introduced twelve intervention measures,allowing us to explore optimal decision-making strategies and assess their corresponding *** model selection results demonstrated the superior performance of the Graph Neural Network(GNN)model across various *** simulations driven by the GNN model,we identified a set of optimal intervention strategies for reducing disease burden,specifically tailored to the seven major regions:East Asia and Pacific,Europe and Central Asia,Latin America and the Caribbean,Middle East and North Africa,North America,South Asia,and Sub-Saharan *** mitigation and adaptation measures,acting upon our categories of Infrastructure&Community,Ecosystem Resilience,and Health System Capacity,exhibited particularly strong performance for various regions and *** out of twelve interventions were included in the optimal intervention package for each region,including raising low-carbon energy use,increasing energy intensity,improving

关键词： High temperature-related diseases Data-driven simulation Optimal intervention Disease burden Graph neural network Global warming

Monitoring the source of mesenchymal stem cells in patients after transplantation of mismatched-sex hematopoietic stem cells plus thirdparty cells

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Chinese Medical Journal 2013年第22期126卷 4254-4259页

作者： WANG Jing HUANG Xiao-jun XU Lan-ping LIU Dai-hong CHEN Huan CHEN yu-hong lai yue-yun HOU Rui-qin QIN Xiao-ying LIU Kai-yan Peking University Institute of Hematology Peking University People's Hospital Beijing 100044 China

Background In bone marrow transplant patients, the microenvironment in bone marrow is damaged after chemotherapy or radiotherapy. Subsequent to allogenic hematopoietic stem cell transplantation in patients with clinically successful engraftments, the source of mesenchymal stem cells （MSCs） remains controversial. To further verify the stimulatory effect of the simultaneous transplantation of cells from second donors on engraftment success for hematopoietic stem cell transplantation in support of donor MSCs engraftments, the aim of this study is to monitor the dynamics of the engraftment of bone marrow-derived MSCs in patients after transplantation with mismatched-sex hematopoietic stem and third-party cells. Methods In this study, the hematopoietic stem cells from 32 clinical donors of different sexes that resulted in successful engraftments were selected for transplantation and were classified into three groups for research purposes： group A consisted of 14 cases of transplantation with bone marrow and recruited peripheral hematopoietic stem cell transplantation, group B contained 8 cases of simultaneous re-transfusion of MSCs from the second donor, and group C contained 10 cases of simultaneous re-transfusion of umbilical blood from the second donor. The bone marrow from 32 patients with successful engraftments of hematopoietic transplantation were selected and sub-cultured with MSCs. Flow cytometry （FCM） was used to measure the expression of surface antigens on MSCs. Denaturing high-performance liquid chromatography （DHPLC） in combination with polymerase chain reaction amplification of short tandem repeats （STR- PCR） was used to measure the engraftment status of fifth-generation MSCs in patients. Fluorescence in situ hybridization （FISH） revealed the sex origin of the fifth-generation MSCs in 32 patients. Dynamic examinations were performed on patients receiving donor transplantations. Results The progenies of fifth-generation MSCs were successfully cultured in 32

关键词： hematopoietic stem cell transplantation mesenchymal stem cells source of engraftment

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抑郁症和糖尿病共病患者的临床特征对照研究

实用临床医药杂志 2009年第10期13卷 4-5页

作者：余来洪南京医科大学附属脑科医院江苏南京210029

目的探讨抑郁症和糖尿病共病患者的临床特征。方法使用自制调查表,收集30例抑郁症和糖尿病共病患者和30例单纯抑郁症患者的社会人口学资料和病情资料。结果抑郁症和糖尿病共病患者的平均病程、平均发病次数和平均住院日均显著高于单纯... 详细信息

目的探讨抑郁症和糖尿病共病患者的临床特征。方法使用自制调查表,收集30例抑郁症和糖尿病共病患者和30例单纯抑郁症患者的社会人口学资料和病情资料。结果抑郁症和糖尿病共病患者的平均病程、平均发病次数和平均住院日均显著高于单纯抑郁症患者;抑郁症和糖尿病共病患者的临床症状显著重于单纯抑郁症患者;抑郁症和糖尿病共病患者的出院疗效显著差于单纯抑郁症患者。结论抑郁症和糖尿病共病患者的临床症状重、治疗难度大。

关键词：抑郁症糖尿病共病

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参数化有限元分析的液压机机身轻量化设计

工程图学学报 2010年第1期31卷 20-25页

作者：赵韩陈兴玉董玉德张坚余来宏合肥工业大学机械与汽车工程学院安徽合肥230009 合肥压力机械有限责任公司安徽合肥230031

建立了液压机机身的参数化有限元模型。通过正交试验模拟实际工况进行了应力和角变形的分析计算。从试验样本出发,采用基于最小二乘法的回归模型构建了机身最大应力及角变形与结构主参数间的映射关系。在库恩-塔克条件下构造了优化的数... 详细信息

建立了液压机机身的参数化有限元模型。通过正交试验模拟实际工况进行了应力和角变形的分析计算。从试验样本出发,采用基于最小二乘法的回归模型构建了机身最大应力及角变形与结构主参数间的映射关系。在库恩-塔克条件下构造了优化的数学模型,并通过仿真运算提出了合理的机身轻量化设计方案。结果表明,轻量化效果明显,改进后的方案能完全符合实际工况的要求。

关键词：计算机应用轻量化设计最小二乘回归液压机机身

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基于XML的YH30型液压机设计方法研究

工程图学学报 2009年第6期30卷 30-35页

作者：董玉德李年丰陈兴玉张坚余来宏合肥工业大学机械与汽车工程学院安徽合肥230009 合肥压力机械有限公司安徽合肥230031

以YH30型液压机为例,根据零件的特征参数利用DOM自动创建XML文档,并通过解析XML文档获取存储在文档节点中的零件尺寸,将它作为SolidWorks参数化建模中的关键尺寸。这种方法实现了SolidWorks参数化设计技术和XML数据库技术的结合,为异构... 详细信息

以YH30型液压机为例,根据零件的特征参数利用DOM自动创建XML文档,并通过解析XML文档获取存储在文档节点中的零件尺寸,将它作为SolidWorks参数化建模中的关键尺寸。这种方法实现了SolidWorks参数化设计技术和XML数据库技术的结合,为异构CAD平台的数据交换和信息集成提供了一条有效途径。

关键词：计算机应用液压机设计参数化设计数据交换

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构建高等学校廉政风险防控机制研究

沈阳农业大学学报（社会科学版） 2016年第1期18卷 48-51页

作者：王洪玉崔来成沈阳农业大学纪检监察处辽宁沈阳110161

自党的十八大以来,"全面从严治党"纳入"四个全面"战略布局,各级党委从落实"全面领导责任"到"主体责任"的转变,教育部加强高等学校监督体制改革,支持高等学校设立二级纪委,都为高等学校廉政风险防控机制建设形成了有利的形势。但是,高等... 详细信息

自党的十八大以来,"全面从严治党"纳入"四个全面"战略布局,各级党委从落实"全面领导责任"到"主体责任"的转变,教育部加强高等学校监督体制改革,支持高等学校设立二级纪委,都为高等学校廉政风险防控机制建设形成了有利的形势。但是,高等学校廉政风险防控也存在权力配置不合理、风险预警作用难以发挥、高等学校纪委的监督乏力等困境。在新形势下构建适应高等学校发展的廉政风险防控机制,需要科学合理配置权力,突出廉政风险防控的顶层设计;加强信息化建设,发挥廉政风险的预警作用;进一步完善监督体制,加强二级单位纪委的制度设计;落实党委主体责任,发挥高等学校党委的优势。

关键词：高等学校纪委廉政风险权力运行二级学院

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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高述情障碍女学生的健康焦虑与人格特征研究

中国妇幼健康研究 2016年第2期27卷 198-199,209页

作者：余来洪张钰群毛圣芹赵月秋南京医科大学附属脑科医院精神科江苏南京210000 东南大学附属中大医院心理精神科江苏南京210009 江苏联合职业技术学院南京卫生分院江苏南京210000

目的探讨高述情障碍女学生的健康焦虑与人格特征及相互关系。方法对382名高述情障碍和382名无述情障碍女学生的简式健康焦虑量表(SHAI)和艾森克个性问卷(EPQ)结果进行比较,并对高述情障碍女学生的多伦多述情障碍量表(TAS-20)评分与SHAI... 详细信息

目的探讨高述情障碍女学生的健康焦虑与人格特征及相互关系。方法对382名高述情障碍和382名无述情障碍女学生的简式健康焦虑量表(SHAI)和艾森克个性问卷(EPQ)结果进行比较,并对高述情障碍女学生的多伦多述情障碍量表(TAS-20)评分与SHAI和EPQ各维度评分作Pearson相关分析。结果高述情障碍组TAS-20总分为65.94±4.88分,显著高于低述情障碍组的45.47±5.29分,两组比较差异有统计学意义(t=55.606,P<0.001);高述情障碍组与低述情障碍组比较,健康焦虑发生率(x^2=58.770)及SHAI和EPQ各维度评分(t=-5.161~8.467)差异均有统计学意义(均P<0.05)。SHAI总分及2个因子分与TAS-20总分及F1、F2呈显著正相关(r=0.106~0.306,均P<0.01)。TAS-20总分及F1与EPQ的P因子和N因子均呈显著正相关(r=0.122~0.160,均P<0.05);TAS-20总分及F1与EPQ的L因子呈显著负相关(r值分别为-0.110、-0.136,均P<0.01)。结论高述情障碍女学生存在显著的健康焦虑,人格特征为内向、高神经质和精神质、低掩饰性。述情障碍中的难以识别和描述自已情感的2个因子与健康焦虑、人格特征关系更密切。

关键词：女学生述情障碍健康焦虑人格

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图形自动编程在火焰切割机系统开发中的实现

西安工程大学学报 2014年第2期28卷 235-240页

作者：杨旭董玉德余来宏李东亚张震霄合肥工业大学机械与汽车工程学院安徽合肥230009 合肥压力机械有限责任公司安徽合肥230031

为提高切割机效率,应用C++语言,开发出一套基于图形自动编程的火焰切割机数控系统.系统实现了图形文件的处理与加工程序的读取,自动切割加工,原迹返回加工等功能;提出单环和套环图形的处理,气体半径补偿,添加切入引线,加工过程的仿真跟... 详细信息

为提高切割机效率,应用C++语言,开发出一套基于图形自动编程的火焰切割机数控系统.系统实现了图形文件的处理与加工程序的读取,自动切割加工,原迹返回加工等功能;提出单环和套环图形的处理,气体半径补偿,添加切入引线,加工过程的仿真跟踪等关键问题的解决方法.该数控系统已成功应用于企业的火焰切割机中.

关键词：图形自动编程火焰切割机运动控制卡