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Simulation and experimental comparison of the performance of four-corner-readout plastic scintillator muon-detector system

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Nuclear Science and Techniques 2024年第11期35卷 1-12页

作者： Lie he Si-yuan Luo Xiang-Man Liu yu-Cheng Zou Hai-Feng Zhang Wan-Cheng Xiao yu-he huang Xiao-Dong Wang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Key Laboratory of Advanced Nuclear Energy Design and Safety(MOE) University of South ChinaHengyang 421001China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Physical Sciences University of Science and Technology of ChinaHefei 230026China

Cosmic-ray muons are highly penetrating background-radiation particles found in natural *** this study,we develop and test a plastic scintillator muon detector based on machine-learning *** detector underwent muon position-resolution tests at the Institute of Modern Physics in Lanzhou using a multiwire drift chamber(MWDC)experimental *** the simulation,the same structural and performance parameters were maintained to ensure the reliability of the simulation *** Gaussian process regression(GPR)algorithm was used as the position-reconstruction algorithm owing to its optimal *** results of the Time Difference of Arrival algorithm were incorporated as one of the features of the GPR model to reconstruct the muon hit *** accuracy of the position reconstruction was evaluated by comparing the experimental results with Geant4 simulation *** the simulation,large-area plastic scintillator detectors achieved a position resolution better than 20 *** the experimental-platform tests,the position resolutions of the test detectors were 27.9 *** also analyzed factors affecting the position resolution,including the critical angle of the total internal reflection of the photomultiplier tubes and distribution of muons in the *** were performed to image both large objects and objects with different atomic *** results showed that the system could image high-and low-Z materials in the constructed model and distinguish objects with significant density *** study demonstrates the feasibility of the proposed system,thereby providing a new detector system for muon-imaging applications.

关键词： Monte Carlo simulation Muon tomography TDOA Machine learning Image reconstruction

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A novel 4D resolution imaging method for low and medium atomic number objects at the centimeter scale by coincidence detection technique of cosmic-ray muon and its secondary particles

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Nuclear Science and Techniques 2022年第1期33卷 13-23页

作者： Xuan-Tao Ji Si-yuan Luo yu-he huang Kun Zhu Jin Zhu Xiao-yu Peng Min Xiao Xiao-Dong Wang School of Nuclear Science and Technology University of South ChinaHengyang 421001China

The muon radiography imaging technique for high-atomic-number objects(Z)and large-volume objects via muon transmission imaging and muon multiple scattering imaging remains a popular topic in the field of radiation detection ***,few imaging studies have been reported on low and medium Z objects at the centimeter *** paper presents an imaging system that consists of three layers of a position-sensitive detector and four plastic scintillation *** acquires data by coincidence detection technique of cosmic-ray muon and its secondary particles.A 3D imaging algorithm based on the density of the coinciding muon trajectory was developed,and 4D imaging that takes the atomic number dimension into account by considering the secondary particle ratio information was *** resultant reconstructed 3D images could distinguish between a series of cubes with 5-mm-side lengths and *** the imaging time is more than 20 days,this method can distinguish intervals with a width of 1 *** 4D images can specify target objects with low,medium,and high Z values.

关键词： Image reconstruction Monte Carlo simulation Non-destructive detection

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Hybrid model for muon tomography and quantitative analysis of image quality

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Nuclear Science and Techniques 2022年第7期33卷 1-13页

作者： Si-yuan Luo yu-he huang Xuan-Tao Ji Lie he Wan-Cheng Xiao Feng-Jiao Luo Song Feng Min Xiao Xiao-Dong Wang School of Nuclear Science and Technology University of South ChinaHengyang 421001China

Muon tomography is a novel method for the non-destructive imaging of materials based on muon rays,which are highly penetrating in natural background ***,the most commonly used imaging methods include muon radiography and muon tomography.A previously studied method known as coinciding muon trajectory density tomography,which utilizes muonic secondary particles,is proposed to image low and medium atomic number(Z)***,scattering tomography is mostly used to image high-Z materials,and coinciding muon trajectory density tomography exhibits a hollow phenomenon in the imaging results owing to the self-absorption *** address the shortcomings of the individual imaging methods,hybrid model tomography combining scattering tomography and coinciding muon trajectory density tomography is proposed and *** addition,the peak signal-to-noise ratio was introduced to quantitatively analyze the image *** imaging models were simulated using the Geant4 toolkit to confirm the advantages of this innovative *** simulation results showed that hybrid model tomography can image centimeter-scale materials with low,medium,and high Z *** high-Z materials with similar atomic numbers,this method can clearly distinguish those with apparent differences in *** to the peak signal-to-noise ratio of the analysis,the reconstructed image quality of the new method was significantly higher than that of the individual imaging *** study provides a reliable approach to the compatibility of scattering tomography and coinciding muon trajectory density tomography.

关键词： Monte Carlo simulation Muon tomography Image reconstruction

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Safety and clinical efficacy of linezolid in children:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第2期19卷 129-138页

作者： Yi Shi Hai-Lan Wu yu-Hang Wu Shuang Li Li-Ya Zhang Shan-Shan Xu he-yu huang Chun-Hong Zhang Xu-Ben yu Kang Cai Jing Zhang Li-Su huang Department of Infectious Disease Xinhua Children’s HospitalXinhua HospitalShanghai Jiao Tong University School of MedicineShanghai200092China National Clinical Research Center for Child health Children’s HospitalZhejiang University School of MedicineHangzhou310052China Institute of Antibiotics Huashan HospitalFudan UniversityShanghai200040China Department of Pharmacy the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China

Background We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial *** A systematic literature search was conducted up to April 23,2021,using linezolid and its synonyms as search *** reviewers independently identified and extracted relevant randomized controlled trials and prospective cohort *** extracted studies were included in a single-rate meta-analysis of adverse events and clinical outcomes using random-effects *** A total of 1082 articles were identified,and nine studies involving 758 children were included in the *** overall proportion of adverse events was 8.91%[95%confidence interval(CI)=1.64%–36.52%],with diarrhea(2.24%),vomiting(2.05%),and rash(1.72%)being the most *** incidences of thrombocytopenia and anemia were 0.68%and 0.16%,*** specific adverse events,including rash and gastrointestinal events,were more frequent in the oral administration *** terms of efficacy,the overall proportion of clinical improvement was 88.80%(95%CI=81.31%–93.52%).Children with a history of specific bacteriological diagnosis or concomitant antibiotic therapy had a 1.13-fold higher clinical improvement than children without such *** proportion of microbial eradication was 92.68%(95%CI=84.66%–96.68%).The proportion of all-cause mortality was 0.16%(95%CI=0.00%–7.75%).Conclusions Linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events,such as anemia,thrombocytopenia,and ***,linezolid was effective in children with diagnosed and suspected Gram-positive infections.

关键词： Children Efficacy Linezolid Meta-analysis Safety

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Novel Mutations in the 3β-hydroxy-A5-C27-steroid Dehydrogenase Gene （HSD3B7）in a Patient with Neonatal Cholestasis

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Chinese Medical Journal 2016年第1期129卷 98-100页

作者： he-yu huang Hua Zhou Hong Wang Ya-Xian Chen Feng Fang Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Internal Medicine Genetic Diagnostic Centre Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Bile acid synthetic defect （BASD） is a rare category of genetic disorders that are responsible for approximately 2% of persistent cholestasis in infants. Until date, four enzynles responsible for congenital defects of bile acid synthesis （CBAS） have been identified. 313-hydroxy-A5-C27-steroid dehydrogenase （3β-HSD）, the deficiency of which can cause CBAS 1 （OMIM No. 607765）, is encoded by the gene HSD3B7 and works in the second step of transforming the steroid into primary bile acids.

关键词： HSD3B7 Mutation Neonatal Cholestasis

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Numerical investigation on flow process of liquid metals in melt delivery nozzle during gas atomization process for fine metal powder production

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Transactions of Nonferrous Metals Society of China 2021年第10期31卷 3192-3204页

作者： Chang LIU Xin LI Shi SHU yu-he huang Xing-gang LI Qiang ZHU Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials Shenzhen 518055China Hunan Industrial Technical Center Co. Ltd.Changsha 410201China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China

Based on volume of fluid(VoF)interface capturing method and shear-stress transport(SST)k-ω turbulence model,numerical simulation was performed to reveal the flow mechanism of metal melts in melt delivery nozzle(MDN)during gas atomization(GA)*** experimental validation indicated that the numerical models could give a reasonable prediction on the melt flow process in the *** the decrease of the MDN inner-diameter,the melt flow resistance increased for both molten aluminum and iron,especially achieving an order of 10^(2) kPa in the case of the MDN inner-diameter≤1 *** on the conventional GA process,the positive pressure was imposed on the viscous aluminum alloy melt to overcome its flow resistance in the MDN,thus producing powders under different MDN *** the MDN inner-diameter was reduced from 4 to 2 mm,the yield of fine powder(he surface quality of powders has also been improved when using a smaller inner-diameter MDN.

关键词： gas atomization melt delivery nozzle liquid metal flow resistance metal powder

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan he Weitai Chai Meng Tian Huali yu Xiaoxiao he Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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Occluded Gait Emotion Recognition Based on Multi-Scale Suppression Graph Convolutional Network

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Computers, Materials & Continua 2025年第1期82卷 1255-1276页

作者： yuxiang Zou Ning he Jiwu Sun Xunrui huang Wenhua Wang Beijing Key Laboratory of Information Service Engineering Beijing Union UniversityBeijing100101China College of Smart City Beijing Union UniversityBeijing100101China

In recent years,gait-based emotion recognition has been widely applied in the field of computer ***,existing gait emotion recognition methods typically rely on complete human skeleton data,and their accuracy significantly declines when the data is *** enhance the accuracy of gait emotion recognition under occlusion,this paper proposes a Multi-scale Suppression Graph ConvolutionalNetwork(MS-GCN).TheMS-GCN consists of three main components:Joint Interpolation Module(JI Moudle),Multi-scale Temporal Convolution Network(MS-TCN),and Suppression Graph Convolutional Network(SGCN).The JI Module completes the spatially occluded skeletal joints using the(K-Nearest Neighbors)KNN interpolation *** MS-TCN employs convolutional kernels of various sizes to comprehensively capture the emotional information embedded in the gait,compensating for the temporal occlusion of gait *** SGCN extracts more non-prominent human gait features by suppressing the extraction of key body part features,thereby reducing the negative impact of occlusion on emotion recognition *** proposed method is evaluated on two comprehensive datasets:Emotion-Gait,containing 4227 real gaits from sources like BML,ICT-Pollick,and ELMD,and 1000 synthetic gaits generated using STEP-Gen technology,and ELMB,consisting of 3924 gaits,with 1835 labeled with emotions such as“Happy,”“Sad,”“Angry,”and“Neutral.”On the standard datasets Emotion-Gait and ELMB,the proposed method achieved accuracies of 0.900 and 0.896,respectively,attaining performance comparable to other ***,on occlusion datasets,the proposedmethod significantly mitigates the performance degradation caused by occlusion compared to other methods,the accuracy is significantly higher than that of other methods.

关键词： KNN interpolation multi-scale temporal convolution suppression graph convolutional network gait emotion recognition human skeleton

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穿心莲内酯调控HaCaT细胞中Nrf2/ARE通路的抗氧化作用机制研究

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中国药学杂志 2019年第10期54卷 777-782页

作者：何思蓉余黄合杨珍曾嵘湖南中医药大学药学院长沙410208 中药成药性与制剂制备湖南省重点实验室长沙410208

目的探讨穿心莲内酯通过诱导Ha Ca T细胞中Nrf2/ARE信号通路介导的HO-1、NQO1、AKR1C1的表达,减少细胞因氧化应激而受到的损伤。方法通过CCK-8方法检测穿心莲内酯对Ha Ca T细胞的活力影响以及过氧化氢诱导的细胞存活率的影响。用穿心莲... 详细信息

目的探讨穿心莲内酯通过诱导Ha Ca T细胞中Nrf2/ARE信号通路介导的HO-1、NQO1、AKR1C1的表达,减少细胞因氧化应激而受到的损伤。方法通过CCK-8方法检测穿心莲内酯对Ha Ca T细胞的活力影响以及过氧化氢诱导的细胞存活率的影响。用穿心莲内酯不同浓度预处理Ha Ca T细胞24 h,分别通过Western blot以及实时荧光定量PCR分析检测Ha Ca T细胞中Nrf2、HO-1、AKR1C1、NQO1的表达水平;通过胞质胞核分离以及免疫荧光的方法分析Nrf2蛋白核内表达情况。结果穿心莲内酯不影响细胞存活率,并剂量依赖性的降低H2O2诱导的细胞死亡,差异具有统计学意义。穿心莲内酯能显著增强抗氧化酶Nrf2、HO-1、AKR1C1、NQO1的蛋白和mRNA表达,增加Nrf2的细胞核内的分布,并上调ARE的表达活性。穿心莲内酯能够上调上游蛋白激酶AMPKα的磷酸化(p-AMPKα)水平。结论穿心莲内酯降低H2O2诱导的细胞死亡,其作用机制可能是通过激活Nrf2/ARE信号通路,从而调控HO-1、AKR1C1、NQO1的表达水平。

关键词：穿心莲内酯抗氧化 HO-1 NQO1 AKR1C1 Nrf2/ARE

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