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The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans

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Neural Regeneration Research 2023年第6期18卷 1386-1392页

作者： Hui-Qiang Long Jin gao Shu-Qing He Jian-Fang han yu Tu Na Chen Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhouJiangsu ProvinceChina Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions SuzhouJiangsu ProvinceChina

Ionizing radiation can cause changes in nervous system ***,the underlying mechanism remains *** this study,Coenorhabditis elegans(***)was irradiated with 75 Gy of ^(60)Co whole-body γ *** indicators(head thrashes,touch avoidance,and foraging),and the development of dopaminergic neurons related to behavioral function,were evaluated to assess the effects of ionizing radiation on nervous system function in *** behaviors were impaired after whole-body irradiation and degeneration of dopamine neurons was *** suggests that 75 Gy of γ radiation is sufficient to induce nervous system *** genes nhr-76 and crm-1,which are reported to be related to nervous system function in human and mouse,were screened by transcriptome sequencing and bioinformatics analysis after irradiation or sham *** expression levels of these two genes were increased after ***,RNAi technology was used to inhibit the expression of crm-1,a gene whose homologs are associated with motor neuron development in other *** of crm-1 expression effectively alleviated the deleterious effects of ionizing radiation on head thrashes and touch *** was also found that the expression level of crm-1 was regulated by the nuclear receptor gene *** results of this study suggest that knocking down the expression level of nhr-76 can reduce the expression level of crm-1,while down-regulating the expression level of crm-1 can alleviate behavioral disorders induced by ionizing ***,inhibition of crm-1 may be of interest as a potential therapeutic target for ionizing radiation-induced neurological dysfunction.

关键词： behavior Caenorhabditis elegans degeneration disorder dysfunction nerve injury nervous system neurodevelopment neuron radiation

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中药调控成骨细胞铁死亡治疗激素性股骨头坏死

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中国组织工程研究 2025年第1期29卷 185-192页

作者：张绵钰韩杰曾浩陈相汕高振罡广西中医药大学研究生学院广西壮族自治区南宁市530000 广西中医药大学附属瑞康医院广西壮族自治区南宁市530011

背景:有研究发现成骨细胞铁死亡可作为重要的发病机制诱导激素性股骨头坏死的发生与发展。随着祖国医学的发展,有学者发现某些中药单体、中药复方及中成药等可通过多种通路机制调控成骨细胞铁死亡,最终起到治疗激素性股骨头坏死的作用... 详细信息

背景:有研究发现成骨细胞铁死亡可作为重要的发病机制诱导激素性股骨头坏死的发生与发展。随着祖国医学的发展,有学者发现某些中药单体、中药复方及中成药等可通过多种通路机制调控成骨细胞铁死亡,最终起到治疗激素性股骨头坏死的作用。目的:探讨成骨细胞铁死亡与激素性股骨头坏死的关系及中草药调控成骨细胞铁死亡治疗激素性股骨头坏死的作用机制,为激素性股骨头坏死的诊治提供新的思路。方法:以“铁死亡,激素性股骨头坏死,成骨细胞,中草药,糖皮质激素,铁代谢,活性氧,谷胱甘肽过氧化物酶”为中文检索词,以“ferroptosis,Hormonal necrosis of the femoral head,osteoblast,Chinese herbal medicine,glucocorticoid,iron metabolism,ROS,GPX4”为英文检索词,检索中国知网、Pub Med、万方及维普数据库,筛选各数据库建库至2023年成骨细胞铁死亡与激素性股骨头坏死及中草药干预调控研究相关的文章,最终纳入74篇文献进行综述分析。结果与结论:(1)成骨细胞铁死亡在激素性股骨头坏死发病中起重要作用。(2)成骨细胞铁死亡的发生受到多种机制通路调控,如细胞内铁超载引起铁死亡;细胞发生脂质过氧化损伤细胞膜引起铁死亡;细胞膜上胱氨酸/谷氨酸逆向转运蛋白通过影响谷胱甘肽水平和谷胱甘肽过氧化物酶4活性,从而诱导铁死亡;细胞内发生芬顿反应产生大量活性氧引起铁死亡等。(3)中药单体淫羊藿苷等、中药复方青娥丸等及中成药补肾活血颗粒等均可通过调控成骨细胞铁死亡的发生,有助于防治激素性股骨头坏死。(4)目前关于成骨细胞铁死亡相关机制尚不明确,继续深入探明两者的作用机制,有望为临床治疗激素性股骨头坏死提供新选择。

关键词：股骨头坏死铁死亡中医药成骨细胞糖皮质激素铁代谢活性氧谷胱甘肽谷胱甘肽过氧化物酶脂质过氧化

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Trot Gait Design and CPG Method for a Quadruped Robot

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Journal of Bionic Engineering 2014年第1期11卷 18-25页

作者： Jiaqi Zhang Feng gao Xiaolei han Xianbao Chen Xueying han School of Mechanical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 P. R. China State Key Laboratory of Mechanical System and Vibration 800 Dongchuan Road Shanghai 200240 P. R. China Ecology Evolution and Marine Biology University of California at Santa Barbara CA 93106 USA

Developing efficient walking gaits for quadruped robots has intrigued investigators for years. Trot gait, as a fast locomotion gait, has been widely used in robot control. This paper follows the idea of the six determinants of gait and designs a trot gait for a parallel-leg quadruped robot, Baby Elephant. The walking period and step length are set as constants to maintain a relatively fast speed while changing different foot trajectories to test walking quality. Experiments show that kicking leg back improves body stability. Then, a steady and smooth trot gait is designed. Furthermore, inspired by Central Pattern Generators （CPG）, a series CPG model is proposed to achieve robust and dynamic trot gait. It is generally believed that CPG is capable of producing rhythmic movements, such as swimming, walking, and flying, even when isolated from brain and sensory inputs. The proposed CPG model, inspired by the series concept, can automatically learn the previous well-designed trot gait and reproduce it, and has the ability to change its walking frequency online as well. Experiments are done in real world to verify this method.

关键词： quadruped robot trot gait series CPG model foot trajectory

Immunological and virological characteristics of human immunodeficiency virus type i superinfection： implications in vaccine design

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Frontiers of Medicine 2017年第4期11卷 480-489页

作者： Yang gao Wen Tian Xiaoxu han Feng gao Key Laboratory of AIDS Immunology of Nattonal Health and Famdy Plannmg Commtsston Department of Laboratory Medicme The First Affiliated Hospital China Medical University Shenyang 110001 China National Engineering Laboratory for AIDS Vaccine School of Life Sciences Jilin University Changehun 130012 China Department of Medicine Duke University Medical Center Durham NC 27710 USA

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I （HIV-1）. Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

关键词： human immunodeficiency virus type I superinfection incidence immtme response

Interaction of moiréexcitons with cavity photons in two-dimensional semiconductor hetero-bilayers

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Journal of Semiconductors 2023年第1期44卷 68-73页

作者： yuchen gao yu Ye State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Moirématerials,composed of two single-layer two-dimensional semiconductors,are important because they are good platforms for studying strongly correlated *** them,moirématerials based on transition metal dichalcogenides(TMDs)have been intensively *** hetero-bilayer can support moiréinterlayer excitons if there is a small twist angle or small lattice constant difference between the TMDs in the hetero-bilayer and form a type-Ⅱ band *** coupling of moiréinterlayer excitons to cavity modes can induce exotic ***,we review recent advances in the coupling of moiréinterlayer excitons to cavities,and comment on the current difficulties and possible future research directions in this field.

关键词： moiréinterlayer excitons optical cavity exciton-polariton Bose-Einstein condensation

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Automatic diagnosis of strawberry water stress status based on machine vision

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International Journal of Agricultural and Biological Engineering 2019年第1期12卷 159-164页

作者： han Li Jian Yin Man Zhang Nick Sigrimis yu gao Wengang Zheng Key Laboratory for Modern Precision Agriculture System Integration Research Ministry of EducationChina Agricultural UniversityBeijing 100083China Department of Natural Resources Management and Agricultural Engineering Agricultural University of AthensAthens 11855Greece School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China National Research Center of Intelligent Equipment for Agriculture Beijing 100097China

Water stress status of plants is very important for irrigation ***,plant water stress status monitoring has become the bottleneck of irrigation *** this study,an automatic water stress status monitoring method for strawberry plant was proposed and realized using combined RGB and infrared image *** image and infrared images were obtained using RGB digital camera and infrared thermal camera,which were placed in a fixed shell in *** the first experimental stage,three kinds of water stress treatments were carried out on three groups of strawberry plants,and each group includes three *** point plant temperature,dry surface temperature,wet surface temperature were *** the second experimental stage,the infrared and visible light images of the canopy leaves were ***,plant temperature,dry surface temperature,wet surface temperature,and stomatal conductance were measured not only for single point but also for plant area temperature *** information of infrared image and visible light image was analyzed using image processing technology,to calculate the average temperature of plant *** on single point temperature,area temperature,dry surface temperature and wet surface temperature of the plant,single point crop water stress index(CWSI)and area CWSI were *** analysis of variance(ANOVA),the experimental results showed that CWSI measured for plants under different treatments,were significantly *** correlation analysis,the experimental results showed that,determination coefficient between area CWSI and the corresponding stomatal conductance of three strawberry groups were 0.8834,0.8730 and 0.8851,respectively,which were larger than that of single-point CWSI and stomatal *** results showed that area CWSI is more suitable to be used as the criteria for automatic diagnosis of plants.

关键词： automatic diagnosis water stress crop water stress index machine vision strawberry

Correlating the electronic structures of metallic/semiconducting MoTe2 interface to its atomic structures

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National Science Review 2021年第2期8卷 108-114页

作者： Bo han Chen Yang Xiaolong Xu yuehui Li Ruochen Shi Kaihui Liu Haicheng Wang yu Ye Jing Lu Dapeng yu Peng gao Electron Microscopy Laboratory and International Center for Quantum Materials School of PhysicsPeking University Department of Material Physics and Chemistry University of Science and Technology Beijing State Key Laboratory for Artificial Microstructure &Mesoscopic Physics School of PhysicsPeking University Academy for Advanced Interdisciplinary Studies Peking University Collaborative Innovation Center of Quantum Matter State Key Laboratory of Advanced Materials for Smart Sensing GRINM Group Co.Ltd.Beijingand GRIMAT Engineering Institute Co.Ltd. Shenzhen Key Laboratory of Quantum Science and Engineering

Contact interface properties are important in determining the performances of devices that are based on atomically thin two-dimensional（2D） materials, especially for those with short channels. Understanding the contact interface is therefore important to design better devices. Herein, we use scanning transmission electron microscopy, electron energy loss spectroscopy, and first-principles calculations to reveal the electronic structures within the metallic（1T）-semiconducting（2H） MoTe;2;coplanar phase boundary across a wide spectral range and correlate its properties to atomic structures. We find that the 2 H-MoTe;2;excitonic peaks cross the phase boundary into the 1 T phase within a range of approximately 150 nm. The1 T-MoTe;2;crystal field can penetrate the boundary and extend into the 2H phase by approximately two unit-cells. The plasmonic oscillations exhibit strong angle dependence, that is a red-shift of π +σ（approximately 0.3–1.2 e V） occurs within 4 nm at 1 T/2 H-MoTe;2;boundaries with large tilt angles, but there is no shift at zero-tilted boundaries. These atomic-scale measurements reveal the structure–property relationships of the 1 T/2 H-MoTe;2;boundary, providing useful information for phase boundary engineering and device development based on 2 D materials.

关键词： MoTe2 phase engineering coplanar phase boundary EELS

Generating barcodes for nanopore sequencing data with PRO

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Fundamental Research 2024年第4期4卷 785-794页

作者： Ting yu Zitong Ren Xin gao Guojun Li Renmin han Research Center for Mathematics and Interdisciplinary Sciences Frontiers Science Center for Nonlinear Expectations(Ministry of Education)Shandong UniversityShandong 266000China Computer Electrical and Mathematical Sciences and Engineering Division&Computational Bioscience Research CenterKing Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia

DNA barcodes,short and unique DNA sequences,play a crucial role in sample identification when processing many samples simultaneously,which helps reduce experimental ***,the low quality of long-read sequencing makes it difficult to identify barcodes accurately,which poses significant challenges for the design of barcodes for large numbers of samples in a single sequencing ***,we present a comprehensive study of the generation of barcodes and develop a tool,PRO,that can be used for selecting optimal barcode sets and *** formulate the barcode design problem as a combinatorial problem and prove that finding the optimal largest barcode set in a given DNA sequence space in which all sequences have the same length is theoretically *** practical applications,we developed the novel method PRO by introducing the probability divergence between two DNA sequences to expand the capacity of barcode kits while ensuring demultiplexing ***,the maximum size of the barcode kits designed by PRO is 2,292,which keeps the length of barcodes the same as that of the official ones used by Oxford Nanopore Technologies(ONT).We validated the performance of PRO on a simulated nanopore dataset with high error *** demultiplexing accuracy of PRO reached 98.29%for a barcode kit of size 2,922,4.31%higher than that of Guppy,the official demultiplexing *** the size of the barcode kit generated by PRO is the same as the official size provided by ONT,both tools show superior and comparable demultiplexing accuracy.

关键词： Third-generation sequencing Nanopore sequencing DNA barcode Farthest point sampling algorithm High throughput

Enhancing crystal structure prediction by decomposition and evolution schemes based on graph theory

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Fundamental Research 2021年第4期1卷 466-471页

作者： Hao gao Jun jie Wang yu han JianSun National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Crystal structure prediction algorithms have become powerful tools for materials discovery in recent years, however, they are usually limited to relatively small systems. The main challenge is that the number of local minima grows exponentially with the system size. In this work, we proposed two crossover-mutation schemes based on graph theory to accelerate the evolutionary structure searching by automatic decomposition methods. These schemes can detect molecules or clusters inside periodic networks using quotient graphs for crystals, and the decomposition can dramatically reduce the searching space. Sufficient examples for test, including the high-pressure phases of methane, ammonia, MgAl2O4 and boron, show that these new evolution schemes can significantly improve the success rate and searching efficiency compared with the standard method in both isolated and extended systems.

关键词： Structure prediction method Graph theory Modular decomposition Molecular crystal Crystal structure searching Evolutionary algorithm