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Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia

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Traditional Medicine Research 2024年第11期9卷 12-26页

作者： Jie-Hui Kuang Tao Hu Lu-Yong Zhang yu-feng yao Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527500China.

Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac ***,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic *** objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat ***:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of *** integration of network pharmacology and metabolomics was conducted to investigate the *** docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated ***:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart *** results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for *** network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl ***:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.

关键词： chronic myocardial ischemia metabolomics network pharmacology serum metabolites Shenzao dripping pill

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1阶和2阶Schrödinger代数的Poisson代数结构

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数学学报（中文版） 2024年第4期67卷 652-665页

作者：闫琳璐姚裕丰上海海事大学理学院上海201306

Poisson代数是指同时具有结合代数结构与李代数结构的一类代数,其结合代数结构和李代数结构满足Leibniz法则.本文中确定了1阶和2阶Schrödinger代数的Poisson代数结构.

关键词： Poisson代数 Schrödinger代数 2阶Schrödinger代数 Leibniz法则

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Character Formulas for a Class of Simple Restricted Modules over the Simple Lie Superalgebras of Witt Type

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 49-60页

作者： yu-feng yao Department of Mathematics Shanghai Maritime UniversityShanghai 201306China

Let F be an algebraically closed field of prime characteristic, and W(m, n, 1) be the simple restricted Lie superalgebra of Witt type over F, which is the Lie superalgebra of superderivations of the superalgebra ■(m;1) ■∧(n), where ■(m;1) is the truncated polynomial algebra with m indeterminants and ∧(n) is the Grassmann algebra with n indeterminants. In this paper, the author determines the character formulas for a class of simple restricted modules of W(m, n, 1) with atypical weights of type Ⅰ.

关键词： Restricted Lie superalgebra Witt type Lie superalgebra Restricted representation Typical(atypical) weight Character formula

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Commuting variety of Witt algebra

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Frontiers of Mathematics in China 2018年第5期13卷 1179-1187页

作者： yu-feng yao Hao CHANG Department of Mathematics Shanghai Maritime University Shanghai 201306 China School of Mathematics and Statistics Central China Normal University Wuhan 430079 China

Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮（g） = {（x,y） ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie algebras of P. Levy [J. Algebra, 2002, 250： 473-484], we show that the variety ∮（g） is reducible, and not equidimensional. Irreducible components of ∮（g） and their dimensions are precisely given. As a consequence, the variety ∮（g） is not normal.

关键词： Witt algebra irreducible component dimension commuting variety

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Borel Subalgebras of the Witt Algebra

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Acta Mathematica Sinica,English Series 2015年第8期31卷 1348-1358页

作者： yu feng yao Hao CHANG Department of Mathematics Shanghai Maritime University Department of Mathematics East China Normal University

Let F be an algebraically closed field of characteristic p 〉 3, and g be the Witt algebra over F. Let N be the nilpotent cone of g. An explicit description of N is given, so that the conjugacy classes of Borel subalgebras of g under the automorphism group of g are determined. In contrast with only one conjugacy class of Borel subalgebras in a classical simple Lie algebra, there are two conjugacy classes of Borel subalgebras in g. The representatives of conjugacy classes of Borel subalgebras, i.e.,the so-called standard Borel subalgebras, are precisely given.

关键词： Witt algebra Borel subalgebra nilpotent element nilpotent cone automorphism group

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Pathogenic mutations of TGFBI and CHST6 genes in Chinese patients with Avellino,lattice,and macular corneal dystrophies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 687-693页

作者： Ya-nan HUO yu-feng yao Ping yu Department of Ophthalmology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Sir Run Run Shaw Institute of Clinical Medicine Zhejiang UniversityHangzhou 310016China Department of Medical Genetics School of MedicineZhejiang UniversityHangzhou 310058China

Objective:To investigate gene mutations associated with three different types of corneal dystrophies(CDs),and to establish a phenotype-genotype ***:Two patients with Avellino corneal dystrophy(ACD),four patients with lattice corneal dystrophy type I(LCD I) from one family,and three patients with macular corneal dystrophy type I(MCD I) were subjected to both clinical and genetic *** lamp examination was performed for all the subjects to assess their corneal *** DNA was extracted from peripheral blood *** coding regions of the human transforming growth factor β-induced(TGFBI) gene and carbohydrate sulfotransferase 6(CHST6) gene were amplified by polymerase chain reaction(PCR) and subjected to direct *** samples from 50 healthy volunteers were used as ***:Clinical examination showed three different phenotypes of *** examination identified that two ACD subjects were associated with homozygous R124H mutation of TGFBI,and four LCD I subjects were all associated with R124C heterozygous *** MCD I subject was associated with a novel S51X homozygous mutation in CHST6,while the other two MCD I subjects harbored a previously reported W232X homozygous ***:Our study highlights the prevalence of codon 124 mutations in the TGFBI gene among the Chinese ACD and LCD I ***,we found a novel mutation among MCD I patients.

关键词： Transforming growth factor-β-induced(TGFBI) gene Carbohydrate sulfotransferase 6(CHST6) gene Corneal dystrophy Mutation

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On Chevalley Restriction Theorem for Semi-reductive Algebraic Groups and Its Applications

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Acta Mathematica Sinica,English Series 2022年第8期38卷 1421-1435页

作者： Ke OU Bin SHU yu feng yao School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221P.R.China School of Mathematical Sciences East China Normal UniversityShanghai 200241P.R.China Department of Mathematics Shanghai Maritime UniversityShanghai 201306P.R.China

An algebraic group is called semi-reductive if it is a semi-direct product of a reductive subgroup and the unipotent *** a semi-reductive algebraic group naturally arises and also plays a key role in the study of modular representations of non-classical finite-dimensional simple Lie algebras in positive characteristic,and some other *** G be a connected semi-reductive algebraic group over an algebraically closed field F and g=Lie(G).It turns out that G has many same properties as reductive groups,such as the Bruhat *** this note,we obtain an analogue of classical Chevalley restriction theorem for g,which says that the G-invariant ring F[g]~G is a polynomial ring if g satisfies a certain“positivity”condition suited for lots of cases we are interested *** applications,we further investigate the nilpotent cones and resolutions of singularities for semi-reductive Lie algebras.

关键词： Semi-reductive algebraic groups semi-reductive Lie algebras Chevalley restriction theorem nilpotent cone Steinberg map Springer resolution

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On Blocks in Restricted Representations of Lie Superalgebras of Cartan Type

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1061-1075页

作者： Fei Fei DUAN Bin SHU yu feng yao School of Mathematical Sciences Hebei Normal UniversityShijiazhuang 050024P.R.China School of Mathematical Sciences East China Normal UniversityShanghai 200241P.R.China Department of Mathematics Shanghai Maritime UniversityShanghai 201306P.R.China

Let g be a restricted Lie superalgebra of Cartan type W(n),S(n)or H(n)over an alge-braically closed field k of prime characteristic p>3,in the sense of modular version of Kac's definition in *** this note,we show that the restricted representation category over g has only one block(reckoning parities in).This phenomenon is very diff erent from the case of characteristic zero.

关键词： Lie superalgebra of Cartan type restricted representation block

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Inverse Limits in Representations of a Restricted Lie Algebra

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Acta Mathematica Sinica,English Series 2012年第12期28卷 2463-2474页

作者： yu feng yao Bin SHU Yi Yang LI Department of Mathematics Shanghai Maritime University Department of Mathematics East China Normal University School of Fundamental Studies Shanghai University of Engineering Science

Let （g, [p]） be a restricted Lie algebra over an algebraically closed field of characteristic p 〉 O. Then the inverse limits of ＂higher＂ reduced enveloping algebras {uxs （g） I s ∈ N} with X running over g＊ make representations of g split into different ＂blocks＂. In this paper, we study such an infinite- dimensional algebra Ax （g）：=lim Uxs （g） for a given X C g＊. A module category equivalence is built between subcategories of U（g）-rnod and Ax（g）-mod. In the case of reductive Lie algebras, （quasi） generalized baby Verma modules and their properties are described. Furthermore, the dimensions of projective covers of simple modules with characters of standard Levi form in the generalized x-reduced module category are precisely determined, and a higher reciprocity in the case of regular nilpotent is obtained, generalizing the ordinary reciprocity.

关键词： Restricted Lie algebra reductive Lie algebra inverse limit projective module standard Levi form

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Long-term comparison of full-bed deep anterior lamellar keratoplasty and penetrating keratoplasty in treating keratoconus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 438-450页

作者： Yong-ming ZHANG Shuang-qing WU yu-feng yao Department of Ophthalmology Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University

Objective: To compare postoperative outcomes of full-bed deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in treating keratoconus. Methods: Seventy-five eyes of 64 patients who received full-bed DALK and 52 eyes of 51 patients who received PK between June 2000 and August 2010 were included in this retrospective study. Full-bed DALK was performed using yao's hooking-detaching technique. PK was performed using a standard technique. Intraoperative and postoperative complications, visual acuity, rejection, graft survival, endothelial cell density, corneal sensation recovery, and re-innervation were compared between the two groups. Results: A best correct visual acuity of 0.5 or better was achieved in 90.7% of eyes after full-bed DALK and in 92.3% of eyes after PK (P=0.75). By the fifth postoperative year, graft endothelial cell loss reached 34.6% in the PK group vs. 13.9% in the full-bed DALK group (P0.05). Intraoperative microperforation occurred in seven out of 75 (9.3%) eyes with a temporally postoperative double anterior chamber in two eyes in the full-bed DALK group. Postoperative complications in the PK vs. the full-bed DALK groups respectively were: rejection (7.7% vs. 0%, P=0.015), high intraocular pressure (IOP) (46.2% vs. 1.3%, P<0.001), secondary glaucoma (9.6% vs. 0%, P=0.006), complicated cataract (19.2% vs. 0%, P<0.001), and wound dehiscence (9.6% vs. 0%, P=0.006). Conclusions: Both full-bed DALK and PK can offer long-term satisfactory visual outcomes for keratoconus. Graft rejection, secondary glaucoma, complicated cataracts, and constant endothelial cell loss were observed in eyes only after PK.

关键词： Full-bed deep anterior lamellar keratoplasty Penetrating keratoplasty Keratoconus Forceps hooking Viscoelastic detaching

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