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The endo-beta mannase MAN7 contributes to cadmium tolerance by modulating root cell wall binding capacity in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2023年第7期65卷 1670-1686页

作者： Qi Wu yu Ting Meng Zhi Hang feng Ren fang Shen Xiao fang Zhu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China

The heavy metal cadmium(Cd) is detrimental to crop growth and threatens human health through the food chain. To cope with Cd toxicity,plants employ multiple strategies to decrease Cd uptake and its root-to-shoot translocation. However, genes that participate in the Cd-induced transcriptional regulatory network, including those encoding transcription factors, remain largely unidentified. In this study, we demonstrate that ENDO-BETA-MANNASE 7(MAN7) is necessary for the response of Arabidopsis thaliana to toxic Cd levels. We show that MAN7 is responsible for mannase activity and modulates mannose content in the cell wall, which plays a role in Cd compartmentalization in the cell wall under Cd toxicity conditions. Additionally,the repression of root growth by Cd was partially reversed via exogenous application of mannose,suggesting that MAN7-mediated cell wall Cd redistribution depends on the mannose ***, we identified a basic leucine zipper(bZIP) transcription factor, bZIP44, that acts upstream of MAN7 in response to Cd *** dual-luciferase assays indicated that bZIP44 directly binds to the MAN7 promoter region and activates its transcription. Loss of bZIP44 function was associated with greater sensitivity to Cd treatment and higher accumulation of the heavy metal in roots and ***, MAN7 overexpression relieved the inhibition of root elongation seen in the bzip44mutant under Cd toxicity conditions. This study thus reveals a pathway showing that MAN7-associated Cd tolerance in Arabidopsis is controlled by bZIP44 upon Cd exposure.

关键词： Arabidopsis thaliana bZIP44 cadmium cell wall MAN7 mannose

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The Preparation of the Carbosilane Dendrimers with Pentafluorophenyl Groups

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Chinese Chemical Letters 2006年第9期17卷 1159-1161页

作者： Rui fang GUAN Chuan Jian ZHOU Sheng yu feng School of Materials Science and Engineering Ji＇nan University Ji＇nan 250022 School of Materials Science and Engineering Shandong University Ji＇nan 250061 School of Chemistry and Chemical Engineering Shandong University Ji＇nan 250100

Polysiloxane was a good solvent for hydrosilation reaction of carbosilane dendrimers with pentafluorophenyl core and HSiMeE（CH2）3C6F5. A new kind of dendrimer with both pentafluorophenyl core and terminal groups was synthesized. The studies showed that with the increase of fluorination, the viscosity values of carbosilane dendrimers decreased.

关键词： Polysiloxane hydrosilation carbosilane dendrimer pentafluorobenzene low viscosity.

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Connexin:a potential novel target for protecting the central nervous system?

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Neural Regeneration Research 2015年第4期10卷 659-666页

作者： Hong-yan Xie yu Cui fang Deng Jia-chun feng Departmet of Neurology the First Hospital of Jilin University Department of Neurosurgery the First People’s Hospital of Xianyang

Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings re-garding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Peli-zaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.

关键词： connexin gap junction biosynthetic pathways biodegradation brain central nervous system diseases

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Detecting visually salient scene areas and deriving their relative spatial relations from continuous street-view panoramas

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International Journal of Digital Earth 2020年第12期13卷 1504-1531页

作者： fangli Guan Zhixiang fang Tao yu Mingxiang feng Fan Yang State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanPeople’s Republic of China Collaborative Innovation Center of Geospatial Technology WuhanPeople’s Republic of China School of Computer Science and Technology Wuhan University of TechnologyWuhanPeople’s Republic of China

A salient scene is an area within an image that contains visual elements that stand out from surrounding *** are important for distinguishing landmarks in first-person-view(FPV)applications and determining spatial relations in *** relative spatial relation between salient scenes acts as a visual guide that is easily accepted and understood by users in FPV ***,current digitally navigable maps and location-based services fall short of providing information on visual spatial relations for *** shortcoming has a critical influence on the popularity and innovation of FPV *** paper addresses the issue by proposing a method for detecting visually salient scene areas(SSAs)and deriving their relative spatial relationships from continuous *** method includes three critical ***,an SSA detection approach is introduced by fusing region-based saliency derived from super-pixel segmentation and the frequency-tuned saliency *** method focuses on a segmented landmark area in a ***,a street-view-oriented SSA generation method is introduced by matching and merging the visual SSAs from continuous ***,a continuous geotagged panorama-based referencing approach is introduced to derive the relative spatial relationships of SSAs from continuous *** information includes the relative azimuth,elevation angle,and the relative *** results show that the error for the SSA relative azimuth angle is approximately±6°(with an average error of 2.67°),and the SSA relative elevation angle is approximately±4°(with an average error of 1.32°)when using Baidu street-view *** results demonstrate the feasibility of the proposed *** method proposed in this study can facilitate the development of FPV applications such as augmented reality(AR)and pedestrian navigation using proper spatial relation.

关键词： Street-view panorama visually salient scene area relative spatial relation pedestrian navigation firstperson view

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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Generalized bounds on the partial periodic correlation of complex roots of unity sequence set

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 207-210页

作者： Li-fang feng Institute of Mobile Communication Southwest Jiaotong University Chengdu 610031 China

In this paper,the generalized bounds are derived on the partial periodic correlation of complex roots of unity sequence set with zero or low correlation zone(ZCZ/LCZ)as the important criteria of the sequence design and *** derived bounds are with respect to family size,subsequence length,maximum partial autocorrelation sidelobe,maximum partial cross-correlation value and the ZCZ/*** results show that the derived bounds include the previous periodic bounds,such as Sarwate bound,Welch bound,Peng-Fan bound and Paterson-Lothian bound,as special cases.

关键词： Partial correlation Zero correlation zone (ZCZ) Low correlation zone (LCZ) CDMA

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电解质溶液复介电常数测量中气泡影响的分析

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信息与电子工程 2007年第1期5卷 52-56页

作者：方峪枫胡荣骅杨晓庆黄卡玛四川大学电子信息学院四川成都610064

电解质溶液复介电常数的准确测量对于生物电磁学和微波化学等领域是至关重要的,简单而有效的测量方法就是使用开口同轴线。由于电化学反应,插入溶液的测量探头表面容易产生气泡,对测量结果产生影响。文中针对气泡的不同位置和大小对氯... 详细信息

电解质溶液复介电常数的准确测量对于生物电磁学和微波化学等领域是至关重要的,简单而有效的测量方法就是使用开口同轴线。由于电化学反应,插入溶液的测量探头表面容易产生气泡,对测量结果产生影响。文中针对气泡的不同位置和大小对氯化钠溶液复介电常数测量的影响进行了数值分析,计算结果表明,电解质溶液复介电常数测量值的实部受气泡影响很小,而虚部受气泡的位置、大小和个数的影响。

关键词：复介电常数电解质溶液微波测量气泡开口同轴线

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Rapid and reversible Na deposition onto Al nanosheet arrays

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Journal of Energy Chemistry 2022年第11期31卷 1-7,I0002页

作者： fang Tang Rongqing Xia Dong Chen yu Yao Lin Liu yuezhan feng Xianhong Rui Yan yu School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006GuangdongChina Hefei National Research Center for Physical Sciences at the Microscale Department of Materials Science and EngineeringNational Synchrotron Radiation LaboratoryCAS Key Laboratory of Materials for Energy ConversionUniversity of Science and Technology of ChinaHefei 230026AnhuiChina Key Laboratory of Materials Processing and Mold(Ministry of Education) Zhengzhou UniversityZhengzhou 450002HenanChina

Sodium metal battery(SMB)is regarded as a promising candidate for next-generation high-energy battery due to high theoretical capacity and abundant natural ***,the growth of sodium dendrites and large volume expansion during the processes of sodium plating and stripping seriously restrict the practical application of ***,a three-dimensional skeleton of aluminum nanosheet arrays(Al NSARs)is constructed by a facile etching approach to achieve rapid and reversible Na plating/*** Al NSARs with large geometric specific surface and plentiful cavities can provide rich active nucleation sites,reduce local current density and accommodate Na volume change,which lead to uniform deposition of sodium with dendrite-free *** a result,Na plating/stripping on Al NSARs can stably operate over 650 cycles at 2 mA cm^(-2)/2 mAh cm^(-2)with average Coulombic efficiency(CE)of 100.0%and low potential polarization of 27 ***,the full cell of Na_(s)V_(2)(PO_(4))_(3)||Al NSARs@Na can run for over 1800 cycles at a high rate of *** superior properties,combined with relatively low cost and weight of Al,enable our AlNSARs to begreat prospect for practical applications.

关键词： Sodiummetal battery Sodiummetal anode Three-dimensional skeleton Al nanosheet arrays Dendrite-freebehavior

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A closure model on velocity structure functions in homogeneous isotropic turbulence

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Applied Mathematics and Mechanics(English Edition) 2017年第11期38卷 1627-1634页

作者： Le fang feng GAO Laboratory of Mathematics and Physics Ecole Centrale de Pekin Beihang University Beijing 100191 China Co-Innovation Center for Advanced Aero-Engine Beihang University Beijing 100191 China Faculty of Engineering and Physical Sciences University of Surrey Guildford GU2 7XH U. K.

Closure models started from Chou＇s work have been developed for more than 70 years, aiming at providing analytical tools to describe turbulent flows in the spectral space. In this study, a preliminary attempt is presented to introduce a closure model in the physical space, using the velocity structure functions as key parameters. The present closure model appears to qualitatively reproduce the asymptotic scaling behav- iors at small and large scales, despite some inappropriate behaviors such as oscillations. Therefore, further improvements of the present model are expected to provide appropriate descriptions of turbulent flows in the physical space.

关键词： homogeneous isotropic turbulence closure model structure function

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The influence of metabolic syndrome on atrial fibrillation recurrence: five-year outcomes after a single cryoballoon ablation procedure

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Journal of Geriatric Cardiology 2021年第12期18卷 1019-1028页

作者： yu XIA Xiao-feng LI Jun LIU Miao yu Pi-Hua fang Shu ZHANG State Key Laboratory of Cardiovascular Disease Cardiac Arrhythmia CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND Metabolic syndrome(MetS)has been reported as a risk factor of atrial fibrillation(AF)recurrence after radi-ofrequency catheter *** study aimed to investigate the long-term influence of MetS on paroxysmal AF recurrence after a single cryoballoon ablation procedure,which was scarcely investigated yet in Chinese *** In total,137 paroxysmal AF patients who had successfully completed a single cryoballoon ablation procedure at Fuwai Hospital,Beijing,China from December 2013 to October 2015 were *** for patients with AF recurrence,all patients were followed up for no less than five *** predictors of AF recurrence were determined by Cox propor-tional hazards regression *** Among 137 paroxysmal AF patients,91 patients(66.4%)had successfully achieved overall five-year follow-up after a single cryoballoon ablation procedure,and 44 patients(32.1%)had *** with MetS had a significant lower incidence of freedom from AF recurrence than those without MetS(50.0%vs.74.2%,log-rank P<0.01)during the five-year ***(HR=1.95,95%CI:1.069−3.551,P=0.030)was an independent predictor of AF recurrence after adjusting for multiple *** the second year post cryoballoon ablation procedure,the recurrence rate of AF gradually increased in patients with MetS,in con-trast,decreased recurrence rate of AF in patients without *** MetS is an independent predictor for five-year AF recurrence after a single cryoballoon ablation procedure in paroxysmal AF *** therapy of AF and MetS may improve the long-term outcomes of AF patients.

关键词： balloon fibrillation atrial

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