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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong Wang Yong Wu yu-fa miao Rui Fu yu-Wei Zhao Chang-fa fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen fa Shen Chang Cheng yu-Han Wang Wen-Chao Cheng De-Zhi yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Prolongation structure for nonlinear integrable couplings of a KdV soliton hierarchy

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Chinese Physics B 2012年第11期21卷 18-23页

作者： yu fa-Jun School of Mathematics and Systematic Sciences Shenyang Normal UniversityShenyang 110034China

In this paper, a new nonlinear integrable coupling system of the soliton hierarchy is presented. Prom the Lax pairs, the coupled KdV equations are constructed successfully. Based on the prolongation method of Wahlquis... 详细信息

关键词： nonlinear integrable coupling system prolongation structure KdV soliton hierarchy

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Infinite Conservation Laws for Nonlinear Integrable Couplings of Toda Hierarchy

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Chinese Physics Letters 2012年第9期29卷 1-4页

作者： yu fa-Jun School of Mathematics and Systematic Sciences Shenyang Normal UniversityShenyang 110034

We construct nonlinear integrable couplings of discrete soliton hierarchy,then the infinite conservation laws for the nonlinear integrable couplings of the lattice hierarchy are *** explicit application of the method proposed,the infinite conservation laws of nonlinear integrable couplings of the Toda lattice hierarchy are *** obtained integrable couplings of the Toda lattice equations and conservation laws can be used to describe the possible formation mechanisms for hydrodynamics,solid state physics and plasma physics,respectively.

关键词： integrable nonlinear lattice

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Conservation Laws and Self-Consistent Sources for a Super-Classical-Boussinesq Hierarchy

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Chinese Physics Letters 2011年第12期28卷 1-4页

作者： yu fa-Jun College of Maths and Systematic Science Shenyang Normal UniversityShenyang 110034

The super-classical-Boussinesq hierarchy with self-consistent sources is ***,infinitely many conservation laws for the integrable super-classical-Boussinesq hierarchy are established.

关键词： Boussinesq infinitely integrable

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Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis B virus infection

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World Journal of Gastroenterology 2013年第40期19卷 6888-6893页

作者： Xiao-miao Zhao yu-Feng Gao Qin Zhou fa-Ming Pan Xu Li Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Department of Hepatopathy The Second Affiliated Hospital of Anhui Medical University Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical University

AIM:To identify the relationship between tag single nucleotide polymorphisms(tag SNPs) of interleukin-6(IL-6) gene and susceptibility to chronic hepatitis B virus(HBV) infection in a Han Chinese ***:We performed a case-control study of501 Chinese patients with chronic HBV infection and301 self-limiting HBV-infected individuals as *** DNA was isolated from the whole blood of all subjects using phenol/chloroform with MaXtract highdensity tubes. Tag SNPs were identified using genotype data from the panel(Han Chinese in Beijing) of the phase II HapMap Project. Four tag SNPs in IL-6(rs17147230A/T,rs2066992G/T,rs2069837A/G and rs2069852A/G) were genotyped by the Multiplex Snapshot technique. The genotype and allele frequencies were calculated and ***:Five haplotypes were involved in the analysis,with frequencies higher than 0.03. One of the haplotypes,TTAA,was significantly different between the two groups. Overall haplotype P values were:ATAA,P = 0.605,OR(95%CI) = 1.056(0.860-1.297); TGAG,P = 0.385,OR(95%CI) = 1.179(0.813-1.709); TGGG,P = 0.549,OR(95%CI) = 1.087(0.827-1.429); TTAA,P = 0.004,OR(95%CI) = 0.655(0.491-0.873); TTAG,P = 0.266,OR(95%CI) = 1.272(0.832-1.944). However,the four SNPs showed no significant genotype/allele associations with susceptibility to chronic HBV infection. Overall allele P values were:rs17147230,P = 0.696,OR(95%CI) = 1.041(0.850-1.276); rs2066992,P = 0.460,OR(95%CI)= 1.090(0.868-1.369); rs2069837,P = 0.898,OR(95%CI) = 0.983(0.759-1.274); rs2069852,P = 0.165,OR(95%CI) = 0.859(0.693-1.064). Overall genotype P values were:rs17147230,P = 0.625; rs2066992,P= 0.500; rs2069837,P = 0.853; and rs2069852,P =***:The four tag SNPs of IL-6 gene may be associated with susceptibility to chronic HBV infection in the Han Chinese population.

关键词： Chronic hepatitis B virus infection Interleukin-6 Single nucleotide polymorphism Genetic susceptibility Haplotype

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On (2+1)-Dimensional Non-isospectral Toda Lattice Hierarchy and Integrable Coupling System

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Communications in Theoretical Physics 2008年第3期49卷 549-554页

作者： yu fa-Jun College of Maths and Systematic Science Shenyang Normal University Shenyang 110034 China Department of Mathematics Dalian University of Technology Dalian 116024 China

By considering （2＋1）-dimensional non-isospectral discrete zero curvature equation, the （2＋1）-dimensional non-isospectral Toda lattice hierarchy is constructed in this article. It follows that some reductions of the （2＋1）- dimensional Toda lattice hierarchy are given. Finally, the （2＋1）-dimensional integrable coupling system of the Toda lattice hierarchy is obtained through enlarging spectral problem.

关键词： discrete zero curvature equation non-isospectral Toda lattice integrable coupling

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The Hippo pathway in tissue homeostasis and regeneration

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Protein & Cell 2017年第5期8卷 349-359页

作者： yu Wang Aijuan yu fa-Xing yu Children's Hospital and Institutes of Biomedical Sciences Fudan University Shanghai 200032 China Collaborative Innovation Center of Genetics and Development School of Life Sciences Fudan University Shanghai 200433 China Key Laboratory of Reproduction Regulation of NPFPC SIPPR IRD Fudan University Shanghai 200032 China

While several organs in mammals retain partial regen- erative capability following tissue damage, the underly- ing mechanisms remain unclear. Recently, the Hippo signaling pathway, better known for its function in organ size control, has been shown to play a pivotal role in regulating tissue homeostasis and regeneration. Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway, is transiently induced, which in turn promotes expansion of tissue-resident progenitors and facilitates tissue regeneration. In this review, with a general focus on the Hippo pathway, we will discuss its major components, functions in stem cell biology, involvement in tissue regeneration in different organs, and potential strategies for developing Hippo pathway- targeted regenerative medicines.

关键词： Hippo YAP regeneration

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Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders

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Zoological Research 2024年第1期45卷 152-159页

作者： yu-fa Luo Shu-Qiang Li School of Life and Environmental Sciences Shaoxing UniversityShaoxingZhejiang 312000China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level(61 species in the thoracica group and 84 species of Scytodes)using DNA data from six *** results indicated that the thoracica group initially dispersed from Southeast Asia to East Africa between 46.5 and 33.0 million years ago,and dispersal events intensified between Southeast/South Asia and East/South Africa from the early to late *** timing of these events indicates that Asian-African faunal exchange of the thoracica group was driven by the Indian monsoon,and the pattern of dispersal suggests that colonialization took root when the Indian monsoon shifted from a North-South direction to an East-West direction from the middle Eocene.

关键词： Geological event Climate change Ballooning organism faunal exchange Species distribution

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Hermitizable, isospectral complex second-order differential operators

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Frontiers of Mathematics in China 2020年第5期15卷 867-889页

作者： Mu-fa CHEN Jin-yu LI Research Institute of Mathematical Science Jiangsu Normal UniversityXuzhou 221116China School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China Laboratory of Mathematics and Complex Systems(Beijing Normal University) Ministry of EducationBeijing 100875China

The first aim of the paper is to study the Hermitizability of secondorder differential operators,and then the corresponding isospectral *** explicit criteria for the Hermitizable or isospectral properties are *** second aim of the paper is to study a non-Hermitian model,which is now well *** a regular sense,the model does not belong to the class of Hermitizable operators studied in this paper,but we will use the theory developed in the past years,to present an alternative and illustrated proof of the discreteness of its *** harmonic function plays a critical role in the study of *** constructions of the function are *** required conclusion for the discrete spectrum is proved by some comparison technique.

关键词： Hermitizable isospectral differential operators non-Hermitianmodel discrete spectrum

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