检索结果-南通市图书馆

Theoretical Exploration of Alloying Effects on Stabilities and Mechanical Properties ofγʹPhase in Novel Co–Al–Nb-Base Superalloys

引用

Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1238-1248页

作者： Guan-cheng Gu Zhao-Jing Han Ze-yu chen Zhao-Xuan Li Sheng-Bao Xia Zheng-ning Li Hua Jin Wei-Wei Xu Xing-Jun Liu Shenzhen Research Institute of Xiamen university School of Aerospace EngineeringXiamen UniversityXiamen361005China Institute of Materials Genome and Big Data Harbin Institute of TechnologyShenzhen518055China

The new developedγ/γʹCo–Al–Nb-base alloys show great potentials as high-temperature ***,finding appropriate compositions to improve performance of alloys still poses a great challenge to the development of Co–Al–Nb-base *** by the lack of alloying effects on fundamental properties of criticalγʹphase,we systematically performed a theoretical investigation on the effect of alloying elements TM(TM:Ti,V,Cr,Zr,Mo,Ta,W,Re,and Ru)on phase stabilities and mechanical properties of L1_(2)-typeγʹ(Co,Ni)_(3)(Al,Nb).By analyzing the stability ofγʹphase with respect to its competitive B2 and D0_(19) phases,the results shown that Ti,V,and Cr enhance the L1_(2) stability and widen the L1_(2)–D0_(19) energy barrier,in which V yields the maximum *** analysis of electronic structure indicated that the alternation of valence electrons at fermi level would be the atomic origin for doping TM inγʹ*** calculated results of mechanical properties shown that V and Cr are expected to be optimal dopant for enhancing the strength and the ductility ofγʹ*** addition of Ta is also beneficial for enhancing the strength at the slight expense of ductility ofγʹ*** drawing the mechanical maps,the preferred composition range for the phases with desired properties is roughly demarcated in theory for the multi-addition of V/Cr and V/Ta inγʹ*** findings would be useful for optimizing the performance of novelγ/γʹCo–Al–Nb-base superalloys.

关键词： Co-Al-Nb-base superalloys γ/γʹdual-phase Phase stability Mechanical properties First-principle methods

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unveiling the next generation of MRI contrast agents:current insights and perspectives on ferumoxytol-enhanced MRI

引用

National science Review 2024年第05期11卷 385-404页

作者： Guangxiang Si yue Du Peng Tang Gao Ma Zhaochen Jia Xiaoyue Zhou Dan Mu Yan Shen Yi Lu yu Mao Chuan chen Yan Li ning Gu Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics School of Biomedical Engineering and InformaticsNanjing Medical University Department of Radiology the First Affiliated Hospital of Nanjing Medical University MR Collaboration Siemens Healthineers Ltd. Department of Radiology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School School of Mathematical sciences Capital Normal University Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower HospitalMedical SchoolNanjing University

Contrast-enhanced magnetic resonance imaging(CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced MRI(FE-MRI) has significantly reshaped CE-MRI practices. Unlike MRI that is enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher MRI time efficiency and the capability for molecular imaging. As a leading superparamagnetic iron oxide contrast agent, ferumoxytol is heralded as the next generation of contrast agents. This review delineates the pivotal clinical applications and inherent technical superiority of FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging the gap between clinical demands and engineering innovations. Concurrently, we spotlight the emerging imaging themes and new technical breakthroughs. Lastly, we share our own insights on the potential trajectory of FE-MRI, shedding light on its future within the medical imaging realm.

关键词： ferumoxytol contrast agent contrast-enhanced MRI ferumoxytol-enhanced MRI

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Molecular characteristics analysis and B-cell linear epitopes， key amino acids identification of the sesame allergen Ses i 3

引用

Food science and Human Wellness 2024年

作者： ning yu yufei Qin Wenhan Kang Jiukai Zhang Lijia chen Hongtian Wang Xiaoyan Wang Ying chen Chinese Academy of Inspection and Quarantine College of Food science and Engineering， Nanjing university of Finance and Economics Food Allergy Department， beijing Shijitan Hospital， Capital Medical university

Sesame is one of the eight major allergens that cause food allergies. Study of the epitopes of sesame allergens is important for understanding their sensitization mechanisms. Currently， less information is available on the epitope studies of sesame allergens. In this study， we analyzed the molecular characteristics， structure and homology of Ses i 3， one of the important sesame allergens. We predicted the B-cell linear epitopes of Ses i 3 using bioinformatics tools and characterized them by slot blot immuno-microarrays technology. Eight peptides as B-cell linear epitopes of Ses i 3 were identified， in addition， key amino acids in these epitopes were predicted and leucine 422 was identified as a key amino acid. The present work will contribute to further understanding of the sesame allergen and provide some help in the prevention and treatment of sesame allergy.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

引用

World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： yu-Hua Du Jian-Jun Zhao Xia Li Shi-Cong Huang Na ning Guo-Qing chen Yi Yang Yi Nan Ling yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Pachymic acid(PA)is derived from Poria *** has a variety of pharmacological and inhibitory effects on various ***,the mechanism of action of PA in gastric cancer(GC)remains *** To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental *** The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA *** the STRING database,a protein-protein interaction network was constructed and core targets were *** analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core ***,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot *** According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment *** experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell *** Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of *** has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model

引用

Journal of Genetics and Genomics 2024年第2期51卷 256-259页

作者： Ming Jin Jiajia Lin yu Zhang Qingquan Xiao Xiangfeng Kong Xiumei Zhang Zhurui Shao Yin Wang yuyang yu Jinjing Li Wan-Jin chen Guoling Li Hui Yang ning Wang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350004China HUIDAGENE Therapeutics Co. Ltd.Shanghai 200131China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Duchenne muscular dystrophy(DMD)is a severe neuromuscular disorder caused by mutations in the dystrophin gene,which encodes the essential protein *** genetic condition,affecting approximately 1 in 5000 male births worldwide(Birnkrant et al.,2018),is characterized by progressive muscle weakness and wasting,leading to premature death in the second or third decade of life(Farini et al.,2016).The absence of dystrophin protein causes instability in the sarcolemma,which predisposes individuals to myonecrosis and activation of inflammatory signaling ***,there is currently no effective cure for DMD,and glucocorticoid steroids are commonly used in clinical settings to delay symptom development(Merlini et al.,2003).

关键词： dystrophy Duchenne

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nomogram prediction of vessels encapsulating tumor clusters in small hepatocellular carcinoma≤3 cm based on enhanced magnetic resonance imaging

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1808-1820页

作者： Hui-Lin chen Rui-Lin He Meng-Ting Gu Xing-yu Zhao Kai-Rong Song Wen-Jie Zou ning-Yang Jia Wan-Min Liu School of Health science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology The Third Affiliated Hospital of Shanghai Naval Military Medical UniversityShanghai 200438China Department of Radiology Tongji University Affiliated Tongji HospitalShanghai 200065China

BACKGROUND Vessels encapsulating tumor clusters(VETC)represent a recently discovered vascular pattern associated with novel metastasis mechanisms in hepatocellular carcinoma(HCC).However,it seems that no one have focused on predicting VETC status in small HCC(sHCC).This study aimed to develop a new nomogram for predicting VETC positivity using preoperative clinical data and image features in sHCC(≤3 cm)*** To construct a nomogram that combines preoperative clinical parameters and image features to predict patterns of VETC and evaluate the prognosis of sHCC *** A total of 309 patients with sHCC,who underwent segmental resection and had their VETC status confirmed,were included in the *** patients were recruited from three different hospitals:Hospital 1 contributed 177 patients for the training set,Hospital 2 provided 78 patients for the test set,and Hospital 3 provided 54 patients for the validation *** predictors of VETC were identified through univariate and multivariate logistic *** independent predictors were then used to construct a VETC prediction model for *** model’s performance was evaluated using the area under the curve(AUC),calibration curve,and clinical decision ***,Kaplan-Meier survival analysis was performed to confirm whether the predicted VETC status by the model is associated with early recurrence,just as it is with the actual VETC status and early *** Alpha-fetoprotein_lg10,carbohydrate antigen 199,irregular shape,non-smooth margin,and arterial peritumoral enhancement were identified as independent predictors of *** model incorporating these predictors demonstrated strong predictive *** AUC was 0.811 for the training set,0.800 for the test set,and 0.791 for the validation *** calibration curve indicated that the predicted probability was consistent with the actual VETC status in all three ***,the decision curve analysis demonstr

关键词： Small hepatocellular carcinoma Vessels encapsulating tumor clusters Nomogram Magnetic resonance imaging Multicenter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Martian crustal magnetic field on its ionosphere

引用

science china(Technological sciences) 2010年第6期53卷 1717-1724页

作者： ZOU Hong,chen HongFei,yu ning,SHI WeiHong,yu XiangQian,ZOU JiQing & ZHONG WeiYing Institute of Space Physics and Applied technology,Peking university,beijing 100871,china 1. Institute of Space Physics and Applied technology Peking University Beijing 100871 China

The effect of the Martian crustal magnetic field is one of the hot topics of the study of Martian *** studies on this topic are summarized in this *** data of the Martian ionosphere were resulted from radio occultation *** to the observations,the electron density scale height and the peak electron density of the Martian ionosphere are influenced by its crustal magnetic *** strong horizontal magnetic field prevents the vertical diffusion of the plasma and makes the electron density scale height in the topside ionosphere close to that in the photo equilibrium *** the cusp-like regions with strong vertical magnetic field,the enhanced vertical diffusion leads to a larger electron density scale height in the diffusion equilibrium *** observation of radio occultation experiment onboard Mars Global Surveyor (MGS) showed that the averaged peak electron density observed in the southern hemisphere with strong crustal magnetic field was slightly larger than that in the northern hemisphere with weak crustal magnetic *** Mars advanced radar for subsurface and ionosphere sounding (MARSIS) onboard Mars Express (MEX) was the first topside sounder to be used to observe Martian *** MARSIS results confirmed that the enhancement of the peak electron density occurred in cusp-like regions with open field lines,and the amount of the enhancement was much larger than that observed by the radio occultation *** are two possible mechanisms for the peak electron density enhancement in the cusp-like crustal magnetic field regions:One is the precipitation of the energetic particles and the other is the heating by the waves excited by plasma ***'s difficult to determine which one is the key mechanism for the peak electron density *** on these studies,several interesting problems on the Martian ionosphere and plasma environment are presented.

关键词： Mars exploration Martian crustal megnetic field Martian ionosphere energetic particles detection plasma wave detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental Study on Ammonia Co-Firing with Coal for Carbon Reduction in the Boiler of a 300-MW Coal-Fired Power Station

引用

Engineering 2024年第9期40卷 247-259页

作者： Qifu Lin Wangping Sun Haiyan Li Yangjiong Liu yuwei chen chengzhou Liu Yiman Jiang yu cheng ning Ma Huaqing Ya Longwei chen Shidong Fang Hansheng Feng Guang-Nan Luo Jiangang Li Kaixin Xiang Jie Cong cheng cheng Institute of Energy Hefei Comprehensive National Science Center(Anhui Energy Laboratory)Hefei 230088China Anbang technology Co.Ltd Tongling 244000China Institute of Plasma Physics Hefei Institute of Matter ScienceChinese Academy of SciencesHefei 230031China

To reduce CO_(2) emissions from coal-fired power plants,the development of low-carbon or carbon-free fuel combustion technologies has become *** a new zero-carbon fuel,ammonia(NH_(3))can be used to address the storage and transportation issues of hydrogen *** it is not feasible to completely replace coal with ammonia in the short term,the development of ammonia-coal co-combustion technology at the current stage is a fast and feasible approach to reduce CO_(2) emissions from coal-fired power *** study focuses on modifying the boiler and installing two layers of eight pure-ammonia burners in a 300-MW coal-fired power plant to achieve ammonia-coal co-combustion at proportions ranging from 20%to 10%(by heat ratio)at loads of 180-to 300-MW,*** results show that,during ammonia-coal co-combustion in a 300-MW coal-fired power plant,there was a more significant change in NO_(x) emissions at the furnace outlet compared with that under pure-coal combustion as the boiler oxygen levels ***,ammonia burners located in the middle part of the main combustion zone exhibited a better high-temperature reduction performance than those located in the upper part of the main combustion *** all ammonia co-combustion conditions,the NH_(3) concentration at the furnace outlet remained below 1 parts per million(ppm).Compared with that under pure-coal conditions,the thermal efficiency of the boiler slightly decreased(by 0.12%-0.38%)under different loads when ammonia co-combustion reached 15 t·h^(-1).Ammonia co-combustion in coal-fired power plants is a potentially feasible technology route for carbon reduction.

关键词： Coal-fired boiler Coal mixing with ammonia Ammonia-coal co-firing Nitrogen oxide(NO_(x)) CO_(2)reduction Boiler thermal efficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South china

引用

Petroleum science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-ning Qi yu-Chong Wang Da-Wei Qiao Xiao-Shuai chen Li-Zhi Wu Meng Tian Long chen Yi Wei Liao-yuan Song Jian Li Zi-Gang Wu yun-Qian Liu Xuan-Chun Liu An-Qing chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： Dou-Dou Lu Ling yuan Zhao-Zhao Wang Jian-Jun Zhao yu-Hua Du Na ning Guo-Qing chen Shi-Cong Huang Yi Yang Zhe Zhang Yi Nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 ***,the mechanism of its anti-gastric cancer and regulate immunity are still remains *** To explore the mechanism of YGS anti-gastric cancer and immune *** Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric ***,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub *** the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were ***,molecular docking was used to verify the binding ability of YGS active ingredient and hub *** Firstly,obtained 55 common targets of gastric cancer and *** Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub *** 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer ***,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic *** YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer Yigong San Mechanism Immune

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：