检索结果-南通市图书馆

维普期刊数据库博看期刊

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第5期15卷 646-651页

作者： Wen yu Zan Wan xue-feng Qiu yun Chen yu-Tian Dai Department of Urology Affiliated Drum Tower Hospital School of Medicine Nanjing University Nanjing 210008 China

The high incidence of erectile dysfunction （ED） in diabetes highlights a need for effective treatment strategies. Resveratrol, an activator of silent information regulator 2-related enzymes 1 （sirtuinl, SIRT1）, has received attention for its valuable effects in cancer, neurodegenerative diseases, longevity and cardiovascular disease. To explore the effects of resveratrol in diabetes-induced ED, resveratrol was administered to rats with streptozocin （65 mg kg-1）-induced diabetes. Erectile function, cavernous structure, tissue protein expression of silent information regulator 2-related enzymes 1 （sirtuinl, SIRT1）, p53 and forkhead transcription factor 0 3a （FOXO3a）, superoxide dismutase （SOD） activity and malondialdehyde （MDA） levels in the corpora cavernosa were studied. We found that SIRT1 was expressed in cavernosal tissue, and it was downregulated in the corpora of diabetic rats. The administration of resveratrol upregulated the expression of SI RT1 and restored erectile function. In contrast, resveratrol downregulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Furthermore, the resveratrol-treated group showed an improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group. Therefore, the ability of resveratrol to improve diabetes-induced ED is likely related to its activation of SIRT1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress.

关键词： apoptosis erectile dysfunction oxidative stress resveratrol

Distribution behavior of collector in the desilication system of bauxite flotation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University of Technology 2001年第2期8卷 125-129页

作者： JIANG yu ren,xue yu lan,CAO xue feng,XIA Zhong (Department of Mineral Engineering,Central South University, Changsha 410083,China) Department of Mineral Engineering Central South University Changsha China

The distribution behavior of the HZB collector (a kind of long chain fatty acid) in the desilication system of bauxite flotation was studied. The results show that the collector tends towards froth products in the steps of the roughing, the first cleaning and the second cleaning, while towards the tailing product in the step of the scavenging, and in each job except scavenging the collector is mainly on the surface of solids. As for the froth product in the step of the scavenging, it is mainly in solution. To the tailing products of every step, it is mainly in the respective solutions. The collector added to the flotation system is mainly taken out by the last concentrate, by which the taken one occupies 65.2% of the whole, among which, 57.8% is by solid and 7.4% by solution, respectively. And the one by the last tail occupies 34.8% of the whole, among which, 8.8% is by solid and 26.0% by solution, respectively. The sum of the collector in the solution of the last concentrate and tailing is 33.4% of the amount of addition collector, and recycling the solutions will be in favor of decreasing the dosage of collector.

关键词： distribution of collector desilication flotation of bauxite

Generation and detection of squeezed state

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2008年第3期4卷 231-233页

作者： SHANG Xu-dong yu Li feng xue-dong YANG Bo-jun Key Laboratory of Optical Communication and Light wave Technologies Ministry of Education Beijing University ofPosts and Telecommunications Beijing 100876 China

Soliton amplitude squeezed state is obtained and dctected by using asymmetric Sagnac interferometer and balanced homodyne detecting system. An improved photo detector circuit for quantum state detection is introduced. The circuit has a bandwidth of 10MHz and the saturation power is about 19 mW. A maximum photocurrent noise reduction of 1.1 dB below the shot noise is achieved. Taking the detection efficiency into account,the squeezing will be about 1.5 dB.

关键词：压缩态检测技术孤波不对称性

Machine learning accelerated carbon neutrality research using big data-from predictive models to interatomic potentials

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2022年第10期65卷 2274-2296页

作者： WU LingJun XU ZhenMing WANG ZiXuan CHEN ZiJian HUANG ZhiChao PENG Chao PEI XiangDong LI XiangGuo MAILOA Jonathan P HSIEH Chang-yu WU Tao yu xue-feng ZHAO HaiTao Materials Interfaces Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Multiscale Crystal Materials Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China College of Computer National University of Defense TechnologyChangsha 410073China School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Quantum Laboratory TencentShenzhen 518057China China Beacons Institute The University of Nottingham Ningbo ChinaNingbo 315100China

Carbon neutrality has been proposed as a solution for the current severe energy and climate crisis caused by the overuse of fossil fuels, and machine learning(ML) has exhibited excellent performance in accelerating related research owing to its powerful capacity for big data processing. This review presents a detailed overview of ML accelerated carbon neutrality research with a focus on energy management, screening of novel energy materials, and ML interatomic potentials(MLIPs), with illustrations of two selected MLIP algorithms: moment tensor potential(MTP) and neural equivariant interatomic potential(NequIP). We conclude by outlining the important role of ML in accelerating the achievement of carbon neutrality from global-scale energy management, unprecedented screening of advanced energy materials in massive chemical space, to the revolution of atomicscale simulations of MLIPs, which has the bright prospect of applications.

关键词： carbon neutrality machine learning big data molecular dynamics interatomic potentials

同方期刊数据库

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao yu-Gui Peng Peng Wu Zong-Lin Li xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于数字信号处理的时钟抖动测量与分析

计量学报 2008年第3期29卷 271-274页

作者：余学锋 63870部队

讨论了时钟抖动测量中的一些问题,并给出了基于数字信号处理技术的一种测量方法。为了对新方法的性能进行估计,模拟了含有时间抖动的时钟信号,对不同抖动幅度和叠加不同噪声情况下的时钟抖动进行了测试。结果表明,新方法降低了测量精度... 详细信息

讨论了时钟抖动测量中的一些问题,并给出了基于数字信号处理技术的一种测量方法。为了对新方法的性能进行估计,模拟了含有时间抖动的时钟信号,对不同抖动幅度和叠加不同噪声情况下的时钟抖动进行了测试。结果表明,新方法降低了测量精度对触发电平的稳定度、被测时钟叠加的噪声和上升沿斜率的敏感度。

关键词：计量学时钟抖动数字信号处理测量

Altered Taurine Release in Hypothalamus of Aquaporin-4 Knockout Mice

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第3期26卷 406-408页

作者： ZHANG Hong-guo XIAO Ying-hong YANG Long-fei SU Wei-heng GUAN Xin-gang WANG yu feng xue-chao MA Tong-hui Membrane Channel Research Laboratory Northeast Normal University Changchun 130024 P. R. China

Taurine is concentrated in glial cells in the hypothalamus and released in an osmo-dependent manner through volume-sensitive anion channels. Released tanrine acts on glycine receptors on vasopressin neurons to control vasopressin secretion. Water channel AQP4 is abundant in astrocytes in osmosensory areas such as the supraoptic nucleus of hypothalamus. An HPLC-based method was established to quantify taurine release from isolated hypothalamus tissues in wildtype and AQP4 knockout mice. Under the basal condition, there was no difference in taurine release from AQP4^＋/＋ and AQP4^-/- hypothalamuses. Taurine release from AQP4^-/- hypothalamus under hypoosmotic stimulation was significantly lower than that from AQP4^＋/＋ mice. AQP4 expression in the glial cells of the hypothalamus may play an important role in osmoregulation oftaurine release and subsequent vasopressin secretion.

关键词： Aquaporin-4 Taurine Hypothalamus HPLC Precolumn derivatization

在线全文

学校读者我要写书评

暂无评论

模糊聚类迭代模型在洪水灾害度划分中应用

大连理工大学学报 2005年第1期45卷 128-131页

作者：于雪峰陈守煜大连理工大学土木水利学院

介绍了陈守煜的模糊聚类迭代模型.利用该模型的计算结果可对聚类样本作进一步的排序.即先求各个类对模糊划分的相对隶属度,以此相对隶属度为权重,根据各聚类样本对各类以相对隶属度加权,求得样本对模糊概念的类别特征值,并根据其大小对... 详细信息

介绍了陈守煜的模糊聚类迭代模型.利用该模型的计算结果可对聚类样本作进一步的排序.即先求各个类对模糊划分的相对隶属度,以此相对隶属度为权重,根据各聚类样本对各类以相对隶属度加权,求得样本对模糊概念的类别特征值,并根据其大小对聚类样本进行排序.将其应用于"96.7"洪水灾害分析,较清晰地划分出了各受灾地受灾程度的轻重.

关键词：模糊聚类类别特征值洪水灾害相对隶属度模糊数学

PRELIMINARY STUDIES ON THE SYNTHESIS AND CHARACTERIZATION OF OXY-AND THIO-DIACETIC ACID HYDRAZITION AND THEIR FIRST-ROW TRANSITION METAL COMPLEXES

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1991年第9期2卷 725-726页

作者： Bao yu xue Zhen feng Xi Si Guo yuAN Dou Man JIN Henan Institute of Chemistry,Zhengzhou 450003

It has been made certain that thio-and oxy-diacetic acid hydrazides are potential anticancer ***,their ability to form complexes with transition metals and the properties of the complexes thus formed have not been *** a new potential anticancer ligand 1,2-bis(thioacetic acid hydrazide)ethane prepared in our lab,along with ligands oxydiacetic hydrazide and 1,2-bis(oxyacetic acid hydrazide) ethane,a series of 11 new first-row transition metal(M=Zn^(2+),Cu^(2+),Co^(2+), Ni^(2+))complexes with each of the above three ligands have been synthesized and characterized by means of elemental analyses,IR,TG and X-ray powder diffraction.

关键词： IR PRELIMINARY STUDIES ON THE SYNTHESIS AND CHARACTERIZATION OF OXY-AND THIO-DIACETIC ACID HYDRAZITION AND THEIR FIRST-ROW TRANSITION METAL COMPLEXES ACID